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2.946 Aktuelle Fachpublikationen von Future Medicine

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Analytical validation of a proliferation-based molecular signature used as a prognostic marker in early stage lung adenocarcinoma

09.07.2015 | M Bryan Warf; Placede G Fosso; Elisha Hughes; Michael Perry; Krystal L Brown; Julia E Reid; Kathryn A Kolquist; Susa ..., Biomarkers in Medicine, 2015

Aims: The aim of these studies was to validate the analytical performance of a cell cycle progression (CCP) gene signature that provides prognostic information for early stage lung adenocarcinomas. Materials & methods: Formalin-fixed paraffin-embedded (FFPE) lung resections were evaluated by ...

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Monitoring performance of progression assessment criteria for cancer antigen 125 among patients with ovarian cancer compared by computer simulation

06.07.2015 | Suher Othman Abu Hassan; Per Hyltoft Petersen; Flemming Lund; Dorte L Nielsen; Malgorzata K Tuxen; György Sölétormos, Biomarkers in Medicine, 2015

Background: Cancer antigen 125 (CA125) is used to monitor tumor burden among patients with advanced serous epithelial ovarian cancer. The purpose is to compare the monitoring performance of seven previously proposed criteria. Materials & methods: The CA125 assessment criteria were applied to ...

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Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry

30.06.2015 | Ana Alfirevic; Jill Durocher; Anisa Elati; Wilfrido León; David Dickens; Steffen Rädisch; Helen Box; Marco Siccardi; ..., Pharmacogenomics, 2015

Aim: Misoprostol, a prostaglandin analogue used for the treatment of postpartum hemorrhage and termination of pregnancy, can cause high fevers. Genetic susceptibility may play a role in misoprostol-induced fever. Subjects & methods: Body temperature of women treated with misoprostol for ...

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Effect of gender and CYP2C9 and CYP2C8 polymorphisms on the pharmacokinetics of ibuprofen enantiomers

30.06.2015 | Dolores Ochoa; Rocío Prieto-Pérez; Manuel Román; María Talegón; Angela Rivas; Ignacio Galicia; Francisco Abad-Santos ..., Pharmacogenomics, 2015

Aim: To evaluate the effect of polymorphisms in CYP2C9 and CYP2C8 and gender on the pharmacokinetics of the enantiomeric forms of ibuprofen. Materials & methods: 122 healthy volunteers were genotyped for polymorphisms in CY2C8 and CYP2C9 using real-time PCR. Results: CYP2C8 polymorphisms affected ...

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How close are we to a pharmacogenomic test for clozapine-induced agranulocytosis?

30.06.2015 | Moira Verbelen; Cathryn M Lewis, Pharmacogenomics, 2015

Pharmacogenomics Ahead of Print, Pages 1-3.

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BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients

30.06.2015 | Romain Colle; Eric Deflesselle; Séverine Martin; Denis J David; Patrick Hardy; Adéla Taranu; Bruno Falissard; Céline ..., Pharmacogenomics, 2015

We propose an extensive review of the literature about BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients. Five genome-wide association studies and 30 association studies were included. Twenty seven studies focused on the Val66Met polymorphism ...

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Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy

29.06.2015 | Françoise Van Bambeke, Future Microbiology, 2015

ABSTRACT  Delafloxacin is a fluoroquinolone lacking a basic substituent in position 7. It shows MICs remarkably low against Gram-positive organisms and anaerobes and similar to those of ciprofloxacin against Gram-negative bacteria. It remains active against most fluoroquinolone-resistant strains, ...

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Wohlfahrtiimonas chitiniclastica-associated osteomyelitis: a rare case report

29.06.2015 | Karthika Suryalatha; Joby John; Sabu Thomas, Future Microbiology, 2015

ABSTRACT  Wohlfahrtiimonas chitiniclastica is a rare pathogen that was first isolated from a parasitic fly, Wohlfahrtia magnifica. It is a very rare but an emerging human pathogen reported only in Europe and South America. Recently, it is reported to be an egressing zoonotic pathogen from ...

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Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies

29.06.2015 | Fabian D Liechti; Denis Grandgirard; Stephen L Leib, Future Microbiology, 2015

ABSTRACT  Bacterial meningitis is associated with high mortality and morbidity rates. Bacterial components induce an overshooting inflammatory reaction, eventually leading to brain damage. Pathological correlates of neurofunctional deficits include cortical necrosis, damage of the inner ear and ...

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Mycobacterium tuberculosis virulence: insights and impact on vaccine development

29.06.2015 | Giovanni Delogu; Roberta Provvedi; Michela Sali; Riccardo Manganelli, Future Microbiology, 2015

ABSTRACT  The existing TB vaccine, the attenuated Mycobacterium bovis strain BCG, is effective in protecting infants from severe forms of the disease, while its efficacy in protecting adults from pulmonary TB is poor. In the last two decades, a renewed interest in TB resulted in the development ...

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