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Aktuelle Fachpublikationen

Differential development of retroactive and proactive interference during post-learning wakefulness [BRIEF COMMUNICATIONS]

Newly encoded, labile memories are prone to disruption during post-learning wakefulness. Here we examine the contributions of retroactive and proactive interference to daytime forgetting on an auditory classification task in a songbird. While both types of interference impair performance, t ... mehr

T-type calcium channels in the orbitofrontal cortex mediate sensory integration as measured using a spontaneous oddity task in rats [RESEARCH]

The roles of low-voltage-activated (T-type) calcium channels in brain diseases have been studied extensively. Less is known regarding the involvement of T-type channels in cognition and behavior. Sensory integration (SI) is a cognitive process whereby the brain uses unimodal or multimodal s ... mehr

Properties of visual episodic memory following repeated encounters with objects [RESEARCH]

A person sees an object once, and then seconds, minutes, hours, days, or weeks later, she sees it again. How is the person's visual memory for that object changed, improved, or degraded by the second encounter, compared to a situation in which she will have only seen the object once? The an ... mehr

Cued fear memory generalization increases over time [RESEARCH]

Fear memory is a highly stable and durable form of memory, even over vast (remote) time frames. Nevertheless, some elements of fear memory can be forgotten, resulting in generalization. The purpose of this study is to determine how cued fear memory generalizes over time and measure underlyi ... mehr

Spared perception of object geometry and object components after hippocampal damage [BRIEF COMMUNICATIONS]

We tested the proposal that medial temporal lobe (MTL) structures support not just memory but also high-level object perception. In one task, participants decided whether a line drawing could represent an object in three-dimensional space and, in another task, they saw the components of an ... mehr

Alle Fachpublikationen

C-PUGP: A cluster-based positive unlabeled learning method for disease gene prediction and prioritization

Publication date: October 2018 Source:Computational Biology and Chemistry, Volume 76 Author(s): Akram Vasighizaker, Saeed Jalili Disease gene detection is an important stage in the understanding disease processes and treatment. Some candidate disease genes are identified using man ... mehr

Identification of new drug-like compounds from millets as Xanthine oxidoreductase inhibitors for treatment of Hyperuricemia: A molecular docking and simulation study

Publication date: October 2018 Source:Computational Biology and Chemistry, Volume 76 Author(s): Rajesh Kumar Pathak, Ayushi Gupta, Rohit Shukla, Mamta Baunthiyal Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation during purine cataboli ... mehr

An intronic enhancer of Bmp6 underlies evolved tooth gain in sticklebacks

by Phillip A. Cleves, James C. Hart, Rachel M. Agoglia, Monica T. Jimenez, Priscilla A. Erickson, Linda Gai, Craig T. Miller Threespine stickleback fish offer a powerful system to dissect the genetic basis of morphological evolution in nature. Marine sticklebacks have repeatedly invaded a ... mehr

A subset of plasma membrane-localized PP2C.D phosphatases negatively regulate SAUR-mediated cell expansion in Arabidopsis

by Hong Ren, Mee Yeon Park, Angela K. Spartz, Jeh Haur Wong, William M. Gray The plant hormone auxin regulates numerous growth and developmental processes throughout the plant life cycle. One major function of auxin in plant growth and development is the regulation of cell expansion. Our ... mehr

Convergent evolution of gene expression in two high-toothed stickleback populations

by James C. Hart, Nicholas A. Ellis, Michael B. Eisen, Craig T. Milller Changes in developmental gene regulatory networks enable evolved changes in morphology. These changes can be in cis regulatory elements that act in an allele-specific manner, or changes to the overall trans regulatory ... mehr

Alle Fachpublikationen zu Biotechnologie

Clinical Experience of Laboratory Follow‐Up with Non‐Invasive Prenatal Testing Using Cell‐Free Dna and Positive Microdeletion Results in 349 Cases

Abstract Objective Screening via non‐invasive prenatal testing (NIPT) involving the analysis of cell‐free DNA (cfDNA) from plasma has become readily available to screen for chromosomal and DNA aberrations through maternal blood. This report reviews a laboratory's experience with follow ... mehr

Patient‐controlled tissue collection for genetic testing after early pregnancy loss, a pilot study

Abstract Objective To determine how frequently and effectively products of conception can be obtained among women pursuing medical management of early pregnancy loss. Methods This pilot study was conducted to assess products of conception recovery outcomes for participants optin ... mehr

Noninvasive reconstruction of placental methylome from maternal plasma DNA: potential for prenatal testing and monitoring

Abstract Objective During human pregnancy, the DNA methylation of placental tissue is highly relevant to the normal growth and development of the fetus, therefore methylomic analysis of the placental tissue possesses high research and clinical value in prenatal testing and monitoring. ... mehr

