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2.530 Aktuelle Fachpublikationen von Future Medicine


Biomarkers in congenital heart disease

13.10.2014 | Richard Dobson; Hamish A Walker; Niki L Walker, Biomarkers in Medicine, 2014

The population of adults with congenital heart disease (CHD) now exceeds the population of children with CHD. The long-term management of these patients relies on sequential assessment of anatomy and physiology and integration with symptoms, all targeted toward decision making around ...


No association between CYP3A4*22 and statin effectiveness in reducing the risk for myocardial infarction

10.10.2014 | Maarten Leusink; Catherine E de Keyser; N Charlotte Onland-Moret; Albert Hofman; Loes E Visser; Bruno H Stricker; Pa ..., Pharmacogenomics, 2014

Aim: Genetic variation has been shown to influence statin response in terms of lowering LDL cholesterol. The recently discovered CYP3A4*22 allele (defined as rs35599367) has been shown to affect statin-induced LDL cholesterol lowering. Our objective was to investigate whether this polymorphism ...


Pharmacogenetics of erectile dysfunction: navigating into uncharted waters

10.10.2014 | Riccardo Lacchini; Jose E Tanus-Santos, Pharmacogenomics, 2014

Sildenafil and other PDE-5 inhibitors have revolutionized erectile dysfunction (ED) treatment. However, a significant number of patients do not respond or present adverse reactions to these drugs. While genetic polymorphisms may underlie this phenomenon, very little research has been undertaken ...


GRIK4 polymorphism and its association with antidepressant response in depressed patients: a meta-analysis

10.10.2014 | Daniel M Kawaguchi; Stephen J Glatt, Pharmacogenomics, 2014

Aim: This study aimed to evaluate the relationship between a human GRIK4 gene polymorphism (rs1954787) and responsiveness to antidepressant treatment in depressed patients. Methods: A meta-analysis was carried out on five studies. Pooled odds ratios (ORs), 95% CIs and a χ2 test measuring ...


Relationship between the CYP2C9 IVS8-109A>T polymorphism and high losartan hydroxylation in healthy Ecuadorian volunteers

10.10.2014 | Pedro Dorado; Alicia Gallego; Eva Peñas-LLedó; Enrique Terán; Adrián LLerena, Pharmacogenomics, 2014

Aim: The CYP2C9 IVS8-109T allele was recently found to be more frequent among Swedish individuals, who have the highest losartan metabolic ratio (MR; losartan:E-3174). Thus, the influence of the CYP2C9 IVS8-109A>T polymorphism on the losartan MR was evaluated among healthy Ecuadorians. In ...


Is there a role for the MTHFR 677C>T and 1298A>C polymorphisms in methotrexate-induced liver toxicity?

10.10.2014 | D Maroeska WM te Loo; Melanie M Hagleitner; Marieke JH Coenen, Pharmacogenomics, 2014

Pharmacogenomics August 2014, Vol. 15, No. 11, Pages 1401-1403.


Pharmacokinetic and CYP3A5 pharmacogenetic differences between once- and twice-daily tacrolimus from the first dosing day to 1 year after renal transplantation

10.10.2014 | Shigeru Satoh; Takenori Niioka; Hideaki Kagaya; Kazuyuki Numakura; Takamitsu Inoue; Mitsuru Saito; Naoki Komine; Shi ..., Pharmacogenomics, 2014

Aim & patients & methods: This study investigated 24-h pharmacokinetic and CYP3A5 pharmacogenetic differences between once-daily tacrolimus (Tac-q.d.) versus twice-daily tacrolimus (Tac-b.i.d.) pretransplantation and at 1 month and 1 year post-transplantaion. Results: The dose-adjusted trough ...


Pharmacogenomic testing: the case for CYP2C19 proton pump inhibitor gene–drug pairs

10.10.2014 | John J Lima; James P Franciosi, Pharmacogenomics, 2014

The use of proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux and related diseases is increasing, especially in the pediatric population. Prolonged use of PPIs has been associated with several adverse effects, including potentially life-threatening gastric and respiratory ...


From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity

10.10.2014 | Nataša Karas-Kuželički; Alenka Šmid; Riin Tamm; Andres Metspalu; Irena Mlinarič-Raščan, Pharmacogenomics, 2014

Aim: In the present study, the influence of SAM on TPMT activity in vivo on human subjects was investigated. Subjects & methods: A total of 1017 donors from the Estonian Genome Center of the University of Tartu (Estonia) were genotyped for common TPMT variants, evaluated for TPMT activity, SAM ...


HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population

10.10.2014 | Fanping Yang; Bo Gu; Lirong Zhang; Jiekun Xuan; Heng Luo; Peng Zhou; Qinyuan Zhu; Sijia Yan; Sheng-an Chen; Zhihao C ..., Pharmacogenomics, 2014

Aim: Salazosulfapyridine (SASP) frequently causes several adverse reactions, such as drug rash with eosinophilia and systemic symptoms (DRESS). This study aims to assess whether there is an association between SASP-induced DRESS and HLA-A, -B and -C alleles in the Chinese Han population. Subjects ...


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