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2.786 Aktuelle Fachpublikationen von Future Medicine

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Implementation and evaluation of a CYP2C19 genotype-guided antiplatelet therapy algorithm in high-risk coronary artery disease patients

31.03.2015 | John Andrew Lee; Craig R Lee; Brent N Reed; David C Plitt; Melissa J Polasek; Lucius A Howell; Jonathan D Cicci; Kri ..., Pharmacogenomics, 2015

Aim: An algorithm that uses clinical factors and CYP2C19 genotype to guide P2Y12 inhibitor selection in high-risk patients undergoing percutaneous coronary intervention was implemented at our institution. We sought to evaluate use of this algorithm and identify which factors influenced P2Y12 ...

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A multifaceted ‘omics’ approach for addressing the challenge of antimicrobial resistance

27.03.2015 | Asi Cohen; Louis Bont; Dan Engelhard; Edward Moore; David Fernández; Racheli Kreisberg-Greenblatt; Kfir Oved; Eran E ..., Future Microbiology, 2015

ABSTRACT  The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently ...

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Carbapenemase-producing Gram-negative bacteria: current epidemics, antimicrobial susceptibility and treatment options

27.03.2015 | Shio-Shin Jean; Wen-Sen Lee; Carlos Lam; Chin-Wang Hsu; Ray-Jade Chen; Po-Ren Hsueh, Future Microbiology, 2015

ABSTRACT  Carbapenemases, with versatile hydrolytic capacity against β-lactams, are now an important cause of resistance of Gram-negative bacteria. The genes encoding for the acquired carbapenemases are associated with a high potential for dissemination. In addition, infections due to ...

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RfiA, a novel PAP2 domain-containing polytopic membrane protein that confers resistance to the FtsZ inhibitor PC190723

27.03.2015 | Ximing Chen; Binglin Zhang; Jianxi Xiao; Furong Ju; Shuyan Li; Cuiling Ren; Lizhe An; Tuo Chen; Guangxiu Liu; Paul F ..., Future Microbiology, 2015

ABSTRACT  Background: As an essential protein for bacterial cell division, the tubulin-like FtsZ protein has been selected as a target for development of next generation antimicrobials. PC190723 is a fluoride-containing benzamide compound developed as a FtsZ inhibitor that selectively inhibits ...

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Emerging issues in antimicrobial resistance of bacteria from food-producing animals

27.03.2015 | Geovana Brenner Michael; Christin Freitag; Sarah Wendlandt; Christopher Eidam; Andrea T Feßler; Graciela Volz Lopes; ..., Future Microbiology, 2015

ABSTRACT  During the last decade, antimicrobial resistance in bacteria from food-producing animals has become a major research topic. In this review, different emerging resistance properties related to bacteria of food-producing animals are highlighted. These include: extended-spectrum ...

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Analytical validation of a melanoma diagnostic gene signature using formalin-fixed paraffin-embedded melanocytic lesions

27.03.2015 | M Bryan Warf; Darl D Flake II; Doug Adams; Alexander Gutin; Kathryn A Kolquist; Richard J Wenstrup; Benjamin B Roa, Biomarkers in Medicine, 2015

Aim: These studies were to validate the analytical performance of a gene expression signature that differentiates melanoma and nevi, using RNA expression from 14 signature genes and 9 normalization genes that generates a melanoma diagnostic score (MDS). Materials & Methods: Formalin-fixed ...

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Prospects of untreatable gonorrhea and ways forward

27.03.2015 | David M Whiley; Monica M Lahra; Magnus Unemo, Future Microbiology, 2015

Future Microbiology March 2015, Vol. 10, No. 3, Pages 313-316.

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Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria

27.03.2015 | Yves Briers; Rob Lavigne, Future Microbiology, 2015

ABSTRACT  The emergence and spread of antibiotic-resistant bacteria drives the search for novel classes of antibiotics to replenish our armamentarium against bacterial infections. This is particularly critical for Gram-negative pathogens, which are intrinsically resistant to many existing classes ...

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Fighting antibiotic resistance in the intensive care unit using antibiotics

27.03.2015 | Nienke L Plantinga; Bastiaan HJ Wittekamp; Pleun J van Duijn; Marc JM Bonten, Future Microbiology, 2015

ABSTRACT  Antibiotic resistance is a global and increasing problem that is not counterbalanced by the development of new therapeutic agents. The prevalence of antibiotic resistance is especially high in intensive care units with frequently reported outbreaks of multidrug-resistant organisms. In ...

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The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates

27.03.2015 | Henan Li; Xiaojuan Wang; Yawei Zhang; Chunjiang Zhao; Hongbin Chen; Sen Jiang; Feifei Zhang; Hui Wang, Future Microbiology, 2015

ABSTRACT  Aim: To analyze the expression and regulation of resistance-nodulation-division (RND) efflux systems in clinical tigecycline-nonsusceptible (TNS) Acinetobacter baumannii. Materials & methods: Comparisons of molecular and clinical characteristics were performed between 52 TNS and 53 ...

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