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1.170 Aktuelle Fachpublikationen aus der Branche Medizin

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Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight

01.02.2016 | Steven K. Engle; David E. Watson, Toxicological Sciences, 2016

Cardiovascular (CV) toxicity is an important cause of failure during drug development. Blood-based biomarkers can be used to detect CV toxicity during preclinical development and prioritize compounds at lower risk of causing such toxicities. Evidence of myocardial degeneration can be detected by ...

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The genetic background affects the vascular response in T‐type calcium channels 3.2 deficient mice

22.01.2016 | Per Svenningsen, Pernille B.L. Hansen, Acta Physiologica, 2016

Abstract Voltage‐gated calcium channels (Cav) are important regulators of vascular tone and are attractive targets for pharmacological treatment of hypertension. The clinical used calcium blockers are often not selective for one channel but affect several types of calcium channels (Hansen ...

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Factors associated with timing of early neurological improvement after thrombolysis for ischaemic stroke

20.01.2016 | S. Guettier, J. Cogez, A.‐L. Bonnet, P. Dean, M. Apoil, T. Tchoumi, L. Dubuc, J. Arzur, V. Sayette, L.‐K. Kouassi, F ..., European Journal of Neurology, 2016

Background Early neurological improvement (ENI) after fibrinolysis for ischaemic stroke is strongly associated with recanalization and favourable outcome. However, it remains unknown why some patients recover within the first hour after treatment (very ENI, VENI) whereas others recover later ...

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Cardiovascular risk factors and TIA characteristics in 19,872 Swedish TIA patients

18.01.2016 | J. O. Ström, A. Tavosian, P. Appelros, Acta Neurologica Scandinavica, 2016

Background Transient ischemic attack (TIA) constitutes a major risk factor for stroke, making TIA patients an important group for secondary intervention. The aim of this study was to account for risk factor prevalence in TIA patients and analyze the association between TIA characteristics and ...

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Endothelial Dysfunction and Vascular Disease ‐ A Thirthieth Anniversary Update

26.12.2015 | P.M. Vanhoutte, H. Shimokawa, M. Feletou, E.H.C. Tang, Acta Physiologica, 2015

Abstract The endothelium can evoke relaxations of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium‐derived relaxing factor (EDRF) is nitric oxide (NO) which activates soluble guanylyl cyclase in the vascular smooth muscle cells, ...

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Sympathetic regulation of blood pressure in normotension and hypertension: When sex matters

18.12.2015 | L.J.B. Briant, N. Charkoudian, E.C. Hart, Experimental Physiology, 2015

The sympathetic nervous system has a central role in the regulation of arterial blood pressure (BP) and in the development of hypertension in humans. Recent evidence points to differences between the sexes in the integrative mechanisms by which BP is controlled, suggesting that the development ...

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Effects of mineralocorticoid receptor antagonists in patients with hypertension and diabetes mellitus: a systematic review and meta-analysis

17.12.2015 | S Takahashi; J Katada; H Daida; F Kitamura; K Yokoyama, Journal of Human Hypertension, 2015

Effects of mineralocorticoid receptor antagonists in patients with hypertension and diabetes mellitus: a systematic review and meta-analysis Journal of Human Hypertension advance online publication, December 17 2015. doi:10.1038/jhh.2015.119 Authors: S Takahashi, J Katada, H Daida, ...

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Pulse blood pressure and cardiovascular mortality in a population-based cohort of elderly Costa Ricans

17.12.2015 | L Rosero-Bixby; F Coto-Yglesias; W H Dow, Journal of Human Hypertension, 2015

Pulse blood pressure and cardiovascular mortality in a population-based cohort of elderly Costa Ricans Journal of Human Hypertension advance online publication, December 17 2015. doi:10.1038/jhh.2015.117 Authors: L Rosero-Bixby, F Coto-Yglesias & W H Dow

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Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodeling in spontaneously hypertensive rats

07.12.2015 | Satoshi Kameshima, Yuzaburo Sakamoto, Muneyoshi Okada, Hideyuki Yamawaki, Acta Physiologica, 2015

Abstract Aim Visceral adipose tissue‐derived serine protease inhibitor (vaspin) is a relatively novel adipocytokine with protective effects on metabolic diseases including obesity and type II diabetes. We have previously demonstrated that vaspin exerts anti‐inflammatory and anti‐migratory ...

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Endoplasmic reticulum stress in the brain subfornical organ contributes to sex differences in angiotensin‐dependent hypertension in rats

07.12.2015 | Shu‐Yan Dai, Jie Fan, Ying Shen, Jing‐Jing He, Wei Peng, Acta Physiologica, 2015

Abstract Aim Endoplasmic reticulum (ER) stress in the brain subfornical organ (SFO), a key cardiovascular regulatory center, has been implicated in angiotensin (ANG) II‐induced hypertension in males; however, the contribution of ER stress to ANG II‐induced hypertension in females is unknown. ...

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