01.05.2013 | Iwaoka, Michio; Arai, Kenta, Chemical Biology, 2013

Abstract: Since the finding that selenium is an essential micronutrient for our life as well as the discovery of selenocysteine (Sec) as the twenty-first proteinogenic amino acid that is expressed by using the information encoded in genes, research fields in chemical biology and ...

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01.05.2013 | Indira Priyadarsini, K.; G Singh, Beena; Kunwar, Amit, Chemical Biology, 2013

Abstract: In the last one decade, researchers are exploring the possibility of developing less toxic selenium compounds as alternate class of antioxidants. Since most of the biological effects of selenium are mediated through selenoproteins such as glutathione peroxidase (GPx), new ...

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01.05.2013 | I Bunik, Victoria; Raddatz, Guenter; Strumilo, Slawomir, Chemical Biology, 2013

Abstract: Enzymes are catalysts designed to function in the metabolic networks of biological systems. This review shows mechanisms underlying chemical contribution to the biological system performance and adaptations in permanently changing environment. The catalyst is exemplified by ...

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01.05.2013 | A Bayse, Craig; M Whitty, Sean; Antony, Sonia, Chemical Biology, 2013

Abstract: One potential mechanism for the effectiveness of organoselenium compounds against a number of cancer cell lines is the interaction of selenium with zinc signaling processes. Reducible selenium (rSe) compounds such as diselenides, selenenyl halides and seleninic acids release ...

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01.05.2013 | Santi, Claudio; Tidei, Caterina; Scalera, Claudia; Piroddi, Marta; Galli, Francesco, Chemical Biology, 2013

Abstract: Oxidative stress results from the formation of reactive oxygen species (ROS) such as peroxides that cause damage to cell membranes and react with various biomolecules in mammalian cells. The selenoenzyme glutathione peroxidase (GPx) destroys peroxides by catalyzing their ...

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01.05.2013 | Mugesh, Govindasamy, Chemical Biology, 2013

Abstract: Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a lipid-soluble organoselenium compound, exhibits numerous biological activities both in vitro and in vivo systems. This compound is undergoing clinical trials for a number of disease states such as stroke and hearing loss. ...

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01.05.2013 | H Gandhi, Ujjawal; P Nagaraja, Tejo; Sandeep Prabhu, K., Chemical Biology, 2013

Abstract: The discovery of selenocysteine as the 21st amino acid has revolutionized the understanding of the significance of the essential micronutrient selenium in human and animal health. About 25 different selenoproteins have been identified that collectively function to detoxify ...

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27.03.2013 | Tian, Li-Ping; Liu, Lizhi; Wu, Fang-Xiang, Current Bioinformatics, 2013

Abstract: With advances in biotechnology, a huge amount of high throughput biological data has been and will continuously be produced. The information contained in such data is very useful in understanding the biological process from which such data is collected. Generally, high ...

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27.03.2013 | Wang, Mingjun; Sun, Zhongwei; Akutsu, Tatsuya; Song, Jiangning, Current Bioinformatics, 2013

Abstract: Owing to the biological significance of single amino acid polymorphism (SAP), there has been an increasing interest in understanding how certain amino acid substitutions give rise to functional change and consequent disease association, while others remain neutral ...

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27.03.2013 | M Golubovskaya, Vita, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: This review is focused on the role of Focal Adhesion Kinase (FAK) signaling in cancer stem cells. The recent data demonstrate the important role of FAK in cancer stem cell proliferation, differentiation, motility, and invasion. We showed recently that the transcription factor ...

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