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2.659 Aktuelle Fachpublikationen von Future Medicine

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Conference report from International Congress on Infectious Diseases 2014: part 2

17.12.2014 | Hilda McLoughlin, Future Microbiology, 2014

ABSTRACT  This second and final instalment of the conference report from International Congress on Infectious Diseases 2014 follows on from part one, published in Future Microbiology (volume 9/issue 11). The 16th International Congress on Infectious Diseases was held in Cape Town this year, ...

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Exposure to extremely low-frequency magnetic field affects biofilm formation by cystic fibrosis pathogens

17.12.2014 | Giovanni Di Bonaventura; Arianna Pompilio; Valentina Crocetta; Serena De Nicola; Filippo Barbaro; Livio Giuliani; En ..., Future Microbiology, 2014

SUMMARY  Aims: To evaluate the in vitro effects of extremely low-frequency magnetic field (ELF-MF) on growth and biofilm formation by Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia strains from cystic fibrosis patients. Materials & methods: ...

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Structure and function of bacteriophage T4

17.12.2014 | Moh Lan Yap; Michael G Rossmann, Future Microbiology, 2014

ABSTRACT  Bacteriophage T4 is the most well-studied member of Myoviridae, the most complex family of tailed phages. T4 assembly is divided into three independent pathways: the head, the tail and the long tail fibers. The prolate head encapsidates a 172 kbp concatemeric dsDNA genome. The 925 ...

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Candida albicans and Streptococcus mutans: a potential synergistic alliance to cause virulent tooth decay in children

17.12.2014 | Hyun Koo; William H Bowen, Future Microbiology, 2014

Future Microbiology December 2014, Vol. 9, No. 12, Pages 1295-1297.

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Genetic risk signatures of opioid-induced respiratory depression following pediatric tonsillectomy

10.12.2014 | Jacek Biesiada; Vidya Chidambaran; Michael Wagner; Xue Zhang; Lisa J Martin; Jaroslaw Meller; Senthilkumar Sadhasivam, Pharmacogenomics, 2014

Background: Respiratory depression is a clinically and economically important but preventable complication of opioids. Genetic factors can help identify patients with high risk for respiratory depression. Methods: In this prospective genotype blinded clinical study, we evaluated the effect of a ...

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Pharmacogenetics of cardiac inotropy

10.12.2014 | Anastasios Lymperopoulos; Dilayda Garcia; Karlee Walklett, Pharmacogenomics, 2014

The ability to stimulate cardiac contractility is known as positive inotropy. Endogenous hormones, such as adrenaline and several natural or synthetic compounds possess this biological property, which is invaluable in the modern cardiovascular therapy setting, especially in acute heart failure or ...

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Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting

10.12.2014 | Otito F Iwuchukwu; QiPing Feng; Wei-Qi Wei; Lan Jiang; Min Jiang; Hua Xu; Joshua C Denny; Russell A Wilke; Ronald M ..., Pharmacogenomics, 2014

Aim: Simvastatin is a lactone prodrug that exists in equilibrium with its active hydroxyacid through a process mediated by UGT1A enzymes. The UGT1A locus has been associated with simvastatin response and disposition in humans. Therefore, we fine-mapped the UGT1A locus to identify genetic ...

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Personalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease

10.12.2014 | Edward D Esplin; Ling Oei; Michael P Snyder, Pharmacogenomics, 2014

The potential for personalized sequencing to individually optimize medical treatment in diseases such as cancer and for pharmacogenomic application is just beginning to be realized, and the utility of sequencing healthy individuals for managing health is also being explored. The data produced ...

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Pilot study: incorporation of pharmacogenetic testing in medication therapy management services

10.12.2014 | Susanne B Haga; Nancy M Allen LaPointe; Jivan Moaddeb; Rachel Mills; Mahesh Patel; William E Kraus, Pharmacogenomics, 2014

Aim: To describe the rationale and design of a pilot study evaluating the integration of pharmacogenetic (PGx) testing into pharmacist-delivered medication therapy management (MTM). Study rationale: Clinical delivery approaches of PGx testing involving pharmacists may overcome barriers of limited ...

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PDE3A-SLCO1C1 locus is associated with response to anti-tumor necrosis factor therapy in psoriatic arthritis

10.12.2014 | Antonio Julià; Jesús Rodríguez; José Luis Fernández-Sueiro; Jordi Gratacós; Rubén Queiró; Carlos Montilla; Juan Carl ..., Pharmacogenomics, 2014

Aim: Variation at PDE3A-SLCO1C1 locus has been recently associated with the response to anti-TNF therapy in rheumatoid arthritis. We undertook the present study to determine whether PDE3A-SLCO1C1 is also associated with the response to anti-TNF therapy in psoriatic arthritis. Patients & methods: ...

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