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2.530 Aktuelle Fachpublikationen von Future Medicine

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Targeting pathways downstream of KRAS in lung adenocarcinoma

10.10.2014 | Zehua Zhu; Hadrien G Golay; David A Barbie, Pharmacogenomics, 2014

Oncogenic KRAS activation is responsible for the most common genetic subtype of lung cancer. Although many of the major downstream signaling pathways that KRAS engages have been defined, these discoveries have yet to translate into effective targeted therapy. Much of the current focus has been ...

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CYP2B6 genotype, but not rifampicin-based anti-TB cotreatments, explains variability in long-term efavirenz plasma exposure

10.10.2014 | Jackson K Mukonzo; Sarah Nanzigu; Paul Waako; Jasper Ogwal-Okeng; Lars L Gustafson; Eleni Aklillu, Pharmacogenomics, 2014

Aim: We investigated the effects of rifampicin-based anti-TB treatment on plasma efavirenz exposure and the implications of CYP2B6 genotype. Patients & methods: Antiretroviral therapy-naive Ugandan HIV patients without (n = 157) or with TB coinfection (n = 106) were enrolled and treated with ...

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Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies

10.10.2014 | Sujatha Suthandiram; Gin-Gin Gan; Shamsul Mohd Zain; Ping-Chong Bee; Lay-Hoong Lian; Kian-Meng Chang; Tee-Chuan Ong; ..., Pharmacogenomics, 2014

Aim: Pharmacogenetics of methotrexate (MTX) contributes to interindividual differences in toxicity. We aimed to evaluate the impact of SNPs within the MTX pathway genes on MTX-induced toxicity and MTX plasma levels at 48 h following treatment in Asian adults with acute lymphoblastic leukemia or ...

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The road from next-generation sequencing to personalized medicine

07.10.2014 | Manuel L Gonzalez-Garay, Personalized Medicine, 2014

Moving from a traditional medical model of treating pathologies to an individualized predictive and preventive model of personalized medicine promises to reduce the healthcare cost on an overburdened and overwhelmed system. Next-generation sequencing (NGS) has the potential to accelerate the ...

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Whole-genome sequencing: not yet making the clinical grade

07.10.2014 | Joanne Ngeow; Charis Eng, Personalized Medicine, 2014

Personalized Medicine July 2014, Vol. 11, No. 5, Pages 471-475.

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Challenges for the implementation of high-throughput testing and liquid biopsies in personalized medicine cancer trials

07.10.2014 | Loic Verlingue; Marie Alt; Maud Kamal; Marie-Paule Sablin; Mustapha Zoubir; Nabil Bousetta; Jean-Yves Pierga; Nicola ..., Personalized Medicine, 2014

During recent decades, major advances in the comprehension of biology and in biotechnologies have paved the way for what is commonly named personalized medicine. For cancer therapy, personalized medicine represents a paradigm shift in which patient treatment is based on biology in addition to ...

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Personalizing busulfan therapy for children undergoing hematopoietic stem cell transplantation

07.10.2014 | Anuj K Tyagi; Patricia Huezo-Diaz; Marc Ansari, Personalized Medicine, 2014

Personalized Medicine July 2014, Vol. 11, No. 5, Pages 463-466.

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News & Views in ... Personalized Medicine

07.10.2014 | Personalized Medicine, 2014

Personalized Medicine July 2014, Vol. 11, No. 5, Pages 467-470.

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The future of genomic testing in primary care: the changing face of personalized medicine

07.10.2014 | Gillian Bartlett; Vaso Rahimzadeh; Cristina Longo; Lori A Orlando; Martin Dawes; Jean Lachaine; Murielle Bochud; Fre ..., Personalized Medicine, 2014

Primary care is recognized worldwide as a key component for improving health outcomes in the population. At the same time, healthcare systems are rapidly changing with increasing expectations from technological advances. Genomics is a major driver in changing how medicine is being practiced; ...

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Creating policy frameworks for public health genomics to benefit developing countries

07.10.2014 | Tikki Pang; Mikkel Oestergaard, Personalized Medicine, 2014

Unprecedented advances in life sciences, as exemplified by the revolution in genomics, are yet to translate into effective public health interventions to benefit the health of populations living in the developing world. The developing countries continue to bear the major burden of disease ...

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