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58.775 Aktuelle Fachpublikationen aus der Branche Medizin

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Inside and outside the pituitary: comparative analysis of Gnrhr expression provides insight into the mechanisms underlying the evolution of gene expression

03.01.2015 | Anne‐Laure Schang, Journal of Neuroendocrinology, 2015

Abstract DNA cis‐acting elements involved in gene regulation may actively contribute to adaptation processes because they are submitted to lower evolutionary constraints than coding DNA. In this regard, comparison of the mechanisms underlying basal and regulated Gnrhr expression have revealed ...

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Silent cerebral events/lesions related to atrial fibrillation ablation: A clinical review

03.01.2015 | Thomas Deneke, Pierre Jais, Marco Scaglione, Rainer Schmitt, Luigi di Biase, Georgios Christopoulos, Anja Schade, An ..., Journal of Cardiovascular Electrophysiology, 2015

ABSTRACT Brain magnetic resonance imaging (MRI) has identified a high incidence of cerebral ischemia in asymptomatic patients after atrial fibrillation (AF) ablation (silent). Detection of cerebral ischemic events on MRI is based on acute hyperintense lesions on diffusion‐weighted imaging. In ...

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Time course of clinical and neuroradiological effects of delayed‐release dimethyl fumarate in multiple sclerosis

02.01.2015 | L. Kappos, G. Giovannoni, R. Gold, J. T. Phillips, D. L. Arnold, C. Hotermans, A. Zhang, V. Viglietta, R. J. Fox,, European Journal of Neurology, 2015

Background and purpose Delayed‐release dimethyl fumarate (DMF, also known as gastro‐resistant DMF), demonstrated efficacy and safety in relapsing−remitting multiple sclerosis in the 2‐year, randomized, placebo‐controlled, phase 3 DEFINE and CONFIRM trials. A post hoc analysis of integrated ...

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Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension

02.01.2015 | Wei‐Wei Chen, Xiao‐Qing Xiong, Qi Chen, Yue‐Hua Li, Yu‐Ming Kang, Guo‐Qing Zhu, Acta Physiologica, 2015

Abstract Persistent excessive sympathetic activation greatly contributes to the pathogenesis of chronic heart failure (CHF) and hypertension. Cardiac sympathetic afferent reflex (CSAR) is a sympathoexcitatory reflex with positive feedback characteristics. Humoral factors such as bradykinin, ...

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Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma

02.01.2015 | P N Valdmanis; B Roy-Chaudhuri; H K Kim; L C Sayles; Y Zheng; C-H Chuang; D R Caswell; K Chu; Y Zhang; M M Winslow; ..., Oncogene, 2015

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma Oncogene 34, 94 (02 January 2015). doi:10.1038/onc.2013.523 Authors: P N Valdmanis, B Roy-Chaudhuri, H K Kim, L C Sayles, Y Zheng, C-H Chuang, D R Caswell, K Chu, Y Zhang, M M Winslow, E A ...

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CRL4B promotes tumorigenesis by coordinating with SUV39H1|[sol]|HP1|[sol]|DNMT3A in DNA methylation-based epigenetic silencing

02.01.2015 | Y Yang; R Liu; R Qiu; Y Zheng; W Huang; H Hu; Q Ji; H He; Y Shang; Y Gong; Y Wang, Oncogene, 2015

CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing Oncogene 34, 104 (02 January 2015). doi:10.1038/onc.2013.522 Authors: Y Yang, R Liu, R Qiu, Y Zheng, W Huang, H Hu, Q Ji, H He, Y Shang, Y Gong & Y Wang

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Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

02.01.2015 | J R Smith; E de Billy; S Hobbs; M Powers; C Prodromou; L Pearl; P A Clarke; P Workman, Oncogene, 2015

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins Oncogene 34, 15 (02 January 2015). doi:10.1038/onc.2013.519 Authors: J R Smith, E de Billy, S Hobbs, M Powers, C Prodromou, L Pearl, P A Clarke & P Workman

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Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis

02.01.2015 | L Wu; A de Bruin; H Wang; T Simmons; W Cleghorn; L E Goldenberg; E Sites; A Sandy; A Trimboli; S A Fernandez; C Eng; ..., Oncogene, 2015

Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis Oncogene 34, 119 (02 January 2015). doi:10.1038/onc.2013.511 Authors: L Wu, A de Bruin, H Wang, T Simmons, W Cleghorn, L E Goldenberg, E Sites, A Sandy, A Trimboli, S A Fernandez, C Eng, C Shapiro & G ...

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MiR-106b expression determines the proliferation paradox of TGF-|[beta]| in breast cancer cells

02.01.2015 | C Gong; S Qu; B Liu; S Pan; Y Jiao; Y Nie; F Su; Q Liu; E Song, Oncogene, 2015

MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells Oncogene 34, 84 (02 January 2015). doi:10.1038/onc.2013.525 Authors: C Gong, S Qu, B Liu, S Pan, Y Jiao, Y Nie, F Su, Q Liu & E Song

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Clinical Snippets

01.01.2015 | Journal of Investigative Dermatology, 2015

Clinical Snippets Journal of Investigative Dermatology 135, 5 (January 2015). doi:10.1038/jid.2014.469

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