08.05.2013 | Zhixiu Li; Yuedong Yang; Jian Zhan; Liang Dai; Yaoqi Zhou, Annual Review of Biophysics, 2013

In the past decade, a concerted effort to successfully capture specific tertiary packing interactions produced specific three-dimensional structures for many de novo designed proteins that are validated by nuclear magnetic resonance and/or X-ray crystallographic techniques. However, the ...

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08.05.2013 | Ken A. Dill, Annual Review of Biophysics, 2013

Annual Review of Biophysics Volume 42, May 2013.

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08.05.2013 | Edo Kussell, Annual Review of Biophysics, 2013

This review presents a broad survey of experimental microbial evolution, covering diverse topics including trade-offs, epistasis, fluctuating conditions, spatial dynamics, cooperation, aging, and stochastic switching. Emphasis is placed on examples that highlight key conceptual points or ...

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08.05.2013 | Scott Forth; Maxim Y. Sheinin; James Inman; Michelle D. Wang, Annual Review of Biophysics, 2013

Methods for exerting and measuring forces on single molecules have revolutionized the study of the physics of biology. However, it is often the case that biological processes involve rotation or torque generation, and these parameters have been more difficult to access experimentally. Recent ...

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08.05.2013 | Ross C. Wilson; Jennifer A. Doudna, Annual Review of Biophysics, 2013

Small RNA molecules regulate eukaryotic gene expression during development and in response to stresses including viral infection. Specialized ribonucleases and RNA-binding proteins govern the production and action of small regulatory RNAs. After initial processing in the nucleus by Drosha, ...

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08.05.2013 | Ruth Nussinov; Chung-Jung Tsai; Buyong Ma, Annual Review of Biophysics, 2013

Allosteric propagation results in communication between distinct sites in the protein structure; it also encodes specific effects on cellular pathways, and in this way it shapes cellular response. One example of long-range effects is binding of morphogens to cell surface receptors, which ...

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08.05.2013 | Christof Grewer; Armanda Gameiro; Thomas Mager; Klaus Fendler, Annual Review of Biophysics, 2013

Active transport in biological membranes has been traditionally studied using a variety of biochemical and biophysical techniques, including electrophysiology. This review focuses on aspects of electrophysiological methods that make them particularly suited for the investigation of ...

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08.05.2013 | Yuhai Tu, Annual Review of Biophysics, 2013

We review the recent developments in understanding the bacterial chemotaxis signaling pathway by using quantitative modeling methods. The models developed are based on structural information of the signaling complex and the dynamics of the underlying biochemical network. We focus on two ...

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08.05.2013 | Sandrine Morlot; Aurélien Roux, Annual Review of Biophysics, 2013

In eukaryotic cells, membrane compartments are split into two by membrane fission. This ensures discontinuity of membrane containers and thus proper compartmentalization. The first proteic machinery implicated in catalyzing membrane fission was dynamin. Dynamin forms helical collars at the ...

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08.05.2013 | Huan-Xiang Zhou; Timothy A. Cross, Annual Review of Biophysics, 2013

The number of membrane protein structures in the Protein Data Bank is becoming significant and growing. Here, the transmembrane domain structures of the helical membrane proteins are evaluated to assess the influences of the membrane mimetic environments. Toward this goal, many of the ...

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