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60.443 Aktuelle Fachpublikationen aus der Branche Medizin

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Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling

12.04.2015 | Giedre Valiuliene, Ieva Stirblyte, Dovile Cicenaite, Algirdas Kaupinis, Mindaugas Valius, Ruta Navakauskiene, Journal of Cellular and Molecular Medicine, 2015

Abstract Epigenetic changes play a significant role in leukaemia pathogenesis, therefore histone deacetylases (HDACis) are widely accepted as an attractive strategy for acute promyelocytic leukaemia (APL) treatment. Belinostat (Bel, PXD101), a hydroxamate‐type HDACi, has proved to be a ...

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Sustained activation of GABAA receptors in the suprachiasmatic nucleus mediates light‐induced phase delays of the circadian clock: a novel function of ionotropic receptors

11.04.2015 | Daniel L. Hummer, J. Christopher Ehlen, Tony E. Larkin, John K. McNeill, John R. Pamplin, Colton A. Walker, Phillip ..., European Journal of Neuroscience, 2015

Abstract The suprachiasmatic nucleus (SCN) contains a circadian clock that generates endogenous rhythmicity and entrains that rhythmicity with the day‐night cycle. The neurochemical events that transduce photic input within the SCN and mediate entrainment by resetting the molecular clock have ...

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A novel maternally inherited 8q24.3 and a rare paternally inherited 14q23.3 CNVs in a family with neurodevelopmental disorders

11.04.2015 | Jie Hu, Malini Sathanoori, Sally Kochmar, Meron Azage, Susan Mann, Suneeta Madan‐Khetarpal, Amy Goldstein, Urvashi Surti, American Journal of Medical Genetics Part A, 2015

A 7‐year‐old female with developmental delay (DD), autism spectrum disorder (ASD), intellectual disability (ID), attention deficit hyperactivity disorder (ADHD), and seizures was referred to our laboratory for oligomicroarray analysis. The analysis revealed a 540 kb microdeletion in the ...

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Exercise modality effect on VO2 off‐transient kinetics at VO2max intensity

10.04.2015 | Ana Sousa, Ferran A. Rodríguez, Leandro Machado, J. Paulo Vilas‐Boas, Ricardo J. Fernandes, Experimental Physiology, 2015

The kinetics of oxygen uptake (VO2) during recovery (off‐transient kinetics) to different exercise modes is largely unexplored, hampering the prescription of training/ recovery to enhance performance. The purpose of this study was to compare the VO2 off‐transient kinetics response between ...

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Correction: The Arabidopsis miR472-RDR6 Silencing Pathway Modulates PAMP- and Effector-Triggered Immunity through the Post-transcriptional Control of Disease Resistance Genes

10.04.2015 | Martine Boccara et al., PLoS Pathogens, 2015

by Martine Boccara, Alexis Sarazin, Odon Thiébeauld, Florence Jay, Olivier Voinnet, Lionel Navarro, Vincent Colot

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Structural asymmetry of the insula is linked to the lateralization of gesture and language

10.04.2015 | Szymon P. Biduła, Gregory Króliczak, European Journal of Neuroscience, 2015

Abstract The control of gesture is one of the most left‐lateralized functions, and the insular cortex is one of the most left‐biased structures in the human brain. Therefore, we investigated whether structural asymmetries of the insula are linked to the organization of functional activity ...

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Sensitive and precise HPLC method with back‐extraction clean‐up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study

10.04.2015 | Beata Strach, Elżbieta Wyska, Krzysztof Pociecha, Anna Krupa, Renata Jachowicz, Biomedical Chromatography, 2015

Abstract A sensitive HPLC method was developed and validated for the determination of sildenafil concentrations in rat plasma (200 μL) using a liquid–liquid extraction procedure and paroxetine as an internal standard. In order to eliminate interferences and improve the peak shape, a ...

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Polymorphisms in folate pathway genes are not associated with somatic nondisjunction in Turner syndrome

10.04.2015 | Adriana Valéria Sales Bispo, Luana Oliveira dos Santos, Juliana Vieira de Barros, Andrea Rezende Duarte, Jacqueline ..., American Journal of Medical Genetics Part A, 2015

Folate metabolism dysfunction can lead to DNA hypomethylation and abnormal chromosomal segregation. Previous investigations of this association have produced controversial results. Here we performed a case‐control study in patients with Turner syndrome (TS) to determine the effects of genetic ...

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TAM Receptor Signaling in Immune Homeostasis

10.04.2015 | Carla V. Rothlin; Eugenio A. Carrera-Silva; Lidia Bosurgi; Sourav Ghosh, Annual Review of Immunology, 2015

The TAM receptor tyrosine kinases (RTKs)—TYRO3, AXL, and MERTK—together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes ...

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Early T Cell Activation: Integrating Biochemical, Structural, and Biophysical Cues

10.04.2015 | Bernard Malissen; Pierre Bongrand, Annual Review of Immunology, 2015

T cells carry out the formidable task of identifying small numbers of foreign antigenic peptides rapidly and specifically against a very noisy environmental background of endogenous self-peptides. Early steps in T cell activation have thus fascinated biologists and are among the best-studied ...

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