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3.827 Aktuelle Fachpublikationen von Future Medicine

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Corrigendum

27.01.2017 | Pharmacogenomics, 2017

Pharmacogenomics February 2017, Vol. 18, No. 3, Pages 318-319.

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miRNAs as biomarkers of neurodegenerative disorders

26.01.2017 | Vijitha Viswambharan; Ismail Thanseem; Mahesh M Vasu; Suresh A Poovathinal; Ayyappan Anitha, Biomarkers in Medicine, 2017

Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons, ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing therapies are mainly aimed at treating the most bothersome symptoms. Since early treatment is crucial in NDDs, ...

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Contribution of maternal hypertension to autism etiology in a murine model; cerebellar gene expression

25.01.2017 | Hind N Moussa; Baha M Sibai; Sean C Blackwell; Mateo G Leon; Michael J Hylin; John B Redell; Yin Liu; Pramod K Dash; ..., Future Neurology, 2017

Aim: To study the contribution of maternal hypertension to autism spectrum disorders’ (ASD) phenotype, and gene expression, in a murine model. Materials & methods: To examine the effects of maternal hypertension, we used a well-described transgenic mouse model lacking functional endothelial ...

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Noncoding RNA for personalized prostate cancer treatment: utilizing the ‘dark matters’ of the genome

25.01.2017 | Junjie Hua; Jennifer Lu; Keren Isaev; Fraser Soares; Haiyang Guo; Musaddeque Ahmed; Housheng Hansen He, Personalized Medicine, 2017

Prostate cancer is the most commonly diagnosed cancer in men in western countries, with significant health impact. Clinically, it is complicated with the lack of biomarkers and effective treatments for aggressive disease, particularly castration-resistant prostate cancer. Although we have gained ...

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What can the topology of white matter structural networks tell us about mild cognitive impairment?

25.01.2017 | Rok Berlot; Michael J O'Sullivan, Future Neurology, 2017

The focus of investigation in cognitive disorders has shifted from single regional motifs toward brain networks. White matter connections collectively form the connectome, and provide the underpinnings of distributed patterns of brain activity. We examine findings about large-scale properties of ...

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Dysregulation of miRNA-146a contributes to the development of lupus nephritis via targeting of TRAF6

24.01.2017 | Shupeng Wu; Jing Wang; Fang Li, Personalized Medicine, 2017

Aim: The objective of this study was to identify the association between genotypes of miR-146a rs2910164 and expression of TRAF6 as well as the risk of lupus nephritis (LN). Results: A total of 567 systemic lupus erythematosus patients both with and without LN were included in the study. The ...

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Erratum

24.01.2017 | Future Neurology, 2017

Future Neurology Ahead of Print.

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Genomic medicine practice among physicians in Taiwan

24.01.2017 | Lei-Shih Chen; Fung-Wei Chang; Minjung Kim; Divya Talwar; Shixi Zhao, Personalized Medicine, 2017

Aim: To examine genomic medicine (GM) practice and associated factors (i.e., attitudes, intention, self-efficacy, previous training in genomics, and demographic characteristics) among Taiwanese physicians. Methods: A survey was distributed to physicians attending an internal training workshop at ...

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Precision medicine in circadian rhythm sleep–wake disorders: current state and future perspectives

24.01.2017 | Henry Keijzer; Mark A Snitselaar; Marcel G Smits; Karen Spruyt; Phyllis C Zee; Friederike Ehrhart; Leopold MG Curfs, Personalized Medicine, 2017

In circadian rhythm sleep–wake disorders precision medicine is less developed than in other medical disciplines mainly because homeostatic sleep and circadian timing have a very complex phenotype with multiple genetic regulation mechanisms. However, biomarkers, phenotyping and psychosocial ...

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Beyond the Genetic Information Nondiscrimination Act: ethical and economic implications of the exclusion of disability, long-term care and life insurance

24.01.2017 | Jessica D Tenenbaum; Kenneth W Goodman, Personalized Medicine, 2017

The Genetic Information Nondiscrimination Act (GINA) was intended to protect individuals in the USA from discrimination based on their genetic data, but does not apply to life, long-term care or disability insurance. Patient advocates and ethicists have argued that GINA does not go far enough. ...

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