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2.934 Aktuelle Fachpublikationen von Future Medicine

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Increase of widespread A, B1 and D Escherichia coli clones producing a high diversity of CTX-M-types in a Portuguese hospital

29.06.2015 | Carla Rodrigues; Elisabete Machado; João Pires; Helena Ramos; Ângela Novais; Luísa Peixe, Future Microbiology, 2015

ABSTRACT  Aim: To characterize temporal shifts in extended-spectrum β-lactamases (ESBLs) and clones of clinical Escherichia coli isolates. Materials & methods: All ESBL-producing E. coli isolates from a Portuguese hospital (n = 112; June 2006–June 2007 and January–December 2010) were ...

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Clinical experience with the use of daptomycin in a tertiary care teaching hospital in Barcelona, Spain

29.06.2015 | Nancy Sandoval; Santiago Grau; Luisa Sorlí; Milagro Montero; Erika Esteve; Juan Pablo Horcajada, Future Microbiology, 2015

ABSTRACT  Aim: We reviewed the clinical use of daptomycin in daily practice. Materials & methods: Efficacy and safety were assessed in 175 consecutive patients given daptomycin for at least 72 h. Results: Daptomycin was given as rescue treatment in 50.9% of cases. Bloodstream infection (34.8%) ...

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Antibodies as a source of anti-infective peptides: an update

29.06.2015 | Walter Magliani; Laura Giovati; Tecla Ciociola; Martina Sperindè; Claudia Santinoli; Giorgio Conti; Stefania Conti; ..., Future Microbiology, 2015

ABSTRACT  This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab–drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides ...

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Antimicrobial peptides: has their time arrived?

29.06.2015 | Enea Sancho-Vaello; Kornelius Zeth, Future Microbiology, 2015

Future Microbiology Ahead of Print, Pages 1-4.

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Pharmacogenetics in electroconvulsive therapy and adjunctive medications

26.06.2015 | Hooman Mirzakhani; Martijn S van Noorden; Jesse Swen; Ala Nozari; Henk-Jan Guchelaar, Pharmacogenomics, 2015

Electroconvulsive therapy (ECT) has shown apparent efficacy in treatment of patients with depression and other mental illnesses who do not respond to psychotropic medications or need urgent control of their symptoms. Pharmacogenetics contributes to an individual's sensitivity and response to a ...

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Role of cytochrome P450 2C8*3 (CYP2C8*3) in paclitaxel metabolism and paclitaxel-induced neurotoxicity

26.06.2015 | Mi-Young Lee; María Apellániz-Ruiz; Inger Johansson; Svante Vikingsson; Troels K Bergmann; Kim Brøsen; Henrik Green; ..., Pharmacogenomics, 2015

Aim: The CYP2C8*3 allele has been suggested as a risk factor for paclitaxel-induced neuropathy but the data hitherto published are conflicting. Materials & methods: In total 435 patients were investigated with respect to maximum neuropathy grade and accumulated paclitaxel dose. The enzymatic ...

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Effects of IGF2BP2, KCNQ1 and GCKR polymorphisms on clinical outcome in metastatic gastric cancer treated with EOF regimen

26.06.2015 | Xin Liu; Zhiyu Chen; Xiaoying Zhao; Mingzhu Huang; Chenchen Wang; Wei Peng; Jiliang Yin; Jin Li; Guang He; Xin Li; X ..., Pharmacogenomics, 2015

Aim: The present study analyzed Type 2 diabetes mellitus (T2D)-related gene polymorphisms and their impacts on chemotherapeutic response and survival in patients with metastatic gastric cancer (MGC). Patients & methods: This retrospective study enrolled 108 MGC patients treated with first-line ...

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Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation

24.06.2015 | Ignacio Sánchez-Lázaro; María José Herrero; Consuelo Jordán-De Luna; Virginia Bosó; Luis Almenar; Luis Rojas; Luis M ..., Pharmacogenomics, 2015

Aim: Studying the possible influence of SNPs on efficacy and safety of calcineurin inhibitors upon heart transplantation. Materials & methods: In 60 heart transplant patients treated with tacrolimus or cyclosporine, we studied a panel of 36 SNPs correlated with a series of clinical parameters ...

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Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children

24.06.2015 | Angela M Devlin; Constadina Panagiotopoulos, Pharmacogenomics, 2015

Second-generation antipsychotics (SGAs) are increasingly being used to treat children for a range of mental health conditions, for example, anxiety disorder, attention deficit hyperactivity disorder and bipolar disorder. SGA treatment is associated with weight gain and cardiometabolic side ...

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Psychiatric pharmacists’ perception on the use of pharmacogenomic testing in the mental health population

23.06.2015 | Ilona Shishko; Kenneth Almeida; Richard J Silvia; Gary R Tataronis, Pharmacogenomics, 2015

Aim: Pharmacogenomics could play a role in improving patient care, reducing adverse drug reactions and overall healthcare costs. However, whether it is utilized may be determined by how it is perceived by healthcare professionals, including pharmacists. Methods: A cross-sectional web-based survey ...

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