Myocardial Injury in Fetal Aortic Stenosis: Insights from Amniotic Fluid Analysis

Abstract Objective Fetal aortic stenosis (AS) imposes pressure load on the developing left ventricle (LV) and leads to derangements in myocardial structure and function via mechanisms that are not well characterized. Methods We compared amniotic fluid NT‐BNP and troponin levels ... mehr

Ultrasound findings provide clues to investigate founder mutations expressed as runs of homozygosity in chromosomal microarray studies

Abstract Objectives Chromosomal microarray (CMA) analysis is effectively applied prenatally to detect copy number changes. SNP probes included in the microarray platform can detect regions of excessive homozygosity (ROH) and identical‐by‐descent genomic stretches. The utility of the la ... mehr

Alle Fachpublikationen zu Diagnostik

Lack of plakoglobin impairs integrity and wound healing in corneal epithelium in mice

We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ... mehr

Lack of plakoglobin impairs integrity and wound healing in corneal epithelium in mice

We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ... mehr

Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling

Atherosclerosis is the most common cause of heart disease and stroke. The use of animal models has advanced our understanding of the molecular signaling that contributes to atherosclerosis. Further understanding of this degenerative process in humans will require human tissue. Plaque remove ... mehr

BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling

Transforming growth factor-β (TGF-β) plays a central role in hepatic fibrogenesis. This study investigated the function and mechanism of bone morphogenetic protein-2 (BMP-2) in regulation of hepatic fibrogenesis. BMP-2 expression in fibrotic liver was measured in human tissue microarray and ... mehr

S100A4 protects mice from high-fat diet-induced obesity and inflammation

As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and t ... mehr

Alle Fachpublikationen zu Labortechnik

Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Jostein Grip, Rolf Einar Engstad, Ingrid Skjæveland, Nataša Škalko-Basnet, Johan Isaksson, Purusotam Basnet, Ann Mari Holsæter The increased prevalence of chronic w ... mehr

Melt-electrospinning as a method to improve the dissolution and physical stability of a poorly water-soluble drug

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Kristian Semjonov, Andres Lust, Karin Kogermann, Ivo Laidmäe, Sirkka Liisa Maunu, Sami-Pekka Hirvonen, Jouko Yliruusi, Gunnar Nurk, Enn Lust, Jyrki Heinämäki ... mehr

Semisolid self-microemulsifying drug delivery systems (SMEDDSs): Effects on pharmacokinetics of acyclovir in rats

Publication date: 30 August 2018 Source:European Journal of Pharmaceutical Sciences, Volume 121 Author(s): Ljiljana Djekic, Jovana Janković, Aleksandar Rašković, Marija Primorac Semisolid self-microemulsifying drug delivery system (SMEDDS) with optimized drug loading capacity, ... mehr

Marine Drugs, Vol. 16, Pages 212: Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mit ...

Marine Drugs, Vol. 16, Pages 212: Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression Marine Drugs doi: 10.3390/md16060212 Authors: Yu-C ... mehr

Marine Drugs, Vol. 16, Pages 211: Collagen from Cartilaginous Fish By-Products for a Potential Application in Bioactive Film Composite

Marine Drugs, Vol. 16, Pages 211: Collagen from Cartilaginous Fish By-Products for a Potential Application in Bioactive Film Composite Marine Drugs doi: 10.3390/md16060211 Authors: Emna Ben Slimane Saloua Sadok The acid solubilised collagen (ASC) and pepsin solubilised colla ... mehr

Alle Fachpublikationen zu Pharma

Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis

by Madushi Wanaguru, David J. Barry, Donald J. Benton, Nicola J. O’Reilly, Kate N. Bishop The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) and stabilises ... mehr

Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH

by Man Shun Fu, Carolina Coelho, Carlos M. De Leon-Rodriguez, Diego C. P. Rossi, Emma Camacho, Eric H. Jung, Madhura Kulkarni, Arturo Casadevall Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with macrophages is a key event determining the outcome of i ... mehr

A MFS-like plasma membrane transporter required for Leishmania virulence protects the parasites from iron toxicity

by Maria Fernanda Laranjeira-Silva, Wanpeng Wang, Tamika K. Samuel, Fernando Y. Maeda, Vladimir Michailowsky, Iqbal Hamza, Zhongchi Liu, Norma W. Andrews Iron is essential for many cellular processes, but can generate highly toxic hydroxyl radicals in the presence of oxygen. Therefore, in ... mehr

CRISPR-Cas antimicrobials: Challenges and future prospects

by Elizabeth Pursey, David Sünderhauf, William H. Gaze, Edze R. Westra, Stineke van Houte mehr

Reflections on an inflection: From virology to parasitology guided by POLARIS

by Akhil B. Vaidya mehr

Alle Fachpublikationen zu Medizin
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