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14.733 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Spatial embedding of structural similarity in the cerebral cortex [Neuroscience]

18.11.2014 | H. Francis Song; Henry Kennedy; Xiao-Jing Wang, Proceedings of the National Academy of Sciences current issue, 2014

Recent anatomical tracing studies have yielded substantial amounts of data on the areal connectivity underlying distributed processing in cortex, yet the fundamental principles that govern the large-scale organization of cortex remain unknown. Here we show that functional similarity between areas ...

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Defense mutualisms enhance plant diversification [Evolution]

18.11.2014 | Marjorie G. Weber; Anurag A. Agrawal, Proceedings of the National Academy of Sciences current issue, 2014

The ability of plants to form mutualistic relationships with animal defenders has long been suspected to influence their evolutionary success, both by decreasing extinction risk and by increasing opportunity for speciation through an expanded realized niche. Nonetheless, the hypothesis that ...

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Disentangling the effects of CO2 and short-lived climate forcer mitigation [Sustainability Science]

18.11.2014 | Joeri Rogelj; Michiel Schaeffer; Malte Meinshausen; Drew T. Shindell; William Hare; Zbigniew Klimont; Guus J. M. Vel ..., Proceedings of the National Academy of Sciences current issue, 2014

Anthropogenic global warming is driven by emissions of a wide variety of radiative forcers ranging from very short-lived climate forcers (SLCFs), like black carbon, to very long-lived, like CO2. These species are often released from common sources and are therefore intricately linked. However, ...

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Late Miocene episodic lakes in the arid Tarim Basin, western China [Earth, Atmospheric, and Planetary Sciences]

18.11.2014 | Weiguo Liu; Zhonghui Liu; Zhisheng An; Jimin Sun; Hong Chang; Ning Wang; Jibao Dong; Huanye Wang, Proceedings of the National Academy of Sciences current issue, 2014

The Tibetan Plateau uplift and Cenozoic global cooling are thought to induce enhanced aridification in the Asian interior. Although the onset of Asian desertification is proposed to have started in the earliest Miocene, prevailing desert environment in the Tarim Basin, currently providing much of ...

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Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex [Immunology and Inflammation]

18.11.2014 | Gregory J. Fredericks; FuKun W. Hoffmann; Aaron H. Rose; Hanna J. Osterheld; Franz M. Hess; Frederic Mercier; Peter ..., Proceedings of the National Academy of Sciences current issue, 2014

Calcium (Ca2+) is a secondary messenger in cells and Ca2+ flux initiated from endoplasmic reticulum (ER) stores via inositol 1,4,5-triphosphate (IP3) binding to the IP3 receptor (IP3R) is particularly important for the activation and function of immune cells. Previous studies demonstrated that ...

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Inner Workings: Story of an empire encased in tree rings [Inner Workings]

18.11.2014 | Danielle Venton, Proceedings of the National Academy of Sciences current issue, 2014

A centuries old lava flow, spreading from the base of the now dormant Khorgo volcano in Central Mongolia, seems an unlikely place to find history lessons. However, on spotting it, Amy Hessl wanted to explore. In this lava flow, Hessl supposed, could be clues to how, many centuries ago, a...

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Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis [Medical Sciences]

18.11.2014 | Shan-Shan Wang; Yi-Feng Gu; Nicholas Wolff; Karoliina Stefanius; Alana Christie; Anwesha Dey; Robert E. Hammer; Xian ..., Proceedings of the National Academy of Sciences current issue, 2014

Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes relative to one another influences tumor predisposition is unknown. Renal cancer presents a unique opportunity to explore this question. ...

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New pasture plants intensify invasive species risk [Sustainability Science]

18.11.2014 | Don A. Driscoll; Jane A. Catford; Jacob N. Barney; Philip E. Hulme; Inderjit; Tara G. Martin; Aníbal Pauchard; Petr ..., Proceedings of the National Academy of Sciences current issue, 2014

Agricultural intensification is critical to meet global food demand, but intensification threatens native species and degrades ecosystems. Sustainable intensification (SI) is heralded as a new approach for enabling growth in agriculture while minimizing environmental impacts. However, the SI ...

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Isotopic signals of summer denitrification in a northern hardwood forested catchment [Environmental Sciences]

18.11.2014 | Sarah K. Wexler; Christine L. Goodale; Kevin J. McGuire; Scott W. Bailey; Peter M. Groffman, Proceedings of the National Academy of Sciences current issue, 2014

Despite decades of measurements, the nitrogen balance of temperate forest catchments remains poorly understood. Atmospheric nitrogen deposition often greatly exceeds streamwater nitrogen losses; the fate of the remaining nitrogen is highly uncertain. Gaseous losses of nitrogen to denitrification ...

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RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation [Cell Biology]

18.11.2014 | Woosook Kim; David A. Barron; Rebeca San Martin; Keith S. Chan; Linda L. Tran; Feng Yang; Steven J. Ressler; David R ..., Proceedings of the National Academy of Sciences current issue, 2014

Myofibroblasts are a key cell type in wound repair, cardiovascular disease, and fibrosis and in the tumor-promoting microenvironment. The high accumulation of myofibroblasts in reactive stroma is predictive of the rate of cancer progression in many different tumors, yet the cell types of origin ...

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