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59.114 Aktuelle Fachpublikationen aus der Branche Medizin

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IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration

01.03.2015 | Naoyuki Makita; Yoshiyuki Hizukuri; Kyoko Yamashiro; Masao Murakawa; Yasuhiro Hayashi, International Immunology, 2015

M2 macrophages have been subdivided into subtypes such as IL-4-induced M2a and IL-10-induced M2c in vitro. Although it was reported that IL-10 stimulation leads to an increase in IL-4Rα, the effect of IL-4 and IL-10 in combination with macrophage subtype differentiation remains unclear. Thus, we ...

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The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells

01.03.2015 | Valerio Chiurchiù; Mirko Lanuti; Marco De Bardi; Luca Battistini; Mauro Maccarrone, International Immunology, 2015

G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found prominent roles for this receptor in inflammatory pain, gut and bone physiology, as well as cancer. However, little ...

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A novel function of interferon regulatory factor-1: inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection

01.03.2015 | Saho Maruyama; Makoto Kanoh; Akira Matsumoto; Makoto Kuwahara; Masakatsu Yamashita; Yoshihiro Asano, International Immunology, 2015

Infection with certain pathogens induces a shift of the Th subset balance to a Th1 dominant state. This, in turn, results in the suppression of Th2 responses. We focused on the involvement of interferon regulatory factor-1 (IRF-1) in the suppression of Th2 cells during Listeria infection. We ...

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Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

01.03.2015 | Andrea Malaspina; Fabiola Puentes; Sandra Amor, International Immunology, 2015

The immune system is inextricably linked with many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor cell function with an average survival of 3 years from symptoms onset. In ALS, there is a dynamic interplay between the ...

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Drak2 is not required for tumor surveillance and suppression

01.03.2015 | Benjamin A. Edwards; Tarsha L. Harris; Helen Floersh; John R. Lukens; Md. Hasan Zaki; Peter Vogel; Thirumala-Devi Ka ..., International Immunology, 2015

Drak2 is a promising therapeutic target to treat organ-specific autoimmune diseases such as type 1 diabetes and multiple sclerosis without causing generalized immune suppression. Inhibition of Drak2 may also prevent graft rejection following organ transplantation. However, Drak2 may function as a ...

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The warrior in the machine: neuroscience goes to war

01.03.2015 | Irene Tracey; Rod Flower, Nature Reviews Neuroscience, 2015

Nature Reviews Neuroscience 16, 184 (2015). doi:10.1038/nrn3914 Author: Irene Tracey & Rod Flower Nature Reviews Neuroscience15, 825–834 (2014)In table 1, methylxanthines should have been listed as adenosine A1 and A2 receptor antagonists (rather than agonists). This has been ...

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Corrigendum: Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages

01.03.2015 | Sushil Kumar Pathak; Sanchita Basu; Kunal Kumar Basu; Anirban Banerjee; Shresh Pathak; Asima Bhattacharyya; Tsuneyas ..., Nature Immunology, 2015

Nature Immunology 16, 326 (2015). doi:10.1038/ni0315-326b Author: Sushil Kumar Pathak, Sanchita Basu, Kunal Kumar Basu, Anirban Banerjee, Shresh Pathak, Asima Bhattacharyya, Tsuneyasu Kaisho, Manikuntala Kundu & Joyoti Basu

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Corrigendum: The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3

01.03.2015 | Manira Rayamajhi; Edward A Miao, Nature Immunology, 2015

Nature Immunology 16, 326 (2015). doi:10.1038/ni0315-326c Author: Manira Rayamajhi & Edward A Miao

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Corrigendum: Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

01.03.2015 | Monica Rimoldi; Marcello Chieppa; Valentina Salucci; Francesca Avogadri; Angelica Sonzogni; Gianluca M Sampietro; An ..., Nature Immunology, 2015

Nature Immunology 16, 326 (2015). doi:10.1038/ni0315-326a Author: Monica Rimoldi, Marcello Chieppa, Valentina Salucci, Francesca Avogadri, Angelica Sonzogni, Gianluca M Sampietro, Angelo Nespoli, Giuseppe Viale, Paola Allavena & Maria Rescigno

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Basics of Immunohistochemistry

01.03.2015 | Vivien Schacht; Johannes S Kern, Journal of Investigative Dermatology, 2015

Basics of Immunohistochemistry Journal of Investigative Dermatology 135, e30 (March 2015). doi:10.1038/jid.2014.541 Authors: Vivien Schacht & Johannes S Kern

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