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Correlations between the enantio- and regio-selective metabolisms of warfarin

20.12.2016 | Harumi Takahashi; Minami Ohara; Soichi Shibata; Ming Ta Michael Lee; Larisa H Cavallari; Edith A Nutescu; Maria G Sc ..., Pharmacogenomics, 2016

Aim: To clarify whether the activities of multiple CYPs associated with warfarin metabolism would be correlated with each other. Methods: Oral clearances (CLpo) of warfarin enantiomers were estimated in 378 Chinese, Caucasians and African–Americans. The partial metabolic clearances (CLm) for ...


Welcome to volume 12 of the journal Future Microbiology

20.12.2016 | Frances Adlam, Future Microbiology, 2016

Future Microbiology January 2017, Vol. 12, No. 1, Pages 1-3.


Trough concentration and ABCG2 polymorphism are better to predict imatinib response in chronic myeloid leukemia: a meta-analysis

19.12.2016 | Zhi-Ping Jiang; Xie-Lan Zhao; Naoto Takahashi; Sabrina Angelini; Biswajit Dubashi; Li Sun; Ping Xu, Pharmacogenomics, 2016

Aim: The present study aimed to conduct a series of meta-analyses to investigate the influence of imatinib trough concentration (C0), as well as ABCB1 and ABCG2 polymorphisms, on the clinical response in patients with chronic myeloid leukemia (CML). Methods: A literature search was conducted ...


Fine-mapping of antipsychotic response genome-wide association studies reveals novel regulatory mechanisms

19.12.2016 | Ellen S Ovenden; Britt I Drögemöller; Lize van der Merwe; Bonginkosi Chiliza; Laila Asmal; Robin A Emsley; Louise Wa ..., Pharmacogenomics, 2016

Aim: Noncoding variation has demonstrated regulatory effects on disease treatment outcomes. This study investigated the potential functionality of previously implicated noncoding variants on schizophrenia treatment response. Materials & methods: Predicted regulatory potential of variation ...


What is the future of pharmacogenomics in pain management?

19.12.2016 | Ana M Peiró; César Margarit; Adrián LLerena, Pharmacogenomics, 2016

Pharmacogenomics January 2017, Vol. 18, No. 2, Pages 101-103.


Are gene polymorphisms related to treatment outcomes of methotrexate in patients with rheumatoid arthritis? A systematic review and meta-analysis

19.12.2016 | Yuehong Chen; Kun Zou; Jianhong Sun; Yuan Yang; Gang Liu, Pharmacogenomics, 2016

Aim: Identifying the predictors of responsiveness and adverse events in methotrexate (MTX) treated patients with rheumatoid arthritis (RA) has been the focus of most concern, but still without consistent consensus. Methods: PubMed and OVID EMBASE were searched to collect relevant studies that ...


Foodborne enterotoxigenic Escherichia coli: from gut pathogenesis to new preventive strategies involving probiotics

16.12.2016 | Charlène Roussel; Adeline Sivignon; Tom Van de Wiele; Stéphanie Blanquet-Diot, Future Microbiology, 2016

Enterotoxigenic Escherichia coli (ETEC) are a major cause of traveler's diarrhea and infant mortality in developing countries. Given the rise of antibiotic resistance worldwide, there is an urgent need for the development of new preventive strategies. Among them, a promising approach is the use ...


Fatty acid amide hydrolase–morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children

15.12.2016 | Vidya Chidambaran; Valentina Pilipenko; Kristie Spruance; Raja Venkatasubramanian; Jing Niu; Tsuyoshi Fukuda; Tomoyu ..., Pharmacogenomics, 2016

Aim: Fatty acid amide hydrolase (FAAH) degrades anandamide, an endogenous cannabinoid. We hypothesized that FAAH variants will predict risk of morphine-related adverse outcomes due to opioid–endocannabinoid interactions. Patients & methods: In 101 postsurgical adolescents receiving morphine ...


Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing

15.12.2016 | Omar Fernando Cruz-Correa; Rafael Baltazar Reyes León-Cachón; Hugo Alberto Barrera-Saldaña; Xavier Soberón, Pharmacogenomics, 2016

Aim: To use variants found by next-generation sequencing to predict atorvastatin plasmatic concentration profiles (AUC) in healthy volunteers. Subjects & methods: A total of 60 healthy Mexican volunteers were enrolled in this study. We used variants with a predicted functional effect across 20 ...


Pharmacogenetics of ustekinumab in patients with moderate-to-severe plaque psoriasis

15.12.2016 | Rocío Prieto-Pérez; Mar Llamas-Velasco; Teresa Cabaleiro; Guillermo Solano-López; Beatriz Márquez; Manuel Román; Dol ..., Pharmacogenomics, 2016

Aim/Materials & methods: Few studies have evaluated the influence of pharmacogenetics in psoriatic patients treated with ustekinumab. We evaluated 121 polymorphisms to study a possible association between these SNPs and the response to ustekinumab (PASI75 at 4 months; n = 69). Results/Conclusion: ...


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