01.07.2013 | Delphine Callu; Joëlle Lopez; Nicole El Massioui, Learning & Memory, 2013

To determine the role of the interpositus nuclei of cerebellum in rule-based learning and optimization processes, we studied (1) successive transfers of an initially acquired response rule in a cross maze and (2) behavioral strategies in learning a simple response rule in a T maze in ...

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01.07.2013 | Johnatan Ceccom; Emilie Bouhsira; Hélène Halley; Stéphanie Daumas; Jean Michel Lassalle, Learning & Memory, 2013

One peculiarity of the hippocampal CA3 mossy fiber terminals is the co-release of zinc and glutamate upon synaptic transmission. How these two players act on hippocampal-dependent memories is still unclear. To decipher their respective involvement in memory consolidation, a pharmacological ...

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01.07.2013 | Ming Zhang; Hongbing Wang, Learning & Memory, 2013

There is significant interest in understanding the contribution of intracellular signaling and synaptic substrates to memory flexibility, which involves new learning and suppression of obsolete memory. Here, we report that enhancement of Ca2+-stimulated cAMP signaling by overexpressing type ...

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01.06.2013 | Valentina Proserpio; Raffaella Fittipaldi; James G. Ryall; Vittorio Sartorelli; Giuseppina Caretti, Genes & Development, 2013

Elucidating the epigenetic mechanisms underlying muscle mass determination and skeletal muscle wasting holds the potential of identifying molecular pathways that constitute possible drug targets. Here, we report that the methyltransferase SMYD3 modulates myostatin and c-Met transcription in ...

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01.06.2013 | Hédia Maamar; Moran N. Cabili; John Rinn; Arjun Raj, Genes & Development, 2013

Recently, researchers have uncovered the presence of many long noncoding RNAs (lncRNAs) in embryonic stem cells and believe they are important regulators of the differentiation process. However, there are only a few examples explicitly linking lncRNA activity to transcriptional regulation. ...

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01.06.2013 | Fa-Xing Yu; Yifan Zhang; Hyun Woo Park; Jenna L. Jewell; Qian Chen; Yaoting Deng; Duojia Pan; Susan S. Taylor; Zhi-C ..., Genes & Development, 2013

The Hippo tumor suppressor pathway plays an important role in tissue homeostasis that ensures development of functional organs at proper size. The YAP transcription coactivator is a major effector of the Hippo pathway and is phosphorylated and inactivated by the Hippo pathway kinases ...

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01.06.2013 | Gozde Yucel; Banu Altindag; Natalia Gomez-Ospina; Anshul Rana; Georgia Panagiotakos; Maria Fernanda Lara; Ricardo Do ..., Genes & Development, 2013

The signals regulating stem cell activation during tissue regeneration remain poorly understood. We investigated the baldness associated with mutations in the voltage-gated calcium channel (VGCC) Cav1.2 underlying Timothy syndrome (TS). While hair follicle stem cells express Cav1.2, they ...

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01.06.2013 | Alejandro López-Juárez; Jennifer Howard; Kristy Ullom; Lindsey Howard; Andrew Grande; Andrea Pardo; Ronald Waclaw; Y ..., Genes & Development, 2013

Neural stem cells (NSCs) reside in widespread regions along the lateral ventricle and generate diverse olfactory bulb (OB) interneuron subtypes in the adult mouse brain. Molecular mechanisms underlying their regional diversity, however, are not well understood. Here we show that the ...

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01.06.2013 | Yang Liu; Hannah K. Salter; Andrew N. Holding; Christopher M. Johnson; Elaine Stephens; Peter J. Lukavsky; John Wals ..., Genes & Development, 2013

Cytoplasmic dynein is the major minus end-directed microtubule motor in eukaryotes. However, there is little structural insight into how different cargos are recognized and linked to the motor complex. Here we describe the 2.2 Å resolution crystal structure of a cargo-binding region of the ...

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01.06.2013 | Soji Sebastian; Hervé Faralli; Zizhen Yao; Patricia Rakopoulos; Carmen Palii; Yi Cao; Kulwant Singh; Qi-Cai Liu; Alp ..., Genes & Development, 2013

Alternate splicing contributes extensively to cellular complexity by generating protein isoforms with divergent functions. However, the role of alternate isoforms in development remains poorly understood. Mef2 transcription factors are essential transducers of cell signaling that modulate ...

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