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18.740 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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NLRP12 provides a critical checkpoint for osteoclast differentiation [Immunology and Inflammation]

18.08.2015 | Jennifer L. Krauss; Rong Zeng; Cynthia L. Hickman-Brecks; Justin E. Wilson; Jenny P.-Y. Ting; Deborah V. Novack, Proceedings of the National Academy of Sciences current issue, 2015

The alternative or noncanonical nuclear factor kappa B (NF-κB) pathway regulates the osteoclast (OC) response to receptor activator of nuclear factor kappa B ligand (RANKL) and thus bone metabolism. Although several lines of evidence support the emerging concept that nucleotide-binding ...

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Heritable symbiosis: The advantages and perils of an evolutionary rabbit hole [Colloquium Paper]

18.08.2015 | Gordon M. Bennett; Nancy A. Moran, Proceedings of the National Academy of Sciences current issue, 2015

Many eukaryotes have obligate associations with microorganisms that are transmitted directly between generations. A model for heritable symbiosis is the association of aphids, a clade of sap-feeding insects, and Buchnera aphidicola, a gammaproteobacterium that colonized an aphid ancestor 150 ...

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Switching of perpendicularly polarized nanomagnets with spin orbit torque without an external magnetic field by engineering a tilted anisotropy [Engineering]

18.08.2015 | Long You; OukJae Lee; Debanjan Bhowmik; Dominic Labanowski; Jeongmin Hong; Jeffrey Bokor; Sayeef Salahuddin, Proceedings of the National Academy of Sciences current issue, 2015

Spin orbit torque (SOT) provides an efficient way to significantly reduce the current required for switching nanomagnets. However, SOT generated by an in-plane current cannot deterministically switch a perpendicularly polarized magnet due to symmetry reasons. On the other hand, perpendicularly ...

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Correction to Supporting Information for Kurcon et al., miRNA proxy approach reveals hidden functions of glycosylation [SI Corrections]

18.08.2015 | Proceedings of the National Academy of Sciences current issue, 2015

SYSTEMS BIOLOGY Correction to Supporting Information for “miRNA proxy approach reveals hidden functions of glycosylation,” by Tomasz Kurcon, Zhongyin Liu, Anika V. Paradkar, Christopher A. Vaiana, Sujeethraj Koppolu, Praveen Agrawal, and Lara K. Mahal, which appeared in issue 23, June 9, 2015, of ...

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Creative template-dependent synthesis by human polymerase mu [Biochemistry]

18.08.2015 | Andrea F. Moon; Rajendrakumar A. Gosavi; Thomas A. Kunkel; Lars C. Pedersen; Katarzyna Bebenek, Proceedings of the National Academy of Sciences current issue, 2015

Among the many proteins used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family X DNA polymerases, Pol λ and Pol µ. Which of these two polymerases is preferentially used for filling DNA gaps during NHEJ partly depends on sequence complementarity at the ...

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Self-control forecasts better psychosocial outcomes but faster epigenetic aging in low-SES youth [Psychological and Cognitive Sciences]

18.08.2015 | Gregory E. Miller; Tianyi Yu; Edith Chen; Gene H. Brody, Proceedings of the National Academy of Sciences current issue, 2015

There are persistent socioeconomic disparities in many aspects of child development in America. Relative to their affluent peers, children of low socioeconomic status (SES) complete fewer years of education, have a higher prevalence of health problems, and are convicted of more criminal offenses. ...

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Synthetic physical interactions map kinetochore regulators and regions sensitive to constitutive Cdc14 localization [Cell Biology]

18.08.2015 | Guðjón Ólafsson; Peter H. Thorpe, Proceedings of the National Academy of Sciences current issue, 2015

The location of proteins within eukaryotic cells is often critical for their function and relocation of proteins forms the mainstay of regulatory pathways. To assess the importance of protein location to cellular homeostasis, we have developed a methodology to systematically create binary ...

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Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides [Chemistry]

18.08.2015 | Benjamin E. Allred; Peter B. Rupert; Stacey S. Gauny; Dahlia D. An; Corie Y. Ralston; Manuel Sturzbecher-Hoehne; Rol ..., Proceedings of the National Academy of Sciences current issue, 2015

Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide transport is instrumental in managing human contamination. Here we show that ...

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How amide hydrogens exchange in native proteins [Biophysics and Computational Biology]

18.08.2015 | Filip Persson; Bertil Halle, Proceedings of the National Academy of Sciences current issue, 2015

Amide hydrogen exchange (HX) is widely used in protein biophysics even though our ignorance about the HX mechanism makes data interpretation imprecise. Notably, the open exchange-competent conformational state has not been identified. Based on analysis of an ultralong molecular dynamics ...

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Countering antivaccination attitudes [Medical Sciences]

18.08.2015 | Zachary Horne; Derek Powell; John E. Hummel; Keith J. Holyoak, Proceedings of the National Academy of Sciences current issue, 2015

Three times as many cases of measles were reported in the United States in 2014 as in 2013. The reemergence of measles has been linked to a dangerous trend: parents refusing vaccinations for their children. Efforts have been made to counter people’s antivaccination attitudes by providing ...

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