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The immune system must be tightly regulated to prevent unwanted tissue damage caused by exaggerated immune and inflammatory reactions. Inhibitory and activating immune receptors play a crucial role in this function via phosphotyrosine‐dependent signaling pathways. A significant body of evidence has accumulated suggesting that the siglec family of sialic acid binding Ig‐like lectins makes an important contribution to this immunoregulation. The CD33‐related siglecs are a distinct subset of inhibitory and activating receptors, expressed primarily on leukocytes in a cell type‐specific manner. Here, we critically assess the in vitro and in vivo evidence on the functional role for CD33‐related siglecs in modulation of inflammatory and immune responses.
| Autoren: | Paul R. Crocker, Sarah J. McMillan, Hannah E. Richards | |
| Journal: | Annals of the New York Academy of Sciences | |
| Band: | 1253 | |
| Ausgabe: | 1 | |
| Jahrgang: | 2012 | |
| Seiten: | 102 | |
| DOI: | 10.1111/j.1749-6632.2011.06449.x | |
| Erscheinungsdatum: | 21.02.2012 |
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