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3.607 Aktuelle Fachpublikationen von Future Medicine

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Association between DCK 35708 T>C variation and clinical outcomes of acute myeloid leukemia in South Chinese patients

22.08.2016 | Dao-Yu Zhang; Xiao-Qing Yuan; Han Yan; Shan Cao; Wei Zhang; Xiao-Lin Li; Hui Zeng; Xiao-Ping Chen, Pharmacogenomics, 2016

Aim: DCK is a rate-limiting enzyme in cytarabine activation. rs4643786 and rs67437265 (P122S) variants are reported to affect DCK activity. Patients & methods: A total of 282 newly diagnosed acute myeloid leukemia (AML) patients were treated with cytarabine combined chemotherapy and genotyped for ...

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Corynebacterium ulcerans, an emerging human pathogen

22.08.2016 | Elena Hacker; Camila A Antunes; Ana L Mattos-Guaraldi; Andreas Burkovski; Andreas Tauch, Future Microbiology, 2016

While formerly known infections of Corynebacterium ulcerans are rare and mainly associated with contact to infected cattle, C. ulcerans has become an emerging pathogen today. In Western Europe, cases of respiratory diphtheria caused by C. ulcerans have been reported more often than infections by ...

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Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion

22.08.2016 | Natalia Muñoz-Wolf; Analía Rial; Delphine Fougeron; Julien Tabareau; Jean-Claude Sirard; José A Chabalgoity, Future Microbiology, 2016

Aim: To evaluate efficacy of sublingual flagellin to treat acute pneumonia. Materials & methods: Mice were treated sublingually with flagellin and challenged intranasally with a lethal dose of pneumococcus. Flagellins lacking TLR5 or NLRC4 activation domains were used to assess their contribution ...

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Design and evaluation of an oral multiparticulate system for dual delivery of amoxicillin and Lactobacillus acidophilus

22.08.2016 | Mershen Govender; Yahya E Choonara; Sandy van Vuuren; Pradeep Kumar; Lisa C du Toit; Viness Pillay, Future Microbiology, 2016

Aim: A delayed-release dual delivery system for amoxicillin and the probiotic Lactobacillus acidophilus was developed and evaluated. Materials & methods: Statistical optimization of a cross-linked denatured ovalbumin protective matrix was first synthesized using a Box–Behnken experimental design ...

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Long noncoding RNAs to predict survival in acute myeloid leukemia: a step toward personalized medicine?

22.08.2016 | Bhavana Bhatnagar; Ramiro Garzon, Biomarkers in Medicine, 2016

Biomarkers in Medicine Ahead of Print.

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Diversity of Acinetobacter species isolated from different environments in Lebanon: a nationwide study

22.08.2016 | Ahmad Al Atrouni; Monzer Hamze; Rayane Rafei; Matthieu Eveillard; Marie-Laure Joly-Guillou; Marie Kempf, Future Microbiology, 2016

Aim: To investigate the extrahospital reservoirs of Acinetobacter spp. in Lebanon. Materials & methods: Two thousand three hundred and sixty-one samples from different ecological niches were analyzed by culture methods. Species identification was confirmed by rpoB-gene sequencing. Multilocus ...

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Acyldepsipeptide antibiotics as a potential therapeutic agent against Clostridium difficile recurrent infections

22.08.2016 | Fernando Gil; Daniel Paredes-Sabja, Future Microbiology, 2016

Alternative antimicrobial therapies based on acyldepsipeptides may hold promising results, based on the fact that they have shown to efficiently eradicate persister cells, stationary cells and cell in biofilm structures of several pathogenic bacteria from the infected host. Clostridium difficile ...

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Minimum information required for a DMET experiment reporting

22.08.2016 | Judit Kumuthini; Mamana Mbiyavanga; Emile R Chimusa; Jyotishman Pathak; Panu Somervuo; Ron HN Van Schaik; Vita Dolza ..., Pharmacogenomics, 2016

Aim: To provide pharmacogenomics reporting guidelines, the information and tools required for reporting to public omic databases. Material & methods: For effective DMET data interpretation, sharing, interoperability, reproducibility and reporting, we propose the Minimum Information required for a ...

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New tests for detection of Mycobacterium tuberculosis infection: sufficient to meet the WHO 2035 targets?

22.08.2016 | Morten Ruhwald; Peter L Andersen, Future Microbiology, 2016

Future Microbiology Ahead of Print.

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Appropriate surveillance methodology for assessing childhood antibiotic resistance: where do we stand?

22.08.2016 | Julia A Bielicki; Paul T Heath; Mike Sharland, Future Microbiology, 2016

Future Microbiology Ahead of Print.

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