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Abstract
Prevalence and predictors of Transmitted Drug Resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral‐naïve HIV‐1infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010.
3163 HIV‐1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non‐B). TDR significantly declined overall and for the single drug classes. Older age independently predicted an increased odd whereas a more recent GRT, a higher HIV‐RNA and C‐ versus B‐subtype lower odds of TDR.
© 2012 The Authors Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases
| Autoren: | M Colafigli, C Torti, EM Trecarichi, L Albini, A Rosi, V Micheli, N Manca, G Penco, B Bruzzone, G Punzi, P Corsi, G Parruti, P Bagnarelli, L Monno, A Gonnelli, R Cauda, S Di Giambenedetto ,; M. Colafigli, C. Torti, E. M. Trecarichi, L. Albini, A. Rosi, V. Micheli, N. Manca, G. Penco, B. Bruzzone, G. Punzi, P. Corsi, G. Parruti, P. Bagnarelli, L. Monno, A. Gonnelli, R. Cauda, S. Di Giambenedetto, | |
| Journal: | Clinical Microbiology and Infection | |
| Jahrgang: | 2012 | |
| Seiten: | no | |
| DOI: | 10.1111/j.1469-0691.2012.03847.x | |
| Erscheinungsdatum: | 27.04.2012 |
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