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3.105 Aktuelle Fachpublikationen von Future Medicine


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The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis

29.09.2015 | Rocío Prieto-Pérez; Guillermo Solano-López; Teresa Cabaleiro; Manuel Román; Dolores Ochoa; María Talegón; Ofelia Ban ..., Pharmacogenomics, 2015

Psoriasis improves when IL-17 is blocked. Anti-TNF drugs reduce the IL-17 signaling pathway, and anti-IL-17 drugs are being developed to treat moderate-to-severe psoriasis. We analyzed three SNPs in IL-17A (rs2275913 and rs10484879) and IL-17F (rs763780) to look for an association with psoriasis ...


TPMT gene expression is increased during maintenance therapy in childhood acute lymphoblastic leukemia patients in a TPMT gene promoter variable number of tandem repeat-dependent manner

28.09.2015 | Nikola Kotur; Lidija Dokmanovic; Dragana Janic; Biljana Stankovic; Nada Krstovski; Natasa Tosic; Theodora Katsila; G ..., Pharmacogenomics, 2015

Aims: 6-mercaptopurine influences in vitro TPMT gene expression in a TPMT promoter variable number of tandem repeats (VNTR)-dependent manner. We studied TPMT expression following 6-mercaptopurine and methotrexate administration in childhood acute lymphoblastic leukemia (ALL) patients and the ...


Clinical application of pharmacogenetics: focusing on practical issues

28.09.2015 | Matthew T Chang; Jeanette J McCarthy; Jaekyu Shin, Pharmacogenomics, 2015

Recent large-scale genetic-based studies have transformed the field of pharmacogenetics to identify, characterize and leverage genetic information to inform patient care. Genetic testing can be used to alter drug selection, optimize drug dosing and prevent unnecessary adverse events. As precision ...


The future of patient-derived tumor xenografts in cancer treatment

24.09.2015 | Daniela Sia; Agrin Moeini; Ismail Labgaa; Augusto Villanueva, Pharmacogenomics, 2015

Over the last decades, major technological advancements have led to a better understanding of the molecular drivers of human malignancies. Nonetheless, this progress only marginally impacted the cancer therapeutic approach, probably due to the limited ability of experimental models to predict ...


Systems medicine, personalized health and therapy

24.09.2015 | Gérard Siest; Charles Auffray; Naoyuki Taniguchi; Magnus Ingelman-Sundberg; Helena Murray; Sophie Visvikis-Siest; Ma ..., Pharmacogenomics, 2015

The 7th Santorini Conference was held in Santorini, Greece, and brought together 200 participants from 40 countries in several continents, including Europe, USA but also Japan, Korea, Brazil and South Africa. The attendees had the opportunity to: listen to 60 oral presentations; participate in ...


BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence

24.09.2015 | Sri-arun Iamjan; Samur Thanoi; Paritat Watiktinkorn; Sutisa Nudmamud-Thanoi; Gavin P Reynolds, Pharmacogenomics, 2015

Aim: Association of the brain-derived neurotrophic factor (BDNF) genetic polymorphism rs6265 (Val66Met) with methamphetamine (METH) dependence and METH-induced psychosis was investigated in the Thai population. Materials & methods: The rs6265 genotype was determined in 100 male METH-dependent ...


IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients

24.09.2015 | Di Xiao; Si-Min Zhang; Xi Li; Ji-Ye Yin; Wei-Jing Gong; Yi Zheng; Xiao-Jing Xu; Xu Lin; Li-Nong Ji; Rang-Ru Liu; Qia ..., Pharmacogenomics, 2015

Aim: To investigate the potential genetic effect on metformin efficacy in overweight or obese Chinese Type 2 diabetes mellitus (T2DM) patients. Patients & methods: 768 SNPs in or close to 207 genes were genotyped in 84 patients treated with metformin + glibenclamide/Xiaoke Pill. Significant SNPs ...


The use of genetic information in the prediction of Type 2 diabetes

23.09.2015 | Fotios Drenos, Personalized Medicine, 2015

Type 2 diabetes (T2D) is a metabolic disorder characterized by high blood glucose levels and elevated risk of cardiovascular events. The progression of T2D can be delayed, or prevented, so early prediction is of high importance. More than 70 genetic loci are associated with T2D risk, raising the ...


Personalized medicine in pancreatic cancer: the revolution has begun

21.09.2015 | Raphaël Maréchal; Francesco Puleo; Anne Demols; Gontran Verset; Jean-Luc Van Laethem, Personalized Medicine, 2015

Pancreatic ductal adenocarcinoma carries a dismal prognosis. Both chemotherapy and targeted therapies have been disappointing when administered to unselected populations. Recently, progress has been made in our understanding of the genomic landscape of this cancer which displays remarkable ...


Personalizing the management of gastroesophageal cancer

21.09.2015 | Elizabeth C Smyth, Personalized Medicine, 2015

Personalized Medicine Ahead of Print.


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