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BACE1 levels are increased in plasma of Alzheimer's disease patients compared with matched cognitively healthy controls

13.09.2016 | Patricia Regina Manzine; Matheus da Silva Souza; Márcia Regina Cominetti, Personalized Medicine, 2016

Aim: BACE1 is the secretase that acts in Aβ production in Alzheimer's disease (AD). Materials & methods: We investigated mRNA expression in total blood and the levels of plasma protein BACE1 in AD patients compared with cognitively healthy subjects. Probable AD (n = 47) and non-AD control group ...


The biology of glucagon and the consequences of hyperglucagonemia

09.09.2016 | Nicolai J Wewer Albrechtsen; Rune E Kuhre; Jens Pedersen; Filip K Knop; Jens J Holst, Biomarkers in Medicine, 2016

The proglucagon-derived peptide hormone, glucagon, comprises 29 amino acids. Its secretion from the pancreatic α cells is regulated by several factors. Glucagon increases blood glucose levels through gluconeogenesis and glycogenolysis. Elevated plasma concentrations of glucagon, ...


Chromogranin A as biomarker in diabetes

09.09.2016 | Kasper Broedbaek; Linda Hilsted, Biomarkers in Medicine, 2016

Chromogranin A (CgA) is an established plasma marker of neuroendocrine tumors and has been suggested to also have a role as biomarker in other diseases. Whether CgA has any role as biomarker in diabetes is, however, unresolved, but its widespread distribution in the secretory granules in ...


Decreased risk of developing cancer in subjects carrying SLC52A3 rs13042395 polymorphism: proof from a meta-analysis

07.09.2016 | Jun Li; Shilong Wang; Man Li; Hui Xu; Dandan Li; Can Yin; Jin Zhao; Feng Li, Biomarkers in Medicine, 2016

Aim: This study aimed to conduct a meta-analysis to explore the association between SLC52A3 rs13042395 polymorphism and cancer risk. Materials & methods: A comprehensive literature search was performed to confirm the relationship evaluated using STATA 12.0 software. Results: Overall, SLC52A3 ...


Direct detection of Helicobacter pylori in biopsy specimens using a high-throughput multiple genetic detection system

06.09.2016 | Yanmei Zhang; Shiwen Wang; Binjie Hu; Fuju Zhao; Ping Xiang; Danian Ji; Fei Chen; Xiaoli Liu; Feng Yang; Yong Wu; Mi ..., Future Microbiology, 2016

Aim: We evaluated the direct high-throughput multiple genetic detection system (dHMGS) for Helicobacter pylori in gastric biopsies. Materials & methods: One hundred and thirty-three specimens were concurrently analyzed by dHMGS, rapid urease test, culture and sequencing. Results: dHMGS was highly ...


Circulating cell-derived microparticles as biomarkers in cardiovascular disease

02.09.2016 | Åsa Thulin; Christina Christersson; Jenny Alfredsson; Agneta Siegbahn, Biomarkers in Medicine, 2016

Cardiovascular diseases (CVDs) are a common cause of death, and a search for biomarkers for risk stratification is warranted. Elevated levels of cell-derived microparticles (MPs) are found in patients with CVD and in groups with risk factors for CVD. Subpopulations of MPs are promising biomarkers ...


Prognostic significance of immunohistochemical epithelial–mesenchymal transition markers in skin melanoma patients

02.09.2016 | Malgorzata Pieniazek; Piotr Donizy; Agnieszka Halon; Marek Leskiewicz; Rafal Matkowski, Biomarkers in Medicine, 2016

Aim: To investigate secreted protein acidic and rich in cystein (SPARC) and neural cadherin (NCAD), which are associated with epithelial–mesenchymal transition in primary skin melanoma and nodal metastases and their prognostic impact in melanoma patients. Methods: Expression of proteins was ...


Urinary C-type natriuretic peptide excretion: a promising biomarker to detect underlying renal injury and remodeling both acutely and chronically

02.09.2016 | Peng Hu; Si Yan Liu; Dong Dong Zhang; Yao Xu; Xun Xia, Biomarkers in Medicine, 2016

Acute kidney injury (AKI) refers to a sudden decline in renal function. A growing body of evidence demonstrates that AKI is a risk factor for the future development or accelerated progression of chronic kidney disease (CKD), whereas the actual distinction between AKI and CKD remains unknown. CNP ...


Identification of Staphylococcus argenteus in Eastern China based on a nonribosomal peptide synthetase (NRPS) gene

26.08.2016 | Dao-Feng Zhang; Xuebin Xu; Qifa Song; Yalong Bai; Yi Zhang; Minghui Song; Chunlei Shi; Xianming Shi, Future Microbiology, 2016

Aim: To investigate whether the Staphylococcus argenteus is present in Eastern China and to verify the utility of a new screening process. Materials & methods: Phenotype observation, PCR assay targeting a hypothetical nonribosomal peptide synthetase (NRPS) gene, phylogenetic analysis of rpoB and ...


Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine

26.08.2016 | Elena De Mattia; Erika Cecchin; Rossana Roncato; Giuseppe Toffoli, Pharmacogenomics, 2016

Great research effort has been focused on elucidating the contribution of host genetic variability on pharmacological outcomes in cancer. Nuclear receptors have emerged as mediators between environmental stimuli and drug pharmacokinetics and pharmacodynamics. The pregnane X receptor, constitutive ...


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