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Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

22.06.2017 | Niloufar Farzan; Susanne J Vijverberg; Anand K Andiappan; Lambang Arianto; Vojko Berce; Natalia Blanca-López; Hans B ..., Pharmacogenomics, 2017

Aim: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. Materials & methods: Investigators of each study participating in PiCA provided data on the ...


Neurotransmitter receptor genotypes associated with mental and behavioral disorders

22.06.2017 | Ekrem Varoglu; Adil Seytanoglu; Esra Asilmaz; Bahar Taneri, Personalized Medicine, 2017

Aim: Investigation of association studies within the field of mental and behavioral disorders is of value given their complex molecular etiology including epistatic interactions of multiple genes with small effects. Materials & methods: Utilizing biomedical text mining, associations are uncovered ...


CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles

22.06.2017 | Anne B Koopmans; David J Vinkers; Petra JA Gelan; Hans W Hoek; Peter N van Harten, Pharmacogenomics, 2017

Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic ...


MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy

22.06.2017 | Matthew Goblirsch; Georg Richtig; Ondrej Slaby; Ioana Berindan-Neagoe; Armin Gerger; Martin Pichler, Pharmacogenomics, 2017

Colorectal cancer is a common type of malignant disease with high rates of morbidity and mortality. Although treatment options have been expanded over the last years, the mainstay of curative treatment remains surgical removal of the tumor-bearing organ. Systemic treatment options include classic ...


Healthcare provider education to support integration of pharmacogenomics in practice: the eMERGE Network experience

22.06.2017 | Carolyn R Rohrer Vitek; Noura S Abul-Husn; John J Connolly; Andrea L Hartzler; Terrie Kitchner; Josh F Peterson; Luk ..., Pharmacogenomics, 2017

Ten organizations within the Electronic Medical Records and Genomics Network developed programs to implement pharmacogenomic sequencing and clinical decision support into clinical settings. Recognizing the importance of informed prescribers, a variety of strategies were used to incorporate ...


MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy

22.06.2017 | Karin Vos; Carlotta Lo Sciuto; Rita Piedade; Michael Ashton; Anders Björkman; Billy Ngasala; Andreas Mårtensson; Jos ..., Pharmacogenomics, 2017

Aim: To investigate the potential involvement of the hepatic ATP-binding cassette transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with uncomplicated Plasmodium falciparum malaria. Materials & methods: The tag SNPs MDR1/ABCB1 C3435T and MRP2/ABCC2 C1515Y were ...


Biomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects

16.06.2017 | Lais Osmani; Qing Kay Li, Biomarkers in Medicine, 2017

Biomarkers in Medicine May 2017, Vol. 11, No. 5, Pages 405-407.


SLC28A3 rs7853758 as a new biomarker of tacrolimus elimination and new-onset hypertension in Chinese liver transplantation patients

16.06.2017 | Yuan Liu; Tao Zhang; Changcan Li; Ling Ye; Haitao Gu; Lin Zhong; Hongcheng Sun; Yahuang Sun; Zhihai Peng; Junwei Fan, Biomarkers in Medicine, 2017

Aim: The effect of SLC28A3 on tacrolimus disposition and new-onset hypertension (NOHP) after liver transplantation (LT) remains unclear. Methodology & results: A total of 169 patients in two cohorts from the China Liver Transplant Registry database were included. Rs7853758 in recipients’SLC28A3 ...


Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis

16.06.2017 | Delin Zhang; Jianzhao Huang; Dan Luo; Xinfu Feng; Yan Liu, Biomarkers in Medicine, 2017

Aim: This research is to explore the glycosylation change of alpha-1-acid glycoprotein (AGP) in hepatocellular carcinoma (HCC), cirrhosis and controls. Methods: The affinity chromatography and lectin affinity techniques were used to separate and enrich glycosylated AGP, and combined with mass ...


Preoperative serum TMAO level is a new prognostic marker for colorectal cancer

16.06.2017 | Xiaomei Liu; Heng Liu; Caijun Yuan; Yinxu Zhang; Wei Wang; Shuding Hu; Lei Liu; Ying Wang, Biomarkers in Medicine, 2017

Aim: This study is aimed to determine whether trimethylamine-N-oxide (TMAO) is a predictor of prognosis of patients with colorectal cancer. Methods: Pretreatment TMAO serum levels were determined in 108 patients with colorectal cancer and 30 healthy controls. Results: Median serum TMAO level was ...


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