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Aktuelle Fachpublikationen

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles

Nature Protocols 12, 1400 (2017). doi:10.1038/nprot.2017.031 Authors: Stefan Harmsen, Matthew A Wall, Ruimin Huang & Moritz F Kircher The unique spectral signatures and biologically inert compositions of surface-enhanced resonance Raman scattering (SERRS) nanoparticles ma ... mehr

A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation

Nature Protocols 12, 1387 (2017). doi:10.1038/nprot.2017.041 Authors: Ana Beloqui, David J Brayden, Per Artursson, Véronique Préat & Anne des Rieux The specialized microfold cells (M cells) in the follicle-associated epithelium (FAE) of intestinal Peyer's patches serve as ... mehr

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

Nature Reviews Microbiology 15, 447 (2017). doi:10.1038/nrmicro.2017.69 Author: Mark C. Field, David Horn, Alan H. Fairlamb, Michael A. J. Ferguson, David W. Gray, Kevin D. Read, Manu De Rycker, Leah S. Torrie, Paul G. Wyatt, Susan Wyllie & Ian H. Gilbert Nature Reviews M ... mehr

Alle Fachpublikationen

Visualization of RNA structure models within the Integrative Genomics Viewer [BIOINFORMATICS]

Analyses of the interrelationships between RNA structure and function are increasingly important components of genomic studies. The SHAPE-MaP strategy enables accurate RNA structure probing and realistic structure modeling of kilobase-length noncoding RNAs and mRNAs. Existing tools for visu ... mehr

A genetic screen implicates a CWC16/Yju2/CCDC130 protein and SMU1 in alternative splicing in Arabidopsis thaliana [ARTICLE]

To identify regulators of pre-mRNA splicing in plants, we developed a forward genetic screen based on an alternatively spliced GFP reporter gene in Arabidopsis thaliana. In wild-type plants, three major splice variants issue from the GFP gene but only one represents a translatable GFP mRNA. ... mehr

Dual nature of pseudouridylation in U2 snRNA: Pus1p-dependent and Pus1p-independent activities in yeasts and higher eukaryotes [REPORT]

The pseudouridine at position 43 in vertebrate U2 snRNA is one of the most conserved post-transcriptional modifications of spliceosomal snRNAs; the equivalent position is pseudouridylated in U2 snRNAs in different phyla including fungi, insects, and worms. Pseudouridine synthase Pus1p acts ... mehr

Topological and thermodynamic factors that influence the evolution of small networks of catalytic RNA species [ARTICLE]

An RNA-directed recombination reaction can result in a network of interacting RNA species. It is now becoming increasingly apparent that such networks could have been an important feature of the RNA world during the nascent evolution of life on the Earth. However, the means by which such sm ... mehr

Integrative analysis unveils new functions for the Drosophila Cutoff protein in noncoding RNA biogenesis and gene regulation [ARTICLE]

Piwi-interacting RNAs (piRNAs) are central components of the piRNA pathway, which directs transposon silencing and guarantees genome integrity in the germ cells of several metazoans. In Drosophila, piRNAs are produced from discrete regions of the genome termed piRNA clusters, whose expressi ... mehr

Alle Fachpublikationen zu Biotechnologie

The natural history of fetal diagnosed isolated ventricular septal defect

Abstract Objective This study was undertaken to clarify the natural course of ventricular septal defect, and to find an index that would help in prenatal counseling. Methods Between January 2010 and December 2014, 18188 fetuses underwent echocardiographic examinations. Of these, ... mehr

Renal vascularization indexes and fetal hemodynamics in fetuses with growth restriction

Abstract Objective To identify the correlation between the renal vascularization index (VI), the flow index (FI) and the vascularization and flow index (VFI) and placental and fetal hemodynamics in fetuses with growth restriction. Method Bidimensional ultrasound and three‐dimens ... mehr

Fetal intracranial hemorrhage: role of fetal MRI

Abstract Objective To date, prenatal diagnosis of intracranial hemorrhage (ICH) is mainly based on ultrasound (US) findings rather than magnetic resonance imaging (MRI). We aimed to: investigate the role of MRI in the diagnosis of fetal ICH among pregnancies referred to fetal MRI and t ... mehr

SonoCAD. A Software To Solve The Dilemma Of The Prenatal Diagnosis Of Fetal Syndromes

