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Aktuelle Fachpublikationen

Clinical Snippets

Clinical Snippets Journal of Investigative Dermatology 135, 1466 (June 2015). doi:10.1038/jid.2015.131 mehr

Editors' Picks

Editors' Picks Journal of Investigative Dermatology 135, 1468 (June 2015). doi:10.1038/jid.2015.133 mehr

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

Nature Reviews Microbiology 13, 343 (2015). doi:10.1038/nrmicro3456 Authors: Tiago R. D. Costa, Catarina Felisberto-Rodrigues, Amit Meir, Marie S. Prevost, Adam Redzej, Martina Trokter & Gabriel Waksman Bacteria have evolved a remarkable array of sophisticated nanomachine ... mehr

Cells to Surgery Quiz: May 2015

Cells to Surgery Quiz: May 2015 Journal of Investigative Dermatology 135, e14 (June 2015). doi:10.1038/jid.2015.136 Authors: Leyre Falto-Aizpurua, Mohammad-Ali Yazdani Abyaneh, Brian J Simmons, Fleta N Bray, Mohammed Alsaidan & Keyvan Nouri mehr

What's in a name?

Nature Chemical Biology 11, 363 (2015). doi:10.1038/nchembio.1832 Chemical biology may elude simple definitions, but there remains no question that chemical biologists have crafted a compelling interdisciplinary narrative that advances science and benefits society. mehr

Alle Fachpublikationen

Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta

Inherited dental malformations constitute a clinically and genetically heterogeneous group of disorders. Here, we report on four families, three of them consanguineous, with an identical phenotype, characterized by significant short stature with brachyolmia and hypoplastic amelogenesis impe ... mehr

A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption

Carotenoids are currently investigated regarding their potential to lower the risk of chronic disease and to combat vitamin A deficiency. Surprisingly, responses to dietary supplementation with these compounds are quite variable between individuals. Genome-wide studies have associated commo ... mehr

Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway

Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway disrupt binding of the encoded proteins, transport into the nucleus and initiation of homologous recombination, thereby increasing cancer risk [Scully, R., Chen, J., Plug, A., Xiao ... mehr

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring

Exposure of a developing foetus to maternal gestational diabetes (GDM) has been shown to programme future risk of diabetes and obesity. Epigenetic variation in foetal tissue may have a mechanistic role in metabolic disease programming through interaction of the pregnancy environment with ge ... mehr

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma

Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved in complex diseases. Still, the detailed understanding of the molecular and physiological mechanisms through which these genes affect disease phenotypes remains a major challenge. ... mehr

Alle Fachpublikationen zu Biotechnologie

Prenatal Diagnosis of Pierre Robin Sequence: accuracy and ability to predict phenotype and functional severity

Abstract Objective To assess the outcome of fetuses who had sonographic features suggestive of Pierre Robin Sequence (PRS). Method All prenatal ultrasounds that mentioned “posterior cleft palate”, or “micro or retrognathia” or “PRS” over 13 and 20 years respectively at 2 obstetr ... mehr

Current knowledge of prenatal diagnosis of mosaic autosomal trisomy in amniocytes: karyotype/phenotype correlations

Abstract Genetic counseling for prenatal diagnosis of autosomal trisomy is complex because of the uncertainty of outcome, which is important for management decisions. Compilation of cases of prenatally diagnosed autosomal trisomies in amniocytes has been done previously in an attempt to ... mehr

The use of human amniotic fluid stem cells as an adjunct to promote pulmonary development in a rabbit model for congenital diaphragmatic hernia

Abstract Objective This study aimed to evaluate the potential benefit of intra‐tracheal injection of human amniotic fluid stem cells (hAFSC) on pulmonary development combined with TO in a rabbit model for CDH. Methods In time mated pregnant does a left diaphragmatic defect was c ... mehr

Evaluating first trimester maternal serum screening combinations for Down syndrome suitable for use with reflexive secondary screening via sequencing of cell free DNA: High det ...

