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Structure and Biomedical Applications of Amyloid Oligomer Nanoparticles

Amyloid oligomers are nonfibrillar polypeptide aggregates linked to diseases, such as Alzheimer’s and Parkinson’s. Here we show that these aggregates possess a compact, quasi-crystalline architecture that presents significant nanoscale regularity. The amyloid oligomers are dynamic assemblies and are able to release their individual subunits. The small oligomeric size and spheroid shape confer diffusible characteristics, electrophoretic mobility, and the ability to enter hydrated gel matrices or cells. We finally showed that the amyloid oligomers can be labeled with both fluorescence agents and iron oxide nanoparticles and can target macrophage cells. Oligomer amyloids may provide a new biological nanomaterial for improved targeting, drug release, and medical imaging.

Autoren:   Senthil T. Kumar; Jessica Meinhardt; Ann-Kathrin Fuchs; Tobias Aumüller; Jörg Leppert; Berthold Büchele; Uwe Knüpfer; Ramadurai Ramachandran; Jay Kant Yadav; Erik Prell; Isabel Morgado; Oliver Ohlenschläger; Uwe Horn; Thomas Simmet; Matthias Görlach; Marcus Fändrich
Journal:   ACS Nano
Jahrgang:   2014
DOI:   10.1021/nn503960h
Erscheinungsdatum:   22.10.2014
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