Abstract Objective The aim of this work is to develop an efficient, user friendly, time saving computer software program specified with prenatal diagnosis, based solely on ultrasound findings provided by the sonographer. Materials and Method SonoCAD (Sonographyic Computer Assist ... mehr

Severe Apparently Isolated Fetal Ventriculomegaly And Neurodevelopmental Outcome

Abstract Objective To assess the neurodevelopmental outcome of children with a prenatal diagnosis of apparently isolated severe ventriculomegaly (SVM). Method Retrospective cohort study from 1994 to 2011. We included fetuses with unilateral or bilateral ventriculomegaly equal to ... mehr

Alle Fachpublikationen zu Diagnostik

Malignant melanoma: from cause to cure

Malignant melanoma: from cause to cure Laboratory Investigation 97, 628 (June 2017). doi:10.1038/labinvest.2017.57 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 492 (May 2017). doi:10.1038/labinvest.2017.38 mehr

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors Laboratory Investigation advance online publication, April 10 2017. doi:10.1038/labinvest.2017.41 Authors: Heather Hardin, Ranran Zhang, Holly Helein, Darya Buehler, Zhenying Guo & Ricardo ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 354 (April 2017). doi:10.1038/labinvest.2017.27 mehr

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy Laboratory Investigation advance online publication, March 27 2017. doi:10.1038/labinvest.2017.25 Authors: Robert Sackstein, Tobias Schatton & Steven R Barthel mehr

Alle Fachpublikationen zu Labortechnik

Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv

Abstract: Backgroud: Pinoresinol (Pin) and pinoresinol monoglucoside (PMG) are plant-derived lignan molecules with multiple functions. We showed previously that an endophytic fungus from Eucommia ulmoides Oliv., Phomopsis sp. XP-8 is able to produce Pin and PMG. Objective: This study was ... mehr

Synthesis and Evaluation of Cytotoxic Activity of Some Pyrroles and Fused Pyrroles

Abstract: Aims: Pyrrole derivatives represent a very interesting class as biologically active compounds. The objective of our study was to investigate the cytotoxic and apoptotic effects and antioxidant activity of the newly synthesized pyrrole derivatives. Method: A series of novel pyrro ... mehr

Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents

Abstract: Background: Protease activated receptor-1 (PAR1) is a G-coupled receptor activated by α-thrombin and other proteases. Several reports have demonstrated the PAR1 involvement in tumorigenesis and tumor progression. In order to investigate on potential use of PAR1 antagonists as ant ... mehr

Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent

Abstract: Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2 cell lines using the MTT assay. Method: Among ... mehr

Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme

Abstract: Objective: A series of novel 2,4-diaminosubstituted pyrrolo[3,2-d]pyrimidines was synthesized together with their corresponding 7-phenyl or 7-isopropyl counterparts. Results: Among the target derivatives, the 7-substituted analogues exhibited interesting cytotoxic activity again ... mehr

Alle Fachpublikationen zu Pharma

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

Adiposity and blood pressure among 55|[thinsp]|000 relatively lean rural adults in southwest of China

Adiposity and blood pressure among 55 000 relatively lean rural adults in southwest of China Journal of Human Hypertension 31, 485 (July 2017). doi:10.1038/jhh.2017.13 Authors: X Chen, H Du, J Zhang, X Chen, G Luo, X Que, N Zhang, Z Bian, Y Guo, L Li, Z Chen & X Wu mehr

Psychosocial correlates of apparent treatment-resistant hypertension in the Jackson Heart Study

Psychosocial correlates of apparent treatment-resistant hypertension in the Jackson Heart Study Journal of Human Hypertension 31, 486 (July 2017). doi:10.1038/jhh.2017.19 Authors: A J Shallcross, M Butler, R M Tanner, A P Bress, P Muntner, D Shimbo, G Ogedegbe, M Sims ... mehr

Definition of healthcare‐associated influenza: a review and results from an international survey

Abstract Aim To describe definitions of healthcare‐associated influenza (HAI) in recent literature and in hospitals participating in a survey of Society for Healthcare Epidemiology of America (SHEA) Research Network (SRN) members. Method A review with PubMed search was undertake ... mehr

Alle Fachpublikationen zu Medizin
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