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70.622 Aktuelle Fachpublikationen aus der Branche Medizin

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The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

04.05.2016 | Danny N. Khalil; Eric L. Smith; Renier J. Brentjens; Jedd D. Wolchok, Nature Clinical Practice Oncology, 2016

Nature Reviews Clinical Oncology. doi:10.1038/nrclinonc.2016.65 Author: Danny N. Khalil, Eric L. Smith, Renier J. Brentjens & Jedd D. Wolchok

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Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection

01.05.2016 | Marc Beyer; Zeinab Abdullah; Jens M Chemnitz; Daniela Maisel; Jil Sander; Clara Lehmann; Yasser Thabet; Prashant V S ..., Nature Immunology, 2016

Nature Immunology 17, 593 (2016). doi:10.1038/ni.3399 Authors: Marc Beyer, Zeinab Abdullah, Jens M Chemnitz, Daniela Maisel, Jil Sander, Clara Lehmann, Yasser Thabet, Prashant V Shinde, Lisa Schmidleithner, Maren Köhne, Jonel Trebicka, Robert Schierwagen, Andrea Hofmann, ...

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DNA polymerase-[alpha] regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

01.05.2016 | Petro Starokadomskyy; Terry Gemelli; Jonathan J Rios; Chao Xing; Richard C Wang; Haiying Li; Vladislav Pokatayev; Ig ..., Nature Immunology, 2016

Nature Immunology 17, 495 (2016). doi:10.1038/ni.3409 Authors: Petro Starokadomskyy, Terry Gemelli, Jonathan J Rios, Chao Xing, Richard C Wang, Haiying Li, Vladislav Pokatayev, Igor Dozmorov, Shaheen Khan, Naoteru Miyata, Guadalupe Fraile, Prithvi Raj, Zhe Xu, Zigang Xu, Lin ...

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Guanosine and its modified derivatives are endogenous ligands for TLR7

01.05.2016 | Takuma Shibata; Umeharu Ohto; Shosaku Nomura; Kayoko Kibata; Yuji Motoi; Yan Zhang; Yusuke Murakami; Ryutaro Fukui; ..., International Immunology, 2016

Toll-like receptor (TLR) 7and 8 were considered to recognize single-strand RNA (ssRNA) from viruses. Although these receptors also respond to synthetic small chemical ligands, such as CL075 and R848, it remains to be determined whether these receptors sense natural small molecules or not. In the ...

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Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

01.05.2016 | Katie Paul Friedman; Eric D. Watt; Michael W. Hornung; Joan M. Hedge; Richard S. Judson; Kevin M. Crofton; Keith A. ..., Toxicological Sciences, 2016

High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that converge on perturbed thyroid hormone (TH) homeostasis. Screening for MIEs specific to TH-disrupting pathways is limited in the U.S. ...

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Cysteinyl leukotriene 1 receptor influences intestinal polyp incidence in a gender-specific manner in the ApcMin/+ mouse model

01.05.2016 | Sayeh Savari; Naveen Kumar Chandrashekar; Janina Osman; Desiree Douglas; Kishan Bellamkonda; Gunilla Jönsson; Maria ..., Carcinogenesis , 2016

There is emerging literature emphasizing the role of inflammatory eicosanoids, including prostaglandins and leukotrienes, in cancer development. Increased expression of both the cysteinyl leukotriene receptor 1 (CysLTR1) and the enzyme responsible for the production of leukotrienes, ...

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Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice

01.05.2016 | Zhongshuang Hu; Taisuke Murakami; Kaori Suzuki; Hiroshi Tamura; Johannes Reich; Kyoko Kuwahara-Arai; Toshiaki Iba; I ..., International Immunology, 2016

LL-37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL-37 can modulate various inflammatory reactions. We previously revealed that LL-37 suppresses the LPS/ATP-induced pyroptosis of ...

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Immunomodulation By Subchronic Low Dose 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin

01.05.2016 | Eun-Ju Yang; John V. Stokes; Evangel Kummari; Jeffrey Eells; Barbara L.F. Kaplan, Toxicological Sciences, 2016

Multiple sclerosis (MS) is an autoimmune neurodegenerative disorder, characterized by demyelination of neurons in the central nervous system. To investigate the pathogenicity of various T cell types in MS, especially IFN-- or IL-17-producing CD4+ cells (TH1 or TH17 cells, respectively), the mouse ...

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Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells

01.05.2016 | Wei Chen; Jin Kyu Yi; Tetsu Shimane; Shebli Mehrazarin; Yi-Ling Lin; Ki-Hyuk Shin; Reuben H. Kim; No-Hee Park; Mo K. ..., Carcinogenesis , 2016

Grainyhead-like 2 (GRHL2) is one of the three mammalian homologues of Drosophila Grainyhead involved in epithelial morphogenesis. We recently showed that GRHL2 also controls normal epithelial cell proliferation and differentiation. In this study, we investigated the role of GRHL2 in oral ...

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Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22

01.05.2016 | Ryota Sakaguchi; Shunsuke Chikuma; Takashi Shichita; Rimpei Morita; Takashi Sekiya; Wenjun Ouyang; Tomomi Ueda; Hiro ..., International Immunology, 2016

Lipopolysaccharide (LPS)-induced acute lung injury (ALI) is known as a mouse model of acute respiratory distress syndrome; however, the function of T-cell-derived cytokines in ALI has not yet been established. We found that LPS challenge in one lung resulted in a rapid induction of innate-type ...

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