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2.745 Aktuelle Fachpublikationen von Future Medicine

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Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics

21.04.2015 | Henrik Berg Rasmussen; Ditte Bjerre; Kristian Linnet; Gesche Jürgens; Kim Dalhoff; Hreinn Stefansson; Thomas Hankeme ..., Pharmacogenomics, 2015

CES1 is involved in the hydrolysis of ester group-containing xenobiotic and endobiotic compounds including several essential and commonly used drugs. The individual variation in the efficacy and tolerability of many drugs metabolized by CES1 is considerable. Hence, there is a large interest in ...

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Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving

16.04.2015 | Ann Chen Wu; Charlene Gay; Melisa D Rett; Natasha Stout; Scott T Weiss; Anne L Fuhlbrigge, Pharmacogenomics, 2015

Aim: To identify the clinical and economic circumstances under which a pharmacogenomic test that predicts response to inhaled corticosteroids might be a cost-effective option for individuals with asthma. Materials & methods: We synthesized published data on clinical and economic outcomes to ...

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Actinomycosis: a frequently forgotten disease

13.04.2015 | Lyudmila Boyanova; Rossen Kolarov; Lyudmila Mateva; Rumyana Markovska; Ivan Mitov, Future Microbiology, 2015

ABSTRACT  Actinomycosis is a rare subacute or chronic, endogenous infection mainly by Actinomyces species, showing low virulence through fimbriae and biofilms. Cervicofacial, thoracic, abdominal, pelvic and sometimes cerebral, laryngeal, urinary and other regions can be affected. Actinomycosis ...

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Coxsackievirus B3 replication and pathogenesis

13.04.2015 | Farshid S Garmaroudi; David Marchant; Reid Hendry; Honglin Luo; Decheng Yang; Xin Ye; Junyan Shi; Bruce M McManus, Future Microbiology, 2015

ABSTRACT  Viruses such as coxsackievirus B3 (CVB3) are entirely host cell-dependent parasites. Indeed, they must cleverly exploit various compartments of host cells to complete their life cycle, and consequently launch disease. Evolution has equipped this pico-rna-virus, CVB3, to use different ...

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T4 bacteriophage-mediated inhibition of adsorption and replication of human adenovirus in vitro

13.04.2015 | Maciej Przybylski; Jan Borysowski; Renata Jakubowska-Zahorska; Beata Weber-Dąbrowska; Andrzej Górski, Future Microbiology, 2015

ABSTRACT  Aim: The objective of this study was to evaluate the effects of T4 phage on adsorption and replication of human adenovirus (HAdV). Materials & methods: Experiments were performed on cell lines A549 and HEK-293. Intracellular HAdV virions were released and titrated by Reed–Muench method. ...

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Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections

13.04.2015 | Nicasio Mancini; Lara Marrone; Nicola Clementi; Giuseppe A Sautto; Massimo Clementi; Roberto Burioni, Future Microbiology, 2015

ABSTRACT  Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely ...

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Cell-autonomous responses in Listeria monocytogenes infection

13.04.2015 | Helena Pillich; Trinad Chakraborty; Mobarak Abu Mraheil, Future Microbiology, 2015

ABSTRACT  Listeria monocytogenes is a facultative intracellular bacterium causing listeriosis, a food-borne infection with a high mortality rate. The mechanisms and the role of cells and tissular components in generating protective adaptive immune responses are well studied, and cell biological ...

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Is there interaction between gut microbial profile and cardiovascular risk in chronic kidney disease patients?

13.04.2015 | Amanda F Barros; Natália A Borges; Dennis C Ferreira; Flávia L Carmo; Alexandre S Rosado; Denis Fouque; Denise Mafra, Future Microbiology, 2015

ABSTRACT  Aim: To evaluate the gut microbial profile in chronic kidney disease (CKD) patients and evaluate the possible relationship with inflammation and cardiovascular risk. Patients & methods: Markers inflammation plasma and bacterial community profile (denaturing gradient gel electrophoresis) ...

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Host–pathogen interactions in Vibrio vulnificus: responses of monocytes and vascular endothelial cells to live bacteria

13.04.2015 | Celia Murciano; Lien-I Hor; Carmen Amaro, Future Microbiology, 2015

ABSTRACT  Aim: To demonstrate that Vibrio vulnificus, a sepsis-related aquatic pathogen, can provoke a strong pro-inflammatory reaction in blood-associated target cells. Materials & methods: We selected two strains of the two main phylogenetic lineages, two human cell lines, monocytes and ...

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Host immunity to Cryptococcus neoformans

13.04.2015 | Soma Rohatgi; Liise-anne Pirofski, Future Microbiology, 2015

ABSTRACT  Cryptococcosis is caused by the fungal genus Cryptococcus. Cryptococcosis, predominantly meningoencephalitis, emerged with the HIV pandemic, primarily afflicting HIV-infected patients with profound T-cell deficiency. Where in use, combination antiretroviral therapy has markedly reduced ...

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