A structural comparative approach to identifying novel antimalarial inhibitors
Publication date: Available online 2 May 2013Source:Computational Biology and Chemistry Author(s): Jimmy Franco , Margaret A.L. Blackie , David Toth , Peter J. Smith , Joseph Capuano , Kurt Fastnacht , Charlotte Berkes Malaria continues to affect millions of people annually. With ... mehr
Stabilizing membrane proteins through protein engineering
Publication date: Available online 29 April 2013Source:Current Opinion in Chemical Biology Author(s): Daniel J Scott , Lutz Kummer , Dirk Tremmel , Andreas Plückthun Integral membrane proteins (IMPs) are crucial components of all cells but are difficult to study in vitro because the ... mehr
Targeting the untargetable: recent advances in the selective chemical modulation of protein phosphatase-1 activity
Publication date: Available online 3 May 2013Source:Current Opinion in Chemical Biology Author(s): Jayanta Chatterjee , Maja Köhn Protein phosphatase-1 (PP1) has long been neglected as a potential drug target owing to its misinterpreted unselective nature. However, growing evidence de ... mehr