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Aktuelle Fachpublikationen

A glycogene mutation map for discovery of diseases of glycosylation

Glycosylation of proteins and lipids involves over 200 known glycosyltransferases (GTs), and deleterious defects in many of the genes encoding these enzymes cause disorders collectively classified as congenital disorders of glycosylation (CDGs). Most known CDGs are caused by defects in glyc ... mehr

Using crystallographic water properties for the analysis and prediction of lectin–carbohydrate complex structures

Understanding protein–ligand interactions is a fundamental question in basic biochemistry, and the role played by the solvent along this process is not yet fully understood. This fact is particularly relevant in lectins, proteins that mediate a large variety of biological processes through ... mehr

Galectin-3: an emerging all-out player in metabolic disorders and their complications

Galectin-3 has been increasingly recognized as an important modulator of several biological functions, by interacting with several molecules inside and outside the cell, and an emerging player in numerous disease conditions. Galectin-3 exerts various and sometimes contrasting effects accord ... mehr

Datura stramonium agglutinin: Cloning, molecular characterization and recombinant production in Arabidopsis thaliana

Datura stramonium seeds contain at least three chitin-binding isolectins [termed Datura stramonium agglutinin (DSA)] as homo- or heterodimers of A and B subunits. We isolated a cDNA encoding isolectin B (DSA-B) from an immature fruit cDNA library; this contained an open reading frame encodi ... mehr

Interactions of human galectins with Trypanosoma cruzi: Binding profile correlate with genetic clustering of lineages

We report here the specific interaction between several members of the human galectin family with the three developmental stages of several genetic lineages of the protozoan parasite Trypanosoma cruzi. We provide data of specific and differential binding of human galectin (gal)-1, -3, -4, - ... mehr

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The adipocyte differentiation protein APMAP is an endogenous suppressor of A{beta} production in the brain

The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by -secretase, an intramembrane-cleaving protease with multiple sub ... mehr

DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcript ...

Although DNA methylation is considered to play an important role during myogenic differentiation, chronological alterations in DNA methylation and gene expression patterns in this process have been poorly understood. Using the Infinium HumanMethylation450 BeadChip array, we obtained a chron ... mehr

Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells

Type II collagen is a major component of cartilage. Heterozygous mutations in the type II collagen gene (COL2A1) result in a group of skeletal dysplasias known as Type II collagenopathy (COL2pathy). The understanding of COL2pathy is limited by difficulties in obtaining live chondrocytes. In ... mehr

Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy

Mutations of FIG4 are responsible for Yunis-Varón syndrome, familial epilepsy with polymicrogyria, and Charcot-Marie-Tooth type 4J neuropathy (CMT4J). Although loss of the FIG4 phospholipid phosphatase consistently causes decreased PtdIns(3,5)P2 levels, cell-specific sensitivity to partial ... mehr

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis

Harlequin ichthyosis (HI) is a severe skin disease which leads to neonatal death in ~50% of cases. It is the result of mutations in ABCA12, a protein that transports lipids required to establish the protective skin barrier needed after birth. To better understand the life-threatening newbor ... mehr

Alle Fachpublikationen zu Biotechnologie

The impact of insonation angle on four chamber view image quality: an observational study on 2866 routine scans.

Abstract Objective To determine insonation angles achieved in routine screening practice, and their impact on image quality. Methods Prospective cross sectional observational survey of 2,866 four‐chamber‐views produced by 287 senor ultrasonographers, from unselected routine seco ... mehr

Belimumab for the treatment of systemic lupus erythematosus

Given their pivotal role in autoantibody production, B-cells have become an attractive therapeutic target in systemic lupus erythematosus (SLE). Belimumab, a fully human monoclonal antibody against B lymphocyte stimulator (BLyS), a B-cell survival factor, was licensed in 2011 for the treatm ... mehr

NOS2 and CCL27: clinical implications for psoriasis and eczema diagnosis and management

Chronic inflammatory skin diseases such as psoriasis and eczema are a major medical challenge. Development of highly specific therapies for both conditions is opposed by the lack of translation of basic knowledge into biomarkers for clinical use. Furthermore, to distinguish psoriasis from e ... mehr

Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve?

