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3.482 Aktuelle Fachpublikationen von Future Medicine

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Cost–effectiveness analysis of personalized antiplatelet therapy in patients with acute coronary syndrome

11.05.2016 | Minghuan Jiang; Joyce HS You, Pharmacogenomics, 2016

Aim: This study aimed to compare the clinical and economic outcomes of pharmacogenetic-guided (PG-guided) and platelet reactivity testing-guided antiplatelet therapy for patients with acute coronary syndrome undergoing percutaneous coronary intervention. Methods: A decision-analytic model was ...

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Pharmacogenetic aspects of the treatment of Type 2 diabetes with the incretin effect enhancers

11.05.2016 | Ivan Tkáč; Ivana Gotthardová, Pharmacogenomics, 2016

Incretin effect enhancers are drugs used in the treatment of Type 2 diabetes and include GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors (gliptins). Variants in several genes were shown to be involved in the physiology of incretin secretion. Only two gene variants have evidence also ...

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Managing tuberculosis infection in children in the USA: an update

10.05.2016 | Andrea T Cruz; Jeffrey R Starke, Future Microbiology, 2016

The rate of tuberculosis (TB) disease has steadily declined in the last two decades in the USA, and over two-thirds of all cases now occur in foreign-born persons. Further declines in the incidence of TB will be most impacted by identifying and treating persons with TB infection. However, ...

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Development of a rapid diagnostic assay based on magnetic bead purification of OXA-β-lactamase mRNA

10.05.2016 | Christian Brandt; Esther Zander; Yvonne Pfeifer; Sascha D Braun; Ralf Ehricht; Oliwia Makarewicz; Mathias W Pletz, Future Microbiology, 2016

Aim: To countermeasure the global spread of β-lactamases, we developed a rapid molecular test for the highly variable OXA-β-lactamases that allows minimizing the time to effective treatment. Methods: OXA-mRNA was specifically enriched from total RNA using group-specific biotinylated DNA probes ...

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Oritavancin: a long-acting antibacterial lipoglycopeptide

10.05.2016 | Achim J Kaasch; Harald Seifert, Future Microbiology, 2016

Oritavancin is a new lipoglycopeptide antibacterial agent with an exceptionally long terminal half-life and a rapid bactericidal effect. Multiple mechanisms of action lead to a broad activity against Gram-positive bacteria, such as staphylococci, streptococci and enterococci, including ...

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Cross-talk and specificity in two-component signal transduction pathways

09.05.2016 | Ruchi Agrawal; Bikash Kumar Sahoo; Deepak Kumar Saini, Future Microbiology, 2016

Two-component signaling systems (TCSs) are composed of two proteins, sensor kinases and response regulators, which can cross-talk and integrate information between them by virtue of high-sequence conservation and modular nature, to generate concerted and diversified responses. However, TCSs have ...

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Phosphatases are emerging as novel druggable targets in Plasmodium

09.05.2016 | Jamal Khalife; Christine Pierrot, Future Microbiology, 2016

Future Microbiology Ahead of Print.

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Gemmata species: Planctomycetes of medical interest

09.05.2016 | Rita Aghnatios; Michel Drancourt, Future Microbiology, 2016

The Planctomycetes genus Gemmata is represented by both uncultured organisms and cultured Gemmata obscuriglobus and ‘Gemmata massiliana’ organisms. Their plasmidless 9.2Mb genomes encode a complex cell plan, cell signaling capacities, antibiotic and trace metal resistance and multidrug ...

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Could physical exercise help modulate the gut microbiota in chronic kidney disease?

09.05.2016 | Marta Esgalhado; Natália A Borges; Denise Mafra, Future Microbiology, 2016

Chronic kidney disease (CKD) patients have several metabolic disorders caused by chronic oxidative stress and inflammation. The imbalance of gut microbiota has been identified as a factor that may contribute to the development of these disorders, which can promote cardiovascular disease in CKD ...

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Membrane-targeting AM-0016 kills mycobacterial persisters and shows low propensity for resistance development

09.05.2016 | Devika Mukherjee; Hanxun Zou; Shouping Liu; Roger Beuerman; Thomas Dick, Future Microbiology, 2016

Aim: To test the hypothesis that targeting the cytoplasmic membrane may be an effective way to kill persister mycobacteria and delay the emergence of resistance. Methods:In vitro activity of AM-0016, a novel xanthone-based antibacterial, was assessed against growing and persister tubercle ...

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