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2.614 Aktuelle Fachpublikationen von Future Medicine

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Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery

19.12.2014 | Christian Albert; Johanna Kube; Anja Haase-Fielitz; Annemarie Dittrich; Denny Schanze; Martin Zenker; Hermann Kuppe; ..., Biomarkers in Medicine, 2014

Aim: To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery. Patients & methods: We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, ...


What can we expect from biomarkers for acute kidney injury?

19.12.2014 | John A Kellum; Prasad Devarajan, Biomarkers in Medicine, 2014

Biomarkers for acute kidney injury have numerous potential roles to play both at the bedside and in the design and conduct of clinical trials. Given the heterogeneous nature of this disease and the difficulty, so far, in developing effective therapies, a strategy that deploys all of our available ...


Novel biomarkers of acute kidney injury: time for implementation?

19.12.2014 | Zoltan H Endre, Biomarkers in Medicine, 2014

Biomarkers in Medicine December 2014, Vol. 8, No. 10, Pages 1185-1188.


Determination of the severity of ureteropelvic junction obstruction using urinary epidermal growth factor and kidney injury molecule 1 levels

19.12.2014 | Hamid Mohammadjafari; Alireza Rafiei; Mehrnoush Kosaryan; Yalda Yeganeh; Seyed Jalal Hosseinimehr, Biomarkers in Medicine, 2014

Aim: This study aimed to assess the urinary concentrations of epidermal growth factor (EGF) and kidney injury molecule 1 (KIM-1) in patients with hydronephrosis. Methods: Neonates with a history of prenatal hydronephrosis were enrolled in three groups. Group 1 included neonates with severe ...


Biomarkers of calcineurin inhibitor nephrotoxicity in transplantation

19.12.2014 | Mangalee Fernando; Philip W Peake; Zoltan H Endre, Biomarkers in Medicine, 2014

Over 35 years of use has demonstrated the revolutionary therapeutic benefits of calcineurin inhibitors (CNI) in not only preventing transplant rejection, but also the renal and nonrenal toxicity of CNI. Acute reversible and insidious irreversible forms of CNI nephrotoxicity have been identified, ...


The identification of three novel biomarkers of major adverse kidney events

19.12.2014 | Michael Haase; Rinaldo Bellomo; Christian Albert; Gregoire Vanpoucke; Griet Thomas; Wouter Laroy; Katleen Verleysen; ..., Biomarkers in Medicine, 2014

Aim: To describe the prognostic value of three novel biomarkers for acute adverse kidney events compared with routine biological markers. Material & methods: We used high-end MS to quantify biomarkers predictive of acute kidney injury (AKI) and major adverse kidney events (MAKE) in 100 adult ...


Biomarkers in IgA nephropathy

19.12.2014 | Vicki J Hwang; Arzu Ulu; Justin van Hoorebeke; Robert H Weiss, Biomarkers in Medicine, 2014

IgA nephropathy is the most common primary glomerulonephritis and presents with gross hematuria and upper respiratory infection, with slow progression to end-stage renal disease in up to 50% of affected patients. Kidney biopsies are the gold standard method of diagnosis and frequently are not ...


Blood HCO3 - concentration predicts the long-term prognosis of acute kidney injury patients

19.12.2014 | Xiajing Che; Yuanyuan Xie; Chunlin Wang; Qin Wang; Minfang Zhang; Chaojun Qi; Zhaohui Ni; Shan Mou, Biomarkers in Medicine, 2014

Aim: To evaluate the value of HCO3 - concentrations in long-term prognosis after acute kidney injury. Patients & methods: A total of 169 AKI patients were included in this study. At the 12‐month follow-up, the patients were divided into recovered and unrecovered groups. Results: The blood HCO3 - ...


Genotype and risk of major bleeding during warfarin treatment

18.12.2014 | Vivian K Kawai; Andrew Cunningham; Susan I Vear; Sara L Van Driest; Abimbola Oginni; Hua Xu; Min Jiang; Chun Li; Jos ..., Pharmacogenomics, 2014

Aim: To determine whether genetic variants associated with warfarin dose variability were associated with increased risk of major bleeding during warfarin therapy. Materials & methods: Using Vanderbilt's DNA biobank we compared the prevalence of CYP2C9, VKORC1 and CYP4F2 variants in 250 cases ...


Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab

18.12.2014 | Giacomo Allegrini; Luigi Coltelli; Paola Orlandi; Andrea Fontana; Andrea Camerini; Antonella Ferro; Marina Cazzaniga ..., Pharmacogenomics, 2014

Aim: To investigate pharmacogenetic interactions among VEGF-A, VEGFR-2, IL-8, HIF-1α, EPAS-1 and TSP-1 SNPs and their role on progression-free survival in a population of metastatic breast cancer patients treated with bevacizumab in combination with first-line paclitaxel. Patients & methods: ...


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