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15.318 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin [Pharmacology]

14.10.2014 | Lynnie Trzoss; Takashi Fukuda; Letícia V. Costa-Lotufo; Paula Jimenez; James J. La Clair; William Fenical, Proceedings of the National Academy of Sciences current issue, 2014

Natural products continue to provide vital treatment options for cancer. Although their translation into chemotherapeutics is complex, collaborative programs continue to deliver productive pipelines for cancer chemotherapy. A new natural product, seriniquinone, isolated from a marine bacterium of ...

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A diagnostic role for dense cells in sickle cell disease [Medical Sciences]

14.10.2014 | Natasha M. Archer, Proceedings of the National Academy of Sciences current issue, 2014

Neonatal screening for sickle cell disease (SCD), when linked to early diagnostic testing, parental education, and comprehensive care, markedly reduces morbidity and mortality from the disease in infancy and early childhood (1, 2). Largely unaddressed, the inability to diagnose SCD rapidly, ...

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Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases [Neuroscience]

14.10.2014 | Michael D. Fox; Randy L. Buckner; Hesheng Liu; M. Mallar Chakravarty; Andres M. Lozano; Alvaro Pascual-Leone, Proceedings of the National Academy of Sciences current issue, 2014

Brain stimulation, a therapy increasingly used for neurological and psychiatric disease, traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and noninvasive approaches, such as transcranial magnetic stimulation. The relationship between these approaches is ...

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Single-spin stochastic optical reconstruction microscopy [Applied Physical Sciences]

14.10.2014 | Matthias Pfender; Nabeel Aslam; Gerald Waldherr; Philipp Neumann; Jörg Wrachtrup, Proceedings of the National Academy of Sciences current issue, 2014

We experimentally demonstrate precision addressing of single-quantum emitters by combined optical microscopy and spin resonance techniques. To this end, we use nitrogen vacancy (NV) color centers in diamond confined within a few ten nanometers as individually resolvable quantum systems. By ...

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Retroviral envelope syncytin capture in an ancestrally diverged mammalian clade for placentation in the primitive Afrotherian tenrecs [Microbiology]

14.10.2014 | Guillaume Cornelis; Cécile Vernochet; Sébastien Malicorne; Sylvie Souquere; Athanasia C. Tzika; Steven M. Goodman; F ..., Proceedings of the National Academy of Sciences current issue, 2014

Syncytins are fusogenic envelope (env) genes of retroviral origin that have been captured for a function in placentation. Syncytins have been identified in Euarchontoglires (primates, rodents, Leporidae) and Laurasiatheria (Carnivora, ruminants) placental mammals. Here, we searched for similar ...

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Designer substrate library for quantitative, predictive modeling of reaction performance [Chemistry]

14.10.2014 | Elizabeth N. Bess; Amanda J. Bischoff; Matthew S. Sigman, Proceedings of the National Academy of Sciences current issue, 2014

Assessment of reaction substrate scope is often a qualitative endeavor that provides general indications of substrate sensitivity to a measured reaction outcome. Unfortunately, this field standard typically falls short of enabling the quantitative prediction of new substrates’ performance. The ...

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Delayed Ras/PKA signaling augments the unfolded protein response [Cell Biology]

14.10.2014 | David Pincus; Andrés Aranda-Díaz; Ignacio A. Zuleta; Peter Walter; Hana El-Samad, Proceedings of the National Academy of Sciences current issue, 2014

During environmental, developmental, or genetic stress, the cell’s folding capacity can become overwhelmed, and misfolded proteins can accumulate in all cell compartments. Eukaryotes evolved the unfolded protein response (UPR) to counteract proteotoxic stress in the endoplasmic reticulum (ER). ...

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Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion [Biophysics and Computational Biology]

14.10.2014 | Damian C. Ekiert; Jeffery S. Cox, Proceedings of the National Academy of Sciences current issue, 2014

Nearly 10% of the coding capacity of the Mycobacterium tuberculosis genome is devoted to two highly expanded and enigmatic protein families called PE and PPE, some of which are important virulence/immunogenicity factors and are secreted during infection via a unique alternative secretory system ...

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Mantle updrafts and mechanisms of oceanic volcanism [Earth, Atmospheric, and Planetary Sciences]

14.10.2014 | Don L. Anderson; James H. Natland, Proceedings of the National Academy of Sciences current issue, 2014

Convection in an isolated planet is characterized by narrow downwellings and broad updrafts—consequences of Archimedes’ principle, the cooling required by the second law of thermodynamics, and the effect of compression on material properties. A mature cooling planet with a conductive ...

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Entrained neural oscillations in multiple frequency bands comodulate behavior [Neuroscience]

14.10.2014 | Molly J. Henry; Björn Herrmann; Jonas Obleser, Proceedings of the National Academy of Sciences current issue, 2014

Our sensory environment is teeming with complex rhythmic structure, to which neural oscillations can become synchronized. Neural synchronization to environmental rhythms (entrainment) is hypothesized to shape human perception, as rhythmic structure acts to temporally organize cortical ...

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