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Aktuelle Fachpublikationen

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

Nuclear landscape of HIV-1 infection and integration

Nature Reviews Microbiology 15, 254 (2017). doi:10.1038/nrmicro.2017.22 Author: Marina Lusic & Robert F. Siliciano Nature Reviews Microbiology15, 69–82 (2017)In the first paragraph of the section 'Sequence specificity and chromatin determinants', at the end of the sixth s ... mehr

Dissection of mechanical force in living cells by super-resolved traction force microscopy

Nature Protocols 12, 783 (2017). doi:10.1038/nprot.2017.009 Authors: Huw Colin-York, Christian Eggeling & Marco Fritzsche Cells continuously exert or respond to mechanical force. Measurement of these nanoscale forces is a major challenge in cell biology; yet such measurem ... mehr

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition Neuropsychopharmacology 42, 1178 (April 2017). doi:10.1038/npp.2016.263 Authors: Alexander McGirr, Tatiana V Lipina, Ho-Suk Mun, John Georgiou, Ahmed H Al-Amri, Enoch N ... mehr

Alle Fachpublikationen

The evolution of tumour phylogenetics: principles and practice

Nature Reviews Genetics 18, 213 (2017). doi:10.1038/nrg.2016.170 Authors: Russell Schwartz & Alejandro A. Schäffer Rapid advances in high-throughput sequencing and a growing realization of the importance of evolutionary theory to cancer genomics have led to a proliferatio ... mehr

A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing [ARTICLE]

Splicing of precursor mRNA occurs via two consecutive steps of transesterification reaction; both require ATP and several proteins. Despite the energy requirement in the catalytic phase, incubation of the purified spliceosome under proper ionic conditions can elicit competitive reversible t ... mehr

Structural basis for guanidine sensing by the ykkC family of riboswitches [ARTICLE]

Regulation of gene expression by cis-encoded riboswitches is a prevalent theme in bacteria. Of the hundreds of riboswitch families identified, the majority of them remain as orphans, without a clear ligand assignment. The ykkC orphan family was recently characterized as guanidine-sensing ri ... mehr

Osmium tetroxide as a probe of RNA structure [REPORT]

Structured RNAs have a central role in cellular function. The capability of structured RNAs to adopt fixed architectural structures or undergo dynamic conformational changes contributes to their diverse role in the regulation of gene expression. Although numerous biophysical and biochemical ... mehr

The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation [REPORT]

The nuclear poly(A) binding protein (PABPN1) has been suggested, on the basis of biochemical evidence, to play a role in mRNA polyadenylation by strongly increasing the processivity of poly(A) polymerase. While experiments in metazoans have tended to support such a role, the results were no ... mehr

Alle Fachpublikationen zu Biotechnologie

Cryopreserved Human Umbilical Cord vs. Biocellulose Film for Antenatal Spina Bifida Repair in a Physiologic Rat Model

Abstract Background Antenatal spina bifida (SB) repair with a regenerative patch may improve neurological outcomes by decreasing inflammatory scarring. Objective To compare cryopreserved human umbilical cord (HUC) and biocellulose film (BCF) patches sutured over SB lesions for r ... mehr

Issue Information

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Preimplantation genetic haplotyping for six Chinese pedigrees with thalassemia using a single nucleotide polymorphism microarray

Abstract Objective To demonstrate the accuracy and feasibility of using single nucleotide polymorphism (SNP) array‐based preimplantation genetic haplotyping (PGH) in Chinese population, as the currently short tandem repeat (STR) method is labor‐intensive and time‐consuming. Metho ... mehr

Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart

Abstract Objective This study investigated the role of oxidative damage and nitric oxide (NO) synthases in the fetal heart using a model of intrauterine growth restriction (IUGR) induced by uteroplacental circulation restriction (UCR). Methods New Zealand white rabbits kept und ... mehr

Prevalence, timing of diagnosis and pregnancy outcome of abdominal wall defects after the introduction of a national prenatal screening program.

