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2.559 Aktuelle Fachpublikationen von Future Medicine


Pharmacogenomics of neuropsychiatric disorders: analysis of genetic variability in 162 identified neuroreceptors using 1000 Genomes Project data

23.10.2014 | Harpreet Kaur; Ajay Jajodia; Sandeep Grover; Nidhi Agarwal; Ruchi Baghel; Ritushree Kukreti, Pharmacogenomics, 2014

Background: Neuroreceptors are considered to be primary drug targets and their abrupt signaling is a notable cause of interindividual drug response variability and treatment failure for complex neuropsychiatric diseases. In view of recent evidence, it is believed that common genetic risk factors ...


The effectiveness of photodynamic therapy on planktonic cells and biofilms and its role in wound healing

23.10.2014 | Steven L Percival; Louise Suleman; Iolanda Francolini; Gianfranco Donelli, Future Microbiology, 2014

ABSTRACT  Photodynamic therapy (PDT) is the application of a photoactive dye followed by irradiation that leads to the death of microbial cells in the presence of oxygen. Its use for controlling biofilms has been documented in many areas, particularly oral care. However, the potential use of PDT ...


Bacterial and cellular RNAs at work during Listeria infection

23.10.2014 | Nina Sesto; Mikael Koutero; Pascale Cossart, Future Microbiology, 2014

ABSTRACT  Listeria monocytogenes is an intracellular pathogen that can enter and invade host cells. In the course of its infection, RNA-mediated regulatory mechanisms provide a fast and versatile response for both the bacterium and the host. They regulate a variety of processes, such as ...


Genetic mutations in head and neck cancer: utilizing existing treatments

23.10.2014 | Noah D Peyser; Jennifer R Grandis, Pharmacogenomics, 2014

Pharmacogenomics September 2014, Vol. 15, No. 12, Pages 1553-1555.



23.10.2014 | Future Microbiology, 2014

Future Microbiology Ahead of Print, Pages 1-1.


Drug susceptibility testing of nontuberculous mycobacteria

23.10.2014 | Jakko van Ingen; Ed J Kuijper, Future Microbiology, 2014

ABSTRACT  Diseases caused by nontuberculous mycobacteria are emerging in many settings. With an increased number of patients needing treatment, the role of drug susceptibility testing is again in the spotlight. This articles covers the history and methodology of drug susceptibility tests for ...


SULT4A1 haplotype: conflicting results on its role as a biomarker of antipsychotic response

23.10.2014 | Dai Wang; Qingqin Li; Reyna Favis; Andrew Jadwin; Hedy Chung; Dong-Jing Fu; Adam Savitz; Srihari Gopal; Nadine Cohen, Pharmacogenomics, 2014

Aim: Based on previous pharmacogenetic findings, we investigated the possible association between SULT4A1-1 haplotype and antipsychotic treatment response. Materials & methods: Using Mixed Model Repeated Measures, we tested the relationship between SULT4A1-1 status (+ carrier, - noncarrier) and ...


Molecular pathogenesis of Klebsiella pneumoniae

23.10.2014 | Bei Li; Yuling Zhao; Changting Liu; Zhenhong Chen; Dongsheng Zhou, Future Microbiology, 2014

ABSTRACT  Typical Klebsiella pneumoniae is an opportunistic pathogen, which mostly affects those with weakened immune systems and tends to cause nosocomial infections. A subset of hypervirulent K. pneumoniae serotypes with elevated production of capsule polysaccharide can affect previously ...


Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort

23.10.2014 | Maja Matic; Elisabeth Norman; Anders Rane; Olof Beck; Maria Andersson; Laure Elens; Dick Tibboel; Vineta Fellman; Ro ..., Pharmacogenomics, 2014

Aim: Assess association between UGT2B7 polymorphism -900G>A (rs7438135, also known as -842G>A) with morphine kinetics in preterm newborns undergoing mechanical ventilation. Materials & methods: Thirty-four infants were enrolled in a randomized clinical trial and allocated to rapid sequence ...


Bacterial glycosidases in pathogenesis and glycoengineering

23.10.2014 | Jonathan Sjögren; Mattias Collin, Future Microbiology, 2014

ABSTRACT  Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to ...


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