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Ceftobiprole medocaril in the treatment of hospital-acquired pneumonia

17.11.2015 | Thomas WL Scheeren, Future Microbiology, 2015

Ceftobiprole medocaril is a fifth-generation cephalosporin approved in Europe as single-agent therapy for hospital-acquired pneumonia (HAP), excluding ventilator-associated pneumonia (VAP). It is rapidly converted to the active metabolite ceftobiprole following intravenous administration. ...


Evaluation of platelet distribution width in chronic obstructive pulmonary disease patients with pulmonary embolism

16.11.2015 | Maofeng Wang; Jun Zhang; Qiaoying Ji; Qiongfang Yang; Fenhua Zhao; Weimin Li; Hao-Teng Chang; Xinyou Xie, Biomarkers in Medicine, 2015

Background: Platelets play an important role in the pathogenesis of pulmonary embolism (PE). We aimed to investigate whether there is a correlation between platelet distribution width (PDW) and chronic obstructive pulmonary disease (COPD) patients with PE. Methods: We conducted a retrospective ...


A joint model based on longitudinal CA125 in ovarian cancer to predict recurrence

13.11.2015 | Chung Chang; An Jen Chiang; Wei-An Chen; Hsueh-Wen Chang; Jiabin Chen, Biomarkers in Medicine, 2015

Aims: To develop a new package of joint model to fit longitudinal CA125 in epithelial ovarian cancer relapse. Patients & methods: Included were 305 epithelial ovarian cancer patients who reached complete remission after cytoreductive surgery and first-line chemotherapy. Univariate and ...


Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy

13.11.2015 | Tsutomu Mieda; Daisuke Nishizawa; Hideyuki Nakagawa; Miki Tsujita; Hirokazu Imanishi; Kazuhisa Terao; Hiroaki Yoshik ..., Pharmacogenomics, 2015

Aims: Opioids are widely used as effective analgesics, but opioid sensitivity is well known to vary widely among individuals and the underlying genetic factors are not fully understood, thus hampering efficient pain treatment. We explored the genetic factors that contribute to individual ...


Impact of recipient ACE I/D genotype on kidney function in renal transplant patients: a meta-analysis of cross-sectional and longitudinal studies

11.11.2015 | Sarah Cargnin; Marco Quaglia; Pier Luigi Canonico; Piero Stratta; Salvatore Terrazzino, Pharmacogenomics, 2015

Aim: To perform a systematic review and meta-analysis of studies evaluating the influence of recipient angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on kidney function in renal transplant recipients. Methods: A comprehensive search was performed through PubMed, Web of ...


Cost–effectiveness analysis of genotyping for HLA-B*5801 and an enhanced safety program in gout patients starting allopurinol in Singapore

10.11.2015 | Di Dong; Wei-Chuen Tan-Koi; Gim Gee Teng; Eric Finkelstein; Cynthia Sung, Pharmacogenomics, 2015

Aims: Allopurinol is an efficacious urate-lowering therapy (ULT), but is associated with rare serious adverse drug reactions of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with higher risk among HLA-B*5801 carriers. We assessed the cost–effectiveness of HLA-B*5801 ...


Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis

10.11.2015 | Hye Duck Choi; Wan Gyoon Shin, Pharmacogenomics, 2015

Aim: Catechol-O-methyltransferase (COMT) is one of the major degradative pathways of dopamine and COMT Val/Met polymorphisms are associated with the enzyme activity, which is related to dopamine involvement in the nicotine addiction process. However, the reported results of several genetic ...


Height outcome of short children with hypochondroplasia after recombinant human growth hormone treatment: a meta-analysis

10.11.2015 | Francesco Massart; Mario Miccoli; Angelo Baggiani; Silvano Bertelloni, Pharmacogenomics, 2015

Hypochondroplasia (HCH) is a genetic skeletal dysplasia, characterized by rhizomelic short height (Ht) with facial dysmorphology and lumbar hyperlordosis. Albeit there are concerns that HCH children may not achieve optimal long-term outcome in response to recombinant human growth hormone (rhGH), ...


A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population

10.11.2015 | Fang Wang; Weifeng Mi; Wenbin Ma; Cuicui Ma; Yongfeng Yang; Hongxing Zhang; Bo Du; Keqing Li; Chenxing Liu; Lifang W ..., Pharmacogenomics, 2015

Aim: We carried out a pharmacogenomic study in order to identify susceptible genes for antipsychotics induced weight gain within the Chinese Han population. Materials & methods: We enrolled 216 patients with schizophrenia in our study. All of them underwent risperidone monotherapy, and fulfilled ...


Yin and yang of cytidine deaminase roles in clinical response to azacitidine in the elderly: a pharmacogenetics tale

10.11.2015 | Raphaelle Fanciullino; Cédric Mercier; Cindy Serdjebi; Geoffroy Venton; Julien Colle; Frédéric Fina; L'Houcine Ouafi ..., Pharmacogenomics, 2015

Azacitidine is a mainstay for treating hematological disorders. Azacitidine is metabolized by cytidine deaminase, coded by a highly polymorphic gene. Here, we present two elderly patients with opposite clinical outcomes after azacitidine treatment. First, an acute myeloid leukemia patient showed ...


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