02.10.2013 | Lawson Eng; Geoffrey Liu, Pharmacogenomics, 2013

With the recent advances in genomic medicine and the development of targeted antiangiogenic therapy for cancer patients, there has been an increased interest in the role of predictive and prognostic markers for antiangiogenic therapy. Here, we provide a summary of the angiogenesis pathway, ...

mehr

02.10.2013 | Kristin M Pearson-Fuhrhop; Steven C Cramer, Pharmacogenomics, 2013

Relatively few pharmacological agents are part of routine care for neural injury, although several are used or under consideration in acute stroke, chronic stroke, traumatic brain injury and secondary stroke prevention. Tissue plasminogen activator is approved for the treatment of acute ...

mehr

02.10.2013 | Marçal Pastor-Anglada, Pharmacogenomics, 2013

Pharmacogenomics , October 2013, Vol. 14, No. 13, Pages 1537-1540.

mehr

02.10.2013 | Geoffrey Gilbert John Reid; Tarek Abdullah Bin Yameen; Jayson Lee Parker, Pharmacogenomics, 2013

The last decade has witnessed the cost of drug development rise dramatically; concurrently, the number of new drug approvals has declined. Clinical trial failure rates have contributed significantly to this ‘innovation’ crisis and are directly related to clinical trial risk. One strategy that ...

mehr

02.10.2013 | Kristina Stenstedt; Sandra Travica; Jia Guo; Isabel Barragan; Klaus Pors; Laurence Patterson; David Ed ..., Pharmacogenomics, 2013

Aim: This study aims to investigate the possible association between the risk of colorectal cancer (CRC) and allelic variants of CYP2W1 and their functional properties. Materials & methods: The distribution of three different CYP2W1 alleles (CYP2W1*1, CYP2W1*2 and CYP2W1*6) in 1785 CRC ...

mehr

02.10.2013 | Pharmacogenomics, 2013

Pharmacogenomics , October 2013, Vol. 14, No. 13, Pages 1541-1543.

mehr

02.10.2013 | Wendy A Teft; Richard B Kim, Pharmacogenomics, 2013

Pharmacogenomics , October 2013, Vol. 14, No. 13, Pages 1533-1536.

mehr

24.09.2013 | Steven P Sinkins, Future Microbiology, 2013

Wolbachia is a maternally inherited intracellular bacteria that can manipulate the reproduction of their insect hosts, and cytoplasmic incompatibility allows them to spread through mosquito populations. When particular strains of Wolbachia are transferred into certain Aedes mosquito species, ...

mehr

24.09.2013 | Heather T Taff; Kaitlin F Mitchell; Jessica A Edward; David R Andes, Future Microbiology, 2013

Candida commonly adheres to implanted medical devices, growing as a resilient biofilm capable of withstanding extraordinarily high antifungal concentrations. As currently available antifungals have minimal activity against biofilms, new drugs to treat these recalcitrant infections are ...

mehr

24.09.2013 | Sophie Edouard; Didier Raoult, Future Microbiology, 2013

The plaque assay was first described for titration of bacterial inoculums and clonal isolation, and was later adapted for testing antibiotics susceptibility and to study virulence factors and motility of bacteria. Over time, the sensitivity and reproducibility of the technique has been ...

mehr