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16.157 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Links that speak: The global language network and its association with global fame [Applied Physical Sciences]

30.12.2014 | Shahar Ronen; Bruno Gonçalves; Kevin Z. Hu; Alessandro Vespignani; Steven Pinker; César A. Hidalgo, Proceedings of the National Academy of Sciences current issue, 2014

Languages vary enormously in global importance because of historical, demographic, political, and technological forces. However, beyond simple measures of population and economic power, there has been no rigorous quantitative way to define the global influence of languages. Here we use the ...

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Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure [Biochemistry]

30.12.2014 | James M. Kovacs; Erik Noeldeke; Heather Jiwon Ha; Hanqin Peng; Sophia Rits-Volloch; Stephen C. Harrison; Bing Chen, Proceedings of the National Academy of Sciences current issue, 2014

The HIV-1 envelope spike [trimeric (gp160)3, cleaved to (gp120/gp41)3] is the mediator of viral entry and the principal target of humoral immune response to the virus. Production of a recombinant preparation that represents the functional spike poses a challenge for vaccine development, because ...

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The curious case of the Arctic mastodons [Earth, Atmospheric, and Planetary Sciences]

30.12.2014 | Duane Froese, Proceedings of the National Academy of Sciences current issue, 2014

In 1796, the French anatomist Georges Cuvier sparked widespread interest in the idea that many organisms, including some large mammals, had gone extinct in the recent geologic past (1). He proposed, based on the morphology and function of molars, that African and Indian elephants were separate ...

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Maternal temperature history activates Flowering Locus T in fruits to control progeny dormancy according to time of year [Plant Biology]

30.12.2014 | Min Chen; Dana R. MacGregor; Anuja Dave; Hannah Florance; Karen Moore; Konrad Paszkiewicz; Nicholas Smirnoff; Ian A. ..., Proceedings of the National Academy of Sciences current issue, 2014

Seasonal behavior is important for fitness in temperate environments but it is unclear how progeny gain their initial seasonal entrainment. Plants use temperature signals to measure time of year, and changes to life histories are therefore an important consequence of climate change. Here we show ...

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GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake [Medical Sciences]

30.12.2014 | Yicong Li; Coedy Hadden; Preeti Singh; Charles P. Mercado; Pamela Murphy; Nafisa K. Dajani; Curtis L. Lowery; Drucil ..., Proceedings of the National Academy of Sciences current issue, 2014

Serotonin (5-HT) transporter (SERT) regulates the level of 5-HT in placenta. Initially, we found that in gestational diabetes mellitus (GDM), whereas free plasma 5-HT levels were elevated, the 5-HT uptake rates of trophoblast were significantly down-regulated, due to impairment in the ...

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Correction for Hodes et al., Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress [Correction]

30.12.2014 | Proceedings of the National Academy of Sciences current issue, 2014

NEUROSCIENCE Correction for “Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress,” by Georgia E. Hodes, Madeline L. Pfau, Marylene Leboeuf, Sam A. Golden, Daniel J. Christoffel, Dana Bregman, Nicole Rebusi, Mitra Heshmati, Hossein ...

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Electrically pumped semiconductor laser with monolithic control of circular polarization [Applied Physical Sciences]

30.12.2014 | Patrick Rauter; Jiao Lin; Patrice Genevet; Suraj P. Khanna; Mohammad Lachab; A. Giles Davies; Edmund H. Linfield; Fe ..., Proceedings of the National Academy of Sciences current issue, 2014

We demonstrate surface emission of terahertz (THz) frequency radiation from a monolithic quantum cascade laser with built-in control over the degree of circular polarization by “fishbone” gratings composed of orthogonally oriented aperture antennas. Different grating concepts for circularly ...

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TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA [Biophysics and Computational Biology]

30.12.2014 | Haina Qin; Liang-Zhong Lim; Yuanyuan Wei; Jianxing Song, Proceedings of the National Academy of Sciences current issue, 2014

Transactivation response element (TAR) DNA-binding protein 43 (TDP-43) is the principal component of ubiquitinated inclusions characteristic of most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia-frontotemporal lobar degeneration with TDP-43–positive inclusions ...

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Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif [Biochemistry]

30.12.2014 | Lanfeng Wang; Oliver Limbo; Jia Fei; Lu Chen; Bong Kim; Jie Luo; Jenny Chong; Ronald C. Conaway; Joan W. Conaway; Je ..., Proceedings of the National Academy of Sciences current issue, 2014

CSB/ERCC6 (Cockayne syndrome B protein/excision repair cross-complementation group 6), a member of a subfamily of SWI2/SNF2 (SWItch/sucrose nonfermentable)-related chromatin remodelers, plays crucial roles in gene expression and the maintenance of genome integrity. Here, we report the mechanism ...

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Economic optimization of a global strategy to address the pandemic threat [Medical Sciences]

30.12.2014 | Jamison Pike; Tiffany Bogich; Sarah Elwood; David C. Finnoff; Peter Daszak, Proceedings of the National Academy of Sciences current issue, 2014

Emerging pandemics threaten global health and economies and are increasing in frequency. Globally coordinated strategies to combat pandemics, similar to current strategies that address climate change, are largely adaptive, in that they attempt to reduce the impact of a pathogen after it has ...

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