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62.412 Aktuelle Fachpublikationen aus der Branche Medizin

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Heart rate recovery in elite athletes: the impact of age and exercise capacity

04.07.2015 | Jelena Suzic Lazic, Milica Dekleva, Ivan Soldatovic, Roman Leischik, Slavica Suzic, Dragan Radovanovic, Biljana Djur ..., Clinical Physiology and Functional Imaging, 2015

Summary There is compelling evidence that postexercise heart rate recovery (HRR) is a valid indicator of sympaticovagal balance. It is also used in prescription and monitoring of athletic training. The purpose of our study was to determine HRR after maximal exercise among elite athletes with ...

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Toxicological screening of human plasma by on‐line SPE‐HPLC‐DAD: identification and quantification of acidic and neutral drugs

04.07.2015 | Ludmila Mut, Thomas Grobosch, Torsten Binscheck‐Domaß, Wolfgang Frenzel, Biomedical Chromatography, 2015

ABSTRACT A multi‐analyte screening method for the quantification of 50 acidic/neutral drugs in human plasma based on on‐line SPE‐HPLC with photodiode array detection (DAD) was developed, validated and applied for clinical investigation. Acetone and methanol for protein precipitation, three ...

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Recombinant HBV vaccine enhances the rate of sustained virological response when early initiated after anti‐HCV combination therapy

04.07.2015 | Amr Shaaban Hanafy, Alaa Ahmad Farag, Hassan Mahmoud Hassanin, Ahmad Mahmoud Hassaneen, Journal of Medical Virology, 2015

Backgrounds: The overall SVR rate for chronic hepatitis C genotype 4 using the Standard of care is 54.3%. HBV infection can be prevented by the administration of effective and safe vaccine. Aims: Evaluation of the vaccination‐induced anti‐HBs response rates in a cohort of HCV Egyptian patients ...

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Comparison of genotypic and virtual phenotypic drug resistance interpretations with laboratory‐based phenotypes among CRF01_AE and subtype B HIV‐infected individuals

04.07.2015 | Awachana Jiamsakul, Romanee Chaiwarith, Nicolas Durier, Sunee Sirivichayakul, Sasisopin Kiertiburanakul, Peter Van D ..., Journal of Medical Virology, 2015

Abstract Objectives HIV drug resistance assessments and interpretations can be obtained from genotyping (GT), virtual phenotyping (VP) and laboratory‐based phenotyping (PT). We compared resistance calls obtained from GT and VP with those from PT (GT‐PT and VP‐PT) among CRF01_AE and subtype B ...

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Population‐based study for human papillomavirus (HPV) infection in women in Japan: A multicenter study by the Japanese human papillomavirus disease education research survey group (J‐HERS)

04.07.2015 | Toshiyuki Sasagawa, Toshiyuki Maehama, Kazuhisa Ideta, Takuya Irie, Fujiko Itoh,, Journal of Medical Virology, 2015

Abstract A multi‐center study was conducted to examine 6,628 eligible Japanese women aged from 16‐50 years for uterine cervical abnormality and HPV infection with a liquid based‐cytology test and a novel HPV test using the PCR‐SSOP‐Luminex® method identifying 31 HPV genotypes. In 3,047 normal ...

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Better therapy requires better response evaluation: Paving the way for minimal residual disease testing for every myeloma patient

03.07.2015 | Ola Landgren, Roger G Owen, Cytometry Part B: Clinical Cytometry, 2015

Abstract In 2015, there is a large body of evidence demonstrating that minimal residual disease (MRD) negativity after therapy is a powerful predictor of progression‐free survival and overall survival in multiple myeloma. Based on available data, we believe MRD provides a meaningful endpoint ...

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Physiologically normal 5% O2 supports neuronal differentiation and resistance to inflammatory injury in neural stem cell cultures

03.07.2015 | Xiaoyun Sun, Ludmila A. Voloboueva, Creed M. Stary, Rona G. Giffard, Journal of Neuroscience Research, 2015

Recent studies have demonstrated that neural stem cell (NSC) culture at physiologically normoxic conditions (2–5% O2) is advantageous in terms of neuronal differentiation and survival. Neuronal differentiation is accompanied by a remarkable shift to mitochondrial oxidative metabolism compared ...

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Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis

03.07.2015 | Yuki Nagahara, Masamitsu Shimazawa, Hirotaka Tanaka, Yoko Ono, Yasuhiro Noda, Kazuki Ohuchi, Kazuhiro Tsuruma, Masah ..., Journal of Neuroscience Research, 2015

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons and subsequent muscular atrophy. The quality of life of patients with ALS is significantly improved by ameliorating muscular symptoms. We previously reported that glycoprotein ...

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Utility of the Child Behavior Checklist as a Screener for Autism Spectrum Disorder

03.07.2015 | K. Alexandra Havdahl, Stephen von Tetzchner, Marisela Huerta, Catherine Lord, Somer L. Bishop, Autism Research, 2015

The Child Behavior Checklist (CBCL) has been proposed for screening of autism spectrum disorders (ASD) in clinical settings. Given the already widespread use of the CBCL, this could have great implications for clinical practice. This study examined the utility of CBCL profiles in differentiating ...

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Advances in genetic therapeutic strategies for Duchenne muscular dystrophy

03.07.2015 | Simon Guiraud, Huijia Chen, David T. Burns, Kay E. Davies, Experimental Physiology, 2015

Duchenne muscular dystrophy (DMD) is a lethal X‐linked disorder caused by mutations in the dystrophin gene. In the absence of the dystrophin protein, the link between the cytoskeleton and extracellular matrix is destroyed and this severely compromises the strength, flexibility and stability of ...

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