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13.633 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition [Cell Biology]

15.04.2014 | Anan Yu; Yoko Shibata; Bijal Shah; Barbara Calamini; Donald C. Lo; Richard I. Morimoto, Proceedings of the National Academy of Sciences current issue, 2014

Protein conformational diseases exhibit complex pathologies linked to numerous molecular defects. Aggregation of a disease-associated protein causes the misfolding and aggregation of other proteins, but how this interferes with diverse cellular pathways is unclear. Here, we show that aggregation ...

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Identifying regulatory mechanisms underlying tumorigenesis using locus expression signature analysis [Systems Biology]

15.04.2014 | Eunjee Lee; Jeroen de Ridder; Jaap Kool; Lodewyk F. A. Wessels; Harmen J. Bussemaker, Proceedings of the National Academy of Sciences current issue, 2014

Retroviral insertional mutagenesis is a powerful tool for identifying putative cancer genes in mice. To uncover the regulatory mechanisms by which common insertion loci affect downstream processes, we supplemented genotyping data with genome-wide mRNA expression profiling data for 97 tumors ...

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Understanding the mechanism of proteasome 20S core particle gating [Chemistry]

15.04.2014 | Michael P. Latham; Ashok Sekhar; Lewis E. Kay, Proceedings of the National Academy of Sciences current issue, 2014

The 20S core particle proteasome is a molecular machine playing an important role in cellular function by degrading protein substrates that no longer are required or that have become damaged. Regulation of proteasome activity occurs, in part, through a gating mechanism controlling the sizes of ...

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Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype [Medical Sciences]

15.04.2014 | Jan M. McAllister; Bhavi Modi; Bruce A. Miller; Jessica Biegler; Richard Bruggeman; Richard S. Legro; Jerome F. Stra ..., Proceedings of the National Academy of Sciences current issue, 2014

Polycystic ovary syndrome (PCOS), characterized by increased ovarian androgen biosynthesis, anovulation, and infertility, affects 5–7% of reproductive-age women. Genome-wide association studies identified PCOS candidate loci that were replicated in subsequent reports, including DENND1A, which ...

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Abscisic acid sensor RCAR7/PYL13, specific regulator of protein phosphatase coreceptors [Plant Biology]

15.04.2014 | Stefan Fuchs; Stefanie V. Tischer; Christian Wunschel; Alexander Christmann; Erwin Grill, Proceedings of the National Academy of Sciences current issue, 2014

The plant hormone abscisic acid (ABA) acts both as a developmental signal and as an integrator of environmental cues such as drought and cold. ABA perception recruits an ABA-binding regulatory component [regulatory component of ABA receptor (RCAR)/PYR1/PYL] and an associated protein phosphatase ...

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From a structural average to the conformational ensemble of a DNA bulge [Biophysics and Computational Biology]

15.04.2014 | Xuesong Shi; Kyle A. Beauchamp; Pehr B. Harbury; Daniel Herschlag, Proceedings of the National Academy of Sciences current issue, 2014

Direct experimental measurements of conformational ensembles are critical for understanding macromolecular function, but traditional biophysical methods do not directly report the solution ensemble of a macromolecule. Small-angle X-ray scattering interferometry has the potential to overcome this ...

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Correction for Tompkins et al., Testing Turing's theory of morphogenesis in chemical cells [Correction]

15.04.2014 | Proceedings of the National Academy of Sciences current issue, 2014

PHYSICS Correction for “Testing Turing’s theory of morphogenesis in chemical cells,” by Nathan Tompkins, Ning Li, Camille Girabawe, Michael Heymann, G. Bard Ermentrout, Irving R. Epstein, and Seth Fraden, which appeared in issue 12, March 25, 2014, of Proc Natl Acad Sci USA (111:4397–4402; first ...

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Neural representations of ethologically relevant hand/mouth synergies in the human precentral gyrus [Neuroscience]

15.04.2014 | Michel Desmurget; Nathalie Richard; Sylvain Harquel; Pierre Baraduc; Alexandru Szathmari; Carmine Mottolese; Angela ..., Proceedings of the National Academy of Sciences current issue, 2014

Complex motor responses are often thought to result from the combination of elemental movements represented at different neural sites. However, in monkeys, evidence indicates that some behaviors with critical ethological value, such as self-feeding, are represented as motor primitives in the ...

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Sumoylation differentially regulates Sp1 to control cell differentiation [Cell Biology]

15.04.2014 | Lili Gong; Wei-Ke Ji; Xiao-Hui Hu; Wen-Feng Hu; Xiang-Cheng Tang; Zhao-Xia Huang; Ling Li; Mugen Liu; Shi-Hua Xiang; ..., Proceedings of the National Academy of Sciences current issue, 2014

The mammalian small ubiquitin-like modifiers (SUMOs) are actively involved in regulating differentiation of different cell types. However, the functional differences between SUMO isoforms and their mechanisms of action remain largely unknown. Using the ocular lens as a model system, we ...

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Angucyclines as signals modulate the behaviors of Streptomyces coelicolor [Microbiology]

15.04.2014 | Weishan Wang; Junjie Ji; Xiao Li; Juan Wang; Shanshan Li; Guohui Pan; Keqiang Fan; Keqian Yang, Proceedings of the National Academy of Sciences current issue, 2014

The angucycline antibiotic jadomycin B (JdB) produced by Streptomyces venezuelae has been found here to induce complex survival responses in Streptomyces coelicolor at subinhibitory concentration. The receptor for JdB was identified as a “pseudo” gamma-butyrolactone receptor, ScbR2, which was ...

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