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Aktuelle Fachpublikationen

Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia

Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia Leukemia advance online publication, May 20 2016. doi:10.1038/leu.2016.124 Authors: S R Cardoso, G Ryan, A J Walne, A Ellison, R Lowe, H Tummala, A Rio-Machin, L Collopy, A A ... mehr

Neural correlates of consciousness: progress and problems

Nature Reviews Neuroscience 17, 395 (2016). doi:10.1038/nrn.2016.61 Author: Christof Koch, Marcello Massimini, Melanie Boly & Giulio Tononi Nature Reviews Neuroscience17, 307–321 (2016)The traces in panel e of Figure 3 were incorrectly colour coded. The colour coding has ... mehr

Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner

Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner The Pharmacogenomics Journal 16, 301 (June 2016). doi:10.1038/tpj.2016.30 Authors: E Theusch, K Kim, K Stevens, J D Smit ... mehr

Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells

Nature Protocols 11, 1101 (2016). doi:10.1038/nprot.2016.061 Authors: Letizia Barbieri, Enrico Luchinat & Lucia Banci In-cell NMR spectroscopy is a unique tool for characterizing biological macromolecules in their physiological environment at atomic resolution. Recent pro ... mehr

Coming of age: ten years of next-generation sequencing technologies

Nature Reviews Genetics 17, 333 (2016). doi:10.1038/nrg.2016.49 Authors: Sara Goodwin, John D. McPherson & W. Richard McCombie Since the completion of the human genome project in 2003, extraordinary progress has been made in genome sequencing technologies, which has led t ... mehr

Alle Fachpublikationen

Coming of age: ten years of next-generation sequencing technologies

Nature Reviews Genetics 17, 333 (2016). doi:10.1038/nrg.2016.49 Authors: Sara Goodwin, John D. McPherson & W. Richard McCombie Since the completion of the human genome project in 2003, extraordinary progress has been made in genome sequencing technologies, which has led t ... mehr

Nearest-neighbor parameters for 7-deaza-adenosine{middle dot}uridine base pairs in RNA duplexes [ARTICLE]

One of the major limitations in RNA structure prediction is the lack of information about the effect of nonstandard nucleotides on stability. The nonstandard nucleotide 7-deaza-adenosine (7DA) is a naturally occurring analog of adenosine that has been studied for medicinal purposes and is c ... mehr

Packaging of Mason-Pfizer monkey virus (MPMV) genomic RNA depends upon conserved long-range interactions (LRIs) between U5 and gag sequences [ARTICLE]

MPMV has great potential for development as a vector for gene therapy. In this respect, precisely defining the sequences and structural motifs that are important for dimerization and packaging of its genomic RNA (gRNA) are of utmost importance. A distinguishing feature of the MPMV gRNA pack ... mehr

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use? [ARTICLE]

RNA-seq is now the technology of choice for genome-wide differential gene expression experiments, but it is not clear how many biological replicates are needed to ensure valid biological interpretation of the results or which statistical tools are best for analyzing the data. An RNA-seq exp ... mehr

Using in-cell SHAPE-Seq and simulations to probe structure-function design principles of RNA transcriptional regulators [ARTICLE]

Antisense RNA-mediated transcriptional regulators are powerful tools for controlling gene expression and creating synthetic gene networks. RNA transcriptional repressors derived from natural mechanisms called attenuators are particularly versatile, though their mechanistic complexity has ma ... mehr

Alle Fachpublikationen zu Biotechnologie

Gestation related karyotype, QF‐PCR and CGH‐array failure rates in diagnostic amniocentesis.

Abstract Background Few data exist describing laboratory related failure rates in prenatal diagnosis. The aim of this study is to assess the laboratory associated failure rate for karyotype, QF‐PCR and CGH‐array following amniocentesis in relation to gestation. Methods Retrospec ... mehr

Fetal brain imaging in isolated congenital heart defects – a systematic review and meta‐analysis

Abstract Congenital heart defects (CHD) are associated with neurodevelopmental (ND) delay. This study aims to assess evidence for impaired prenatal brain development, in fetuses with CHD. A systematical search was performed and 34 studies evaluating the fetal brain (MRI or ultrasound) in ... mehr

