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2.921 Aktuelle Fachpublikationen von Future Medicine

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Evidence for CVD 103-HgR as an effective single-dose oral cholera vaccine

31.07.2015 | Sarah S Jackson; Wilbur H Chen, Future Microbiology, 2015

We propose the ideal oral cholera vaccine (OCV) should be an inexpensive, single, oral dose that rapidly confers immunity for a long duration, and is well tolerated by individuals vulnerable to cholera. Vaccine trials in industrialized countries of a single oral dose of 5 × 108 colony forming ...

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Antimicrobial activity and resistance selection of different bioglass S53P4 formulations against multidrug resistant strains

31.07.2015 | Lorenzo Drago; Elena De Vecchi; Monica Bortolin; Marco Toscano; Roberto Mattina; Carlo Luca Romanò, Future Microbiology, 2015

Aims: This study aimed to evaluate the antimicrobial activity of two different formulations of bioglass BAG-S53P4 against multiresistant microorganisms involved in bone infections, and the capability of bioglass to select for resistance. Methods: Antibacterial activity was evaluated by means of ...

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Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children

31.07.2015 | Henk Visscher; S Rod Rassekh; George S Sandor; Huib N Caron; Elvira C van Dalen; Leontien C Kremer; Helena J van der ..., Pharmacogenomics, 2015

Aim: To identify novel variants associated with anthracycline-induced cardiotoxicity and to assess these in a genotype-guided risk prediction model. Patients & methods: Two cohorts treated for childhood cancer (n = 344 and 218, respectively) were genotyped for 4578 SNPs in drug ADME and toxicity ...

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Using large-scale genomics data to identify driver mutations in lung cancer: methods and challenges

31.07.2015 | Andrew M Hudson; Christopher Wirth; Natalie L Stephenson; Shameem Fawdar; John Brognard; Crispin J Miller, Pharmacogenomics, 2015

Lung cancer is the commonest cause of cancer death in the world and carries a poor prognosis for most patients. While precision targeting of mutated proteins has given some successes for never- and light-smoking patients, there are no proven targeted therapies for the majority of smokers with the ...

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Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: a case series from 2010 to 2014

31.07.2015 | Maria Gabriella Donà; Giuseppe Spriano; Barbara Pichi; Francesca Rollo; Valentina Laquintana; Renato Covello; Raul P ..., Future Microbiology, 2015

Aim: Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinomas (OPSCC) show better prognosis and response to therapy. We evaluated HPV-DNA prevalence, p16 overexpression and HPV-attributable fraction in recent consecutive OPSCCs. Materials & methods: 140 OPSCCs were analyzed ...

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Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry

31.07.2015 | Orna Levran; Einat Peles; Matthew Randesi; Joel Correa da Rosa; Jurg Ott; John Rotrosen; Miriam Adelson; Mary Jeanne ..., Pharmacogenomics, 2015

Background: Drug addiction is influenced by genetic factors. Aim: To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction. Subjects & methods: The study examined 140 polymorphisms in 19 genes in 1855 subjects with ...

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Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients

31.07.2015 | Jia-li Li; Shu Liu; Qian Fu; Yu Zhang; Xue-ding Wang; Xiao-man Liu; Long-shan Liu; Chang-xi Wang; Min Huang, Pharmacogenomics, 2015

Aims: To evaluate the influences of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tacrolimus concentration in early postrenal transplant recipients. Patients & methods: A total of 159 patients were included, dose-adjusted tacrolimus trough concentration on day 7 after transplantation (C0D7/D) ...

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Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis

31.07.2015 | Joyce HS You, Pharmacogenomics, 2015

Aim: This study aims to compare clinical and economic outcomes of CYP2C9 and VKORC1 genotype-guided (PG-DOAC) versus universal use of direct oral anticoagulant (DOAC) for stroke prevention in patients with atrial fibrillation (AF). Methods: Outcomes of oral anticoagulation therapy were simulated ...

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Repurposing the vaginal tampon for endometrial cancer detection

31.07.2015 | Jamie N Bakkum-Gamez, Biomarkers in Medicine, 2015

Biomarkers in Medicine Ahead of Print, Pages 1-3.

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Point-of-care molecular diagnostic devices: an overview

31.07.2015 | Chi Lan Nguyen Vu; Jianxiong Chan; Marian Todaro; Stan Skafidas; Patrick Kwan, Pharmacogenomics, 2015

Point-of-care molecular diagnostic devices are a rapidly expanding market. A variety of technologies are being developed for DNA detection and amplification, mostly aiming to detect pathogens. Of the two devices for detection of human genetic variations, both focus on CYP2C19 and have obtained ...

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