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A 53-year-old woman presented with digitalis toxicity caused by acute overdose that manifested as atrial tachycardia with block, sinus pauses, and competing AV junctional rhythm with atrial fibrillation. Patient admitted to overdosing with digoxin 15–20 h before presentation with intent to commit suicide. Serum digoxin level was 35.6 ng/ml and renal function was normal. Patient was treated with 1,040 mg of digoxin-specific antibody Fab fragment with prompt resolution of arrhythmias and restoration of sinus rhythm. Four hours after digoxin antibody administration, serum digoxin level declined to 0.2 ng/ml. Eighteen hours after treatment with Fab fragment, patient developed premature ventricular complexes, atrial tachycardia with and without atrioventricular block, and non-sustained ventricular tachycardia followed by ventricular fibrillation from which she was successfully resuscitated. Electrocardiogram showed no evidence of acute myocardial infarction, and emergent coronary angiogram did not reveal significant coronary artery disease. Repeat digoxin level was 20.4 ng/ml. A diagnosis of recrudescent digoxin toxicity was made and the patient was treated with one session of plasma exchange with resolution of arrhythmias. Immediately after plasma exchange, digoxin level decreased to 10.4 ng/ml, and after 10 h, the level further decreased to 6.6 ng/ml. The following day, digoxin level had decreased to 2.9 ng/ml. Our experience with this case would suggest that plasma exchange should be considered as a treatment modality for recrudescent digoxin toxicity.
Endothelial nitric oxide synthase polymorphism G298T in association with oxidative DNA damage in coronary atherosclerosis
Content Type Journal Article
Category Research Note
Pages 1-4
DOI 10.1007/s12041-012-0183-1
Authors
RAJESH G. KUMAR, Department of Genetics, Osmania Univers ... mehr
A micropropagation protocol was developed for multiplication of seedless lemon (Citrus limon L. cv. Kaghzi Kalan) using nodal explants. The maximum shoot regeneration was observed on low level of BAP (0.1 mg l−1) or kinetin (0.5 mg l−1). BA was recorded to be better than kinetin in terms of ... mehr
The objective of this study was to evaluate the activity, kinetic behavior, and thermal inactivation kinetics of peroxidase (POD) in aqueous extracts from two kinds of milk ripe stage corn, sweet corn and waxy corn. Optimum activities using guaiacol as the hydrogen donor were obtained for s ... mehr
Die Max-Planck-Gesellschaft und Springer haben sich einvernehmlich darauf verständigt, den Wissenschaftlern aller Max-Planck-Institute und Forschungsgruppen den Zugriff auf sämtliche Inhalte der Onlineplattform SpringerLink zu ermöglichen.
Die Vereinbarung umfasst auch Open ChoiceTM, das O ... mehr
Mit mehr als 18.000 elektronischen Laborprotokollen in den Bereichen Life Sciences und Biomedizin hat der Wissenschaftsverlag Springer sein Online-Angebot für Forschungslabors erheblich ausgebaut. Unter dem Namen Springer Protocols finden Wissenschaftler aus Forschungsinstitutionen und Unte ... mehr
Die Max-Planck-Gesellschaft hat nach schwierigen Verhandlungen ihren langjährigen Lizenzvertrag mit dem Springer Verlag zum 31. Dezember 2007 gekündigt. Die Verhandlungen sind gescheitert, weil laut MPG keine Einigung über ein adäquates Verhältnis von Preis und nachhaltigen Leistungen erzie ... mehr