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2.656 Aktuelle Fachpublikationen von Future Medicine

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Lipidomics applications for disease biomarker discovery in mammal models

18.02.2015 | Ying-Yong Zhao; Xian-Long Cheng; Rui-Chao Lin; Feng Wei, Biomarkers in Medicine, 2015

Lipidomics is a lipid-targeted metabolomics approach focusing on comprehensive analysis of all lipids with which they interact in biology systems. Recent technological advances in MS and chromatography have greatly enhanced the developments and applications of metabolic profiling of diverse ...


Cardiotrophin-1 is associated with increased risk of arterial stiffness

18.02.2015 | Hao-Chang Hung; Feng-Hwa Lu; Horng-Yih Ou; Hung-Tsung Wu; Jin-Shang Wu; Yi-Ching Yang; Chih-Jen Chang, Biomarkers in Medicine, 2015

Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 ...


Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study

18.02.2015 | Bernard Ravina; Shirley Eberly; David Oakes; Anthony E Lang; Vince Dodelet; Pieter Roos; Jennifer Harman; Ira Shouls ..., Biomarkers in Medicine, 2015

Aim: There are no established chemical biomarkers of idiopathic Parkinson's disease (PD). The results of a prior metabolomics-based biomarker study suggested that near-infrared spectroscopy of blood plasma samples may distinguish idiopathic PD from neurologically normal controls. Methods: ...


Seminal fluid: a useful source of prostate cancer biomarkers?

18.02.2015 | Matthew J Roberts; Renee S Richards; Robert A Gardiner; Luke A Selth, Biomarkers in Medicine, 2015

Biomarkers in Medicine February 2015, Vol. 9, No. 2, Pages 77-80.


Circulating microRNAs: potential biomarkers for common malignancies

18.02.2015 | Samantha Khoury; Nham Tran, Biomarkers in Medicine, 2015

MicroRNAs (miRNAs) belong to a class of small noncoding RNAs (ncRNAs), which regulate gene expression at the post-transcriptional level. They are approximately 22 nucleotide sequences in length and have been predicted to control expression of up to 30–60% of all protein-coding genes in mammals. ...


Four-year stability of anthropometric and cardio-metabolic parameters in a prospective cohort of older adults

18.02.2015 | Sarah E Jackson; Cornelia HM van Jaarsveld; Rebecca J Beeken; Marc J Gunter; Andrew Steptoe; Jane Wardle, Biomarkers in Medicine, 2015

Aim: To examine the medium-term stability of anthropometric and cardio-metabolic parameters in the general population. Materials & methods: Participants were 5160 men and women from the English Longitudinal Study of Ageing (age ≥50 years) assessed in 2004 and 2008. Anthropometric data included ...


MyCartis NV

18.02.2015 | Wouter Laroy; Paul Ladestein, Biomarkers in Medicine, 2015

MyCartis NV, a new player on the clinical and translational research market, aims at revolutionizing current healthcare systems. These are mostly based on treating the diseased rather than on caring better and longer for the healthy. The ‘one size fits all’ model is no longer sufficient and is ...


Investigating pertussis toxin and its impact on vaccination

17.02.2015 | Loic Coutte; Camille Locht, Future Microbiology, 2015

ABSTRACT Whooping cough, caused by Bordetella pertussis, remains a major global health problem. Each year around 40 million of pertussis cases resulting in 200,000–400,000 annual deaths occur worldwide. Pertussis toxin is a major virulence factor of B. pertussis. Murine studies have shown its ...


Phages targeting infected tissues: novel approach to phage therapy

17.02.2015 | Andrzej Górski; Krystyna Dąbrowska; Katarzyna Hodyra-Stefaniak; Jan Borysowski; Ryszard Międzybrodzki; Beata Weber-D ..., Future Microbiology, 2015

ABSTRACT While the true efficacy of phage therapy still requires formal confirmation in clinical trials, it continues to offer realistic potential treatment in patients in whom antibiotics have failed. Novel developments and approaches are therefore needed to ascertain that future clinical ...


Prevention of hemodialysis catheter-related blood stream infections using a cotrimoxazole-lock technique

17.02.2015 | Azadeh Moghaddas; Mohammad-Reza Abbasi; Afshin Gharekhani; Simin Dashti-Khavidaki; Effat Razeghi; Atefeh Jafari; Hos ..., Future Microbiology, 2015

ABSTRACT Background & aim: This trial assessed the efficacy of cotrimoxazole lock solution in reducing catheter-related blood stream infections (CRBSIs) among hemodialysis (HD) patients who were dialyzed using tunneled catheters. Method: Patients randomly received either heparin (2500 U/ml) ...


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