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1.123 Aktuelle Fachpublikationen aus der Branche Medizin

mit folgenden Suchkriterien:

Cardiovascular and respiratory outcome of preconditioned rats submitted to chronic intermittent hypoxia

21.07.2015 | Raphael R. Perim, Leni G. H. Bonagamba, Benedito H. Machado, Experimental Physiology, 2015

Rats exposed to chronic intermittent hypoxia (CIH) develop hypertension, which is associated with changes in the coupling of sympathetic and respiratory activities. In this study we hypothesized that previous preconditioning to intermittent or sustained hypoxia would affect cardiovascular and ...


Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice

14.07.2015 | Jie Wang, Tao Guo, Qi‐Sheng Peng, Shou‐Wei Yue, Shuang‐Xi Wang, Journal of Cellular and Molecular Medicine, 2015

Abstract Berberine, as an alkaloid found in many Chinese herbs, improves vascular functions in patients with cardiovascular diseases. We determined the effects of berberine in hypertension and vascular ageing, and elucidated the underlying mechanisms. In isolated aortas, berberine ...


Sex differences and blood pressure regulation in humans

08.07.2015 | Michael J. Joyner, B. Gunnar Wallin, Nisha Charkoudian, Experimental Physiology, 2015

Arterial pressure is a key regulated variable in the cardiovascular system with important health implications. Over the last 12 years we have used physiological measurements including muscle sympathetic nerve activity (MSNA) to explore the balance among mean arterial blood pressure (MAP), ...


Involvement of central relaxin‐3/RXFP3 signalling in sodium (salt) appetite

06.07.2015 | Craig M. Smith, Lesley L. Walker, Berenice E. Chua, Michael J. McKinley, Andrew L. Gundlach, Derek A. Denton, Andrew ..., Experimental Physiology, 2015

Overconsumption of highly salted foods is common in Western diets, and contributes significantly to metabolic disorders such as hypertension, renal dysfunction and diabetes. Sodium appetite, or the desire of terrestrial animals to seek and consume sodium‐containing salts, is a behaviour ...


JHH change in leadership

01.07.2015 | M Stowasser, Journal of Human Hypertension, 2015

JHH change in leadership Journal of Human Hypertension 29, 399 (July 2015). doi:10.1038/jhh.2015.43 Author: M Stowasser


Interactions between local dilator and sympathetic vasoconstrictor influences in skeletal muscle in acute and chronic hypoxia

22.06.2015 | Janice M Marshall, Experimental Physiology, 2015

In resting skeletal muscle, acute systemic hypoxia evokes vasodilatation, while vasoconstriction evoked by increased muscle sympathetic nerve activity (MSNA) is blunted – referred to herein as hypoxic sympatholysis. This review considers the contributions of adenosine, prostaglandin I2, nitric ...


SHR have more orexin neurons in the hypothalamus and enhanced orexinergic input and orexin 2 receptor‐associated nNOS signaling in the RVLM

19.06.2015 | Yen‐Hsien Lee, Min‐Chien Tsai, Tzu‐Ling Li, Yu‐Wen E. Dai, Shang‐Cheng Huang, Ling‐Ling Hwang, Experimental Physiology, 2015

Previous study showed that elevated orexin 2 receptor (OX2R) activity within rostral ventrolateral medulla (RVLM) contributes to hypertension in spontaneously hypertensive rats (SHR). Herein, we investigated the mechanism(s) underlying the elevated OX2R activity. The following results were ...


Personalized hypertension management in practice

05.06.2015 | Patrick A Gladding; Alasdair Patrick; Paul Manley; Laura Mash; Phillip Shepherd; Rinki Murphy; Silas Vilas-Boas; Tod ..., Personalized Medicine, 2015

The revolution occurring in genomic and personalized medicine is likely to have a significant impact on the management of hypertension. However, from the perspective of translating new knowledge into clinical practice, progress has been slow. This review article summarizes recent advances in ...


Impact of renin‐angiotensin system blockade on clinical outcome in glioblastoma

04.06.2015 | E. Januel, R. Ursu, A. Alkhafaji, A. Marantidou, J. Doridam, C. Belin, C. Levy‐Piedbois, A. F. Carpentier, European Journal of Neurology, 2015

Background and purpose Despite surgery, radiotherapy (RT) and temozolomide (TMZ), the prognosis of glioblastoma (GBM) patients remains dismal. Normally prescribed with the aim to lower blood pressure, angiotensin‐II (Ang‐II) inhibitors were reported to reduce angiogenesis and tumour growth in ...


The effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: recalibration against cardiac magnetic resonance

04.06.2015 | J C L Rodrigues; B McIntyre; A G Dastidar; S M Lyen; L E Ratcliffe; A E Burchell; E C Hart; C Bucciarelli-Ducci; M C ..., Journal of Human Hypertension, 2015

The effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: recalibration against cardiac magnetic resonance Journal of Human Hypertension advance online publication, June 4 2015. doi:10.1038/jhh.2015.58 Authors: J C L Rodrigues, B ...


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