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20.518 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Vitamin A-aldehyde adducts: AMD risk and targeted therapeutics [Medical Sciences]

26.04.2016 | Janet R. Sparrow, Proceedings of the National Academy of Sciences current issue, 2016

Although currently available treatment options for age-related macular degeneration (AMD) are limited, particularly for atrophic AMD, the identification of predisposing genetic variations has informed clinical studies addressing therapeutic options such as complement inhibitors and ...

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Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange [Biophysics and Computational Biology]

26.04.2016 | Wookyung Yu; Michael C. Baxa; Isabelle Gagnon; Karl F. Freed; Tobin R. Sosnick, Proceedings of the National Academy of Sciences current issue, 2016

The relationship between folding cooperativity and downhill, or barrier-free, folding of proteins under highly stabilizing conditions remains an unresolved topic, especially for proteins such as λ-repressor that fold on the microsecond timescale. Under aqueous conditions where downhill folding is ...

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Correction for Lee et al., Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice [Correction]

26.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

MICROBIOLOGY Correction for “Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice,” by Eun Kyung Lee, Eun Hye Joo, Kyung-A Song, Bongkum Choi, Miyoung Kim, Seok-Hyung Kim, Sung Joo Kim, and Myung-Soo Kang, which appeared in issue 42, October 20, 2015, of ...

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Correction for Bai et al., Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis [Correction]

26.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOCHEMISTRY Correction for “Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis,” by Lin Bai, Kuan Hu, Tong Wang, Jordan M. Jastrab, K. Heran Darwin, and Huilin Li, which appeared in issue 14, April 5, 2016, of Proc Natl Acad Sci USA (113:E1983–E1992; ...

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Evolution of the knowledge system for agricultural development in the Yaqui Valley, Sonora, Mexico [Sustainability Science]

26.04.2016 | Ellen B. McCullough; Pamela A. Matson, Proceedings of the National Academy of Sciences current issue, 2016

Knowledge systems—networks of linked actors, organizations, and objects that perform a number of knowledge-related functions that link knowledge and know how with action—have played a key role in fostering agricultural development over the last 50 years. We examine the evolution of the knowledge ...

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Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity [Microbiology]

26.04.2016 | Monica Markovski; Jessica L. Bohrhunter; Tania J. Lupoli; Tsuyoshi Uehara; Suzanne Walker; Daniel E. Kahne; Thomas G ..., Proceedings of the National Academy of Sciences current issue, 2016

To fortify their cytoplasmic membrane and protect it from osmotic rupture, most bacteria surround themselves with a peptidoglycan (PG) exoskeleton synthesized by the penicillin-binding proteins (PBPs). As their name implies, these proteins are the targets of penicillin and related antibiotics. We ...

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The role of innovative global institutions in linking knowledge and action [Sustainability Science]

26.04.2016 | Lorrae van Kerkhoff; Nicole A. Szlezák, Proceedings of the National Academy of Sciences current issue, 2016

It is becoming increasingly recognized that our collective ability to tackle complex problems will require the development of new, adaptive, and innovative institutional arrangements that can deal with rapidly changing knowledge and have effective learning capabilities. In this paper, we applied ...

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Moral consequences of becoming unemployed [Economic Sciences]

26.04.2016 | Abigail Barr; Luis Miller; Paloma Ubeda, Proceedings of the National Academy of Sciences current issue, 2016

We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals’ tendencies to acknowledge earned entitlement and incorporate these experiments in a ...

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Resolving the HONO formation mechanism in the ionosphere via ab initio molecular dynamic simulations [Chemistry]

26.04.2016 | Rongxing He; Lei Li; Jie Zhong; Chongqin Zhu; Joseph S. Francisco; Xiao Cheng Zeng, Proceedings of the National Academy of Sciences current issue, 2016

Solar emission produces copious nitrosonium ions (NO+) in the D layer of the ionosphere, 60 to 90 km above the Earth’s surface. NO+ is believed to transfer its charge to water clusters in that region, leading to the formation of gaseous nitrous acid (HONO) and protonated water cluster. The ...

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Cotranslational association of mRNA encoding subunits of heteromeric ion channels [Physiology]

26.04.2016 | Fang Liu; David K. Jones; Willem J. de Lange; Gail A. Robertson, Proceedings of the National Academy of Sciences current issue, 2016

Oligomers of homomeric voltage-gated potassium channels associate early in biogenesis as the nascent proteins emerge from the polysome. Less is known about how proteins emerging from different polysomes associate to form hetero-oligomeric channels. Here, we report that alternate mRNA transcripts ...

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