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Aktuelle Fachpublikationen

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as well as the rapid degradation of messenger RNA. The latter ensures that translation closely follows programming at the level of transcription. Re ... mehr

Triple helical DNA in a duplex context and base pair opening

It is fundamental to explore in atomic detail the behavior of DNA triple helices as a means to understand the role they might play in vivo and to better engineer their use in genetic technologies, such as antigene therapy. To this aim we have performed atomistic simulations of a purine-rich ... mehr

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the pre ... mehr

Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency

Mitochondrial promoters of Saccharomyces cerevisiae share a conserved –8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation factor Mtf1. We used 2-aminopurine fluor ... mehr

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorl ... mehr

Alle Fachpublikationen

Charles Buys (1942|[ndash]|2014)

Charles Buys (1942–2014) European Journal of Human Genetics 22, 1343 (December 2014). doi:10.1038/ejhg.2014.207 Authors: Rolf H Sijmons, Gerard J te Meerman & Robert MW Hofstra mehr

A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression

The p.N478D missense mutation in human mitochondrial poly(A) polymerase (mtPAP) has previously been implicated in a form of spastic ataxia with optic atrophy. In this study, we have investigated fibroblast cell lines established from family members. The homozygous mutation resulted in the l ... mehr

Lack of CCM1 induces hypersprouting and impairs response to flow

Cerebral cavernous malformation (CCM) is a disease of vascular malformations known to be caused by mutations in one of three genes: CCM1, CCM2 or CCM3. Despite several studies, the mechanism of CCM lesion onset remains unclear. Using a Ccm1 knockout mouse model, we studied the morphogenesis ... mehr

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region

Parent-of-origin-specific expression at imprinted genes is regulated by allele-specific DNA methylation at imprinting control regions (ICRs). This mechanism of gene regulation, where one element controls allelic expression of multiple genes, is not fully understood. Furthermore, the mechani ... mehr

Salt-inducible kinase 3, SIK3, is a new gene associated with hearing

Hearing function is known to be heritable, but few significant and reproducible associations of genetic variants have been identified to date in the adult population. In this study, genome-wide association results of hearing function from the G-EAR consortium and TwinsUK were used for meta- ... mehr

Alle Fachpublikationen zu Biotechnologie

The natural history of monoamniotic twin pregnancies: a case series and systematic review of the literature

ABSTRACT Objective To describe the natural history of monoamniotic twin pregnancies in contemporary practice. Method Cohort study of monochorionic monoamniotic twin pregnancies with two live fetuses diagnosed at less than 16 weeks and prospectively followed up between 2004 and 2 ... mehr

Domestic exposure to volatile organic compounds in relation to asthma and allergy in children and adults

Over the past decades, the prevalence of asthma, allergic disease and atopy has increased significantly and in parallel with the increased use of products and materials emitting volatile organic compounds (VOCs) in the indoor environment. The purpose of this review is to examine the evidenc ... mehr

Non‐invasive prenatal diagnostic testing for β‐thalassaemia using cell‐free fetal DNA and next generation sequencing

ABSTRACT Objective To develop an accurate non‐invasive prenatal test using next generation sequencing (NGS) for HbE and the four most common β‐thalassaemia mutations found in South East Asia (namely ‐28A > G, CD17A > T, CD41/42(‐TTCT), and IVS‐II‐654C > T). Methods Cell‐free DNA ... mehr

First‐trimester combined screening for trisomy 21 in women with renal disease

ABSTRACT Objective To evaluate the results of first‐trimester combined screening for Down syndrome in women with chronic renal disease. Method Fifty‐five pregnant women with renal disease were compared with 110 patients matched for maternal age, maternal weight, smoking status, ... mehr

Determination of the myocardial performance index in deteriorating grades of intrauterine growth restriction and its link to adverse outcomes

ABSTRACT Aim To determine the fetal modified myocardial performance index (Mod‐MPI) and E‐wave/A‐wave peak velocities (E/A ratio) in deteriorating grades of intrauterine growth restriction (IUGR) and its link to adverse outcomes defined as perinatal death, hypoxic ischaemic encephalopa ... mehr

Alle Fachpublikationen zu Diagnostik

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats Laboratory Investigation advance online publication, November 10 2014. doi:10.1038/labinvest.2014.134 ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 1186 (November 2014). doi:10.1038/labinvest.2014.127 mehr

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.122 Authors: Kazuyo Yasuda, Toshihiko ... mehr

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.121 Authors: Maki K ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 936 (September 2014). doi:10.1038/labinvest.2014.106 mehr

Alle Fachpublikationen zu Labortechnik

The Interactions of Anticancer Agents with Tea Catechins: Current Evidence from Preclinical Studies

Abstract: Tea catechins exhibit a broad range of pharmacological activities that impart beneficial effects on human health. Epigallocatechin-3-gallate (EGCG), one of the major tea catechins, has been widely associated with cancer prevention and treatment. In addition, tea catechins in comb ... mehr

Acknowledgements to the Reviewers:

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Improving the Efficacy of Plant Polyphenols

Abstract: Plant polyphenols exhibit potentially useful effects in a wide variety of pathophysiological settings. They interact with proteins such as signalling kinases, transcription factors and ion channels, and modulate redox processes, such as those taking place in mitochondria. Biomedi ... mehr

Intracellular Distribution and Biological Effects of Phytochemicals in a Sex Steroid- Sensitive Model of Human Prostate Adenocarcinoma

Abstract: Prostate function is critical for male fertility and its well-known oncological biomarker, namely Prostate-Specific Antigen (PSA), can be also used to monitor prostate epithelial human cells upon treatment with pharmaceutical drugs or natural bioactive compounds. The LNCaP human ... mehr

Graphical Abstracts:

This article is currently available as a free download on ingentaconnect mehr

Alle Fachpublikationen zu Pharma

Skin Care in Organ Transplant Patients Europe Meeting Report from Annual Meeting, Leiden, The Netherlands, 15|[ndash]|18 May 2014

Skin Care in Organ Transplant Patients Europe Meeting Report from Annual Meeting, Leiden, The Netherlands, 15–18 May 2014 Journal of Investigative Dermatology 134, 2861 (December 2014). doi:10.1038/jid.2014.307 Authors: Günther F L Hofbauer, Deniz Seçkin, Petter Gjersv ... mehr

John Steinert Strauss (1926|[ndash]|2014)

John Steinert Strauss (1926–2014) Journal of Investigative Dermatology 134, 2859 (December 2014). doi:10.1038/jid.2014.387 Author: Janet Fairley mehr

Clinical Snippets

Clinical Snippets Journal of Investigative Dermatology 134, 2856 (December 2014). doi:10.1038/jid.2014.431 mehr

Transgenic Mouse Technology in Skin Biology: Generation of Knockin Mice

Transgenic Mouse Technology in Skin Biology: Generation of Knockin Mice Journal of Investigative Dermatology 134, e27 (December 2014). doi:10.1038/jid.2014.434 Authors: Frederik Tellkamp, Farida Benhadou, Jeroen Bremer, Maria Gnarra, Jana Knüver, Sandra Schaffenrath & ... mehr

Editors' Picks

Editors' Picks Journal of Investigative Dermatology 134, 2858 (December 2014). doi:10.1038/jid.2014.433 mehr

Alle Fachpublikationen zu Medizin
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