24.06.2014 | Fernando Santos-Beneit; Lorena T Fernández-Martínez; Antonio Rodríguez García; Seomara Martín-Martín; María Ordóñez- ..., Future Microbiology, 2014

ABSTRACT:  Aim: The main objective of this study is to understand the mechanism of vancomycin resistance in a Streptomyces coelicolor disrupted mutant highly resistant to vancomycin. Materials & methods: Different techniques have been performed in the study including gene disruption, primer ...

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24.06.2014 | Anuradha Chowdhary; Cheshta Sharma; Ferry Hagen; Jacques F Meis, Future Microbiology, 2014

ABSTRACT:  Aspergillus fumigatus, a ubiquitously distributed opportunistic pathogen, is the global leading cause of aspergillosis. Azole antifungals play an important role in the management of aspergillosis. However, over a decade, azole resistance in A. fumigatus isolates has been increasingly ...

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24.06.2014 | Keith A Jolley; Martin CJ Maiden, Future Microbiology, 2014

ABSTRACT:  Multilocus sequence typing (MLST) indexes the sequence variation present in a small number (usually seven) of housekeeping gene fragments located around the bacterial genome. Unique alleles at these loci are assigned arbitrary integer identifiers, which effectively summarizes the ...

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23.06.2014 | Andrzej Pawlik; Ewa Dabrowska-Zamojcin; Violetta Dziedziejko, Pharmacogenomics, 2014

Pharmacogenomics May 2014, Vol. 15, No. 7, Pages 905-907.

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23.06.2014 | Yee Ming Lee; Jessica Eggen; Vinay Soni; Katarzyna Drozda; Edith A Nutescu; Larisa H Cavallari, Pharmacogenomics, 2014

We describe a 64-year-old male of Indian descent with a history of atrial fibrillation who was started on warfarin after hospital admission for acute stroke. He received genotype-guided warfarin dosing as per the standard-of-care at our hospital, with daily dose recommendations provided by the ...

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23.06.2014 | Aizati NA Daud; Jorieke EH Bergman; Marian K Bakker; Hao Wang; Hermien EK de Walle; Torsten Plösch; Bob Wilffert, Pharmacogenomics, 2014

One of the ongoing issues in perinatal medicine is the risk of birth defects associated with maternal drug use. The teratogenic effect of a drug depends, apart from other factors, on the exposition of the fetus to the drug. Transporter proteins are known to be involved in the pharmacokinetics of ...

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23.06.2014 | Hui-Ju Tsai; Sheng-Chang Wang; Sheng-Wen Liu; Ing-Kang Ho; Yao-Sheng Chang; Yu-Ting Tsai; Keh-Ming Lin; Yu-Li Liu, Pharmacogenomics, 2014

Aim: Methadone dose is related to treatment success in individuals under methadone maintenance treatment (MMT). We constructed a gene matrix using previously identified genetic polymorphisms in CYP450 and determined their genetic influence on methadone dose or tolerance. Materials & methods: The ...

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23.06.2014 | Juan Jose Cerezo-Manchado; Vanessa Roldan; Mario Rosafalco; Ana Isabel Anton; Ana Belen Arroyo; Nuria Garcia-Barbera ..., Pharmacogenomics, 2014

Aim: To analyze VKORC1, CYP2C9 and CYP4F2 polymorphisms in relation to the main outcomes in the first stages of acenocoumarol therapy. Patients & methods: Nine hundred and forty one patients who had started therapy and in whom time to stable dosage, time to over-anticoagulation and adverse events ...

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23.06.2014 | Andrew A Somogyi; Daniel T Barratt; Robert L Ali; Janet K Coller, Pharmacogenomics, 2014

Methadone is the major opioid substitution therapy for opioid dependence. Dosage is highly variable and is often controlled by the patient and prescriber according to local and national policy and guidelines. Nevertheless many genetic factors have been investigated including those affecting its ...

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23.06.2014 | Joseph S Rossi; Michael Cammarata; Jayalalitha Dharmavaram; Karen Weck; Christine Walko; Don Gabriel; Jack Kuritzky; ..., Pharmacogenomics, 2014

This pilot study examined the feasibility of outpatient screening and clopidogrel dose adjustment for patients with previous percutaneous coronary intervention and at least one CYP2C19 loss-of-function allele. After screening a total of 211 outpatients, 50 patients were enrolled in a crossover ...

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