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2.751 Aktuelle Fachpublikationen von Future Medicine

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Study of NGEP expression pattern in cancerous tissues provides novel insights into prognostic marker in prostate cancer

26.03.2015 | Monireh Mohsenzadegan; Mehdi Shekarabi; Zahra Madjd; Mojgan Asgari; Maryam Abolhasani; Nader Tajik; Mohammad M Faraj ..., Biomarkers in Medicine, 2015

Aim: The aim of this study was to produce a novel polyclonal antibody against extracellular domain of NGEP protein and explore its role in prognosis of prostate cancer. Materials & methods: Polyclonal antibodies against two peptides (NGEP-p1 and NGEP-p2) derived extracellular domains of NGEP were ...

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An individual reference limit for ‘early’ diagnosis of metastatic breast cancer during postoperative follow-up

26.03.2015 | Andrea Nicolini; Paola Ferrari; Franca Fulceri; Angelo Carpi; Giuseppe Rossi, Biomarkers in Medicine, 2015

Aims: This study is a clinical pilot study with the principal aim to investigate the accuracy of a panel of serum tumor markers for the early diagnosis of relapses. We propose a systematic use of serum CEA-TPA-CA15.3 tumor marker panel and criteria in order to make it an accurate tool for a ...

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Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies

26.03.2015 | Francesco Caiazza; Louise Elliott; David Fennelly; Kieran Sheahan; Glen A Doherty; Elizabeth J Ryan, Biomarkers in Medicine, 2015

Patients with metastatic colorectal cancer have a very poor prognosis. Incorporation of targeted molecular therapies, such as the anti-EGFR receptor monoclonal antibodies cetuximab and panitumumab, into treatment regimens has improved outcomes for patients with wild-type RAS tumors. Yet, response ...

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Plasma fibrinogen and blood platelet counts are associated with response to neoadjuvant therapy in esophageal cancer

26.03.2015 | Aysegül Ilhan-Mutlu; Patrick Starlinger; Thomas Perkmann; Sebastian F Schoppmann; Matthias Preusser; Peter Birner, Biomarkers in Medicine, 2015

Aim: To investigate coagulatory factors in predicting response to neoadjuvant therapy (NeoTr) in esophageal cancer (EC). Methods: We investigated the relevance of coagulatory factors in 84 EC patients (56 adenocarcinomas, 28 squamous cell cancer) who received NeoTr. Plasma fibrinogen (PFR), ...

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Zinc isotopes: a novel approach to biomarkers of breast cancer?

26.03.2015 | Fiona Larner; Sami Shousha; R Charles Coombes, Biomarkers in Medicine, 2015

Biomarkers in Medicine March 2015, Vol. 9, No. 4, Pages 379-382.

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Meta-analysis reveals a specific association of the PNPLA3 I148M polymorphism with ALT level in adolescents

23.03.2015 | Zhengtao Liu; Huaijun Ning; Xiaoyin He; Shuping Que; Lin Zhou, Personalized Medicine, 2015

Aim: To evaluate potential link between the PNPLA3 rs738409 polymorphism and alanine aminotransferase (ALT) levels through an evidence-based study. Materials & Methods: Electronic literature databases, including PubMed, Embase and the Institute for Scientific Information, were searched for ...

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Performance of exome sequencing for pharmacogenomics

23.03.2015 | Eric R Londin; Peter Clark; Marialuisa Sponziello; Larry J Kricka; Paolo Fortina; Jason Y Park, Personalized Medicine, 2015

Aim: We present the potential false-negative rate of exome sequencing for the detection of pharmacogenomic variants. Materials & Methods: Depth of coverage of 1928 pharmacogenomically relevant variant positions was ascertained from 62 exome-sequenced samples. Results: Approximately 14% of the ...

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Attitudes of cystic fibrosis patients and their parents towards direct-to-consumer genetic testing for carrier status

23.03.2015 | Sandra Janssens; Louiza Kalokairinou; Davit Chokoshvilli; Carmen Binst; Inge Mahieu; Lidewij Henneman; Anne De Paepe ..., Personalized Medicine, 2015

Background: An increasing number of direct-to-consumer (DTC) genetic testing companies have started offering tests for carrier status of autosomal recessive disorders. Materials & Methods: A written questionnaire was administered to 47 patients and 65 parents of children with Cystic Fibrosis ...

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Pharmacogenetics and analgesic effects of antidepressants in chronic pain management

23.03.2015 | Frédérique Rodieux; Valérie Piguet; Patricia Berney; Jules Desmeules; Marie Besson, Personalized Medicine, 2015

Antidepressants are widely administered to chronic pain patients, but there is large interindividual variability in their efficacy and adverse effect rates that may be attributed to genetic factors. Studies have attempted to determine the impact of genetic polymorphisms in enzymes and ...

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New trends in spinal cord tissue engineering

04.03.2015 | Šárka Kubinová, Future Neurology, 2015

ABSTRACT  Restoration of lost neuronal function after spinal cord injury still remains a considerable challenge for current medicine. Over the last decade, regenerative medicine has recorded rapid and promising advancements in stem cell research, genetic engineering and the progression of new ...

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