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68.408 Aktuelle Fachpublikationen aus der Branche Medizin

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Duplication 2p25 in a child with clinical features of CHARGE syndrome

06.02.2016 | Ethan D. Sperry, Jane L. Schuette, Conny M. A. van Ravenswaaij‐Arts, Glenn E. Green, Donna M. Martin, American Journal of Medical Genetics Part A, 2016

CHARGE syndrome is a dominant disorder characterized by ocular colobomata, heart defects, choanal atresia, retardation of growth and development, genital hypoplasia, and ear abnormalities including deafness and vestibular disorders. The majority of individuals with CHARGE have pathogenic ...


Acute effects of LSD on circulating steroid levels in healthy subjects

06.02.2016 | Petra Strajhar, Yasmin Schmid, Evangelia Liakoni, Patrick C. Dolder, Katharina M. Rentsch, Denise V. Kratschmar, Ale ..., Journal of Neuroendocrinology, 2016

Abstract Lysergic acid diethylamide (LSD) is a serotonin 5‐hydroxytryptamine‐2A (5‐HT2A) receptor agonist that is used recreationally worldwide. Interest in LSD research in humans waned after the 1970s, but the use of LSD in psychiatric research and practice has recently gained increasing ...


Nanosized titanium dioxide resulted in the activation of TGF‐β/Smads/p38MAPK pathway in renal inflammation and fibration of mice

06.02.2016 | Nan Wu, Yushaung Ge, Yingjun Zhou, Ting Shen, Qian Qiang, Qi Zhang, Ming Chen, Yajing Wang, Ling Wang, Jie Hong, Fas ..., Journal of Biomedical Materials Research Part A, 2016

Abstract Titanium dioxide nanoparticles (TiO2 NPs) have been demonstrated to damage the kidneys. However, whether chronic nephritis leads to renal fibration or the fibrosis is associated with the activation of TGF‐β/Smads/p38MAPK pathway caused by TiO2 NPs exposure is not well understood. ...


Integrated decision strategies for skin sensitization hazard

06.02.2016 | Judy Strickland, Qingda Zang, Nicole Kleinstreuer, Michael Paris, David M. Lehmann, Neepa Choksi, Joanna Matheson, A ..., Journal of Applied Toxicology, 2016

Abstract One of the top priorities of the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) is the identification and evaluation of non‐animal alternatives for skin sensitization testing. Although skin sensitization is a complex process, the key biological ...


Neurothrombectomy in acute ischaemic stroke: a prospective single‐centre study and comparison with randomized controlled trials

06.02.2016 | O. Nikoubashman, M. Jungbluth, K. Schürmann, M. Müller, B. Falkenburger, S. C. Tauber, M. Wiesmann, J. B. Schulz, A. ..., European Journal of Neurology, 2016

Background and purpose In the last few months five multicentre, randomized controlled trials (RCTs) unequivocally showed the superiority of mechanical thrombectomy in large vessel occlusion acute ischaemic stroke compared to systemic thrombolysis. Despite varying inclusion criteria and time ...


Numeric Estimates of Teratogenic Severity from Embryo–Fetal Developmental Toxicity Studies

05.02.2016 | L. David Wise, Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2016

A developing organism exposed to a toxicant will have a response that ranges from none to severe (i.e., death or malformation). The response at a given dosage may be termed teratogenic (or developmental toxic) severity and is dependent on exposure conditions. Prenatal/embryo–fetal developmental ...


Estimation of sparse directed acyclic graphs for multivariate counts data

05.02.2016 | Sung Won Han, Hua Zhong, Biometrics, 2016

Summary The next‐generation sequencing data, called high‐throughput sequencing data, are recorded as count data, which are generally far from normal distribution. Under the assumption that the count data follow the Poisson ‐normal distribution, this article provides an ‐penalized likelihood ...


Protein profile of basal prostate epithelial progenitor cells—stage‐specific embryonal antigen 4 expressing cells have enhanced regenerative potential in vivo

05.02.2016 | Thomas Höfner, Corinna Klein, Christian Eisen, Teresa Rigo‐Watermeier, Axel Haferkamp, Martin R. Sprick, Journal of Cellular and Molecular Medicine, 2016

Abstract The long‐term propagation of basal prostate progenitor cells ex vivo has been very difficult in the past. The development of novel methods to expand prostate progenitor cells in vitro allows determining their cell surface phenotype in greater detail. Mouse (Lin−Sca‐1+ CD49f+ ...


Overexpression of WDR79 in non‐small cell lung cancer is linked to tumour progression

05.02.2016 | Yang Sun, Chao Yang, Jieying Chen, Xin Song, Zhen Li, Minlan Duan, Jianglin Li, Xiaoxiao Hu, Kuangpei Wu, Guobei Yan ..., Journal of Cellular and Molecular Medicine, 2016

Abstract WD‐repeat protein 79 (WDR79), a member of the WD‐repeat protein family, acts as a scaffold protein, participating in telomerase assembly, Cajal body formation and DNA double‐strand break repair. Here, we first report that WDR79 is frequently overexpressed in cell lines and tissues ...


Functional Connectivity of Vim Nucleus in Tremor‐ and Akinetic‐/Rigid‐Dominant Parkinson's Disease

05.02.2016 | Jia‐rong Zhang, Tao Feng, Ya‐nan Hou, Piu Chan, Tao Wu, CNS Neuroscience & Therapeutics, 2016

Summary Aims The aim of this study was to investigate the involvement of the ventral intermediate nucleus of thalamus (Vim) in the tremor‐ and akinetic‐/rigid‐related networks in Parkinson's disease (PD). Methods Tremor‐dominant (TD) and akinetic‐/rigid‐dominant (ARD) PD patients were ...


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