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Implications of the inflammatory response for the identification of biomarkers of chronic obstructive pulmonary disease

14.01.2016 | Jose Luis Lopez-Campos; Carmen Calero-Acuña; Cecilia Lopez-Ramirez; María Abad-Arranz; Eduardo Márquez-Martín; Franc ..., Biomarkers in Medicine, 2016

Chronic obstructive pulmonary disease (COPD) is characterized by both local and systemic inflammation. Because inflammation plays a critical role in the development, course and severity of COPD, inflammatory markers have the potential to improve the current diagnostic and prognostic approaches. ...


CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis

14.01.2016 | Anne Sofie Siebuhr; Anne C Bay-Jensen; Morten Asser Karsdal; Rik J Lories; Kurt de Vlam, Biomarkers in Medicine, 2016

Aim: To investigate if tissue turnover biomarkers were efficacy biomarkers in ankylosing spondylitis and if the biomarkers at baseline predicted a good outcome (BASDAI50). Patients & methods: Twenty-two etanercept treated ankylosing spondylitis patients were investigated for inflammation (CRP, ...


Biomarkers of susceptibility following benzene exposure: influence of genetic polymorphisms on benzene metabolism and health effects

14.01.2016 | Damiano Carbonari; Pieranna Chiarella; Antonella Mansi; Daniela Pigini; Sergio Iavicoli; Giovanna Tranfo, Biomarkers in Medicine, 2016

Benzene is a ubiquitous occupational and environmental pollutant. Improved industrial hygiene allowed airborne concentrations close to the environmental context (1–1000 µg/m3). Conversely, new limits for benzene levels in urban air were set (5 µg/m3). The biomonitoring of exposure to such low ...


Copenhagen uPAR prostate cancer (CuPCa) database: protocol and early results

14.01.2016 | Solvej Lippert; Kasper D Berg; Gunilla Høyer-Hansen; Ida K Lund; Peter Iversen; Ib J Christensen; Klaus Brasso; Mart ..., Biomarkers in Medicine, 2016

Aim: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective ‘Copenhagen uPAR Prostate Cancer’ study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. ...


Polyunsaturated lysophosphatidic acid as a potential asthma biomarker

14.01.2016 | Steven J Ackerman; Gye Young Park; John W Christman; Sharmilee Nyenhuis; Evgeny Berdyshev; Viswanathan Natarajan, Biomarkers in Medicine, 2016

Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. Total LPA levels are increased in bronchoalveolar lavage fluid from asthmatic lung, and are strongly induced following ...


The challenge of small lung nodules identified in CT screening: can biomarkers assist diagnosis?

14.01.2016 | Giulia Veronesi; Fabrizio Bianchi; Maurizio Infante; Marco Alloisio, Biomarkers in Medicine, 2016

Various biomarkers have been developed as noninvasive tests to indicate the presence of lung cancer in asymptomatic persons, and in particular to provide evidence as to whether indeterminate lung nodules detected by screening are malignant. We performed an overview of the range of biomarkers ...


Biomarkers in the clinical development of asthma therapies

14.01.2016 | Tracy L Staton; David F Choy; Joseph R Arron, Biomarkers in Medicine, 2016

Here we review how biomarkers have been used in the design, execution and interpretation of recent clinical studies of therapeutic candidates targeting cytokine-mediated inflammatory pathways in asthma. This review focuses on type 2 inflammation, as there are multiple therapeutics and/or clinical ...


Unraveling the pathophysiology of chronic stroke lesions could yield treatments for stroke-related dementia

11.01.2016 | Kristian P Doyle, Future Neurology, 2016

Future Neurology Ahead of Print.


Lost in translation: understanding the failure of the progesterone/traumatic brain injury Phase III trials

11.01.2016 | Donald G Stein, Future Neurology, 2016

Future Neurology Ahead of Print.


Central post-stroke pain: theories, diagnosis and treatment

11.01.2016 | Jonathan Singer; Steven R Levine, Future Neurology, 2016

Future Neurology Ahead of Print.


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