01.06.2013 | Hong Loan Nguyen; Xi Yang; Curtis J. Omiecinski, RNA, 2013

Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Recently, ...

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01.06.2013 | Sindy Cole; Daniel J. Powell; Gorica D. Petrovich, Learning & Memory, 2013

The amygdala is important for reward-associated learning, but how distinct cell groups within this heterogeneous structure are recruited during appetitive learning is unclear. Here we used Fos induction to map the functional amygdalar circuitry recruited during early and late training ...

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01.06.2013 | Amy Pandya-Jones; Dev M. Bhatt; Chia-Ho Lin; Ann-Jay Tong; Stephen T. Smale; Douglas L. Black, RNA, 2013

The expression of eukaryotic mRNAs is achieved though an intricate series of molecular processes that provide many steps for regulating the production of a final gene product. However, the relationships between individual steps in mRNA biosynthesis and the rates at which they occur are ...

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01.06.2013 | Alexis Bédécarrats; Charles Cornet; John Simmers; Romuald Nargeot, Learning & Memory, 2013

Feeding in Aplysia provides an amenable model system for analyzing the neuronal substrates of motivated behavior and its adaptability by associative reward learning and neuromodulation. Among such learning processes, appetitive operant conditioning that leads to a compulsive-like expression ...

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01.06.2013 | Hsiao-Fu Chang; Chun-Lin Su; Chih-Hua Chang; Yu-Wen Chen; Po-Wu Gean, Learning & Memory, 2013

Leptin, a 167 amino acid peptide, is synthesized predominantly in the adipose tissues and plays a key role in the regulation of food intake and body weight. Recent studies indicate that leptin receptor is expressed with high levels in many brain regions that may regulate synaptic plasticity. ...

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01.06.2013 | Michael J. Axtell, RNA, 2013

Small RNA sequencing allows genome-wide discovery, categorization, and quantification of genes producing regulatory small RNAs. Many tools have been described for annotation and quantification of microRNA loci (MIRNAs) from small RNA-seq data. However, in many organisms and tissue types, ...

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01.06.2013 | Karen L. Montey; Nicolette C. Eaton; Elizabeth M. Quinlan, Learning & Memory, 2013

Severe amblyopia, characterized by a significant reduction in visual acuity through the affected eye, is highly resistant to reversal in adulthood. We have previously shown that synaptic plasticity can be reactivated in the adult rat visual cortex by dark exposure, and the reactivated ...

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01.06.2013 | Jae-Hyung Lee; Jason K. Ang; Xinshu Xiao, RNA, 2013

RNA-sequencing (RNA-Seq) technologies hold enormous promise for novel discoveries in genomics and transcriptomics. In the past year, a surge of reports has analyzed RNA-Seq data to gain a global view of the RNA editome. Opposing results have been presented, giving rise to extensive debate ...

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01.06.2013 | Robert C. Twining; Jennifer J. Tuscher; Elizabeth M. Doncheck; Karyn M. Frick; Devin Mueller, Learning & Memory, 2013

Human and preclinical models of addiction demonstrate that gonadal hormones modulate acquisition of drug seeking. Little is known, however, about the effects of these hormones on extinction of drug-seeking behavior. Here, we investigated how 17β-estradiol (E2) affects expression and ...

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01.06.2013 | Marion Maurel; Nicolas Dejeans; Saïd Taouji; Eric Chevet; Christophe F. Grosset, RNA, 2013

MicroRNAs (miRNA) are generally described as negative regulators of gene expression. However, some evidence suggests that they may also play positive roles. As such, we reported that miR-1291 leads to a GPC3 mRNA expression increase in hepatoma cells through a 3' untranslated region ...

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