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Aktuelle Fachpublikationen

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

Nature Protocols 12, 15 (2017). doi:10.1038/nprot.2016.153 Authors: Nathan J Palpant, Lil Pabon, Clayton E Friedman, Meredith Roberts, Brandon Hadland, Rebecca J Zaunbrecher, Irwin Bernstein, Ying Zheng & Charles E Murry Human pluripotent stem cells (hPSCs) provide a valu ... mehr

Proanthocyanidins potentiate hypothalamic leptin|[sol]|STAT3 signalling and Pomc gene expression in rats with diet-induced obesity

Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity International Journal of Obesity advance online publication, October 18 2016. doi:10.1038/ijo.2016.169 Authors: M Ibars, A Ardid-Ruiz, M Suárez, B Mugue ... mehr

Four Acyltransferases Uniquely Contribute to Phospholipid Heterogeneity in Saccharomyces cerevisiae

Diverse acyl-CoA species and acyltransferase isoenzymes are components of a complex system that synthesizes glycerophospholipids and triacylglycerols. Saccharomyces cerevisiae has four main acyl-CoA species, two main glycerol-3-phosphate 1-O-acyltransferases (Gat1p, Gat2p), and two main 1-a ... mehr

High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chroma ...

Alcohol-induced liver injury (ALD) shows obvious metabolic disorders, categorized by a wide range of metabolite abnormalities. High-throughput metabolomics technology appears to be an appropriate solution. In this study, a urine metabolic profile was assessed using a UPLC-Q-TOF/HDMS (liquid ... mehr

The development of small-molecule modulators for ClpP protease activity

The global spread of antibiotic resistance among important human pathogens emphasizes the need to find new antibacterial drugs with a novel mode of action. The ClpP protease has been shown to demonstrate its pivotal importance to both the survival and the virulence of pathogenic bacteria du ... mehr

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Development, Fabrication and Evaluation of a Novel Biomimetic Human Breast Tissue Derived Breast Implant Surface

Publication date: Available online 2 December 2016 Source:Acta Biomaterialia Author(s): S. Barr, E.W. Hill, A. Bayat Breast implant use has tripled in the last decade with over 320,000 breast implant based reconstructions and augmentations performed in the US per annum. Unfortun ... mehr

Structure-based Optimization of Salt-bridge Network across the Complex Interface of PTPN4 PDZ Domain with Its Peptide Ligands in Neuroglioma

Publication date: Available online 30 November 2016 Source:Computational Biology and Chemistry Author(s): Xian Xiao, Qiang-Hua He, Li-Yan Yu, Song-Qing Wang, Yang Li, Hua Yang, Ai-Hua Zhang, Xiao-Hong Ma, Yu-Jie Peng, Bing Chen The PTP non-receptor type 4 (PTPN4) i ... mehr

PrAS: Prediction of amidation sites using multiple feature extraction

Publication date: February 2017 Source:Computational Biology and Chemistry, Volume 66 Author(s): Tong Wang, Wei Zheng, Qiqige Wuyun, Zhenfeng Wu, Jishou Ruan, Gang Hu, Jianzhao Gao Amidation plays an important role in a variety of pathological processes and serious disea ... mehr

BCOR Upregulation in a Poorly Differentiated Synovial Sarcoma with SS18L1‐SSX1 Fusion – A Pathologic and Molecular Pitfall

ABSTRACT The diagnosis of poorly differentiated synovial sarcoma (PD‐SS) may be challenging due to overlapping morphologic features with other undifferentiated round cell sarcomas (URCS). Particularly relevant is the histologic overlap and shared BCOR overexpression between a subset of S ... mehr

Runs of homozygosity: current knowledge and applications in livestock

Summary This review presents a broader approach to the implementation and study of runs of homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH and their practical implications. ROH are continuous homozygous segments that are common in individuals and ... mehr

Alle Fachpublikationen zu Biotechnologie

Pathogenesis and diagnosis of placental disorders is related to abnormal methylation at promoters of placental vascularization mediating genes

Abstract Objectives To investigate the role of methylation levels at promoter regions of placental vascularization genes (VEGF, EGFR and c‐jun) in pathogenesis and diagnosis of placental disorders. Methods We analyzed DNA and histone methylation at promoters of VEGF, EGFR and c‐ ... mehr

What happens when N = 1 and you want plus 1?

Abstract We present a personal case study of what happens when a family has a child with an undiagnosed genetic disorder yet wishes to have more children free of the disease. After an intractable diagnostic odyssey for our oldest son, our family turned to exome sequencing. Exome sequenci ... mehr

Prenatal cfDNA Screening Results Indicative Of Maternal Neoplasm: Survey Of Current Practice And Management Needs

Abstract Objective To determine genetic counselors’ current practices and management needs for patients with prenatal cfDNA screening results indicative of maternal neoplasm. Methods A survey was completed by genetic counselors recruited via the National Society of Genetic Couns ... mehr

Current controversies in prenatal diagnosis 3: Industry drives innovation in research and clinical application of genetic prenatal diagnosis and screening.

