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65.333 Aktuelle Fachpublikationen aus der Branche Medizin

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Suppressive functions of B cells in infectious diseases

01.11.2015 | Ping Shen; Simon Fillatreau, International Immunology, 2015

B lymphocytes are often essential to successfully control invading pathogens and play a primary role in the protection afforded by successful vaccines through the production of specific antibodies. However, recent studies have highlighted the complex roles of B cells in infectious diseases, ...


The expanding family of regulatory B cells

01.11.2015 | Claudia Mauri; Madhvi Menon, International Immunology, 2015

Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known ...


Regulatory B cells in anti-tumor immunity

01.11.2015 | Yu Zhang; Nicolas Gallastegui; Joseph D. Rosenblatt, International Immunology, 2015

Advances in understanding of the immune microenvironment have highlighted the role of immunosuppressive T cell, myeloid, dendritic and monocytic sub-populations in inhibition of the anti-tumor immune response. The role of B cells in modulating the immune response to solid tumors as well as ...


Signals controlling the development and activity of regulatory B-lineage cells

01.11.2015 | Yoshihiro Baba; Masanori Matsumoto; Tomohiro Kurosaki, International Immunology, 2015

The fundamental concepts surrounding B cells with inhibitory function (regulatory B cells) are now being established. In the context of autoimmune and inflammatory animal models, B cells play an immunomodulatory role via IL-10 production and contribute to limitation of the pathogenesis. Recent ...


Regulatory B cells in human inflammatory and autoimmune diseases: from mouse models to clinical research

01.11.2015 | Tomomitsu Miyagaki; Manabu Fujimoto; Shinichi Sato, International Immunology, 2015

B cells have been generally considered to be positive regulators of immune responses because of their ability to produce antigen-specific antibodies and to activate T cells through antigen presentation. Impairment of B cell development and function may cause inflammatory and autoimmune diseases. ...


Innate response activator B cells: origins and functions

01.11.2015 | Benjamin G. Chousterman; Filip K. Swirski, International Immunology, 2015

Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors granulocyte macrophage colony stimulating factor and IL-3. In mouse models of sepsis and pneumonia, B-1a B cells residing in serosal sites recognize bacteria, migrate to the spleen or ...


Regulatory B cells mediate tolerance to apoptotic self in health: implications for disease

01.11.2015 | Mohini Gray; David Gray, International Immunology, 2015

B cells are able to regulate immune responses through the secretion of IL-10 and other inhibitory cytokines, though no transcription factor that can define ‘regulatory B cells’ as a separate lineage has yet been found. Instead it is likely that this function arises as a result of the immune ...


IL-10-independent regulatory B-cell subsets and mechanisms of action

01.11.2015 | Avijit Ray; Luman Wang; Bonnie N. Dittel, International Immunology, 2015

Although classically B cells are known to play important roles in immune protection via humoral immunity, recently their regulatory mechanisms have been best appreciated in the context of autoimmunity. Several studies have identified different subsets of regulatory B cells that vary not only in ...


Regulatory B10 cell development and function

01.11.2015 | Jacquelyn M. Lykken; Kathleen M. Candando; Thomas F. Tedder, International Immunology, 2015

B cells are known to instigate and promulgate immune responses by producing antibodies and presenting antigens to T cells. However, a rare but potent B-cell subset in both humans and mice is capable of inhibiting immune responses through the production of the anti-inflammatory cytokine IL-10. ...


Chewing‐induced hypertension in afferent baroreflex failure: A sympathetic response?

05.10.2015 | Cristina Fuente Mora, Lucy Norcliffe‐Kaufmann, Jose‐Alberto Palma, Horacio Kaufmann, Experimental Physiology, 2015

Familial dysautonomia (FD) is a rare genetic disease with extremely labile blood pressure due to baroreflex deafferentation. Patients have marked surges in sympathetic activity, frequently surrounding meals. We conducted an observational study to document the autonomic responses to eating in ...


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