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Aktuelle Fachpublikationen

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as well as the rapid degradation of messenger RNA. The latter ensures that translation closely follows programming at the level of transcription. Re ... mehr

Triple helical DNA in a duplex context and base pair opening

It is fundamental to explore in atomic detail the behavior of DNA triple helices as a means to understand the role they might play in vivo and to better engineer their use in genetic technologies, such as antigene therapy. To this aim we have performed atomistic simulations of a purine-rich ... mehr

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the pre ... mehr

Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency

Mitochondrial promoters of Saccharomyces cerevisiae share a conserved –8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation factor Mtf1. We used 2-aminopurine fluor ... mehr

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorl ... mehr

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Rejection of tmRNA{middle dot}SmpB after GTP hydrolysis by EF-Tu on ribosomes stalled on intact mRNA [REPORT]

Messenger RNAs lacking a stop codon trap ribosomes at their 3' ends, depleting the pool of ribosomes available for protein synthesis. In bacteria, a remarkable quality control system rescues and recycles stalled ribosomes in a process known as trans-translation. Acting as a tRNA, transfer-m ... mehr

Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation [ARTICLES]

Kaposi's sarcoma–associated herpesvirus (KSHV) is an oncogenic virus, the etiological agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). One of the key viral proteins that contributes to tumorigenesis is vFLIP, a viral homolog of the FLICE inhibitory protein. This KSHV prot ... mehr

Bacterial noncoding Y RNAs are widespread and mimic tRNAs [REPORT]

Many bacteria encode an ortholog of the Ro60 autoantigen, a ring-shaped protein that is bound in animal cells to noncoding RNAs (ncRNAs) called Y RNAs. Studies in Deinococcus radiodurans revealed that Y RNA tethers Ro60 to polynucleotide phosphorylase, specializing this exoribonuclease for ... mehr

NoFold: RNA structure clustering without folding or alignment [BIOINFORMATICS]

Structures that recur across multiple different transcripts, called structure motifs, often perform a similar function—for example, recruiting a specific RNA-binding protein that then regulates translation, splicing, or subcellular localization. Identifying common motifs between coregulated ... mehr

A kinetic and thermodynamic framework for the Azoarcus group I ribozyme reaction [ARTICLES]

Determination of quantitative thermodynamic and kinetic frameworks for ribozymes derived from the Azoarcus group I intron and comparisons to their well-studied analogs from the Tetrahymena group I intron reveal similarities and differences between these RNAs. The guanosine (G) substrate bin ... mehr

Alle Fachpublikationen zu Biotechnologie

Immunobiology of IL-37: mechanism of action and clinical perspectives

This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate ... mehr

A comprehensive review of myelodysplastic syndrome patients with autoimmune diseases

Primary myelodysplastic syndromes (MDS) are heterogeneous clonal hemopoietic disorders clinically presented with a varying degree of peripheral cytopenias and an increased probability of leukemic evolution. A distinct subset of MDS patients manifests overt autoimmune-inflammatory manifestat ... mehr

Update on the current recommendations and outcomes in pregnant women with antiphospholipid syndrome

Pregnancy morbidity is part of the clinical spectrum of the antiphospholipid syndrome (APS), a chronic autoimmune condition serologically characterized by the persistent positivity of antiphospholipid antibodies (aPL). Antiplatelet and anticoagulant agents are the mainstay of the treatment ... mehr

Tests for evaluating non-immediate allergic drug reactions

Non-immediate drug reactions (NIR) are induced by specific immunological mechanisms and involve the recognition of hapten molecules by the immune system, with the participation of dendritic cells and other antigen-presenting cells. This process is followed by an effector response that can i ... mehr

Apert Syndrome: temporal lobe abnormalities on fetal brain imaging

ABSTRACT Objectives Apert syndrome is characterized by craniosynostosis and complex hand and foot syndactyly, as well as an increased risk of brain, palate, heart and visceral malformations, and intellectual disability. This study aims to describe the structural brain abnormalities det ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 936 (September 2014). doi:10.1038/labinvest.2014.106 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 820 (August 2014). doi:10.1038/labinvest.2014.88 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 704 (July 2014). doi:10.1038/labinvest.2014.74 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 596 (June 2014). doi:10.1038/labinvest.2014.67 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 476 (May 2014). doi:10.1038/labinvest.2014.56 mehr

