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16.674 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression [Immunology and Inflammation]

17.02.2015 | Jinwook Choi; Shin Jeon; Seungjin Choi; Kyungsoo Park; Rho Hyun Seong, Proceedings of the National Academy of Sciences current issue, 2015

Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of ...

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Self-affirmation alters the brain's response to health messages and subsequent behavior change [Neuroscience]

17.02.2015 | Emily B. Falk; Matthew Brook O’Donnell; Christopher N. Cascio; Francis Tinney; Yoona Kang; Matthew D. Lieberman; She ..., Proceedings of the National Academy of Sciences current issue, 2015

Health communications can be an effective way to increase positive health behaviors and decrease negative health behaviors; however, those at highest risk are often most defensive and least open to such messages. For example, increasing physical activity among sedentary individuals affects a wide ...

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Quorum sensing and policing of Pseudomonas aeruginosa social cheaters [Microbiology]

17.02.2015 | Meizhen Wang; Amy L. Schaefer; Ajai A. Dandekar; E. Peter Greenberg, Proceedings of the National Academy of Sciences current issue, 2015

The bacterium Pseudomonas aeruginosa is an opportunistic human pathogen that uses a quorum sensing signal cascade to activate expression of dozens of genes when sufficient population densities have been reached. Quorum sensing controls production of several key virulence factors, including ...

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Revealing the density of encoded functions in a viral RNA [Microbiology]

17.02.2015 | Nikesh Patel; Eric C. Dykeman; Robert H. A. Coutts; George P. Lomonossoff; David J. Rowlands; Simon E. V. Phillips; ..., Proceedings of the National Academy of Sciences current issue, 2015

We present direct experimental evidence that assembly of a single-stranded RNA virus occurs via a packaging signal-mediated mechanism. We show that the sequences of coat protein recognition motifs within multiple, dispersed, putative RNA packaging signals, as well as their relative spacing within ...

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Gold-silica quantum rattles for multimodal imaging and therapy [Medical Sciences]

17.02.2015 | Mathew Hembury; Ciro Chiappini; Sergio Bertazzo; Tammy L. Kalber; Glenna L. Drisko; Olumide Ogunlade; Simon Walker-S ..., Proceedings of the National Academy of Sciences current issue, 2015

Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic ...

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DNA barcoding and metabarcoding of standardized samples reveal patterns of marine benthic diversity [Ecology]

17.02.2015 | Matthieu Leray; Nancy Knowlton, Proceedings of the National Academy of Sciences current issue, 2015

Documenting the diversity of marine life is challenging because many species are cryptic, small, and rare, and belong to poorly known groups. New sequencing technologies, especially when combined with standardized sampling, promise to make comprehensive biodiversity assessments and monitoring ...

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Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution [Chemistry]

17.02.2015 | Katharina Schücker; Thorge Holm; Christian Franke; Markus Sauer; Ricardo Benavente, Proceedings of the National Academy of Sciences current issue, 2015

Synaptonemal complexes (SCs) are meiosis-specific multiprotein complexes that are essential for synapsis, recombination, and segregation of homologous chromosomes, but the molecular organization of SCs remains unclear. We used immunofluorescence labeling in combination with super-resolution ...

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Correction for Das et al., Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers [Correction]

17.02.2015 | Proceedings of the National Academy of Sciences current issue, 2015

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers,” by Nabanita Das, Jian Dai, Ivan Hung, Malini R. Rajagopalan, Huan-Xiang Zhou, and Timothy A. Cross, which appeared in ...

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Generation of reactive oxygen species by lethal attacks from competing microbes [Microbiology]

17.02.2015 | Tao G. Dong; Shiqi Dong; Christy Catalano; Richard Moore; Xiaoye Liang; John J. Mekalanos, Proceedings of the National Academy of Sciences current issue, 2015

Whether antibiotics induce the production of reactive oxygen species (ROS) that contribute to cell death is an important yet controversial topic. Here, we report that lethal attacks from bacterial and viral species also result in ROS production in target cells. Using soxS as an ROS reporter, we ...

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An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [Plant Biology]

17.02.2015 | Siamsa M. Doyle; Ash Haeger; Thomas Vain; Adeline Rigal; Corrado Viotti; Małgorzata Łangowska; Qian Ma; Jiří Friml; ..., Proceedings of the National Academy of Sciences current issue, 2015

Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and abundance at the plasma membrane are ...

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