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3.171 Aktuelle Fachpublikationen von Future Medicine

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Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids

19.11.2015 | Nidhi Bhargava; Sukhvinder P Singh; Anupam Sharma; Prince Sharma; Neena Capalash, Future Microbiology, 2015

Aim: To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii. Methods & results: Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. ...


Staphylococcal adaptation to diverse physiologic niches: an overview of transcriptomic and phenotypic changes in different biological environments

19.11.2015 | Sana S Dastgheyb; Michael Otto, Future Microbiology, 2015

Host niches can differ strongly regarding, for example, oxygen tension, pH or nutrient availability. Staphylococcus aureus and other staphylococci are common colonizers of human epithelia as well as important human pathogens. The phenotypes that they show in different host environments, and the ...


Emerging horizons for tick-borne pathogens: from the ‘one pathogen–one disease’ vision to the pathobiome paradigm

19.11.2015 | Muriel Vayssier-Taussat; Maria Kazimirova; Zdenek Hubalek; Sándor Hornok; Robert Farkas; Jean-François Cosson; Sarah ..., Future Microbiology, 2015

Ticks, as vectors of several notorious zoonotic pathogens, represent an important and increasing threat for human and animal health in Europe. Recent applications of new technology revealed the complexity of the tick microbiome, which may affect its vectorial capacity. Appreciation of these ...


Pharmacogenomic test that predicts response to β2-agonists in adults with asthma is cost effective

19.11.2015 | Ann Chen Wu; Charlene Gay; Melisa D Rett; Anne L Fuhlbrigge, Personalized Medicine, 2015

Background: Pharmacogenomic tests that predict which asthma patients are likely to respond to β2-agonists hold promise to improve care for asthma. Objective: To identify the clinical and economic circumstances under which a pharmacogenomic test that predicts response to β2-agonists might or might ...


Cancer stem cell markers: premises and prospects

19.11.2015 | Madhura Murar; Anuradha Vaidya, Biomarkers in Medicine, 2015

Over the last decade, compelling evidence has shown that cancer stem cells (CSCs) exist in a variety of malignancies. The conventional method for anticancer therapy involves targeting only the proliferating mitotic cells, sparing the slow-cycling cells that eventually evade chemotherapy and ...


Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

19.11.2015 | Tim Hendrikx; Sofie MA Walenbergh; Mike LJ Jeurissen; Tom Houben; Patrick J van Gorp; Patrick J Lindsey; Ger H Koek; ..., Biomarkers in Medicine, 2015

Aim: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. Materials & methods: ...


Toward a synthesis of genotypic typing and phenotypic inference in the genomics era

19.11.2015 | Edward J Feil, Future Microbiology, 2015

Future Microbiology Ahead of Print.


Biological and methodological aspects of assessment of locus specific de novo methylation in blood

19.11.2015 | Tomasz Kazimierz Wojdacz, Biomarkers in Medicine, 2015

Aim: Locus-specific methylation in blood differs between individuals. As those changes may represent de novo methylation, induced by environmental factors, we aimed to evaluate the biological and methodological limitations of detection of methylation in blood. Materials & methods: We used ...


Clinical evaluation of the Heart Check system, a new quantitative measurement of fresh capillary BNP

19.11.2015 | Astrid Monfort; Kelly Da Silva; Nicolas Vodovar; Etienne Gayat; Alain Cohen-Solal; Philippe Manivet, Biomarkers in Medicine, 2015

Aim: We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood. Patients & methods: One-hundred-and-sixty-three patients with stable chronic heart ...


The clinical and therapeutic uses of MDM2 and PSMA and their potential interaction in aggressive cancers

19.11.2015 | Robyn Bradbury; Wen G Jiang; Yu-Xin Cui, Biomarkers in Medicine, 2015

Prostate-specific membrane antigen (PSMA) overexpression is observed in the neovasculature of solid tumors, but not in the vasculature of normal tissues. Increased PSMA expression is positively associated with tumor stage and grade, although its function in cancer remains unclear. Mouse double ...


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