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Aktuelle Fachpublikationen

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice

Nature Chemical Biology 11, 741 (2015). doi:10.1038/nchembio0915-741a Author: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Tho ... mehr

Computational approaches to natural product discovery

Nature Chemical Biology 11, 639 (2015). doi:10.1038/nchembio.1884 Authors: Marnix H Medema & Michael A Fischbach mehr

Corrigendum: Sterol metabolism controls TH17 differentiation by generating endogenous ROR[gamma] agonists

Nature Chemical Biology 11, 741 (2015). doi:10.1038/nchembio0915-741b Author: Xiao Hu, Yahong Wang, Ling-Yang Hao, Xikui Liu, Chuck A Lesch, Brian M Sanchez, Jay M Wendling, Rodney W Morgan, Tom D Aicher, Laura L Carter, Peter L Toogood & Gary D Glick mehr

Short- and long-term effects of chromosome mis-segregation and aneuploidy

Nature Reviews Molecular Cell Biology 16, 576 (2015). doi:10.1038/nrm4047 Author: Stefano Santaguida & Angelika Amon Nature Reviews Molecular Cell Biology16, 473–485 (2015)In the original article, the microtubule attachments to the central, misaligned chromosome in the le ... mehr

Erratum: Hydrolysis of 2[prime]3[prime]-cGAMP by ENPP1 and design of nonhydrolyzable analogs

Nature Chemical Biology 11, 741 (2015). doi:10.1038/nchembio0915-741c Author: Lingyin Li, Qian Yin, Pia Kuss, Zoltan Maliga, José L Millán, Hao Wu & Timothy J Mitchison mehr

Alle Fachpublikationen

Leveraging transcript quantification for fast computation of alternative splicing profiles [BIOINFORMATICS]

Alternative splicing plays an essential role in many cellular processes and bears major relevance in the understanding of multiple diseases, including cancer. High-throughput RNA sequencing allows genome-wide analyses of splicing across multiple conditions. However, the increasing number of ... mehr

Nonorthogonal tRNAFormula for protein and nascent chain labeling [METHODS]

In vitro-transcribed suppressor tRNAs are commonly used in site-specific fluorescence labeling for protein and ribosome-bound nascent chains (RNCs) studies. Here, we describe the production of nonorthogonal Bacillus subtilis tRNAcysAmber from Escherichia coli, a process that is superior to ... mehr

Metazoan tRNA introns generate stable circular RNAs in vivo [REPORTS]

We report the discovery of a class of abundant circular noncoding RNAs that are produced during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric)RNAs, are conserved features of animal transcriptomes. Biogenesis of tricRNAs requires anciently conserved tRNA sequ ... mehr

Cytoplasmic LSM-1 protein regulates stress responses through the insulin/IGF-1 signaling pathway in Caenorhabditis elegans [REPORTS]

Genes coding for members of the Sm-like (LSm) protein family are conserved through evolution from prokaryotes to humans. These proteins have been described as forming homo- or heterocomplexes implicated in a broad range of RNA-related functions. To date, the nuclear LSm2-8 and the cytoplasm ... mehr

Divergent target recognition by coexpressed 5'-isomiRs of miR-142-3p and selective viral mimicry [ARTICLE]

Sequence heterogeneity at the ends of mature microRNAs (miRNAs) is well documented, but its effects on miRNA function are largely unexplored. Here we studied the impact of miRNA 5'-heterogeneity, which affects the seed region critical for target recognition. Using the example of miR-142-3p, ... mehr

Alle Fachpublikationen zu Biotechnologie

Effectiveness of β‐thalassemia prenatal diagnosis in Southern Iran: a cohort study

Abstract Aim The aim of this study was to evaluate the effectiveness of prenatal diagnosis (PND) for the prevention of thalassemia in southern Iran. Methods From 2004 to 2012 1346 couples with β‐thalassemia minor were referred to our center. Mutation analyses utilized different ... mehr

Routine use of Array Comparative Genomic Hybridization (aCGH) as standard approach for prenatal diagnosis of chromosomal abnormalities. Clinical experience of 1,763 prenatal cases

Abstract Objective This study aims to evaluate the diagnostic yield of Comparative Genomic Hybridization microarrays (aCGH) and compare it with conventional karyotype analysis of standard >5 Mb resolution. Method A total of 1,763 prenatal samples were analyzed by aCGH (CytoChip ... mehr

Reasons for declining extended information visit on prenatal screening among pregnant women and their partners

Abstract Objective A two‐step model on information on prenatal screening consists of brief information at the first visit at the Maternal Health Care Centre and an offer of extended information at a separate visit. There is a lack of knowledge why some pregnant women and their partners ... mehr

Outcomes of pregnancies with more than one positive prenatal screening result in the first or second trimester

Abstract Objective To describe adverse outcomes and fetal abnormalities in women with a positive prenatal screening result for more than one disorder. Study Design Study participants were drawn from a population of 452,901 women pregnant with singletons entering the California P ... mehr

