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2.320 Aktuelle Fachpublikationen von Future Medicinerss
13.03.2014 | Eva J Brandl; Arun K Tiwari; Nabilah I Chowdhury; Clement C Zai; Jeffrey A Lieberman; Herbert Y Meltzer; ..., Pharmacogenomics, 2014
Aim: GLP-1 plays a key role in glucose metabolism and influences antipsychotic-induced weight gain (AIWG). Our study is the first to investigate the encoding gene, GCG, and the GLP-1 receptor gene, GLP1R, and association with AIWG. Materials & methods: In 216 schizophrenic patients treated with ...
13.03.2014 | Jennifer N Todd; Jose C Florez, Pharmacogenomics, 2014
The increasing prevalence of Type 2 diabetes has emphasized the need to optimize treatment regimens. Metformin, the most widely used oral agent, is recommended as first-line drug therapy by multiple professional organizations. Response to metformin varies significantly at the individual level; ...
13.03.2014 | Hidayati Mohd Sha‘ari; Batoul Sadat Haerian; Larry Baum; Junji Saruwatari; Hui Jan Tan; Mohd Hanip Rafia ..., Pharmacogenomics, 2014
Aim: To examine the relevance of ABCC2 polymorphisms to drug responsiveness in epilepsy cohorts from the Asia Pacific region. Materials & methods: The rs2273697 and rs3740066 polymorphisms were genotyped in 2056 Malaysian (55%), Hong Kong (32%) and Japanese (13%) epilepsy patients. Results: ...
13.03.2014 | Michele Viana; Salvatore Terrazzino; Armando A Genazzani; Gaetano S Grieco; Sarah Cargnin; Filippo M San ..., Pharmacogenomics, 2014
Migraine is characterized by heterogeneous behavior in response to drugs. Many resources have been invested in attempting to unravel the genetic basis of migraine, while the role of genetics in responses to currently available drugs has received less attention. We performed a systematic ...
13.03.2014 | James T McCracken, Pharmacogenomics, 2014
Pharmacogenomics , March 2014, Vol. 15, No. 4, Pages 403-406.
13.03.2014 | Hong Zhu; Fei-Yan Deng; Xing-Bo Mo; Ying-Hua Qiu; Shu-Feng Lei, Pharmacogenomics, 2014
Rheumatoid arthritis (RA) is a complex, systemic autoimmune disease characterized by chronic inflammation of multiple peripheral joints, which leads to serious destruction of cartilage and bone, progressive deformity and severe disability. Methotrexate (MTX) is one of the first-line drugs ...
13.03.2014 | Siti Norsyuhada Roffeei; Zahurin Mohamed; Gavin P Reynolds; Mas Ayu Said; Ahmad Hatim; Elsa Haniffah Mejia ..., Pharmacogenomics, 2014
Aim:The occurrence of metabolic syndrome (MS) in schizophrenia patients receiving long-term antipsychotics (APs) contributes to their high mortality rate. We aimed to determine whether genetic polymorphisms of identified candidate genes are associated with MS in our study population. Materials & ...
13.03.2014 | Alice Matimba; Fang Li; Alina Livshits; Cher S Cartwright; Stephen Scully; Brooke L Fridley; Gregory J ..., Pharmacogenomics, 2014
Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine cytotoxicity using lymphoblastoid cell lines. We ...
13.03.2014 | José AG Agúndez, Pharmacogenomics, 2014
José AG Agúndez speak to Emma Sinclair, Assistant Commissioning Editor José AG Agúndez is a Doctor of Medicine and Professor in the Department of Pharmacology at the University of Extremadura (Extremadura, Spain) He is involved in pharmacogenomics research and he has taught pharmacology and ...
13.03.2014 | Andrea Gaedigk; J Steven Leeder, Pharmacogenomics, 2014
Pharmacogenomics , March 2014, Vol. 15, No. 4, Pages 407-410.