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1.160 Aktuelle Fachpublikationen aus der Branche Medizin

mit folgenden Suchkriterien:

An HPLC method for the determination of a novel anti‐hypertension agent 6,7‐dimethoxy‐3‐(4‐(4‐fluorobenzyloxy)‐3‐methoxyphenylmethyl)quinazolin‐4(3H)‐one in rat plasma: application to pharmacokinetic study

18.11.2015 | Rui‐Miao Chang, Ai‐Guo Zeng, Wei Du, Xin‐Ya Xu, Sai‐Jie Zuo, Chun Chang, Qiang Fu, Biomedical Chromatography, 2015

ABSTRACT 6,7‐dimethoxy‐3‐(4‐(4‐fluorobenzyloxy)‐3‐methoxyphenylmethyl) quinazolin‐4(3H)‐one (DFMQ‐19), a novel analogue of 3‐benzylquinazolin‐4(3H)‐ones, may be considered as a drug candidate for the treatment of hypertension. The aim of this study was to develop and validate a reverse‐phase ...


Vascular Hyperpolarization in Human Physiology and Cardiovascular Risk Conditions and Disease

13.11.2015 | Francesca Schinzari, Manfredi Tesauro, Carmine Cardillo, Acta Physiologica, 2015

Abstract Hyperpolarization causing smooth muscle relaxation contributes to the maintenance of vascular homeostasis, particularly in small‐caliber arteries and arterioles. It may also become a compensatory vasodilator mechanism upregulated in states with impaired nitric oxide (NO) availability. ...


Endothelium‐dependent hyperpolarization: age, gender and blood pressure, do they matter?

09.11.2015 | Susan W S Leung, Paul M Vanhoutte, Acta Physiologica, 2015

Abstract Under physiological conditions, the endothelium generates vasodilator signals [prostacyclin, nitric oxide (NO) and endothelium‐dependent hyperpolarization (EDH)], for the regulation of vascular tone. The relative importance of these two signals depends on the diameter of the blood ...


Sympathetic over activity occurs before hypertension in the two‐kidney one clip model

05.11.2015 | Elizabeth B. Oliveira‐Sales, Eduardo Colombari, Ana Paula Abdala, Ruy R. Campos, Julian F.R. Paton, Experimental Physiology, 2015

Our knowledge of mechanisms responsible for both the development and maintenance of hypertension remains incomplete in the Goldblatt model (two kidney one clip, 2K1C). We tested the hypothesis that elevated sympathetic nerve activity (SNA) occurs before the onset of hypertension in 2K1C rats ...


A case of bilateral aldosterone-producing adenomas differentiated by segmental adrenal venous sampling for bilateral adrenal sparing surgery

05.11.2015 | R Morimoto; N Satani; Y Iwakura; Y Ono; M Kudo; M Nezu; K Omata; Y Tezuka; K Seiji; H Ota; Y Kawasaki; S Ishidoya; Y ..., Journal of Human Hypertension, 2015

A case of bilateral aldosterone-producing adenomas differentiated by segmental adrenal venous sampling for bilateral adrenal sparing surgery Journal of Human Hypertension advance online publication, November 5 2015. doi:10.1038/jhh.2015.100 Authors: R Morimoto, N Satani, Y Iwakura, ...


Association of leukocyte telomere length in peripheral blood leukocytes with endometrial cancer risk in Caucasian Americans

01.11.2015 | Yuhui Sun; Liren Zhang; Lina Zhao; Xifeng Wu; Jian Gu, Carcinogenesis , 2015

Telomeres are the protective structure at the ends of each chromosome and play an important role in maintaining genomic integrity. Interindividual variation of telomere length in peripheral blood leukocytes has been associated with the risks of developing many human diseases including several ...


Celecoxib prevents pressure overload‐induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress

29.10.2015 | Chi Zhang, Fan Wang, Yingxia Zhang, Yimin Kang, Haisheng Wang, Mingming Si, Liping Su, Xue Xin, Feng Xue, Fei Hao, L ..., Journal of Cellular and Molecular Medicine, 2015

Abstract To explore the effects of celecoxib on pressure overload‐induced cardiac hypertrophy (CH), cardiac dysfunction and explore the possible protective mechanisms. We surgically created abdominal aortic constrictions (AAC) in rats to induce CH. Rats with CH symptoms at 4 weeks after ...


New roles of factors from perivascular tissue in regulation of vascular tone

23.10.2015 | Ulf Simonsen, Ebbe Boedtkjer, Acta Physiologica, 2015

Abstract Vascular tone in the systemic circulation is regulated by the sympathetic innervation, circulating hormones and adaptation to transmural pressure, shear stress, and metabolic factors. It is increasingly recognized that the surrounding perivascular tissue (PVT) also regulates tone ...


Sunitinib-associated hypertension and neutropenia as efficacy biomarkers in metastatic renal cell carcinoma patients

22.10.2015 | Frede Donskov; M Dror Michaelson; Igor Puzanov; Mellar P Davis; Georg A Bjarnason; Robert J Motzer; David Goldstein; ..., British Journal of Cancer, 2015

Sunitinib-associated hypertension and neutropenia as efficacy biomarkers in metastatic renal cell carcinoma patients British Journal of Cancer advance online publication, October 22 2015. doi:10.1038/bjc.2015.368 Authors: Frede Donskov, M Dror Michaelson, Igor Puzanov, Mellar P ...


Altered neurotrophic factors expression profiles in the nucleus of the solitary tract of spontaneously hypertensive rats

20.10.2015 | Sabine S Gouraud, Miwa Takagishi, Akira Kohsaka, Masanobu Maeda, Hidefumi Waki, Acta Physiologica, 2015

Abstract Aim Our previous findings suggest that the nucleus of the solitary tract (NTS), a pivotal region for regulating the set‐point of arterial pressure, exhibits abnormal inflammation in pre‐hypertensive and spontaneously hypertensive rats (SHRs), with elevated anti‐apoptotic and low ...


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