Autoimmune diseases are complex and enigmatic, and have presented particular challenges to researchers seeking to define their etiology and explain progression. Previous studies have implicated epigenetic influences in the development of autoimmunity. Epigenetics describes changes in gene e ... mehr

Expert Review of Clinical Immunology 10-year anniversary issue

Expert Review of Clinical Immunology, Volume 11, Issue 1, Page 1-3, January 2015. mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 2 (January 2015). doi:10.1038/labinvest.2014.152 mehr

Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract

Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract Laboratory Investigation advance online publication, December 22 2014. doi:10.1038/labinvest.2014.162 Authors: Gail H Leeming, Anja Kipar, D ... mehr

Serum amyloid A and inflammation in diabetic kidney disease and podocytes

Serum amyloid A and inflammation in diabetic kidney disease and podocytes Laboratory Investigation advance online publication, December 22 2014. doi:10.1038/labinvest.2014.163 Authors: Robert J Anderberg, Rick L Meek, Kelly L Hudkins, Sheryl K Cooney, Charles E Alpers, Renee C ... mehr

Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic

Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic Laboratory Investigation advance online publication, December 15 2014. doi:10.1038/labinvest.2014.157 Authors: Daniel E Carvajal-Hausdorf, Kurt A Schalper, Veronique M Neumeister & David L Rimm mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 1310 (December 2014). doi:10.1038/labinvest.2014.137 mehr

Alle Fachpublikationen zu Labortechnik

Carrier Mediated Distribution System (CAMDIS): A new approach for the measurement of octanol/water distribution coefficients

Publication date: 20 February 2015 Source:European Journal of Pharmaceutical Sciences, Volume 68 Author(s): Bjoern Wagner , Holger Fischer , Manfred Kansy , Anna Seelig , Frauke Assmus Here we present a miniaturized assay, referred to as Carrier-Mediated Distribution System (CAMD ... mehr

Pharmacokinetics of treosulfan and its active monoepoxide in pediatric patients after intravenous infusion of high-dose treosulfan prior to HSCT

Publication date: 20 February 2015 Source:European Journal of Pharmaceutical Sciences, Volume 68 Author(s): Franciszek Główka , Anna Kasprzyk , Michał Romański , Tomasz Wróbel , Jacek Wachowiak , Dawid Szpecht , Krzysztof Kałwak , Anna Wiela-Hojeńska , Paulina Dziatkiewicz , ... mehr

Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration – A dose escalation study

Publication date: 20 February 2015 Source:European Journal of Pharmaceutical Sciences, Volume 68 Author(s): Anne Brokjær , Mads Kreilgaard , Anne Estrup Olesen , Ulrika S.H. Simonsson , Lona Louring Christrup , Albert Dahan , Asbjørn Mohr Drewes Introduction To safely and effec ... mehr

Statin‐induced Myopathy and Ubiquinone Levels in Serum – Results from a Prospective, Observational Study

Abstract It has been suggested that an impaired ubiquinone (Q10) synthesis may be responsible for muscular side effects caused by statins. The primary aim of the present study was to investigate whether low Q10 levels in serum could be used as a marker to predict the risk of developing s ... mehr

Inhibition of DMBA‐induced Oral Squamous Cell Carcinomas Growth by Brazilian Red Propolis in Rodent Model

Abstract We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA‐induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by Ultra‐Fast Liquid Chromatography (UFLC). Carcinogene ... mehr

Alle Fachpublikationen zu Pharma

Inside and outside the pituitary: comparative analysis of Gnrhr expression provides insight into the mechanisms underlying the evolution of gene expression

Abstract DNA cis‐acting elements involved in gene regulation may actively contribute to adaptation processes because they are submitted to lower evolutionary constraints than coding DNA. In this regard, comparison of the mechanisms underlying basal and regulated Gnrhr expression have rev ... mehr

Silent cerebral events/lesions related to atrial fibrillation ablation: A clinical review

ABSTRACT Brain magnetic resonance imaging (MRI) has identified a high incidence of cerebral ischemia in asymptomatic patients after atrial fibrillation (AF) ablation (silent). Detection of cerebral ischemic events on MRI is based on acute hyperintense lesions on diffusion‐weighted imagin ... mehr

Time course of clinical and neuroradiological effects of delayed‐release dimethyl fumarate in multiple sclerosis

Background and purpose Delayed‐release dimethyl fumarate (DMF, also known as gastro‐resistant DMF), demonstrated efficacy and safety in relapsing−remitting multiple sclerosis in the 2‐year, randomized, placebo‐controlled, phase 3 DEFINE and CONFIRM trials. A post hoc analysis of integrate ... mehr

Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension

Abstract Persistent excessive sympathetic activation greatly contributes to the pathogenesis of chronic heart failure (CHF) and hypertension. Cardiac sympathetic afferent reflex (CSAR) is a sympathoexcitatory reflex with positive feedback characteristics. Humoral factors such as bradykin ... mehr

MiR-106b expression determines the proliferation paradox of TGF-|[beta]| in breast cancer cells

MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells Oncogene 34, 84 (02 January 2015). doi:10.1038/onc.2013.525 Authors: C Gong, S Qu, B Liu, S Pan, Y Jiao, Y Nie, F Su, Q Liu & E Song mehr

Alle Fachpublikationen zu Medizin
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