Implementation of non‐invasive prenatal testing by semiconductor sequencing in a genetic laboratory

Abstract Objectives To implement non‐invasive prenatal testing (NIPT) for fetal aneuploidies with semiconductor sequencing in an academic cytogenomic laboratory and to evaluate the first 15 months experience on clinical samples. Methods We validated a NIPT protocol for cell‐free ... mehr

Issue Information ‐ JIF

No abstract is available for this article. mehr

Issue Information ‐ TOC

No abstract is available for this article. mehr

Alle Fachpublikationen zu Diagnostik

ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease

ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease Laboratory Investigation advance online publication, May 16 2016. doi:10.1038/labinvest.2016.56 Authors: Dimitry A Chistiakov, Alexander N Orekhov & Yuri V Bobryshev mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 494 (May 2016). doi:10.1038/labinvest.2016.47 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 376 (April 2016). doi:10.1038/labinvest.2016.41 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 262 (March 2016). doi:10.1038/labinvest.2016.29 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 114 (February 2016). doi:10.1038/labinvest.2015.165 mehr

Alle Fachpublikationen zu Labortechnik

Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner

Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner The Pharmacogenomics Journal 16, 301 (June 2016). doi:10.1038/tpj.2016.30 Authors: E Theusch, K Kim, K Stevens, J D Smit ... mehr

Subtherapeutic voriconazole concentrations associated with concomitant dexamethasone: case report and review of the literature

Summary What is known and objective Voriconazole has significant drug interactions due to metabolism by CYP enzymes. Subtherapeutic voriconazole concentrations associated with concomitant dexamethasone are not well described. Case description An 84‐year‐old male was started on v ... mehr

Risk of venous thromboembolism in cancer patients treated with epoetins or blood transfusions†

Aims Anaemia is common in cancer patients, with treatments including epoetins and blood transfusions. Although an increased risk of venous thromboembolism (VTE) has been associated with both therapeutics, studies comparing the risk of VTE between epoetins and transfusions in cancer patien ... mehr

Marine Drugs, Vol. 14, Pages 98: Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”

Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their precli ... mehr

Marine Drugs, Vol. 14, Pages 103: Time Dependency of Chemodiversity and Biosynthetic Pathways: An LC-MS Metabolomic Study of Marine-Sourced Penicillium

This work aimed at studying metabolome variations of marine fungal strains along their growth to highlight the importance of the parameter “time” for new natural products discovery. An untargeted time-scale metabolomic study has been performed on two different marine-derived Penicillium str ... mehr

Alle Fachpublikationen zu Pharma

Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia

Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia Leukemia advance online publication, May 20 2016. doi:10.1038/leu.2016.124 Authors: S R Cardoso, G Ryan, A J Walne, A Ellison, R Lowe, H Tummala, A Rio-Machin, L Collopy, A A ... mehr

Neural correlates of consciousness: progress and problems

Nature Reviews Neuroscience 17, 395 (2016). doi:10.1038/nrn.2016.61 Author: Christof Koch, Marcello Massimini, Melanie Boly & Giulio Tononi Nature Reviews Neuroscience17, 307–321 (2016)The traces in panel e of Figure 3 were incorrectly colour coded. The colour coding has ... mehr

Corrigendum: Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

Nature Immunology 17, 740 (2016). doi:10.1038/ni0616-740b Author: Olga Sobolev, Elisa Binda, Sean O'Farrell, Anna Lorenc, Joel Pradines, Yongqing Huang, Jay Duffner, Reiner Schulz, John Cason, Maria Zambon, Michael H Malim, Mark Peakman, Andrew Cope, Ishan Capila, Ganesh V ... mehr

Alcohol: taking a population perspective

Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2016.70 Authors: William Gilmore, Tanya Chikritzhs, Tim Stockwell, David Jernigan, Timothy Naimi & Ian Gilmore mehr

Zika virus update II: Recent development of animal models ‐ proofs of association with human pathogenesis

Abstract Three recent studies in pregnant mice and one ongoing study in rhesus macaques evaluating the effect of ZIKV infection have provided important information about maternal‐fetus transmission and ZIKV‐related pathogenesis, confirming a causal role of ZIKV in neurological problems ... mehr

Alle Fachpublikationen zu Medizin
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