Abstract Objectives Examine primary Down syndrome screening using combinations of first trimester serum markers, with sequencing of cell free DNA as a secondary reflexive test. Methods Samples from 40 Down syndrome cases were matched with five control samples and tested for PAPP ... mehr

Determination of Fetal DNA Fraction from the Plasma of Pregnant Women using Sequence Read Counts

Abstract Objective This study introduces a novel method, referred to as SeqFF, for estimating the fetal DNA fraction in the plasma of pregnant women and to infer the underlying mechanism that allows for such statistical modeling. Methods Autosomal regional read counts from whole ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 454 (May 2015). doi:10.1038/labinvest.2015.56 mehr

Chronic traumatic encephalopathy: A paradigm in search of evidence|[quest]|

Chronic traumatic encephalopathy: A paradigm in search of evidence? Laboratory Investigation advance online publication, April 13 2015. doi:10.1038/labinvest.2015.54 Author: Rudy J Castellani mehr

Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging

Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging Laboratory Investigation advance online publication, March 2 2015. doi:10.1038/labinvest.2015.2 Authors: Richard M Levenson, Alexander D Borowsky & Michael Angelo mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 248 (March 2015). doi:10.1038/labinvest.2015.31 mehr

Application of GFP imaging in cancer

Application of GFP imaging in cancer Laboratory Investigation advance online publication, February 16 2015. doi:10.1038/labinvest.2014.154 Author: Robert M Hoffman mehr

Alle Fachpublikationen zu Labortechnik

Encouraging microRNA-based Therapeutic Strategies for Hepatocellular Carcinoma

Abstract: Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies worldwide with poor prognosis. Most of the HCC patients died quickly because of the rapid tumor progression with no effective therapy except for liver resection or transplantation. Recently, m ... mehr

Molecular Mechanism Behind the Synergistic Activity of Diphenylmethyl Selenocyanate and Cisplatin Against Murine Tumor Model

Abstract: Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to i ... mehr

Epoxomicin Sensitizes Resistant Osteosarcoma Cells to TRAIL Induced Apoptosis

Abstract: Osteosarcoma (OS) is the second most common primary malign bone neoplasm after multiple myeloma. Despite systemic chemotherapy, OS may give rise to local recurrences and metastases. Resistance to chemotherapy is not rare and is likely to occur in a high number of patients. Novel ... mehr

Discovery of Novel N-alkyl 4-anilinofuro[2,3-b]quinoline Derivatives (CIL-102 Derivatives) Against Castration-resistant Human Prostate Cancers

Abstract: A number of N-alkylated 4-anilinofuro[2,3-b]quinoline derivatives were synthesized and evaluated in vitro against PC-3, A549, and MCF-7 cancer cells and M-10 normal human mammary epithelial cells. The known antimitotic CIL-102 was moderately active against the growth of PC-3 pros ... mehr

New Treatments for Cutaneous Metastatic Melanoma: MAPK Pathway-Targeted and Immune Based Therapies

Abstract: Increasing knowledge on cellular biology has permitted rapid changes in the treatment of metastatic melanoma. Until 2011, dacarbazine was the gold standard treatment at our disposal. In 2011 the treatment landscape changed dramatically with the approval by the FDA of ipilimumab a ... mehr

Alle Fachpublikationen zu Pharma

Clinical Snippets

Clinical Snippets Journal of Investigative Dermatology 135, 1466 (June 2015). doi:10.1038/jid.2015.131 mehr

Editors' Picks

Editors' Picks Journal of Investigative Dermatology 135, 1468 (June 2015). doi:10.1038/jid.2015.133 mehr

Cells to Surgery Quiz: May 2015

Cells to Surgery Quiz: May 2015 Journal of Investigative Dermatology 135, e14 (June 2015). doi:10.1038/jid.2015.136 Authors: Leyre Falto-Aizpurua, Mohammad-Ali Yazdani Abyaneh, Brian J Simmons, Fleta N Bray, Mohammed Alsaidan & Keyvan Nouri mehr

Facilitating Translational Research

Facilitating Translational Research Journal of Investigative Dermatology 135, 1463 (June 2015). doi:10.1038/jid.2015.5 Authors: John Parrish, Steve Schachter, Mike Dempsey & John Collins mehr

What Is a Pragmatic Clinical Trial|[quest]|

What Is a Pragmatic Clinical Trial? Journal of Investigative Dermatology 135, e33 (June 2015). doi:10.1038/jid.2015.134 Authors: Hywel C Williams, Esther Burden-Teh & Andrew J Nunn mehr

Alle Fachpublikationen zu Medizin
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