13.05.2013 | Qinqin Zhu; Yueming Jiang; Sen Lin; Lingrong Wen; Dan Wu; Mouming Zhao; Feng Chen; Yongxia Jia; Bao Yang, Biomacromolecules, 2013

Longan is a delicious subtropical fruit with great health-beneficial effects. It has been utilized for disease prevention and health care since ancient age. To explore the chemicals responsible for the health benefits, water-soluble polysaccharides were extracted from longan flesh in this ...

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12.05.2013 | Author(s): S.-h. Hsu , S. Huang , Y.-C. Wang , Y.-C. Kuo, Acta Biomaterialia, 2013

Publication date: June 2013 Source:Acta Biomaterialia, Volume 9, Issue 6 Author(s): S.-h. Hsu , S. Huang , Y.-C. Wang , Y.-C. Kuo Biomimetic nanostructures have a wide range of applications. In particular, biodegradable polymer nanostructures that mimic the subtleties of ...

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08.05.2013 | Anke Tönjes; Peter Kovacs, Pharmacogenomics, 2013

The kidney has attracted the attention of diabetologists as an organ involved in the regulation of glucose homeostasis not only by gluconeogenesis, but also by renal glucose excretion. Sodium–glucose cotransporters (SGLTs), particularly SGLT2, are responsible for reabsorption of up to 99% of ...

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06.05.2013 | S.B. Sainath, CH. Swetha, P. Sreenivasula Reddy, Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 2013

ABSTRACT Melatonin (N‐acetyl‐5‐methoxy‐tryptamine) was first discovered from the bovine pineal gland extract in 1958. Since then, its synthesis, metabolism, physiological, and patho‐physiological functions are well studied in vertebrates; there is an increasing recognition of melatonin ...

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02.05.2013 | Jan Ooyen, Stephan Noack, Michael Bott, Lothar Eggeling, Engineering in Life Sciences, 2013

The wild type of Corynebacterium glutamicum does not excrete L‐lysine, but mutants are developed to use C. glutamicum for the large scale production of this amino acid. L‐lysine is derived from oxaloacetate and pyruvate, a reduced entry of these precursors into the citric acid cycle ...

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25.04.2013 | Yongbo Yuan, Dawn T. Eriksen, Huimin Zhao, Biotechnology and Bioengineering, 2013

Abstract Balancing and increasing the flux through an engineered heterologous pathway in a target organism to achieve high yield and productivity remains an overwhelming challenge in metabolic engineering. Here we report a novel strategy combining directed evolution and promoter ...

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22.04.2013 | Erik K. Read, Scott A. Bradley, Tim A. Smitka, Cyrus D. Agarabi, Scott C. Lute, Kurt A. Brorson, Biotechnology Progress, 2013

Fermentanomics, or a global understanding of a culture state on the molecular level empowered by advanced techniques like NMR, was employed to show that a model hybridoma culture supplied with glutamine and glucose depletes aspartate, cysteine, methionine, tryptophan, and tyrosine during ...

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18.04.2013 | Yu‐Sin Jang, Alok Malaviya, Joungmin Lee, Jung Ae Im, Sang Yup Lee, Julia Lee, Moon‐Ho Eom, Jung‐Hee Cho, Do Young Seung, Biotechnology Progress, 2013

Butanol is considered as a superior biofuel, which is conventionally produced by clostridial acetone‐butanol‐ethanol (ABE) fermentation. Among ABE, only butanol and ethanol can be used as fuel alternatives. Coproduction of acetone thus causes lower yield of fuel alcohols. Thus, this study ...

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16.04.2013 | Matthias König, Hermann‐Georg Holzhütter, Nikolaus Berndt, Biotechnology Journal, 2013

Abstract Characteristics of many tumor types are the reprogramming of metabolism and the occurrence of regional hypoxia. In this work we investigated the hypothesis that metabolic reprogramming in combination with metabolic zonation of cellular energy metabolism are important factors to ...

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16.04.2013 | Christoph Gruber, Stefan Krahulec, Bernd Nidetzky, Regina Kratzer, Biotechnology Journal, 2013

Abstract Generally, recombinant and native microorganisms can be employed as whole cell catalysts. The application of native hosts, however, shortens the process development time by avoiding multiple steps of strain construction. Here, we studied the NAD(P)H‐dependent reduction of ...

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