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2.864 Aktuelle Fachpublikationen von Future Medicine

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ABCG2 gene polymorphisms as risk factors for atorvastatin adverse reactions: a case–control study

18.06.2015 | Nikica Mirošević Skvrce; Viola Macolić Šarinić; Iveta Šimić; Lana Ganoci; Diana Muačević Katanec; Nada Božina, Pharmacogenomics, 2015

Aim: To explore the association between dose-related adverse drug reactions (ADRs) of atorvastatin and polymorphisms of ABCG2, taking into account the influence of CYP3A4 and SLCO1B1 genes. Materials & methods: Sixty patients who experienced atorvastatin dose-related ADRs and 90 matched patients ...

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URAT1 gene polymorphisms influence uricosuric action of losartan in hypertensive patients with hyperuricemia

18.06.2015 | Hong Sun; Qiang Qu; Jian Qu; Xiao-Ya Lou; Yan Peng; Ying Zeng; Guo Wang, Pharmacogenomics, 2015

Aims: To explore the effect of urate transporter 1 (URAT1) polymorphisms on the hypertensive patients with hyperuricemia and the uricosuric action of losartan therapy among hypertensive patients with hyperuricemia. Methods: 101 hypertensive patients with hyperuricemia were detected the genotypes ...

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Is there a role for pharmacogenetics in the treatment of panic disorder?

17.06.2015 | Daniela Caldirola; Giampaolo Perna, Pharmacogenomics, 2015

Pharmacogenomics Ahead of Print, Pages 1-4.

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A review of telavancin activity in in vitro biofilms and animal models of biofilm-associated infections

17.06.2015 | Cynthia Chan; Thomas C Hardin; Jennifer I Smart, Future Microbiology, 2015

ABSTRACT  Tissue- and device-associated biofilm infections are important medical problems. These infections are difficult to treat due to a high-level of tolerance to antibiotics. Telavancin has been studied in several in vitro biofilm models and has demonstrated efficacy against staphylococcal ...

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Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups

17.06.2015 | Yijing He; Janelle M Hoskins; Scott Clark; Nathan H Campbell; Kim Wagner; Alison A Motsinger-Reif; Howard L McLeod, Pharmacogenomics, 2015

Aim: To evaluate the potential usefulness of selected SNPs to predict specific HLA alleles that are associated with drug-induced hypersensitivity reactions (HSR) in different ethnic groups. Methods & results: Five specific HLA alleles known to predict HSR were tagged by seven SNPs ...

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RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia

17.06.2015 | Ajay Abraham; Savitha Varatharajan; Sreeja Karathedath; Chepsy Philip; Kavitha M Lakshmi; Ashok Kumar Jayavelu; Ezhi ..., Pharmacogenomics, 2015

Background: Variation in terms of outcome and toxic side effects of treatment exists among acute myeloid leukemia (AML) patients on chemotherapy with cytarabine (Ara-C) and daunorubicin (Dnr). Candidate Ara-C metabolizing gene expression in primary AML cells is proposed to account for this ...

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Serial inflammatory biomarkers of the severity, course and outcome of late onset acute respiratory distress syndrome in critically ill patients with or at risk for the syndrome after new-onset fever

16.06.2015 | Sandra H Hoeboer; AB Johan Groeneveld; Melanie van der Heijden; Heleen M Oudemans-van Straaten, Biomarkers in Medicine, 2015

Aim: Accurate biomarkers of the acute respiratory distress syndrome (ARDS) may help risk stratification and management. We assessed the relation between several biomarkers and the severity, course and outcome of late onset ARDS in 101 consecutive critically ill patients with new onset fever. ...

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Statistical-based approach in potential diagnostic application of urinary nucleosides in urogenital tract cancer

16.06.2015 | Emilia Daghir-Wojtkowiak; Wiktoria Struck-Lewicka; Malgorzata Waszczuk-Jankowska; Marcin Markuszewski; Roman Kalisza ..., Biomarkers in Medicine, 2015

Aim: We aimed at evaluation the potential diagnostic role of urinary nucleosides in urogenital tract cancer. Materials & methods: Concentrations of 12 nucleosides determined by LC-MS/MS were subjected to correlation, association and interaction analyses. Results: We identified six pairs of ...

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Erratum

16.06.2015 | Biomarkers in Medicine, 2015

Biomarkers in Medicine June 2015, Vol. 9, No. 6, Pages 617-617.

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Biomarkers for CNS involvement in pediatric lupus

16.06.2015 | Tamar B Rubinstein; Chaim Putterman; Beatrice Goilav, Biomarkers in Medicine, 2015

CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there ...

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