What is already known about this topic: Innovation and technological development have commonalities across all disciplines in terms of process, evaluation, and incorporation into use. Many technologies have evolved through traditional methods such as research grant funding, individual ... mehr

Current Controversies in Prenatal Diagnosis 1: In utero therapy for spina bifida is ready for endoscopic repair

What's already known about this topic? There is level 1 (RCT) evidence for improved neurological outcomes after open fetal surgery for spina bifida vs. postnatal surgery. There is a lack of standardization of techniques and comparative outcome data in clinical trials for endoscopic fe ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 1232 (December 2016). doi:10.1038/labinvest.2016.119 mehr

CD68|[sol]|macrosialin: not just a histochemical marker

CD68/macrosialin: not just a histochemical marker Laboratory Investigation advance online publication, November 21 2016. doi:10.1038/labinvest.2016.116 Authors: Dimitry A Chistiakov, Murry C Killingsworth, Veronika A Myasoedova, Alexander N Orekhov & Yuri V Bobryshev mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 1140 (November 2016). doi:10.1038/labinvest.2016.105 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 1038 (October 2016). doi:10.1038/labinvest.2016.98 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 934 (September 2016). doi:10.1038/labinvest.2016.92 mehr

Alle Fachpublikationen zu Labortechnik

Activation of GPER ameliorates experimental pulmonary hypertension in male rats

Publication date: 15 January 2017 Source:European Journal of Pharmaceutical Sciences, Volume 97 Author(s): Allan K. Alencar, Guilherme C. Montes, Tadeu Montagnoli, Ananssa M. Silva, Sabrina T. Martinez, Aline G. Fraga, Hao Wang, Leanne Groban, Roberto T. Sudo, Gisele ... mehr

Is Chelation Therapy Efficient for the Treatment of Intravenous Metallic Mercury Intoxication?

Abstract The efficacy of treatment for intravenous elemental mercury intoxication has not been fully studied with regard to clinical outcomes, and treatment recommendations vary. We treated a 41‐year‐old man with a history of drug abuse and depression who attempted suicide using 1 mL (13 ... mehr

Fragment‐Based Design, Synthesis, and Biological Evaluation of 1‐Substituted‐indole‐2‐carboxylic Acids as Selective Mcl‐1 Inhibitors

Based on a known selective Mcl‐1 inhibitor, 6‐chloro‐3‐(3‐(4‐chloro‐3,5‐dimethylphenoxy)propyl)‐1H‐indole‐2‐carboxylic acid, we applied a fragment‐based approach to obtain new molecules that extended into the p1 pocket of the BH3 groove and then exhibited binding selectivity for the Mcl‐1 o ... mehr

Issue Information ‐ JIP

No abstract is available for this article. mehr

A Novel Method to Synthesize 4-Aryl-1H-1,2,3-Triazoles and its Antihepatoma Activity

Abstract: A novel synthetic method of 4-substituted aryl-1H-1,2,3-triazoles from arylglyoxaldoxime semicarbazone with sodium dithionite and O2 was found to be safer than the Huisgen azide– alkyne dipolar cycloaddition. A total of 17 new structures of 4-substituted aryl-1H-1,2,3- triazoles ... mehr

Alle Fachpublikationen zu Pharma

Proanthocyanidins potentiate hypothalamic leptin|[sol]|STAT3 signalling and Pomc gene expression in rats with diet-induced obesity

Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity International Journal of Obesity advance online publication, October 18 2016. doi:10.1038/ijo.2016.169 Authors: M Ibars, A Ardid-Ruiz, M Suárez, B Mugue ... mehr

Auditory processing in noise is associated with complex patterns of disrupted functional connectivity in autism spectrum disorder

Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typi ... mehr

The impact of caregiver‐mediated JASPER on child restricted and repetitive behaviors and caregiver responses

Restricted and repetitive behaviors (RRBs) are a core feature of autism spectrum disorder (ASD). Compared to the social‐communication impairments children show, we know less about why children engage in these repetitive actions and behaviors and how to help children (and their caregivers) w ... mehr

Ki-67 in endometrial cancer: scoring optimization and prognostic relevance for window studies

Ki-67 in endometrial cancer: scoring optimization and prognostic relevance for window studies Modern Pathology advance online publication, December 2 2016. doi:10.1038/modpathol.2016.203 Authors: Sarah Kitson, Vanitha N Sivalingam, James Bolton, Rhona McVey, Mashid Nickkho-Ami ... mehr

Enhanced in planta Fitness through Adaptive Mutations in EfpR, a Dual Regulator of Virulence and Metabolic Functions in the Plant Pathogen Ralstonia solanacearum

by Anthony Perrier, Rémi Peyraud, David Rengel, Xavier Barlet, Emmanuel Lucasson, Jérôme Gouzy, Nemo Peeters, Stéphane Genin, Alice Guidot Experimental evolution of the plant pathogen Ralstonia solanacearum, where bacteria were maintained on plant lineages for more than 300 generations, r ... mehr

Alle Fachpublikationen zu Medizin
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