01.07.2013 | Zbigniew Korwek; Anna Bielak-Zmijewska; Grazyna Mosieniak; Olga Alster; Maria Moreno-Villanueva; Alexander Burkle; E ..., Mutagenesis, 2013

Curcumin, a phytochemical derived from the rhizome of Curcuma longa, is a very potent inducer of cancer cell death. It is believed that cancer cells are more sensitive to curcumin treatment than normal cells. Curcumin has been shown to act as a prooxidant and induce DNA lesions in normal ...

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01.07.2013 | Haiyan Chu; Dongying Gu; Ming Xu; Zhi Xu; Yonglin Gong; Weida Gong; Yongfei Tang; Jianwei Zhou; Na Tong; Zhengdong Z ..., Mutagenesis, 2013

Endogenous and exogenous factors can induce DNA damage, leading to increased risk of cancer. Nucleotide excision repair (NER) is considered as the most versatile DNA repair pathway to deal with a variety of different DNA lesions. ERCC1 and ERCC2 are the two important proteins in NER pathway. ...

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01.07.2013 | Weichen Zhou; Feng Zhang; Xiaoli Chen; Yiping Shen; James R. Lupski; Li Jin, Human Molecular Genetics, 2013

Environmental factors including ionizing radiation and chemical agents have been known to be able to induce DNA rearrangements and cause genomic structural variations (SVs); however, the roles of intrinsic characteristics of the human genome, such as regional genome architecture, in SV ...

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01.07.2013 | Diana L. Cousminer; Diane J. Berry; Nicholas J. Timpson; Wei Ang; Elisabeth Thiering; Enda M. Byrne; H. Rob Taal; Vi ..., Human Molecular Genetics, 2013

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent ...

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15.06.2013 | Sriganesh Srihari; Mark A. Ragan, Bioinformatics, 2013

Motivation: Deciphering the modus operandi of dysregulated cellular mechanisms in cancer is critical to implicate novel cancer genes and develop effective anti-cancer therapies. Fundamental to this is meticulous tracking of the behavior of core modules, including complexes and pathways ...

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15.06.2013 | Hashem A. Shihab; Julian Gough; David N. Cooper; Ian N. M. Day; Tom R. Gaunt, Bioinformatics, 2013

Motivation: The number of missense mutations being identified in cancer genomes has greatly increased as a consequence of technological advances and the reduced cost of whole-genome/whole-exome sequencing methods. However, a high proportion of the amino acid substitutions detected in cancer ...

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15.06.2013 | Nancy F. Hansen; Jared J. Gartner; Lan Mei; Yardena Samuels; James C. Mullikin, Bioinformatics, 2013

Motivation: Extensive DNA sequencing of tumor and matched normal samples using exome and whole-genome sequencing technologies has enabled the discovery of recurrent genetic alterations in cancer cells, but variability in stromal contamination and subclonal heterogeneity still present a ...

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15.06.2013 | Romal Stewart; Sergei Kozlov; Nicholas Matigian; Gautam Wali; Magtouf Gatei; Ratneswary Sutharsan; Bernadette Bellet ..., Human Molecular Genetics, 2013

The autosomal recessive disorder ataxia-telangiectasia (A-T) is characterized by genome instability, cancer predisposition and neurodegeneration. Although the role of ataxia-telangiectasia mutated (ATM) protein, the protein defective in this syndrome, is well described in the response to DNA ...

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15.06.2013 | Wei Zheng; Ben Zhang; Qiuyin Cai; Hyuna Sung; Kyriaki Michailidou; Jiajun Shi; Ji-Yeob Choi; Jirong Long; Joe Dennis ..., Human Molecular Genetics, 2013

In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily ...

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15.06.2013 | Zsofia Kote-Jarai; Edward J. Saunders; Daniel A. Leongamornlert; Malgorzata Tymrakiewicz; Tokhir Dadaev; Sarah Jugur ..., Human Molecular Genetics, 2013

Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene ...

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