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Pharmacogenetics of anthracyclines

08.06.2016 | Judit C Sági; Nóra Kutszegi; Andrea Kelemen; Lili E Fodor; András Gézsi; Gábor T Kovács; Dániel J Erdélyi; Csaba Sza ..., Pharmacogenomics, 2016

Anthracyclines constitute a fundamental part of the chemotherapy regimens utilized to treat a number of different malignancies both in pediatric and adult patients. These drugs are one of the most efficacious anticancer agents ever invented. On the other hand, anthracyclines are cardiotoxic. ...


Economic analysis of ALK testing and crizotinib therapy for advanced non-small-cell lung cancer

08.06.2016 | Shun Lu; Jie Zhang; Ming Ye; Baoai Wang; Bin Wu, Pharmacogenomics, 2016

Aim: The economic outcome of crizotinib in advanced non–small-cell lung cancer harboring anaplastic lymphoma kinase rearrangement would be investigated. Materials & methods: Based on a mathematical model, the economic outcome of three techniques for testing ALK gene rearrangement combing with ...


Pharmacogenetics of nevirapine excretion into breast milk and infants’ exposure through breast milk versus postexposure prophylaxis

07.06.2016 | Adeniyi Olagunju; Saye Khoo; Andrew Owen, Pharmacogenomics, 2016

Aim: The influence of genetic factors on nevirapine (NVP) breast milk pharmacokinetics and breastfed infants’ exposure were investigated. Patients & methods: Associations between nine SNPs in NVP disposition genes in mothers and its plasma and breast milk concentrations were explored in nursing ...


African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction

07.06.2016 | Orna Levran; Matthew Randesi; Einat Peles; Joel Correa da Rosa; Jurg Ott; John Rotrosen; Miriam Adelson; Mary Jeanne ..., Pharmacogenomics, 2016

Aim: This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence. Patients & methods: The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed. Results: Of the 20 ...


COMT haplotypes, catecholamine metabolites in plasma and clinical response in schizophrenic and bipolar patients

07.06.2016 | Mercedes Zumárraga; Aurora Arrúe; Nieves Basterreche; Isabel Macías; Ana Catalán; Arantza Madrazo; Sonia Bustamante; ..., Pharmacogenomics, 2016

Aim: We examined the association of COMT haplotypes and plasma metabolites of catecholamines in relation to the clinical response to antipsychotics in schizophrenic and bipolar patients. Patients & methods: We studied 165 patients before and after four weeks of treatment, and 163 healthy ...


ABCB1 1199G>A polymorphism (rs2229109) affects the transport of imatinib, nilotinib and dasatinib

07.06.2016 | Géraldine Dessilly; Laure Elens; Nadtha Panin; Linda Karmani; Jean-Baptiste Demoulin; Vincent Haufroid, Pharmacogenomics, 2016

Aim: ABCB1 (or P-glycoprotein) is implicated in the multidrug-resistance phenotype, including the resistance toward anticancer drugs such as tyrosine kinase inhibitors (TKIs). The purpose of this study was to evaluate in vitro the influence of the ABCB1 1199G>A SNP on ABCB1 transport activity ...


Efflux transporter variants as predictors of drug toxicity in lung cancer patients: systematic review and meta-analysis

07.06.2016 | Zoulikha M Zaïr; Donald RJ Singer, Pharmacogenomics, 2016

Chemotherapeutic drugs are underutilized in lung cancer management due in part to serious adverse drug reactions (ADRs). Aim: With studies revealing an association between interindividual patient ADR variation and efflux transporter variants, we carried out a meta-analysis and systemic review, in ...


Pharmacogenomics of multifactorial diseases: a focus on psoriatic arthritis

07.06.2016 | Raffaella Cascella; Claudia Strafella; Giuliana Longo; Mara Maccarone; Paola Borgiani; Federica Sangiuolo; Giuseppe ..., Pharmacogenomics, 2016

This review will outline the current pharmacogenomics knowledge about psoriatic arthritis with a special attention to the perspectives and the challenges for its implementation in the clinical practice. To date, different drugs have been developed to contrast the symptoms and the progression of ...


Common genetic variants in platelet surface receptors and its association with ischemic stroke

07.06.2016 | Lukasz Milanowski; Justyna Pordzik; Piotr K Janicki; Marek Postula, Pharmacogenomics, 2016

Ischemic stroke has been named one of the leading causes of death worldwide. Whereas numerous biological mechanisms and molecules were found to be associated with stroke, platelets are particularly contributive to its pathogenesis. Recent data indicate considerable variability in platelet ...


Gene polymorphism of CYP2C19*2, *3 and CYP3A4*1B and early stent thrombosis: case reports and literature review

06.06.2016 | Nazgul Kulmyrzaeva; Vacis Tatarunas; Vilius Skipskis; Gaziza Smagulova; Nazgul Seitmaganbetova; Audrone Veikutiene; ..., Personalized Medicine, 2016

We present two clinical cases of acute and subacute coronary artery stent thrombosis in patients treated at the Department of Interventional Cardiology in Aktobe, Kazakhstan. Our results draw attention to the impact of CYP3A4*1B on the clinical effect of clopidogrel during dual antiplatelet ...


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