Trophoblast Retrieval and Isolation from the Cervix (TRIC) is unaffected by early gestational age or maternal obesity

Abstract Objective The objective of this study is to evaluate whether trophoblast yield obtained by trophoblast retrieval and isolation from the cervix (TRIC) is affected by pregnancy outcome, gestational age (GA) at retrieval, maternal body mass index (BMI), parity, or maternal age. ... mehr

Alle Fachpublikationen zu Diagnostik

Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1

Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1 Laboratory Investigation advance online publication, August 3 2015. doi:10.1038/labinvest.2015.94 Authors: Liang-I Kang, Kumiko Isse, Kelly Koral, W ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 844 (August 2015). doi:10.1038/labinvest.2015.92 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 700 (July 2015). doi:10.1038/labinvest.2015.75 mehr

Clinical significance of the integrin |[alpha]|6|[beta]|4 in human malignancies

Clinical significance of the integrin α6β4 in human malignancies Laboratory Investigation advance online publication, June 29 2015. doi:10.1038/labinvest.2015.82 Authors: Rachel L Stewart & Kathleen L O'Connor mehr

Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma

Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma Laboratory Investigation advance online publication, June 29 2015. doi:10.1038/labinvest.2015.84 Authors: Liang Hu, Guang-Zhen Yang, Yu Zhang, Dan Fe ... mehr

Alle Fachpublikationen zu Labortechnik

Overexpression of Protein Kinase M|[zeta]| in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory

Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory Neuropsychopharmacology 40, 2487 (September 2015). doi:10.1038/npp.2015.136 Authors: Yan-Xue Xue, Zhen-Zhen Zhu, Hai-Bin Han, Jian-Feng Liu, Shi-Qiu Meng, Chen C ... mehr

Sex Moderates the Effects of the Sorl1 Gene rs2070045 Polymorphism on Cognitive Impairment and Disruption of the Cingulum Integrity in Healthy Elderly

Sex Moderates the Effects of the Sorl1 Gene rs2070045 Polymorphism on Cognitive Impairment and Disruption of the Cingulum Integrity in Healthy Elderly Neuropsychopharmacology 40, 2487 (September 2015). doi:10.1038/npp.2015.137 Authors: Ying Liang, He Li, Chenlong Lv, N ... mehr

Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Antitumor Agents

Abstract: Throughout our evolution, the importance of natural products for medicine and health has been increasing and it continues to be a key source of novel anticancer drugs, leads and new chemical entities. Among natural products, tricyclic heteroaromatic alkaloids such as carbazoles a ... mehr

5-Lipoxygenase and Cyclooxygenase Inhibitory Dammarane Triterpenoid 1 from Borassus flabellifer Seed Coat Inhibits Tumor Necrosis Factor-α Secretion in LPSInduced THP-1 Human M ...

Abstract: Phospholipase A2 (PLA2), Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX) are arachidonic acid metabolizing enzymes and their inhibitors have been developed as therapeutic molecules for cancer and inflammation related disorders. In the present study, PLA2, COX 1&2 and 5-LOX inhibi ... mehr

Novel Series of Coumarinyl Substituted-thiazolidin-2,4-dione Analogs as Anticancer Agents: Design, Synthesis, Spectral Studies and Cytotoxicity Evaluation

Abstract: In this research work, a series of eighteen novel coumarinyl substituted thiazolidin-2,4-dione analogs (4a-4r) have been designed by molecular hybridization approach, synthesized and their structures were established on the basis of FTIR, 1H NMR, 13C NMR and elemental (CHN) analy ... mehr

Alle Fachpublikationen zu Pharma

Clinical Snippets

Clinical Snippets Journal of Investigative Dermatology 135, 2145 (September 2015). doi:10.1038/jid.2015.260 mehr

September 2015 Snapshot Dx Quiz: Linking Science to Patient Care

September 2015 Snapshot Dx Quiz: Linking Science to Patient Care Journal of Investigative Dermatology 135, e32 (September 2015). doi:10.1038/jid.2015.264 Authors: Erin Wei & Mariya Miteva mehr

Flow Cytometry II: Mass and Imaging Cytometry

Flow Cytometry II: Mass and Imaging Cytometry Journal of Investigative Dermatology 135, e36 (September 2015). doi:10.1038/jid.2015.263 Authors: Hung Doan, Garrett M Chinn & Richard R Jahan-Tigh mehr

Editors' Picks

Editors' Picks Journal of Investigative Dermatology 135, 2146 (September 2015). doi:10.1038/jid.2015.262 mehr

Cells to Surgery Quiz: September 2015

Cells to Surgery Quiz: September 2015 Journal of Investigative Dermatology 135, e17 (September 2015). doi:10.1038/jid.2015.265 Authors: Brian J Simmons, Fleta N Bray, Mohammed Alsaidan, Stephanie Mlacker, Vidhi Shah & Keyvan Nouri mehr

Alle Fachpublikationen zu Medizin
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