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Drug repurposing: a new front in the war against Staphylococcus aureus

05.08.2016 | Swetarka Das; Arunava Dasgupta; Sidharth Chopra, Future Microbiology, 2016

Staphylococcus aureus continues its domination of worldwide bacterial infection rates, thereby remaining a pathogen of significant public health interest. A major reason for its continued success is its ability to acquire and maintain diverse drug resistance mechanisms, leading to a paucity of ...


New insights into protecting the brain from the heart

05.08.2016 | Derk W Krieger, Future Neurology, 2016

Future Neurology August 2016, Vol. 11, No. 3, Pages 201-205.


Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese

05.08.2016 | Shinya Kasai; Daisuke Nishizawa; Junko Hasegawa; Naomi Sato; Fumihiko Tanioka; Haruhiko Sugimura; Kazutaka Ikeda, Pharmacogenomics, 2016

Aim: The endogenous opioid system has been reportedly implicated in tobacco/nicotine dependence. Materials & methods: We examined the genetic effects of eight SNPs in opioid receptor-related genes on smoking status and smoking-related traits in Japanese. Results: The genotypic and allelic ...


RpoE promotes invasion and intracellular survival by regulating SPI-1 and SPI-2 in Salmonella enterica serovar Typhi

05.08.2016 | Haifang Zhang; Yanwei Jia; Xiaofang Xie; Min Wang; Yi Zheng; Shungao Xu; Wei Zhang; Qiang Wang; Xinxiang Huang; Hong Du, Future Microbiology, 2016

Aim: To demonstrate the role of RpoE during the later stage of hyperosmotic stress in Salmonella. Materials & methods: Expressions of SPI-1 and SPI-2 under hyperosmotic stress for 120 min were investigated by a microarray, and the invasion and intracellular survival of wild-type and ΔrpoE strains ...


Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis

04.08.2016 | Young Ho Lee; Sung Jae Choi; Jong Dae Ji; Gwan Gyu Song, Pharmacogenomics, 2016

Aim: The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Materials & methods: We conducted a meta-analysis to evaluate the association between the ...


Pharmacogenetics of cystic fibrosis treatment

04.08.2016 | Suzanne C Carter; Edward F McKone, Pharmacogenomics, 2016

Cystic fibrosis (CF) is genetic autosomal recessive disease caused by reduced or absent function of CFTR protein. Treatments for patients with CF have primarily focused on the downstream end-organ consequences of defective CFTR. Since the discovery of the CFTR gene that causes CF in 1989 there ...


Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy

04.08.2016 | Niclas Eriksson; Lars Wallentin; Lars Berglund; Tomas Axelsson; Stuart Connolly; John Eikelboom; Michael Ezekowitz; ..., Pharmacogenomics, 2016

Aims: We investigated associations between genetic variation in candidate genes and on a genome-wide scale with warfarin maintenance dose, time in therapeutic range (TTR), and risk of major bleeding. Materials & methods: In total, 982 warfarin-treated patients from the RE-LY trial were studied. ...


Family health history: an essential starting point for personalized risk assessment and disease prevention

03.08.2016 | Vincent C Henrich; Lori A Orlando, Personalized Medicine, 2016

Family health history (FHH) information is well established as a basis for assessing a patient's personal disease risk, but is underutilized for diagnosis and making medical recommendations. Epidemiological and genetic information have heightened the value of FHH to an individual's health. This ...


Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong

01.08.2016 | Youssef M Roman; Kathleen A Culhane-Pera; Jeremiah Menk; Robert J Straka, Personalized Medicine, 2016

Aim: Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two- to five-fold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese ...


Is there a role for pharmacogenetics in the treatment of anorexia nervosa?

01.08.2016 | Sarah Smith; Blake Woodside, Pharmacogenomics, 2016

Pharmacogenomics August 2016, Vol. 17, No. 13, Pages 1381-1383.


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