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69.913 Aktuelle Fachpublikationen aus der Branche Medizin

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Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection

01.05.2016 | Marc Beyer; Zeinab Abdullah; Jens M Chemnitz; Daniela Maisel; Jil Sander; Clara Lehmann; Yasser Thabet; Prashant V S ..., Nature Immunology, 2016

Nature Immunology 17, 593 (2016). doi:10.1038/ni.3399 Authors: Marc Beyer, Zeinab Abdullah, Jens M Chemnitz, Daniela Maisel, Jil Sander, Clara Lehmann, Yasser Thabet, Prashant V Shinde, Lisa Schmidleithner, Maren Köhne, Jonel Trebicka, Robert Schierwagen, Andrea Hofmann, ...

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DNA polymerase-[alpha] regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

01.05.2016 | Petro Starokadomskyy; Terry Gemelli; Jonathan J Rios; Chao Xing; Richard C Wang; Haiying Li; Vladislav Pokatayev; Ig ..., Nature Immunology, 2016

Nature Immunology 17, 495 (2016). doi:10.1038/ni.3409 Authors: Petro Starokadomskyy, Terry Gemelli, Jonathan J Rios, Chao Xing, Richard C Wang, Haiying Li, Vladislav Pokatayev, Igor Dozmorov, Shaheen Khan, Naoteru Miyata, Guadalupe Fraile, Prithvi Raj, Zhe Xu, Zigang Xu, Lin ...

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Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

27.04.2016 | Jesus M. Banales; Vincenzo Cardinale; Guido Carpino; Marco Marzioni; Jesper B. Andersen; Pietro Invernizzi; Guro E. ..., Nature Clinical Practice Gastroenterology & Hepatology, 2016

Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2016.51 Authors: Jesus M. Banales, Vincenzo Cardinale, Guido Carpino, Marco Marzioni, Jesper B. Andersen, Pietro Invernizzi, Guro E. Lind, Trine Folseraas, Stuart J. Forbes, Laura Fouassier, Andreas Geier, Diego ...

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Metabolic Profiling of Tenacigenin B, Tenacissoside H and Tenacissoside I using UHPLC‐ESI‐Orbitrap MS/MS

23.04.2016 | Can Zhao, Ling‐Yu Han, Wei Ren, Hai‐Yu Zhao, Shu‐Yan Han, Wen‐Xian Zheng, Li‐Na Pang, Xiao‐Hong Li, Ping‐Ping Li, Biomedical Chromatography, 2016

Abstract Marsdenia tenacissima, which is widely used as an anticancer herb in traditional Chinese medicine, has been shown to possess anticancer activity. However, its metabolic profile is poorly investigated. Tenacigenin B is the major steroidal skeleton of C‐21 steroids in M. tenacissima. ...

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A highly sensitive and efficient UPLC‐MS/MS assay for rapid analysis of tedizolid (a novel oxazolidinone antibiotic) in plasma sample

23.04.2016 | Muzaffar Iqbal, Biomedical Chromatography, 2016

Abstract Tedizolid (TDZ) is a novel oxazolidinone class antibiotic, indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in adults. In this study a highly sensitive UPLC‐MS/MS assay was developed and validated for the determination of TDZ in rat plasma ...

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Increased numbers of CD23+CD21hi Bin‐like B cells in human reactive and rheumatoid arthritis lymph nodes

23.04.2016 | Igor I. Kuzin, Stephen L. Kates, Yawen Ju, Longze Zhang, Homaira Rahimi, Wojciech Wojciechowski, Steven H. Bernstein ..., European Journal of Immunology, 2016

A unique population of CD23+ CD21high B cells in inflamed nodes (Bin) has been shown to accumulate in lymph nodes (LNs) draining inflamed joints of TNF‐transgenic (TNF‐tg) mice. Bin cells contribute to arthritis flare in mice by distorting node architecture and hampering lymphatic flow, but ...

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TLR signalling in human antigen‐presenting cells regulates MR1‐dependent activation of MAIT cells

23.04.2016 | James E Ussher, Bonnie Wilgenburg, Rachel F Hannaway, Kerstin Ruustal, Prabhjeet Phalora, Ayako Kurioka, Ted H Hanse ..., European Journal of Immunology, 2016

Mucosal‐associated invariant T (MAIT) cells are an abundant innate‐like T lymphocyte population that are enriched in liver and mucosal tissues. They are restricted by MR1, which presents antigens derived from a metabolic precursor of riboflavin synthesis, a pathway present in many microbial ...

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Simultaneous quantification of tizoxanide and tizoxanide glucuronide in mouse plasma by liquid chromatography‐tandem mass spectrometry

23.04.2016 | Jinqiu Liu, Fanhua Meng, Zhaofeng Li, Lin Yu, Shuangqing Peng, Jifen Guo, Haiyan Xu, Biomedical Chromatography, 2016

Abstract Nitazoxanide (NTZ) is a broad‐spectrum antimicrobial agent. Tizoxanide (T) and tizoxanide glucuronide (TG) are the major circulating metabolites after oral administration of NTZ. A rapid and specific LC − MS/MS method for the simultaneous quantification of T and TG in mouse plasma was ...

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Managing anti‐epileptic drug treatment in adult patients with intellectual disability: a serious conundrum

23.04.2016 | Z. Doran, R. Shankar, M. R. Keezer, C. Dale, B. McLean, M. P. Kerr, J. Devapriam, J. Craig, J. W. Sander, European Journal of Neurology, 2016

Background and purpose About a quarter of people with epilepsy have intellectual disability (ID). This group has communication issues, premature mortality, more treatment resistance, difficulties in making informed choices and greater risks of physical and mental health comorbidities. There is ...

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Carotid plaque echogenicity predicts cerebrovascular symptoms: a systematic review and meta‐analysis

23.04.2016 | F. Jashari, P. Ibrahimi, G. Bajraktari, C. Grönlund, P. Wester, M. Y. Henein, European Journal of Neurology, 2016

Background and purpose Many reports have shown an association between hypoechoic (echolucent) carotid atherosclerotic plaques and unstable features. In this meta‐analysis our aim was to determine the role of carotid plaque echogenicity in predicting future cerebrovascular (CV) ...

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