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14.421 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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DNA looping-dependent autorepression of LEE1 P1 promoters by Ler in enteropathogenic Escherichia coli (EPEC) [Microbiology]

24.06.2014 | Abhayprasad Bhat; Minsang Shin; Jae-Ho Jeong; Hyun-Ju Kim; Hyung-Ju Lim; Joon Haeng Rhee; Soon-Young Paik; Kunio Tak ..., Proceedings of the National Academy of Sciences current issue, 2014

Ler, a homolog of H-NS in enteropathogenic Escherichia coli (EPEC), plays a critical role in the expression of virulence genes encoded by the pathogenic island, locus of enterocyte effacement (LEE). Although Ler acts as an antisilencer of multiple LEE operons by alleviating H-NS–mediated ...

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Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice [Immunology]

24.06.2014 | Joerg Ermann; Tracy Staton; Jonathan N. Glickman; Rene de Waal Malefyt; Laurie H. Glimcher, Proceedings of the National Academy of Sciences current issue, 2014

T-bet−/−.Rag2−/− (TRUC) mice spontaneously develop microbiota-driven, TNF-mediated large bowel inflammation that resembles human ulcerative colitis. We show here that IL-23 and IL-1–dependent secretion of IL-17A by innate lymphoid cells (ILCs; defined as CD45+lin−Thy1hiNKp46−) is a second ...

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Correction for Woo et al., Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases [Correction]

24.06.2014 | Proceedings of the National Academy of Sciences current issue, 2014

PLANT BIOLOGY Correction for “Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases,” by Jongchan Woo, Eunsook Park, and S. P. Dinesh-Kumar, which appeared in issue 2, January 14, 2014, of Proc Natl Acad Sci USA (111:863–868; first published ...

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Immersive audiomotor game play enhances neural and perceptual salience of weak signals in noise [Neuroscience]

24.06.2014 | Jonathon P. Whitton; Kenneth E. Hancock; Daniel B. Polley, Proceedings of the National Academy of Sciences current issue, 2014

All sensory systems face the fundamental challenge of encoding weak signals in noisy backgrounds. Although discrimination abilities can improve with practice, these benefits rarely generalize to untrained stimulus dimensions. Inspired by recent findings that action video game training can impart ...

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Social identification moderates the effect of crowd density on safety at the Hajj [Psychological and Cognitive Sciences]

24.06.2014 | Hani Alnabulsi; John Drury, Proceedings of the National Academy of Sciences current issue, 2014

Crowd safety is a major concern for those attending and managing mass gatherings, such as the annual Hajj or pilgrimage to Mecca (also called Makkah). One threat to crowd safety at such events is crowd density. However, recent research also suggests that psychological membership of crowds can ...

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A pathway of a hundred genes starts with a single mutant: Isolation of sec1-1 [Commentaries]

24.06.2014 | Peter J. Novick, Proceedings of the National Academy of Sciences current issue, 2014

The announcement of the 2013 Nobel Prize for Physiology or Medicine to Randy Schekman, James Rothman, and Thomas Südhof cited a number of papers, including an article published in 1979 in PNAS describing the isolation and characterization of the first yeast secretory mutant, sec 1–1. This paper, ...

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Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1•Nup98) [Biochemistry]

24.06.2014 | Beili Quan; Hyuk-Soo Seo; Günter Blobel; Yi Ren, Proceedings of the National Academy of Sciences current issue, 2014

mRNA export factor 1 (Rae1) and nucleoporin 98 (Nup98) are host cell targets for the matrix (M) protein of vesicular stomatitis virus (VSV). How Rae1 functions in mRNA export and how M protein targets both Rae1 and Nup98 are not understood at the molecular level. To obtain structural insights, ...

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In This Issue [This Week in PNAS]

24.06.2014 | Proceedings of the National Academy of Sciences current issue, 2014

Challenges facing broad-spectrum snakebite treatments Sochurek’s saw-scaled viper (Echis carinatus sochureki), found near Sharjah, United Arab Emirates. Every year, snakebites kill up to 90,000 people worldwide, mostly in impoverished, rural tropical areas. Because snake venoms vary widely, ...

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Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria [Microbiology]

24.06.2014 | Rembrandt J. F. Haft; David H. Keating; Tyler Schwaegler; Michael S. Schwalbach; Jeffrey Vinokur; Mary Tremaine; Jas ..., Proceedings of the National Academy of Sciences current issue, 2014

The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important for biotechnology and bioenergy applications, remain incompletely understood. Genetic studies have identified potential cellular targets for ethanol and have revealed multiple mechanisms of tolerance, but ...

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Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens [Medical Sciences]

24.06.2014 | Chunyu Jin; Liuqing Yang; Min Xie; Chunru Lin; Daria Merkurjev; Joy C. Yang; Bogdan Tanasa; Soohwan Oh; Jie Zhang; K ..., Proceedings of the National Academy of Sciences current issue, 2014

Understanding the mechanisms by which compounds discovered using cell-based phenotypic screening strategies might exert their effects would be highly augmented by new approaches exploring their potential interactions with the genome. For example, altered androgen receptor (AR) transcriptional ...

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