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18.035 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Identification of a triplet pair intermediate in singlet exciton fission in solution [Chemistry]

23.06.2015 | Hannah L. Stern; Andrew J. Musser; Simon Gelinas; Patrick Parkinson; Laura M. Herz; Matthew J. Bruzek; John Anthony; ..., Proceedings of the National Academy of Sciences current issue, 2015

Singlet exciton fission is the spin-conserving transformation of one spin-singlet exciton into two spin-triplet excitons. This exciton multiplication mechanism offers an attractive route to solar cells that circumvent the single-junction Shockley–Queisser limit. Most theoretical descriptions of ...

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Empirical inference of circuitry and plasticity in a kinase signaling network [Biochemistry]

23.06.2015 | Edmund H. Wilkes; Camille Terfve; John G. Gribben; Julio Saez-Rodriguez; Pedro Rodriguez Cutillas, Proceedings of the National Academy of Sciences current issue, 2015

Our understanding of physiology and disease is hampered by the difficulty of measuring the circuitry and plasticity of signaling networks that regulate cell biology, and how these relate to phenotypes. Here, using mass spectrometry-based phosphoproteomics, we systematically characterized the ...

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MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma [Genetics]

23.06.2015 | Ivan Conte; Kristen D. Hadfield; Sara Barbato; Sabrina Carrella; Mariateresa Pizzo; Rajeshwari S. Bhat; Annamaria Ca ..., Proceedings of the National Academy of Sciences current issue, 2015

Ocular developmental disorders, including the group classified as microphthalmia, anophthalmia, and coloboma (MAC) and inherited retinal dystrophies, collectively represent leading causes of hereditary blindness. Characterized by extreme genetic and clinical heterogeneity, the separate groups ...

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Single-molecule analysis reveals widespread structural variation in multiple myeloma [Applied Biological Sciences]

23.06.2015 | Aditya Gupta; Michael Place; Steven Goldstein; Deepayan Sarkar; Shiguo Zhou; Konstantinos Potamousis; Jaehyup Kim; C ..., Proceedings of the National Academy of Sciences current issue, 2015

Multiple myeloma (MM), a malignancy of plasma cells, is characterized by widespread genomic heterogeneity and, consequently, differences in disease progression and drug response. Although recent large-scale sequencing studies have greatly improved our understanding of MM genomes, our knowledge ...

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Random sampling of skewed distributions implies Taylor's power law of fluctuation scaling [Statistics]

23.06.2015 | Joel E. Cohen; Meng Xu, Proceedings of the National Academy of Sciences current issue, 2015

Taylor’s law (TL), a widely verified quantitative pattern in ecology and other sciences, describes the variance in a species’ population density (or other nonnegative quantity) as a power-law function of the mean density (or other nonnegative quantity): Approximately, variance = a(mean)b, a > 0. ...

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Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells [Cell Biology]

23.06.2015 | Muhammad Akhtar Ali; Shady Younis; Ola Wallerman; Rajesh Gupta; Leif Andersson; Tobias Sjöblom, Proceedings of the National Academy of Sciences current issue, 2015

The transcription factor ZBED6 (zinc finger, BED-type containing 6) is a repressor of IGF2 whose action impacts development, cell proliferation, and growth in placental mammals. In human colorectal cancers, IGF2 overexpression is mutually exclusive with somatic mutations in PI3K signaling ...

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Regulation by a chaperone improves substrate selectivity during cotranslational protein targeting [Biochemistry]

23.06.2015 | Aileen Ariosa; Jae Ho Lee; Shuai Wang; Ishu Saraogi; Shu-ou Shan, Proceedings of the National Academy of Sciences current issue, 2015

The ribosome exit site is a crowded environment where numerous factors contact nascent polypeptides to influence their folding, localization, and quality control. Timely and accurate selection of nascent polypeptides into the correct pathway is essential for proper protein biogenesis. To ...

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Calcium activates the light-dependent conductance in melanopsin-expressing photoreceptors of amphioxus [Physiology]

23.06.2015 | Gabriel Peinado; Tomás Osorno; María del Pilar Gomez; Enrico Nasi, Proceedings of the National Academy of Sciences current issue, 2015

Melanopsin, the photopigment of the “circadian” receptors that regulate the biological clock and the pupillary reflex in mammals, is homologous to invertebrate rhodopsins. Evidence supporting the involvement of phosphoinositides in light-signaling has been garnered, but the downstream effectors ...

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Correction for Migliore et al., Sensing of molecules using quantum dynamics [Correction]

23.06.2015 | Proceedings of the National Academy of Sciences current issue, 2015

CHEMISTRY Correction for “Sensing of molecules using quantum dynamics,” by Agostino Migliore, Ron Naaman, and David N. Beratan, which appeared in issue 19, May 12, 2015, of Proc Natl Acad Sci USA (112:E2419–E2428; first published April 24, 2015; 10.1073/pnas.1502000112). The authors note that on ...

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No time for waiting: Statistical structure reflects subjective complexity [Biological Sciences]

23.06.2015 | Aleksandar Aksentijevic, Proceedings of the National Academy of Sciences current issue, 2015

Apparent inability of human observers to understand and mimic randomness has occupied researchers for a long time. According to a recent report, the special status of streaks in randomness perception reflects sensitivity to subtle statistical properties of pattern structure. In PNAS, Sun et al. ...

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