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2.530 Aktuelle Fachpublikationen von Future Medicinerss
10.10.2014 | Zehua Zhu; Hadrien G Golay; David A Barbie, Pharmacogenomics, 2014
Oncogenic KRAS activation is responsible for the most common genetic subtype of lung cancer. Although many of the major downstream signaling pathways that KRAS engages have been defined, these discoveries have yet to translate into effective targeted therapy. Much of the current focus has been ...
10.10.2014 | Jackson K Mukonzo; Sarah Nanzigu; Paul Waako; Jasper Ogwal-Okeng; Lars L Gustafson; Eleni Aklillu, Pharmacogenomics, 2014
Aim: We investigated the effects of rifampicin-based anti-TB treatment on plasma efavirenz exposure and the implications of CYP2B6 genotype. Patients & methods: Antiretroviral therapy-naive Ugandan HIV patients without (n = 157) or with TB coinfection (n = 106) were enrolled and treated with ...
10.10.2014 | Sujatha Suthandiram; Gin-Gin Gan; Shamsul Mohd Zain; Ping-Chong Bee; Lay-Hoong Lian; Kian-Meng Chang; Tee-Chuan Ong; ..., Pharmacogenomics, 2014
Aim: Pharmacogenetics of methotrexate (MTX) contributes to interindividual differences in toxicity. We aimed to evaluate the impact of SNPs within the MTX pathway genes on MTX-induced toxicity and MTX plasma levels at 48 h following treatment in Asian adults with acute lymphoblastic leukemia or ...
07.10.2014 | Manuel L Gonzalez-Garay, Personalized Medicine, 2014
Moving from a traditional medical model of treating pathologies to an individualized predictive and preventive model of personalized medicine promises to reduce the healthcare cost on an overburdened and overwhelmed system. Next-generation sequencing (NGS) has the potential to accelerate the ...
07.10.2014 | Joanne Ngeow; Charis Eng, Personalized Medicine, 2014
Personalized Medicine July 2014, Vol. 11, No. 5, Pages 471-475.
07.10.2014 | Loic Verlingue; Marie Alt; Maud Kamal; Marie-Paule Sablin; Mustapha Zoubir; Nabil Bousetta; Jean-Yves Pierga; Nicola ..., Personalized Medicine, 2014
During recent decades, major advances in the comprehension of biology and in biotechnologies have paved the way for what is commonly named personalized medicine. For cancer therapy, personalized medicine represents a paradigm shift in which patient treatment is based on biology in addition to ...
07.10.2014 | Anuj K Tyagi; Patricia Huezo-Diaz; Marc Ansari, Personalized Medicine, 2014
Personalized Medicine July 2014, Vol. 11, No. 5, Pages 463-466.
07.10.2014 | Gillian Bartlett; Vaso Rahimzadeh; Cristina Longo; Lori A Orlando; Martin Dawes; Jean Lachaine; Murielle Bochud; Fre ..., Personalized Medicine, 2014
Primary care is recognized worldwide as a key component for improving health outcomes in the population. At the same time, healthcare systems are rapidly changing with increasing expectations from technological advances. Genomics is a major driver in changing how medicine is being practiced; ...
07.10.2014 | Tikki Pang; Mikkel Oestergaard, Personalized Medicine, 2014
Unprecedented advances in life sciences, as exemplified by the revolution in genomics, are yet to translate into effective public health interventions to benefit the health of populations living in the developing world. The developing countries continue to bear the major burden of disease ...