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1.169 Aktuelle Fachpublikationen von Oxford University Press

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Coupling Deep Transcriptome Analysis with Untargeted Metabolic Profiling in Ophiorrhiza pumila to Further the Understanding of the Biosynthesis of the Anti-Cancer Alkaloid Camptothecin and Anthraquinones

01.05.2013 | Mami Yamazaki; Keiichi Mochida; Takashi Asano; Ryo Nakabayashi; Motoaki Chiba; Nirin Udomson; Yasuyo Yamazaki; Dayan ..., Plant and Cell Physiology, 2013

The Rubiaceae species, Ophiorrhiza pumila, accumulates camptothecin, an anti-cancer alkaloid with a potent DNA topoisomerase I inhibitory activity, as well as anthraquinones that are derived from the combination of the isochorismate and hemiterpenoid pathways. The biosynthesis of these ...

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Combinatorial Biosynthesis of Legume Natural and Rare Triterpenoids in Engineered Yeast

01.05.2013 | Ery O. Fukushima; Hikaru Seki; Satoru Sawai; Munenori Suzuki; Kiyoshi Ohyama; Kazuki Saito; Toshiya Muranaka, Plant and Cell Physiology, 2013

Triterpenoid saponins are a diverse group of specialized (secondary) metabolites with many biological properties. The model legume Medicago truncatula has an interesting profile of triterpenoid saponins from which sapogenins are differentiated into hemolytic and non-hemolytic types according ...

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CathaCyc, a Metabolic Pathway Database Built from Catharanthus roseus RNA-Seq Data

01.05.2013 | Alex Van Moerkercke; Michele Fabris; Jacob Pollier; Gino J.E. Baart; Stephane Rombauts; Ghulam Hasnain; Heiko Rische ..., Plant and Cell Physiology, 2013

The medicinal plant Madagascar periwinkle (Catharanthus roseus) synthesizes numerous terpenoid indole alkaloids (TIAs), such as the anticancer drugs vinblastine and vincristine. The TIA pathway operates in a complex metabolic network that steers plant growth and survival. Pathway databases ...

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Suppression of {gamma}-Aminobutyric Acid (GABA) Transaminases Induces Prominent GABA Accumulation, Dwarfism and Infertility in the Tomato (Solanum lycopersicum L.)

01.05.2013 | Satoshi Koike; Chiaki Matsukura; Mariko Takayama; Erika Asamizu; Hiroshi Ezura, Plant and Cell Physiology, 2013

Tomatoes accumulate -aminobutyric acid (GABA) at high levels in the immature fruits. GABA is rapidly converted to succinate during fruit ripening through the activities of GABA transaminase (GABA-T) and succinate semialdehyde dehydrogenase (SSADH). Although three genes encoding GABA-T and ...

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Two WUSCHEL-related homeobox Genes, narrow leaf2 and narrow leaf3, Control Leaf Width in Rice

01.05.2013 | Aiko Ishiwata; Misa Ozawa; Hiroshi Nagasaki; Makio Kato; Yusaku Noda; Takahiro Yamaguchi; Misuzu Nosaka; Sae Shimizu ..., Plant and Cell Physiology, 2013

Leaf shape is one of the key determinants of plant architecture. Leaf shape also affects the amount of sunlight captured and influences photosynthetic efficiency; thus, it is an important agronomic trait in crop plants. Understanding the molecular mechanisms governing leaf shape is a central ...

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Transcriptome Analysis of Developing Ovules in Rice Isolated by Laser Microdissection

01.05.2013 | Takahiko Kubo; Masahiro Fujita; Hirokazu Takahashi; Mikio Nakazono; Nobuhiro Tsutsumi; Nori Kurata, Plant and Cell Physiology, 2013

Comprehensive genome-wide gene expression profiles during plant male gametogenesis have been thoroughly analyzed over the last decade. In contrast, gene expression profiles during female gametogenesis have been studied relatively little, and our knowledge concerning plant female ...

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SS-mPMG and SS-GA: Tools for Finding Pathways and Dynamic Simulation of Metabolic Networks

01.05.2013 | Tetsuo Katsuragi; Naoaki Ono; Keiichi Yasumoto; Md. Altaf-Ul-Amin; Masami Y. Hirai; Kansuporn Sriyudthsak; Yuji Sawa ..., Plant and Cell Physiology, 2013

Metabolomics analysis tools can provide quantitative information on the concentration of metabolites in an organism. In this paper, we propose the minimum pathway model generator tool for simulating the dynamics of metabolite concentrations (SS-mPMG) and a tool for parameter estimation by ...

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Peptide Separation Methodologies for In-Depth Proteomics in Arabidopsis

01.05.2013 | Yoichiro Fukao; Masami Yoshida; Rie Kurata; Mami Kobayashi; Miyako Nakanishi; Masayuki Fujiwara; Keiji Nakajima; Ali ..., Plant and Cell Physiology, 2013

In the post-genome era, several tools that have increased our global understanding of the molecular basis of several cell-based phenomena have been developed. However, proteomics has not been efficiently integrated with the other ‘omics’ (e.g. transcriptomics and metabolomics), because of ...

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Copper Regulates Primary Root Elongation Through PIN1-Mediated Auxin Redistribution

01.05.2013 | Hong-Mei Yuan; Heng-Hao Xu; Wen-Cheng Liu; Ying-Tang Lu, Plant and Cell Physiology, 2013

The heavy metal copper (Cu) is an essential microelement required for normal plant growth and development, but it inhibits primary root growth when in excess. The mechanism underlying how excess Cu functions in this process remains to be further elucidated. Here, we report that a higher ...

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Benzylisoquinoline Alkaloid Metabolism: A Century of Discovery and a Brave New World

01.05.2013 | Jillian M. Hagel; Peter J. Facchini, Plant and Cell Physiology, 2013

Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of investigation. Although the ecophysiological functions of most BIAs are unknown, the medicinal properties of many compounds have been exploited for centuries. These ...

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