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Aktuelle Fachpublikationen

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as well as the rapid degradation of messenger RNA. The latter ensures that translation closely follows programming at the level of transcription. Re ... mehr

Triple helical DNA in a duplex context and base pair opening

It is fundamental to explore in atomic detail the behavior of DNA triple helices as a means to understand the role they might play in vivo and to better engineer their use in genetic technologies, such as antigene therapy. To this aim we have performed atomistic simulations of a purine-rich ... mehr

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the pre ... mehr

Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency

Mitochondrial promoters of Saccharomyces cerevisiae share a conserved –8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation factor Mtf1. We used 2-aminopurine fluor ... mehr

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorl ... mehr

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G is for Genes: The Impact of Genetics on Education and Achievement.

G is for Genes: The Impact of Genetics on Education and Achievement. European Journal of Human Genetics 23, 139 (January 2015). doi:10.1038/ejhg.2014.117 Author: Bernard Esquivel mehr

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleot ... mehr

Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot–Marie–Tooth neuropathy

One of the genes involved in Charcot–Marie–Tooth (CMT) disease, an inherited peripheral neuropathy, is GDAP1. In this work, we show that there is a true ortholog of this gene in Drosophila, which we have named Gdap1. By up- and down-regulation of Gdap1 in a tissue-specific manner, we show t ... mehr

Exome sequencing reveals mutation in GJA1 as a cause of keratoderma-hypotrichosis-leukonychia totalis syndrome

Keratoderma-hypotrichosis-leukonychia totalis syndrome (KHLS) is an extremely rare, autosomal-dominant disorder characterized by severe skin hyperkeratosis, congenital alopecia and leukonychia totalis. The genetic defect underlying KHLS remained undetermined. By performing whole-exome seque ... mehr

The novel Cln1R151X mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy

The neuronal ceroid lipofuscinoses (NCLs), also known as Batten disease, are a group of autosomal recessive neurodegenerative disorders in children characterized by the progressive onset of seizures, blindness, motor and cognitive decline and premature death. Patients with mutations in CLN1 ... mehr

Alle Fachpublikationen zu Biotechnologie

The intelligent use and clinical benefits of electronic medical records in multiple sclerosis

Electronic medical records (EMRs) are being quickly adopted in clinics around the world. This advancement can greatly enhance the clinical care of patients with multiple sclerosis (MS) by providing formats that allow easier review of medical documents and more structured avenues to store re ... mehr

Down the line from genome-wide association studies in inflammatory bowel disease: the resulting clinical benefits and the outlook for the future

Inflammatory bowel disease (IBD), consisting of Crohn’s disease and ulcerative colitis, is a chronic inflammatory disease of the gut. The etiology of IBD is complex, involving genetic as well as environmental factors. Genetic studies have identified 163 genetic risk loci for IBD, which have ... mehr

The multifaceted aspects of refractory lupus nephritis

The term refractory lupus nephritis is generally used to indicate cases that do not respond to traditional treatment. However, the clinical presentation of lupus nephritis is variable and the time to response depends on the typology of the underlying renal syndrome. The criteria and the tim ... mehr

Clinical course and outcome of antenatally detected atrioventricular block: experience of a single tertiary centre and review of the literature.

ABSTRACT Objective To study the course and outcome of fetuses with congenital atrioventricular block (AVB) in a single centre. Methods Retrospective analysis of cases diagnosed prenatally with 2nd and 3rd degree AVB. The clinical characteristics and outcome of fetal AVB were eva ... mehr

Incidence and risk factors for subcutaneous immunotherapy anaphylaxis: the optimization of safety

Fatal reactions related to subcutaneous allergen immunotherapy are rare: one event in 2.5 million injections has been reported in the USA and none in Europe. The prevalence of very severe systemic reactions (systemic adverse events [SAEs]) is one in 1 million injections. Though the serious ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 1310 (December 2014). doi:10.1038/labinvest.2014.137 mehr

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats Laboratory Investigation advance online publication, November 10 2014. doi:10.1038/labinvest.2014.134 ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 1186 (November 2014). doi:10.1038/labinvest.2014.127 mehr

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.122 Authors: Kazuyo Yasuda, Toshihiko ... mehr

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.121 Authors: Maki K ... mehr

Alle Fachpublikationen zu Labortechnik

Circumspectives: The Promise of Ketamine

Circumspectives: The Promise of Ketamine Neuropsychopharmacology 40, 257 (January 2015). doi:10.1038/npp.2014.270 Authors: William A Carlezon & Tony P George Keywords: mehr

Intra-Hippocampal Transplantation of Neural Precursor Cells with Transgenic Over-Expression of IL-1 Receptor Antagonist Rescues Memory and Neurogenesis Impairments in an Alzhei ...

Intra-Hippocampal Transplantation of Neural Precursor Cells with Transgenic Over-Expression of IL-1 Receptor Antagonist Rescues Memory and Neurogenesis Impairments in an Alzheimer’s Disease Model Neuropsychopharmacology 40, 524 (January 2015). doi:10.1038/npp.2014.264 ... mehr

BRCA1 as Target for Breast Cancer Prevention and Therapy

Abstract: The Breast Cancer 1 protein (BRCA1) is a tumor suppressor involved in basic cellular functions necessary for cell replication and DNA synthesis, but reduced expression of BRCA1, due to mutations or epigenetic inactivation, leads to impaired mammary gland differentiation and incre ... mehr

A Review on Antiproliferative and Apoptotic Activities of Natural Honey

Abstract: Recent statistics revealed that cancer is one among the main reasons for death throughout the world. Several treatments are available but still there is no cure when it is detected at late stages. One of the treatment modes for cancer is chemotherapy which utilizes anticancer dru ... mehr

Deoxypodophyllotoxin Isolated from Juniperus communis Induces Apoptosis in Breast Cancer Cells

Abstract: The study of anticancer properties from natural products has regained popularity as natural molecules provide a high diversity of chemical structures with specific biological and medicinal activity. Based on a documented library of the most common medicinal plants used by the ind ... mehr

Alle Fachpublikationen zu Pharma

Diagnosis by Numbers: Defining Skin Disease Pathogenesis through Collated Gene Signatures

Diagnosis by Numbers: Defining Skin Disease Pathogenesis through Collated Gene Signatures Journal of Investigative Dermatology 135, 17 (January 2015). doi:10.1038/jid.2014.389 Authors: Amr Salam & John A McGrath mehr

Healing Refractory Venous Ulcers: New Treatments Offer Hope

Healing Refractory Venous Ulcers: New Treatments Offer Hope Journal of Investigative Dermatology 135, 19 (January 2015). doi:10.1038/jid.2014.444 Authors: Robert S Kirsner, Katherine L Baquerizo Nole, Joshua D Fox & Sophia N Liu mehr

Progress in Translational Research

Progress in Translational Research Journal of Investigative Dermatology 135, 1 (January 2015). doi:10.1038/jid.2014.463 Author: Barbara A Gilchrest mehr

Editors' Picks

Editors' Picks Journal of Investigative Dermatology 135, 6 (January 2015). doi:10.1038/jid.2014.471 mehr

Cells to Surgery Quiz: January 2015

Cells to Surgery Quiz: January 2015 Journal of Investigative Dermatology 135, e9 (January 2015). doi:10.1038/jid.2014.474 Authors: Leyre Falto-Aizpurua, Brian J Simmons, Robert D Griffith, Mohammad-Ali Yazdani Abyaneh & Keyvan Nouri mehr

Alle Fachpublikationen zu Medizin
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