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3.252 Aktuelle Fachpublikationen von Future Medicine

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The role of pharmacogenetics and advances in gene therapy in the treatment of diabetic retinopathy

25.01.2016 | Aniruddha Agarwal; Sally A Ingham; Keegan A Harkins; Diana V Do; Quan Dong Nguyen, Pharmacogenomics, 2016

Diabetic retinopathy (DR) and its complications such as diabetic macular edema continue to remain a major cause for legal blindness in the developed world. While the introduction of anti-tVEGF agents has significantly improved visual outcomes of patients with DR, unpredictable response, largely ...

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Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment

25.01.2016 | Lydia WT Cheung; Gordon B Mills, Pharmacogenomics, 2016

The regulatory subunit of PI3K, p85α (encoded by PIK3R1), binds, stabilizes and inhibits the PI3K p110 catalytic subunit. Functional characterization of PIK3R1 mutations has identified not only hypomorphs with reduced inhibition of p110, but also hypomorphs and dominant negative mutants that ...

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Identification of important genes associated with total cholesterol using bioinformatics analysis

25.01.2016 | Xing-Bo Mo; Huan Zhang; Tan Xu; Shu-Feng Lei; Yong-Hong Zhang, Pharmacogenomics, 2016

Aim: The aim of this study was to identify related genes for total cholesterol (TC) and evaluate the functional relevance to provide evidences for prioritizing these genes. Materials & methods: We performed an initial gene-based association study in about 188,578 individuals. Furthermore, we ...

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New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs

22.01.2016 | Lucie Pouché; Jana Stojanova; Pierre Marquet; Nicolas Picard, Pharmacogenomics, 2016

Interindividual variability in immunosuppressive drug responses might be partly explained by genetic variants in proteins involved in the immune response or associated with IS pharmacodynamics. On a general basis, the pharmacogenetics of drug target proteins is less known and understood than that ...

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Potential of circulating tumor cells as blood-based biomarkers in cancer liquid biopsy

22.01.2016 | Thomas Schlange; Klaus Pantel, Pharmacogenomics, 2016

Pharmacogenomics Ahead of Print.

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ATIC 347C>G gene polymorphism may be associated with methotrexate-induced adverse events in south Indian Tamil rheumatoid arthritis

22.01.2016 | Niveditha Muralidharan; Christina M Mariaselvam; Vikramraj K Jain; Reena Gulati; Vir S Negi, Pharmacogenomics, 2016

Aim: To find the association of ATIC 347C>G gene polymorphism with methotrexate (MTX) treatment response and MTX-induced adverse events in south Indian Tamil patients with rheumatoid arthritis. Patients & methods: A total of 319 rheumatoid arthritis and 310 healthy controls were recruited for the ...

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Alterations in pain responsiveness and serum biomarkers in juvenile myoclonic epilepsy: an age- and gender-matched controlled pilot study

22.01.2016 | Lydia Anja Jakobsen; Ali Karshenas; Flemming Winther Bach; Parisa Gazerani, Future Neurology, 2016

Introduction: Serum levels of several biomarkers along with sensory responsiveness were investigated in juvenile myoclonic epilepsy patients in comparison with healthy controls. Methods: Ten epileptic patients (36.1 ± 3.4 years) and ten gender- and age-matched healthy controls were recruited. ...

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Identifying network-based biomarkers of complex diseases from high-throughput data

20.01.2016 | Zhi-Ping Liu, Biomarkers in Medicine, 2016

In this work, we review the main available computational methods of identifying biomarkers of complex diseases from high-throughput data. The emerging omics techniques provide powerful alternatives to measure thousands of molecules in cells in parallel manners. The generated genomic, ...

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MicroRNA-509–3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis

20.01.2016 | Wei Chen; Wenshu Zeng; Xiaodi Li; Weiliang Xiong; Mengdie Zhang; Yan Huang; Longshu Zhou; Songshan Jiang, Pharmacogenomics, 2016

Aims: XIAP is upregulated in chemoresistant epithelial ovarian cancer (EOC). However, the molecular mechanism of this dysregulation remains unclear. Materials & methods: The regulation of XIAP by miR-509–3p was investigated by luciferase reporter assay, real-time PCR and immunobloting, and the ...

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Donor ABCB1 3435 C>T genetic polymorphisms influence early renal function in kidney transplant recipients treated with tacrolimus

19.01.2016 | Lin Yan; Yi Li; Jiang-Tao Tang; Yun-Fei An; Lan-Lan Wang; Yun-Ying Shi, Pharmacogenomics, 2016

Aim: Determine the effect of genetic variants of donors and recipients on early renal function and tacrolimus pharmacokinetics in kidney transplant recipients. Patients & methods: We measured CYP3A5 (6986A>G), ABCB1 (3435C>T, 2677G>T/A, 1236C>T) genetic polymorphisms in 120 renal transplant ...

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