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3.319 Aktuelle Fachpublikationen von Future Medicine

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Alterations in pain responsiveness and serum biomarkers in juvenile myoclonic epilepsy: an age- and gender-matched controlled pilot study

22.01.2016 | Lydia Anja Jakobsen; Ali Karshenas; Flemming Winther Bach; Parisa Gazerani, Future Neurology, 2016

Introduction: Serum levels of several biomarkers along with sensory responsiveness were investigated in juvenile myoclonic epilepsy patients in comparison with healthy controls. Methods: Ten epileptic patients (36.1 ± 3.4 years) and ten gender- and age-matched healthy controls were recruited. ...

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Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines

22.01.2016 | Daniel L Hertz; Megan V Caram; Kelley M Kidwell; Jacklyn N Thibert; Christina Gersch; Nicholas J Seewald; Jeffrey Sm ..., Pharmacogenomics, 2016

Aims: Validation of associations for SNPs in RAC2, NCF4 and SLC28A3, identification of a novel association with a TOP2B SNP and screening 23 SNPs putatively relevant to anthracycline-induced cardiotoxicity. Patients & methods: A total of 166 breast cancer patients treated with doxorubicin ...

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Identifying network-based biomarkers of complex diseases from high-throughput data

20.01.2016 | Zhi-Ping Liu, Biomarkers in Medicine, 2016

In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, ...

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MicroRNA-509–3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis

20.01.2016 | Wei Chen; Wenshu Zeng; Xiaodi Li; Weiliang Xiong; Mengdie Zhang; Yan Huang; Longshu Zhou; Songshan Jiang, Pharmacogenomics, 2016

Aims: XIAP is upregulated in chemoresistant epithelial ovarian cancer (EOC). However, the molecular mechanism of this dysregulation remains unclear. Materials & methods: The regulation of XIAP by miR-509–3p was investigated by luciferase reporter assay, real-time PCR and immunobloting, and the ...

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Donor ABCB1 3435 C>T genetic polymorphisms influence early renal function in kidney transplant recipients treated with tacrolimus

19.01.2016 | Lin Yan; Yi Li; Jiang-Tao Tang; Yun-Fei An; Lan-Lan Wang; Yun-Ying Shi, Pharmacogenomics, 2016

Aim: Determine the effect of genetic variants of donors and recipients on early renal function and tacrolimus pharmacokinetics in kidney transplant recipients. Patients & methods: We measured CYP3A5 (6986A>G), ABCB1 (3435C>T, 2677G>T/A, 1236C>T) genetic polymorphisms in 120 renal transplant ...

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CYP450 genotype and pharmacogenetic association studies: a critical appraisal

18.01.2016 | Rashmi R Shah; Andrea Gaedigk; Adrián LLerena; Michel Eichelbaum; Julia Stingl; Robert L Smith, Pharmacogenomics, 2016

Despite strong pharmacological support, association studies using genotype-predicted phenotype as a variable have yielded conflicting or inconclusive evidence to promote personalized pharmacotherapy. Unless the patient is a genotypic poor metabolizer, imputation of patient's metabolic capacity ...

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The analysis of DKK1 polymorphisms in relation to skeletal phenotypes and bone response to alendronate treatment in Chinese postmenopausal women

18.01.2016 | Jian-yi Wang; Pei-ran Zhou; Yi Liu; Xiao-jie Xu; Dou-dou Ma; Wei-bo Xia; Yan Jiang; Ou Wang; Xiao-ping Xing; Mei Li, Pharmacogenomics, 2016

Aim: To investigate the correlation between DKK1 polymorphisms with bone phenotypes and response to alendronate treatment. Materials & methods: Five tag single nucleotide polymorphisms of DKK1 were analyzed in 639 Chinese postmenopausal women with osteoporosis or osteopenia. Bone mineral density ...

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Dual-coated lactic acid bacteria: an emerging innovative technology in the field of probiotics

18.01.2016 | Guillermo Alvarez-Calatayud; Abelardo Margolles, Future Microbiology, 2016

Probiotics are living micro-organisms that do not naturally have shelf life, and normally are weakly protected against the digestive action of the GI tract. A new dual coating technology has been developed in an effort to maximize survival, that is, to be able to reach the intestine alive and in ...

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Candidate gene analysis of pharmacodynamic targets for antipsychotic dosage

18.01.2016 | Nuwan C Hettige; Gustavo HF de Moraes; James L Kennedy; Vincenzo De Luca, Pharmacogenomics, 2016

Aim: In order to administer antipsychotic medication with the most beneficial outcome, the appropriate drug and dose needs to be identified. Though often not considered in pharmacogenetic studies, dosage plays an important role in treatment outcome. This study set out to analyze the association ...

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Serum endothelial cell specific molecule-1 (endocan) levels in patients with obstructive sleep apnea

14.01.2016 | Zuleyha Bingol; Murat Kose; Aylin Pıhtılı; Timur Akpınar; Tufan Tukek; Esen Kıyan, Biomarkers in Medicine, 2016

Objective: To investigate the level of endothelial cell specific molecule-1 (endocan) in obstructive sleep apnea (OSA). Methods: Study group included subjects with OSA. Control group included subjects who had no OSA on polysomnography and nonobese healthy subjects from population who had no OSA ...

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