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Pharmacogenomics of second-line drugs used for treatment of unresponsive or relapsed osteosarcoma patients

24.11.2016 | Claudia M Hattinger; Serena Vella; Elisa Tavanti; Marilù Fanelli; Piero Picci; Massimo Serra, Pharmacogenomics, 2016

Second-line treatment of high-grade osteosarcoma (HGOS) patients is based on different approaches and chemotherapy protocols, which are not yet standardized. Although several drugs have been used in HGOS second-line protocols, none of them has provided fully satisfactory results and the role of ...



24.11.2016 | Future Microbiology, 2016

Future Microbiology December 2016, Vol. 11, No. 12, Pages 1613-1613.


Should CYP2D6 be genotyped when treating with tamoxifen?

24.11.2016 | Marzia Del Re; Eleonora Rofi; Valentina Citi; Leonardo Fidilio; Romano Danesi, Pharmacogenomics, 2016

Pharmacogenomics Ahead of Print.


Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer

24.11.2016 | Tristan M Sissung; John Deeken; Crystal R Leibrand; Douglas K Price; Sheryl Ehrlich; Seth M Steinberg; David J Liewe ..., Pharmacogenomics, 2016

Aim: Metabolism and transport play major roles in life-long exposure to endogenous and exogenous carcinogens. We therefore explored associations between polymorphisms in absorption, distribution, metabolism and elimination genes and the risk and prognosis of castration-resistant prostate cancer ...


IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease

24.11.2016 | Xiaoyu Hu; Ellie H Jhun; Yingwei Yao; Ying He; Robert E Molokie; Diana J Wilkie; Zaijie J Wang, Pharmacogenomics, 2016

Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a ...


Identification of bile survivin and carbohydrate antigen 199 in distinguishing cholangiocarcinoma from benign obstructive jaundice

22.11.2016 | Yanfeng Liu; Jingxian Sun; Qiangbo Zhang; Bin Jin; Min Zhu; Zongli Zhang, Biomarkers in Medicine, 2016

Aim: To investigate whether bile survivin and carbohydrate antigen 199 (CA199) can be helpful in distinguishing cholangiocarcinoma (malignant obstructive jaundice) from benign obstructive jaundice. Methods: Receiver operating characteristic curve was used to evaluate the feasibility of bile ...


Treatment of hepatitis B virus: an update

18.11.2016 | Haley Ward; Lydia Tang; Bhawna Poonia; Shyam Kottilil, Future Microbiology, 2016

Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however ...


An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials

18.11.2016 | Ryan WJ Steel; Stefan HI Kappe; Brandon K Sack, Future Microbiology, 2016

Malaria remains a significant public health burden with 214 million new infections and over 400,000 deaths in 2015. Elucidating relevant Plasmodium parasite biology can lead to the identification of novel ways to control and ultimately eliminate the parasite within geographic areas. Particularly, ...


Sodium ascorbate kills Candida albicans in vitro via iron-catalyzed Fenton reaction: importance of oxygenation and metabolism

18.11.2016 | Pinar Avci; Fernanda Freire; Andras Banvolgyi; Eleftherios Mylonakis; Norbert M Wikonkal; Michael R Hamblin, Future Microbiology, 2016

Aim: Ascorbate can inhibit growth and even decrease viability of various microbial species including Candida albicans. However the optimum conditions and the mechanism of action are unclear. Materials/methodology:Candida albicans shaken for 90 min in a buffered solution of ascorbate (90 mM) gave ...


Responses to Crizotinib therapy in five patients with non-small-cell lung cancer who tested FISH negative and Ventana immunohistochemistry positive for ALK fusions

15.11.2016 | Jin-Lin Huang; Jing Zeng; Fang Wang; Qi-Tao Huang; Jia-Bin Lu; Xiao-Mei Li; Wei-Qiang Chen; Chong-Mei Zhu; Jie-Tian ..., Personalized Medicine, 2016

Aim: Although immunohistochemistry (IHC) and reverse transcription-PCR can detect ALK rearrangements, the ALK break-apart FISH assay is currently considered the standard method. Materials & methods: Five patients with advanced non-small-cell lung cancer, who had an ALK-negative FISH result that ...


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