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2.127 Aktuelle Fachpublikationen von Future Medicinerss
02.10.2013 | Lawson Eng; Geoffrey Liu, Pharmacogenomics, 2013
With the recent advances in genomic medicine and the development of targeted antiangiogenic therapy for cancer patients, there has been an increased interest in the role of predictive and prognostic markers for antiangiogenic therapy. Here, we provide a summary of the angiogenesis pathway, ...
02.10.2013 | Kristin M Pearson-Fuhrhop; Steven C Cramer, Pharmacogenomics, 2013
Relatively few pharmacological agents are part of routine care for neural injury, although several are used or under consideration in acute stroke, chronic stroke, traumatic brain injury and secondary stroke prevention. Tissue plasminogen activator is approved for the treatment of acute ...
02.10.2013 | Marçal Pastor-Anglada, Pharmacogenomics, 2013
Pharmacogenomics , October 2013, Vol. 14, No. 13, Pages 1537-1540.
02.10.2013 | Geoffrey Gilbert John Reid; Tarek Abdullah Bin Yameen; Jayson Lee Parker, Pharmacogenomics, 2013
The last decade has witnessed the cost of drug development rise dramatically; concurrently, the number of new drug approvals has declined. Clinical trial failure rates have contributed significantly to this ‘innovation’ crisis and are directly related to clinical trial risk. One strategy that ...
02.10.2013 | Kristina Stenstedt; Sandra Travica; Jia Guo; Isabel Barragan; Klaus Pors; Laurence Patterson; David Ed ..., Pharmacogenomics, 2013
Aim: This study aims to investigate the possible association between the risk of colorectal cancer (CRC) and allelic variants of CYP2W1 and their functional properties. Materials & methods: The distribution of three different CYP2W1 alleles (CYP2W1*1, CYP2W1*2 and CYP2W1*6) in 1785 CRC ...
02.10.2013 | Wendy A Teft; Richard B Kim, Pharmacogenomics, 2013
Pharmacogenomics , October 2013, Vol. 14, No. 13, Pages 1533-1536.
24.09.2013 | Steven P Sinkins, Future Microbiology, 2013
Wolbachia is a maternally inherited intracellular bacteria that can manipulate the reproduction of their insect hosts, and cytoplasmic incompatibility allows them to spread through mosquito populations. When particular strains of Wolbachia are transferred into certain Aedes mosquito species, ...
24.09.2013 | Heather T Taff; Kaitlin F Mitchell; Jessica A Edward; David R Andes, Future Microbiology, 2013
Candida commonly adheres to implanted medical devices, growing as a resilient biofilm capable of withstanding extraordinarily high antifungal concentrations. As currently available antifungals have minimal activity against biofilms, new drugs to treat these recalcitrant infections are ...
24.09.2013 | Sophie Edouard; Didier Raoult, Future Microbiology, 2013
The plaque assay was first described for titration of bacterial inoculums and clonal isolation, and was later adapted for testing antibiotics susceptibility and to study virulence factors and motility of bacteria. Over time, the sensitivity and reproducibility of the technique has been ...