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Aktuelle Fachpublikationen

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as well as the rapid degradation of messenger RNA. The latter ensures that translation closely follows programming at the level of transcription. Re ... mehr

Triple helical DNA in a duplex context and base pair opening

It is fundamental to explore in atomic detail the behavior of DNA triple helices as a means to understand the role they might play in vivo and to better engineer their use in genetic technologies, such as antigene therapy. To this aim we have performed atomistic simulations of a purine-rich ... mehr

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the pre ... mehr

Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency

Mitochondrial promoters of Saccharomyces cerevisiae share a conserved –8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation factor Mtf1. We used 2-aminopurine fluor ... mehr

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorl ... mehr

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CMPK1 and RBP3 are associated with corneal curvature in Asian populations

Corneal curvature (CC) measures the steepness of the cornea and is an important parameter for clinically diseases such as astigmatism and myopia. Despite the high heritability of CC, only two associated genes have been discovered to date. We performed a three-stage genome-wide association s ... mehr

Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1

In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions. Thus, study of DISC1 may provide a clue to understand the biology of major mental illness. A neuropeptide precursor VGF has potent ant ... mehr

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide p ... mehr

Linking the genetic architecture of cytosine modifications with human complex traits

Interindividual variation in cytosine modifications could contribute to heterogeneity in disease risks and other complex traits. We assessed the genetic architecture of cytosine modifications at 283 540 CpG sites in lymphoblastoid cell lines (LCLs) derived from independent samples of Europe ... mehr

CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome

Determining the molecular mechanism(s) leading to Purkinje neuron loss in the neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS) is limited by the complex morphology of this cell type. Purkinje neurons are notoriously difficult to isolate and maintain in culture ... mehr

Alle Fachpublikationen zu Biotechnologie

Ventricular non‐compaction cardiomyopathy: prenatal diagnosis and pathology

ABSTRACT Objective To evaluate the prenatal diagnosis of ventricular non‐compaction cardiomyopathy (NCCM) and to report the pathologic features and the characteristic myocardial ultrastructure of fetal NCCM. Method We examined 9 cases of fetal NCCM by prenatal echocardiography f ... mehr

Cranial and cerebral signs in the diagnosis of spina bifida between 18 and 22 weeks of gestation: A German mulicenter study

ABSTRACT Objective Studying secondary cranial signs in fetuses with spina bifida in a precisely defined screening period between 18 + 0 and 22 + 0 weeks of gestation. Method On the basis of retrospective analysis of 627 fetuses with spina bifida, the value of indirect cranial an ... mehr

Biochemical analysis of ascites fluid as an aid to etiological diagnosis: a series of 100 cases of non‐immune fetal ascites

ABSTRACT Objective To analyze the contribution of biochemistry and cytology of fetal ascites fluid to the etiological diagnosis of ascites after ultrasonographic scan, maternal blood sampling and fetal karyotyping. Method Retrospective study of 100 consecutive cases of non‐immun ... mehr

The role of second trimester uterine artery Doppler in pregnancies with systemic lupus erythematosus

ABSTRACT Objective To assess the predictive value of second trimester mean uterine artery Doppler pulsatility‐index (mUtA PI) for pregnancy complications in women with systemic lupus erythematosus (SLE). Methods Cohort study of consecutive pregnancies complicated with SLE during ... mehr

First trimester screening for early and late preeclampsia based on maternal characteristics, biophysical parameters and angiogenic factors

ABSTRACT Objective To develop the best first trimester screening model for preeclampsia (PE) based on maternal characteristics, biophysical parameters, and angiogenic factors in a low‐risk population. Methods A prospective cohort of 9,462 pregnancies undergoing first‐trimester s ... mehr

Alle Fachpublikationen zu Diagnostik

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.122 Authors: Kazuyo Yasuda, Toshihiko ... mehr

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.121 Authors: Maki K ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 936 (September 2014). doi:10.1038/labinvest.2014.106 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 820 (August 2014). doi:10.1038/labinvest.2014.88 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 704 (July 2014). doi:10.1038/labinvest.2014.74 mehr

Alle Fachpublikationen zu Labortechnik

Inconsistencies and Misleading Information in Officially Approved Prescribing Information From Three Major Drug Markets

Inconsistencies and Misleading Information in Officially Approved Prescribing Information From Three Major Drug Markets Clinical Pharmacology & Therapeutics 96, 616 (November 2014). doi:10.1038/clpt.2014.156 Authors: B Pfistermeister, A Saß, M Criegee-Rieck, T Bürkle, ... mehr

Optimizing Dosing of Oncology Drugs

Optimizing Dosing of Oncology Drugs Clinical Pharmacology & Therapeutics 96, 572 (November 2014). doi:10.1038/clpt.2014.153 Authors: L Minasian, O Rosen, D Auclair, A Rahman, R Pazdur & R L Schilsky mehr

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing Clinical Pharmacology & Therapeutics 96, 542 (November 2014). doi:10.1038/clpt.2014.159 Authors: K E Caudle, A E Rettie, M Whirl-Carrillo, L H Smith, S Mi ... mehr

CORRIGENDUM: Genetic Variations in GRIA1 on Chromosome 5q33 Related to Asparaginase Hypersensitivity

CORRIGENDUM: Genetic Variations in GRIA1 on Chromosome 5q33 Related to Asparaginase Hypersensitivity Clinical Pharmacology & Therapeutics 96, 625 (November 2014). doi:10.1038/clpt.2014.152 mehr

In This Issue

In This Issue Clinical Pharmacology & Therapeutics 96, 517 (November 2014). doi:10.1038/clpt.2014.181 mehr

Alle Fachpublikationen zu Pharma

Corrigendum: Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

Nature Immunology 15, 1090 (2014). doi:10.1038/ni1114-1090c Author: Calum C Bain, Alberto Bravo-Blas, Charlotte L Scott, Elisa Gomez Perdiguero, Frederic Geissmann, Sandrine Henri, Bernard Malissen, Lisa C Osborne, David Artis & Allan McI Mowat mehr

Cells to Surgery Quiz: November 2014

Cells to Surgery Quiz: November 2014 Journal of Investigative Dermatology 134, e7 (November 2014). doi:10.1038/jid.2014.395 Authors: Mohammad-Ali Yazdani Abyaneh, Robert D Griffith, Leyre Falto-Aizpurua & Keyvan Nouri mehr

BJD Editor's Choice

BJD Editor's Choice Journal of Investigative Dermatology 134, 2667 (November 2014). doi:10.1038/jid.2014.391 mehr

JID VisualDx Quiz: November 2014

JID VisualDx Quiz: November 2014 Journal of Investigative Dermatology 134, e22 (November 2014). doi:10.1038/jid.2014.394 Authors: Jose E Ollague & Robert S Kirsner mehr

Identifying the Stem Cell

Identifying the Stem Cell Journal of Investigative Dermatology 134, e26 (November 2014). doi:10.1038/jid.2014.393 Authors: Krisztian Nemeth & Sarolta Karpati mehr

Alle Fachpublikationen zu Medizin
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