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RICTOR polymorphisms affect efficiency of platinum-based chemotherapy in Chinese non-small-cell lung cancer patients

27.09.2016 | Shiming Wang; Xiao Song; Xiaoying Li; Xueying Zhao; Hongyan Chen; Jiucun Wang; Junjie Wu; Zhiqiang Gao; Ji Qian; Bao ..., Pharmacogenomics, 2016

Aim: We investigated the association between RICTOR polymorphisms and clinical outcomes of platinum-based chemotherapy for Chinese non-small-cell lung cancer patients. Materials & methods: Ten tag SNPs were genotyped in 1004 patients to assess their association with clinical benefit, overall ...


Metabolic competition as a driver of bacterial population structure

23.09.2016 | Eleanor R Watkins; Martin CJ Maiden; Sunetra Gupta, Future Microbiology, 2016

Understanding the processes whereby diversity arises and is maintained in pathogen populations is pivotal for designing disease control interventions. A particular problem is the maintenance of strain structure in bacterial pathogen populations despite frequent genetic exchange. Although several ...


Metabolic profiles of planktonic and biofilm cells of Candida orthopsilosis

23.09.2016 | Regina Helena Pires; Thaís Regiani Cataldi; Livia Maria Franceschini; Mônica Veneziano Labate; Ana Marisa Fusco-Alme ..., Future Microbiology, 2016

Aim: This study aims to understand which Candida orthopsilosis protein aids fungus adaptation upon its switching from planktonic growth to biofilm. Materials & methods: Ion mobility separation within mass spectrometry analysis combination were used. Results: Proteins mapped for different ...


The new EU regulation on in vitro diagnostics: potential issues at the interface of medicines and companion diagnostics

23.09.2016 | Harald Enzmann; Ralf Meyer; Karl Broich, Biomarkers in Medicine, 2016

The new European regulation for in vitro diagnostics (IVD) divides the certification of IVD including companion diagnostics (CDx) by notified bodies (NB) from the market authorization of medicines. With the new regulation, CDx will require conformity assessment which is expected to include ...


Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment

20.09.2016 | Roelof AJ Smit; Iris Postmus; Stella Trompet; Michael R Barnes; Helen Warren; Benoit J Arsenault; Daniel I Chasman; ..., Pharmacogenomics, 2016

Aims: To utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response. Methods: We investigated effects ...


Patient experiences with pharmacogenetic testing in a primary care setting

20.09.2016 | Susanne B Haga; Rachel Mills; Jivan Moaddeb; Nancy Allen Lapointe; Alex Cho; Geoffrey S Ginsburg, Pharmacogenomics, 2016

Aim: To investigate patient experiences with pharmacogenetic (PGx) testing. Methods: Patients were offered PGx testing through a study on pharmacist-assisted delivery of PGx testing and invited to complete pre- and post-testing surveys about their experience. Results: Of 63 patients tested, 17 ...


Blood cell microparticles as biomarkers of hemostatic abnormalities in patients with implanted cardiac assist devices

19.09.2016 | Walter P Jeske; Jeanine M Walenga; Bryan Menapace; Jeffrey Schwartz; Mamdouh Bakhos, Biomarkers in Medicine, 2016

For heart failure patients unable to undergo cardiac transplantation, mechanical circulatory support with left ventricular assist devices can be utilized. These devices improve quality of life and prolong life expectancy, but they are associated with bleeding and thrombotic complications ...


β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes

19.09.2016 | Katie A McCrink; Ava Brill; Malika Jafferjee; Thairy Reyes Valero; Christine Marrero; Martha M Rodriguez; Genevieve ..., Pharmacogenomics, 2016

Aim: The β1-adrenergic receptor (AR) Arg389Gly polymorphism affects efficacy of its procontractile signaling in cardiomyocytes and carriers’ responses to β-blockers. To identify molecular mechanisms underlying functional differences between Arg389 and Gly389 β1ARs, we examined their binding to ...


TB or not TB? Improving the understanding and diagnosis of tuberculosis through metabolomics

19.09.2016 | Du Toit Loots, Biomarkers in Medicine, 2016

Biomarkers in Medicine Ahead of Print.


Antiphage activity of sera during phage therapy in relation to its outcome

19.09.2016 | Marzanna Łusiak-Szelachowska; Maciej Żaczek; Beata Weber-Dąbrowska; Ryszard Międzybrodzki; Sławomir Letkiewicz; Wojc ..., Future Microbiology, 2016

Aim: The aim was to study the association between the phage neutralization of patients’ sera and the clinical outcome of phage therapy (PT). Patients: About 62 patients with various bacterial infections receiving PT as well as 30 healthy volunteers were studied. Materials & methods: Antiphage ...


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