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2.702 Aktuelle Fachpublikationen von Future Medicine

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The future for early-stage tuberculosis drug discovery

17.02.2015 | Edison S Zuniga; Julie Early; Tanya Parish, Future Microbiology, 2015

ABSTRACT There is an urgent need for new and better drugs to treat tuberculosis due to lengthy and complex treatment regimens and a rising problem of drug resistance. Drug discovery efforts have increased over the past few years, with a larger focus on modern high-throughput screening ...

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Small colony variants of Pseudomonas aeruginosa in chronic bacterial infection of the lung in cystic fibrosis

17.02.2015 | Thomas J Evans, Future Microbiology, 2015

ABSTRACT  Pseudomonas aeruginosa is the most common pathogen that colonizes the lungs of patients with cystic fibrosis. Isolates from sputum are typically all derived from the same strain of bacterium but show extensive phenotypic heterogeneity. One of these variants is the so-called small colony ...

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Aging: an emergent phenotypic trait that contributes to the virulence of Cryptococcus neoformans

17.02.2015 | Tejas Bouklas; Bettina C Fries, Future Microbiology, 2015

ABSTRACT The pathogenic fungus, Cryptococcus neoformans, is known to undergo phenotypic variation, which affects its virulence in the host. Recent investigations on C. neoformans cells in humans have validated the concept that phenotypic variation is present and relevant for the outcome of ...

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Ventana immunohistochemistry ALK (D5F3) detection of ALK expression in pleural effusion samples of lung adenocarcinoma

04.02.2015 | Zheng Wang; Xiaonan Wu; Yuankai Shi; Xiaohong Han; Gang Cheng; Di Cui; Lin Li; Yuhui Zhang; Xinlin Mu; Li Zhang; Li ..., Personalized Medicine, 2015

Aim: To evaluate the Ventana IHC ALK (D5F3) assay for detecting anaplastic lymphoma kinase (ALK) protein expression in pleural effusion samples. Methods: Historical, selected (wild-type EGFR, K-RAS) pleural effusion cytologic blocks of lung adenocarcinoma samples (Study 1) and unselected lung ...

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Low-frequency KRAS mutations are prevalent in lung adenocarcinomas

04.02.2015 | Meagan B Myers; Karen L McKim; Fanxue Meng; Barbara L Parsons, Personalized Medicine, 2015

Aim: This study quantified low-frequency KRAS mutations in normal lung and lung adenocarcinomas, to understand their potential significance in the development of acquired resistance to EGFR-targeted therapies. Materials & methods: Allele-specific Competitive Blocker-PCR was used to quantify KRAS ...

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Protective host immune responses to Salmonella infection

19.01.2015 | Oanh H Pham; Stephen J McSorley, Future Microbiology, 2015

ABSTRACT  Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host–pathogen interactions during Salmonella infection should facilitate the ...

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The need for a decision: the future of biological science and humanity

19.01.2015 | Daniel S Shapiro, Future Microbiology, 2015

Future Microbiology January 2015, Vol. 10, No. 1, Pages 5-7.

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Noroviruses: epidemiology, immunity and prospects for prevention

19.01.2015 | Kimberly Pringle; Benjamin Lopman; Everardo Vega; Jan Vinje; Umesh D Parashar; Aron J Hall, Future Microbiology, 2015

ABSTRACT  In recent years, noroviruses have become recognized as an important cause of both sporadic and epidemic acute gastroenteritis (AGE), largely due to the improved availability of broadly reactive real-time RT-PCR (TaqMan-based RT-PCR) assays. While there is substantial diversity among ...

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Parasitic infections in travelers and immigrants: part I protozoa

19.01.2015 | Francesca F Norman; Begoña Monge-Maillo; Ángela Martínez-Pérez; Jose A Perez-Molina; Rogelio López-Vélez, Future Microbiology, 2015

ABSTRACT  The growth in international commerce, travel and migration contribute to the global emergence of certain parasitic infections. Importation of vectors and food products may contribute to the emergence of protozoan infections in nonendemic countries. Infections such as malaria are ...

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The epidemiology of sexually transmitted infections in the UK: impact of behavior, services and interventions

19.01.2015 | Gwenda Hughes; Nigel Field, Future Microbiology, 2015

ABSTRACT  Sexually transmitted infections (STIs) are a major public health concern. The UK has some of the most advanced STI surveillance systems globally. This article uses national surveillance data to describe remarkable changes in STI epidemiology in the UK over the last century and explores ...

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