Abstract Objective To examine prevalence, time of diagnosis and outcome of fetuses with an exomphalos or gastroschisis, diagnosed since the introduction of a national prenatal screening program in 2007. Methods A prospective cohort study was undertaken in two fetal medicine unit ... mehr

Alle Fachpublikationen zu Diagnostik

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology Laboratory Investigation advance online publication, March 6 2017. doi:10.1038/labinvest.2017.9 Authors: Akinori Kawakami & David E Fisher mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 230 (March 2017). doi:10.1038/labinvest.2017.7 mehr

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance Laboratory Investigation advance online publication, February 27 2017. doi:10.1038/labinvest.2017.8 Authors: Phyu P Aung, Priyadharsini Nagarajan & Victor G Prieto mehr

Drugs with anti-oxidant properties can interfere with cell viability measurements by assays that rely on the reducing property of viable cells

Drugs with anti-oxidant properties can interfere with cell viability measurements by assays that rely on the reducing property of viable cells Laboratory Investigation advance online publication, February 27 2017. doi:10.1038/labinvest.2017.18 Authors: Niraj Shenoy, Mary Stens ... mehr

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing Laboratory Investigation advance online publication, February 20 2017. doi:10.1038/labinvest.2017.5 Authors: Sankhiros Babapoor, Rong Wu, James Koz ... mehr

Alle Fachpublikationen zu Labortechnik

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition Neuropsychopharmacology 42, 1178 (April 2017). doi:10.1038/npp.2016.263 Authors: Alexander McGirr, Tatiana V Lipina, Ho-Suk Mun, John Georgiou, Ahmed H Al-Amri, Enoch N ... mehr

Baclofen and Alcohol‐dependent Patients: A Real Risk of Severe Self‐Poisoning

Abstract Baclofen is often prescribed in high doses to fight cravings experienced by alcohol‐dependent patients. Such an increase in the availability of baclofen is concerning. This study aimed to determine the change in number and profile of self‐poisoning with baclofen over time, since ... mehr

Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery

Publication date: 1 May 2017 Source:European Journal of Pharmaceutical Sciences, Volume 102 Author(s): Jonatan Riis Christensen, Helena Meng-Lund, Holger Grohganz, Antti Poso, Tuomo Laitinen, Ossi Korhonen, Lene Jørgensen, Jari Pajander In recent years, the demand and ... mehr

Development and characterisation of cellulose based electrospun mats for buccal delivery of non-steroidal anti-inflammatory drug (NSAID)

Publication date: 1 May 2017 Source:European Journal of Pharmaceutical Sciences, Volume 102 Author(s): Kazem Nazari, Eleni Kontogiannidou, Rita Haj Ahmad, Aggeliki Gratsani, Manoochehr Rasekh, Muhammad Sohail Arshad, Burde Suheyla Sunar, David Armitage, Nikolaos Bour ... mehr

Supercritical antisolvent co-precipitation of rifampicin and ethyl cellulose

Publication date: 1 May 2017 Source:European Journal of Pharmaceutical Sciences, Volume 102 Author(s): Rania Djerafi, Andri Swanepoel, Christelle Crampon, Lonji Kalombo, Philip Labuschagne, Elisabeth Badens, Yasmine Masmoudi Rifampicin-loaded submicron-sized particles we ... mehr

Alle Fachpublikationen zu Pharma

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

Inflammatory processes in cardiovascular disease: a route to targeted therapies

Nature Reviews Cardiology. doi:10.1038/nrcardio.2017.33 Author: Neil Ruparelia, Joshua T. Chai, Edward A. Fisher & Robin P. Choudhury mehr

T cells and autoimmune kidney disease

Nature Reviews Nephrology. doi:10.1038/nrneph.2017.34 Authors: Abel Suárez-Fueyo, Sean J. Bradley, David Klatzmann & George C. Tsokos mehr

Effect of delayed‐release dimethyl fumarate on no evidence of disease activity in relapsing–remitting multiple sclerosis: integrated analysis of the phase III DEFINE and CONFIR ...

Background and purpose Significant effects on clinical/neuroradiological disease activity have been reported in patients with relapsing–remitting multiple sclerosis treated with delayed‐release dimethyl fumarate (DMF) in phase III DEFINE/CONFIRM trials. We conducted a post hoc analysis of ... mehr

Alle Fachpublikationen zu Medizin
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