Alle Fachpublikationen zu Labortechnik

Effect of two Antiandrogens as Protectors of Prostate and Brain in a Huntington´s Animal Model

Abstract: The purpose of this work is to know the effect of flutamide and a novel synthetic steroid 3β-p-Iodobenzoyloxypregnan-4,16- diene-6,20-dione (IBP) on the levels of dopamine, 5-HIAA (5-hydroxyindole acetic acid), and some oxidative stress markers in animal model with Huntington dis ... mehr

Molecular Markers of Angiogenesis and Metastasis in Lines of Oral Carcinoma after Treatment with Melatonin

Abstract: Background: Oral cancer is the most common type of head and neck cancer and its high rate of mortality and morbidity is closely related to the processes of angiogenesis and tumor metastasis. The overexpression of the pro-angiogenic genes, HIF-1α and VEGF, and pro-metastatic gene, ... mehr

Synthesis and In Vitro Antiproliferative Activity of Thiazole-Based Nitrogen Mustards: The Hydrogen Bonding Interaction between Model Systems and Nucleobases

Abstract: Synthesis, characterization and investigation of antiproliferative activity of eight thiazole-based nitrogen mustard against human cancer cells lines (MV4-11, A549, HCT116 and MCF-7) and normal mouse fibroblast (BALB/3T3) are presented. Their structures were determined using NMR, ... mehr

Follow the ATP: Tumor Energy Production: A Perspective

Abstract: As early as the 1920s, the eminent physician and chemist, Otto Warburg, nominated for a second Nobel Prize for his work on fermentation, observed that the core metabolic signature of cancer cells is a high glycolytic flux. Warburg averred that the prime mover of cancer is defecti ... mehr

Caspases and ROS - Dependent Mechanism of Action Mediated by Combination of WP 631 and Epothilone B

Abstract: In this article, the synergistic effects of WP 631 and epothilone B (Epo B) combination in human ovarian cancer cells (SKOV-3) cells are investigated and the reasons for the exact mechanisms of action of both drugs co-administered are explained. Compared with single drugs, the co ... mehr

Alle Fachpublikationen zu Pharma

Identifying the Stem Cell

Identifying the Stem Cell Journal of Investigative Dermatology 134, e26 (November 2014). doi:10.1038/jid.2014.393 Authors: Krisztian Nemeth & Sarolta Karpati mehr

NF-{kappa}B RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation

Bone remodeling and hematopoiesis are interrelated and bone marrow (BM) macrophages are considered to be important for both bone remodeling and maintenance of the hematopoietic niche. We found that NF-B Rela-deficient chimeric mice, generated by transplanting Rela –/– fetal liver cells int ... mehr

IgG4-related disease and its pathogenesis—cross-talk between innate and acquired immunity

IgG4-related disease (IgG4-RD) is a novel clinical entity proposed in Japan in the 21th century and is attracting strong attention over the world. The characteristic manifestations of IgG4-RD are increased serum IgG4 concentration and tumefaction by IgG4+ plasma cells. Although the clinical ... mehr

A Seat at the Big Table: Expanding the Role of Dermatology at the World Health Organization and Beyond

A Seat at the Big Table: Expanding the Role of Dermatology at the World Health Organization and Beyond Journal of Investigative Dermatology 134, 2663 (November 2014). doi:10.1038/jid.2014.355 Author: Esther E Freeman mehr

NKG2D functions as an activating receptor on natural killer cells in the common marmoset (Callithrix jacchus)

The natural killer group 2 membrane D (NKG2D) receptor is an NK-activating receptor that plays an important role in host defense against tumors and viral infections. Although the marmoset is an important and reliable animal model, especially for the study of human-specific viral infections, ... mehr

Alle Fachpublikationen zu Medizin
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