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Discriminatory usefulness of pulsed-field gel electrophoresis and sequence-based typing in Legionella outbreaks

18.05.2016 | Sara Quero; Marian García-Núñez; Noemí Párraga-Niño; Irene Barrabeig; Maria L Pedro-Botet; Mercè de Simon; Nieves So ..., Future Microbiology, 2016

Aim: To compare the discriminatory power of pulsed-field gel electrophoresis (PFGE) and sequence-based typing (SBT) in Legionella outbreaks for determining the infection source. Materials & methods: Twenty-five investigations of Legionnaires’ disease were analyzed by PFGE, SBT and Dresden ...


Current problems associated with the microbiological point-of-care testing of respiratory tract infections in primary care

17.05.2016 | Wendy E Kaman; Gijs Elshout; Patrick JE Bindels; Konstantinos Mitsakakis; John P Hays, Future Microbiology, 2016

Future Microbiology May 2016, Vol. 11, No. 5, Pages 607-610.


Multilevel models improve precision and speed of IC50 estimates

16.05.2016 | Daniel J Vis; Lorenzo Bombardelli; Howard Lightfoot; Francesco Iorio; Mathew J Garnett; Lodewyk FA Wessels, Pharmacogenomics, 2016

Aim: Experimental variation in dose–response data of drugs tested on cell lines result in inaccuracies in the estimate of a key drug sensitivity characteristic: the IC50. We aim to improve the precision of the half-limiting dose (IC50) estimates by simultaneously employing all dose–responses ...


Vincristine pharmacokinetics pathway and neurotoxicity during early phases of treatment in pediatric acute lymphoblastic leukemia

16.05.2016 | Elixabet Lopez-Lopez; Angela Gutierrez-Camino; Itziar Astigarraga; Aurora Navajas; Aizpea Echebarria-Barona; Purific ..., Pharmacogenomics, 2016

Aim: Vincristine is an important component of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early phases of treatment. Recently, a genome-wide association study ...


Evaluation of clinical implementation of prospective DPYD genotyping in 5-fluorouracil- or capecitabine-treated patients

16.05.2016 | Carin ATC Lunenburg; Maurice C van Staveren; Hans Gelderblom; Henk-Jan Guchelaar; Jesse J Swen, Pharmacogenomics, 2016

Aim: Fluoropyrimidines are commonly used anti-cancer drugs, but lead to severe toxicity in 10–30% of patients. Prospective DPYD screening identifies patients at risk for toxicity and leads to a safer treatment with fluoropyrimidines. This study evaluated the routinely application of prospective ...


Predictive role of host constitutive variants in neoadjuvant therapy of esophageal cancer

16.05.2016 | Enrica Rumiato; Elisa Boldrin; Alberto Amadori; Daniela Saggioro, Pharmacogenomics, 2016

Chemoradiotherapy followed by surgery is at present the standard therapeutic approach for esophageal cancer (EC) in patients with resectable tumor. However, response to neoadjuvant therapy is characterized by a strong interpatient variability, and the identification of markers predictive of ...


Previously reported PDE3A–SLCO1C1 genetic variant does not correlate with anti-TNF response in large UK rheumatoid arthritis cohort

16.05.2016 | Samantha Louise Smith; Darren Plant; Xiu Hue Lee; Jonathan Massey; Kimme Hyrich; Ann W Morgan; Anthony G Wilson; Joh ..., Pharmacogenomics, 2016

Aim: A genetic variant has recently reached genome-wide significance for association with TNF-inhibitor response in rheumatoid arthritis patients. Here we undertake a replication study in a UK Caucasian population to test for association with TNF-inhibitor response. Materials & methods: The ...


Nucleotide excision repair and response and survival to chemotherapy in colorectal cancer patients

16.05.2016 | Elisabeth J Kap; Odilia Popanda; Jenny Chang-Claude, Pharmacogenomics, 2016

Several new chemotherapeutic agents have become available for the treatment of colorectal cancer, which has led to increased complexity in treatment planning. Treatment decision making for individual patients could be facilitated if guided by predictive and prognostic markers. As most cytotoxic ...


Pancreatic cancer screening using a multiplatform human serum metabolomics system

12.05.2016 | Arata Sakai; Makoto Suzuki; Takashi Kobayashi; Shin Nishiumi; Kodai Yamanaka; Yuichi Hirata; Takashi Nakagawa; Takes ..., Biomarkers in Medicine, 2016

Aim: To examine a novel screening method for pancreatic cancer involving gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry-based metabolomics analysis. Materials & methods: Sera from pancreatic cancer patients (n = 59) and healthy volunteers (n = 59) were allocated ...


Identifying joint biomarker panel from multiple level dataset by an optimization model

12.05.2016 | Meng Zou; Peng-Jun Zhang; Luonan Chen; Ya-Ping Tian; Yong Wang, Biomarkers in Medicine, 2016

Aim: Joint biomarker panel takes advantage of coherence across multiple level datasets and holds the promise to improve disease diagnosis accuracy. Methods: We collected 101 colorectal cancer and 95 benign samples, measured the molecular concentrations by serum assays and mass spectra, and ...


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