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3.040 Aktuelle Fachpublikationen von Future Medicine

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Rash in lapatinib-treated patients is not associated with human leukocyte antigen polymorphisms

12.08.2015 | Laura R Parham; Linda P Briley; Karen S King; Julie Byrne; Erica Rappold; Paul E Goss; Colin F Spraggs, Pharmacogenomics, 2015

Rash is a common side effect of lapatinib treatment. Since human leukocyte antigen (HLA) alleles have been implicated in multiple drug-induced cutaneous reactions, this study investigated the association of HLA alleles with lapatinib-induced rash. 1191 participants from a large lapatinib ...

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Predicting paclitaxel-induced neutropenia using the DMET platform

12.08.2015 | Annemieke JM Nieuweboer; Marcel Smid; Anne-Joy M de Graan; Samira Elbouazzaoui; Peter de Bruijn; John W Martens; Ron ..., Pharmacogenomics, 2015

Aim: The use of paclitaxel in cancer treatment is limited by paclitaxel-induced neutropenia. We investigated the ability of genetic variation in drug-metabolizing enzymes and transporters to predict hematological toxicity. Patients & methods: Using a discovery and validation approach, we ...

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Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination

12.08.2015 | Litaty Céphanoée Mbatchi; Antonin Schmitt; Fabienne Thomas; Yoann Cazaubon; Jacques Robert; Serge Lumbroso; Jean-Pau ..., Pharmacogenomics, 2015

Aim: The goal of our study was to assess the impact of patients’ genetic background on their sensitivity to carboplatin/paclitaxel hematotoxicity. Patients & methods: Parameters describing sensitivity to neutropenia and to thrombocytopenia of 201 patients were extracted from a previous ...

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Genetic markers of recurrence in colorectal cancer

12.08.2015 | Maria Anna Smolle; Martin Pichler; Johannes Haybaeck; Armin Gerger, Pharmacogenomics, 2015

Colorectal cancer (CRC) worldwide belongs to one of the most frequent cancers affecting both genders. Surgery and 5-fluorouracil-based adjuvant chemotherapy are recommended for patients with high-risk stage II and stage III colon carcinoma. Mutations of genes encoding for specific proteins may ...

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Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score

12.08.2015 | Linda M Henricks; Carin ATC Lunenburg; Didier Meulendijks; Hans Gelderblom; Annemieke Cats; Jesse J Swen; Jan HM Sch ..., Pharmacogenomics, 2015

The dihydropyrimidine dehydrogenase enzyme (DPD, encoded by the gene DPYD) plays a key role in the metabolism of fluoropyrimidines. DPD deficiency occurs in 4–5% of the population and is associated with severe fluoropyrimidine-related toxicity. Several SNPs in DPYD have been described that lead ...

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Serotonergic gene variation in substance use pharmacotherapy: a systematic review

12.08.2015 | Isabelle E Bauer; David P Graham; Jair C Soares; David A Nielsen, Pharmacogenomics, 2015

Drug addiction is a serious disease with damaging effects on the brain and physical health. Despite the increase in the number of affected individuals, there are few effective pharmacological treatment options for substance use disorders. The study of the influence of an individual's genetic ...

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Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders

12.08.2015 | Guillermo Gervasini; Carmen Gamero-Villarroel, Pharmacogenomics, 2015

In addition to the identification of mutations clearly related to Mendelian forms of obesity; genome-wide association studies and follow-up studies have in the last years pinpointed several loci associated with BMI. These genetic alterations are located in or near genes expressed in the ...

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Dissecting ancestry genomic background in substance dependence genome-wide association studies

12.08.2015 | Renato Polimanti; Can Yang; Hongyu Zhao; Joel Gelernter, Pharmacogenomics, 2015

Aims: To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. Materials & methods: We investigated 24 genes ...

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Genome-wide association study of warfarin maintenance dose in a Brazilian sample

12.08.2015 | Esteban J Parra; Mariana R Botton; Jamila A Perini; S Krithika; Stephane Bourgeois; Todd A Johnson; Tatsuhiko Tsunod ..., Pharmacogenomics, 2015

Aim: Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. Methods: Patients receiving low (≤20 mg/week; n = 180) or high stable warfarin doses (≥42.5 mg/week; n = 187) were ...

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Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score

12.08.2015 | Linda M Henricks; Carin ATC Lunenburg; Didier Meulendijks; Hans Gelderblom; Annemieke Cats; Jesse J Swen; Jan HM Sch ..., Pharmacogenomics, 2015

The dihydropyrimidine dehydrogenase enzyme (DPD, encoded by the gene DPYD) plays a key role in the metabolism of fluoropyrimidines. DPD deficiency occurs in 4–5% of the population and is associated with severe fluoropyrimidine-related toxicity. Several SNPs in DPYD have been described that lead ...

mehr

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