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1.119 Aktuelle Fachpublikationen aus der Branche Medizin

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JHH change in leadership

01.07.2015 | M Stowasser, Journal of Human Hypertension, 2015

JHH change in leadership Journal of Human Hypertension 29, 399 (July 2015). doi:10.1038/jhh.2015.43 Author: M Stowasser


Interactions between local dilator and sympathetic vasoconstrictor influences in skeletal muscle in acute and chronic hypoxia

22.06.2015 | Janice M Marshall, Experimental Physiology, 2015

In resting skeletal muscle, acute systemic hypoxia evokes vasodilatation, while vasoconstriction evoked by increased muscle sympathetic nerve activity (MSNA) is blunted – referred to herein as hypoxic sympatholysis. This review considers the contributions of adenosine, prostaglandin I2, nitric ...


SHR have more orexin neurons in the hypothalamus and enhanced orexinergic input and orexin 2 receptor‐associated nNOS signaling in the RVLM

19.06.2015 | Yen‐Hsien Lee, Min‐Chien Tsai, Tzu‐Ling Li, Yu‐Wen E. Dai, Shang‐Cheng Huang, Ling‐Ling Hwang, Experimental Physiology, 2015

Previous study showed that elevated orexin 2 receptor (OX2R) activity within rostral ventrolateral medulla (RVLM) contributes to hypertension in spontaneously hypertensive rats (SHR). Herein, we investigated the mechanism(s) underlying the elevated OX2R activity. The following results were ...


Personalized hypertension management in practice

05.06.2015 | Patrick A Gladding; Alasdair Patrick; Paul Manley; Laura Mash; Phillip Shepherd; Rinki Murphy; Silas Vilas-Boas; Tod ..., Personalized Medicine, 2015

The revolution occurring in genomic and personalized medicine is likely to have a significant impact on the management of hypertension. However, from the perspective of translating new knowledge into clinical practice, progress has been slow. This review article summarizes recent advances in ...


Impact of renin‐angiotensin system blockade on clinical outcome in glioblastoma

04.06.2015 | E. Januel, R. Ursu, A. Alkhafaji, A. Marantidou, J. Doridam, C. Belin, C. Levy‐Piedbois, A. F. Carpentier, European Journal of Neurology, 2015

Background and purpose Despite surgery, radiotherapy (RT) and temozolomide (TMZ), the prognosis of glioblastoma (GBM) patients remains dismal. Normally prescribed with the aim to lower blood pressure, angiotensin‐II (Ang‐II) inhibitors were reported to reduce angiogenesis and tumour growth in ...


The effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: recalibration against cardiac magnetic resonance

04.06.2015 | J C L Rodrigues; B McIntyre; A G Dastidar; S M Lyen; L E Ratcliffe; A E Burchell; E C Hart; C Bucciarelli-Ducci; M C ..., Journal of Human Hypertension, 2015

The effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: recalibration against cardiac magnetic resonance Journal of Human Hypertension advance online publication, June 4 2015. doi:10.1038/jhh.2015.58 Authors: J C L Rodrigues, B ...


Maternal factors in the origin of isolated oesophageal atresia: A population‐based case–control study

28.05.2015 | Gábor Vermes, Ákos Mátrai, Andrew E. Czeizel, Nándor Ács, Birth Defects Research Part A: Clinical and Molecular Teratology, 2015

Background: In most patients affected by isolated oesophageal atresia (IOA) the etiology is largely unknown. Thus, the aim of this study was to analyze potential risk factors in mothers. Methods: The study samples included 221 cases with IOA, 356 matched and 38,151 population controls without ...


Aboriginal vascular health and insights into atherosclerosis

28.05.2015 | J A Stone; J E Stone, Journal of Human Hypertension, 2015

Aboriginal vascular health and insights into atherosclerosis Journal of Human Hypertension advance online publication, May 28 2015. doi:10.1038/jhh.2015.54 Authors: J A Stone & J E Stone


Effects of chymostatin, A chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, and renal haemodynamics and excretion in two models of hypertension in the rat

26.05.2015 | Malwina Monika Roszkowska‐Chojecka, Agnieszka Walkowska, Olga Gawryś, Iwona Baranowska, Małgorzata Kalisz, Anna Litw ..., Experimental Physiology, 2015

Chymase is presumably a crucial enzyme of the non‐ACE pathway of Ang II generation in tissues, a process involved in vascular remodelling and development of hypertension. We examined the role of chymase in hypertension induced by exposure of uninephrectomized rats to high dietary salt intake ...


The giraffe kidney tolerates high arterial blood pressure by high renal interstitial pressure and low glomerular filtration rate

23.05.2015 | Mads Damkjær, Tobias Wang, Emil Brøndum, Kristine H. Østergaard, Ulrik Baandrup, Arne Hørlyck, J. Michael Hasenkam, ..., Acta Physiologica, 2015

Abstract Background The tallest animal on Earth, the giraffe (Giraffa camelopardalis) is endowed with a mean arterial blood pressure (MAP) twice that of other mammals. The kidneys reside at heart level and show no sign of hypertension related damage. We hypothesized that a species‐specific ...


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