Total synthesis of proteins by modern chemical ligation methods has enabled the routine use of mirror‐image protein molecules in structural biology as well as the synthesis of crystalline protein molecules with full enzymatic activity. A practical total chemical synthesis of insulin has been achieved via a key ester‐linked protein molecule of novel topology. Racemic protein crystallography has enabled the determination of X‐ray structures of recalcitrant protein molecules.
We studied 17,576 members of 166 MLH1 and 224 MSH2 mutation‐carrying families from the Colon Cancer Family Registry. Average cumulative risks of colorectal cancer (CRC), endometrial cancer (EC) and other cancers for carriers were estimated using modified segregation analysis co ... mehr
Flavonoids have well‐known antioxidant, anti‐inflammatory, and anti‐cancer activities. Isoflavone genistein is considered a potent antioxidant agent against oxidative stress. Although several mechanisms have been proposed, a clear antioxidant mechanism of genistein is still remain ... mehr
People can get oral cancers from UV (290‐400 nm) exposures. Besides high outdoor UV exposures, high indoor UV exposures to oral tissues can occur when consumers use UV‐emitting tanning devices to either tan or whiten their teeth. We compared the carcinogenic risks of skin to or ... mehr