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3.586 Aktuelle Fachpublikationen von Future Medicine

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Drug repurposing: a new front in the war against Staphylococcus aureus

05.08.2016 | Swetarka Das; Arunava Dasgupta; Sidharth Chopra, Future Microbiology, 2016

Staphylococcus aureus continues its domination of worldwide bacterial infection rates, thereby remaining a pathogen of significant public health interest. A major reason for its continued success is its ability to acquire and maintain diverse drug resistance mechanisms, leading to a paucity of ...

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New insights into protecting the brain from the heart

05.08.2016 | Derk W Krieger, Future Neurology, 2016

Future Neurology August 2016, Vol. 11, No. 3, Pages 201-205.

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Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese

05.08.2016 | Shinya Kasai; Daisuke Nishizawa; Junko Hasegawa; Naomi Sato; Fumihiko Tanioka; Haruhiko Sugimura; Kazutaka Ikeda, Pharmacogenomics, 2016

Aim: The endogenous opioid system has been reportedly implicated in tobacco/nicotine dependence. Materials & methods: We examined the genetic effects of eight SNPs in opioid receptor-related genes on smoking status and smoking-related traits in Japanese. Results: The genotypic and allelic ...

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RpoE promotes invasion and intracellular survival by regulating SPI-1 and SPI-2 in Salmonella enterica serovar Typhi

05.08.2016 | Haifang Zhang; Yanwei Jia; Xiaofang Xie; Min Wang; Yi Zheng; Shungao Xu; Wei Zhang; Qiang Wang; Xinxiang Huang; Hong Du, Future Microbiology, 2016

Aim: To demonstrate the role of RpoE during the later stage of hyperosmotic stress in Salmonella. Materials & methods: Expressions of SPI-1 and SPI-2 under hyperosmotic stress for 120 min were investigated by a microarray, and the invasion and intracellular survival of wild-type and ΔrpoE strains ...

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Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis

04.08.2016 | Young Ho Lee; Sung Jae Choi; Jong Dae Ji; Gwan Gyu Song, Pharmacogenomics, 2016

Aim: The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Materials & methods: We conducted a meta-analysis to evaluate the association between the ...

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Pharmacogenetics of cystic fibrosis treatment

04.08.2016 | Suzanne C Carter; Edward F McKone, Pharmacogenomics, 2016

Cystic fibrosis (CF) is genetic autosomal recessive disease caused by reduced or absent function of CFTR protein. Treatments for patients with CF have primarily focused on the downstream end-organ consequences of defective CFTR. Since the discovery of the CFTR gene that causes CF in 1989 there ...

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Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy

04.08.2016 | Niclas Eriksson; Lars Wallentin; Lars Berglund; Tomas Axelsson; Stuart Connolly; John Eikelboom; Michael Ezekowitz; ..., Pharmacogenomics, 2016

Aims: We investigated associations between genetic variation in candidate genes and on a genome-wide scale with warfarin maintenance dose, time in therapeutic range (TTR), and risk of major bleeding. Materials & methods: In total, 982 warfarin-treated patients from the RE-LY trial were studied. ...

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Family health history: an essential starting point for personalized risk assessment and disease prevention

03.08.2016 | Vincent C Henrich; Lori A Orlando, Personalized Medicine, 2016

Family health history (FHH) information is well established as a basis for assessing a patient's personal disease risk, but is underutilized for diagnosis and making medical recommendations. Epidemiological and genetic information have heightened the value of FHH to an individual's health. This ...

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Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong

01.08.2016 | Youssef M Roman; Kathleen A Culhane-Pera; Jeremiah Menk; Robert J Straka, Personalized Medicine, 2016

Aim: Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two- to five-fold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese ...

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Is there a role for pharmacogenetics in the treatment of anorexia nervosa?

01.08.2016 | Sarah Smith; Blake Woodside, Pharmacogenomics, 2016

Pharmacogenomics August 2016, Vol. 17, No. 13, Pages 1381-1383.

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