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Aktuelle Fachpublikationen

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

Null EPAC mutants reveal a sequential order of versatile cAMP effects during Drosophila aversive odor learning [RESEARCH]

Here, we define a role of the cAMP intermediate EPAC in Drosophila aversive odor learning by means of null epac mutants. Complementation analysis revealed that EPAC acts downstream from the rutabaga adenylyl cyclase and in parallel to protein kinase A. By means of targeted knockdown and gen ... mehr

The structure of an E. coli tRNAFormula A1-U72 variant shows an unusual conformation of the A1-U72 base pair [ARTICLE]

Translation initiation in eukaryotes and archaea involves a methionylated initiator tRNA delivered to the ribosome in a ternary complex with e/aIF2 and GTP. Eukaryotic and archaeal initiator tRNAs contain a highly conserved A1–U72 base pair at the top of the acceptor stem. The importance of ... mehr

Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling [RESEARCH]

Recent human exome-sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several intellectual disabilities and cognitive disorders, including autism. However, it remains unclear how mutations in BAF comple ... mehr

Alle Fachpublikationen

The structure of an E. coli tRNAFormula A1-U72 variant shows an unusual conformation of the A1-U72 base pair [ARTICLE]

Translation initiation in eukaryotes and archaea involves a methionylated initiator tRNA delivered to the ribosome in a ternary complex with e/aIF2 and GTP. Eukaryotic and archaeal initiator tRNAs contain a highly conserved A1–U72 base pair at the top of the acceptor stem. The importance of ... mehr

A complex of Arabidopsis DRB proteins can impair dsRNA processing [ARTICLE]

Small RNAs play an important role in regulating gene expression through transcriptional and post-transcriptional gene silencing. Biogenesis of small RNAs from longer double-stranded (ds) RNA requires the activity of dicer-like ribonucleases (DCLs), which in plants are aided by dsRNA binding ... mehr

High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection [ARTICLE]

Nonsense-mediated mRNA decay (NMD) plays an important role in eukaryotic gene expression, yet the scope and the defining features of NMD-targeted transcripts remain elusive. To address these issues, we reevaluated the genome-wide expression of annotated transcripts in yeast cells harboring ... mehr

Structure of the Escherichia coli ProQ RNA-binding protein [ARTICLE]

The protein ProQ has recently been identified as a global small noncoding RNA-binding protein in Salmonella, and a similar role is anticipated for its numerous homologs in divergent bacterial species. We report the solution structure of Escherichia coli ProQ, revealing an N-terminal FinO-li ... mehr

Legal approaches regarding health-care decisions involving minors: implications for next-generation sequencing

Legal approaches regarding health-care decisions involving minors: implications for next-generation sequencing European Journal of Human Genetics 25, 658 (May 2017). doi:10.1038/ejhg.2017.41 Authors: Karine Sénécal, Kristof Thys, Danya F Vears, Kristof Van Assche, Bart ... mehr

Alle Fachpublikationen zu Biotechnologie

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Fetal left‐sided cardiac structural dimensions in left‐sided congenital diaphragmatic hernia ‐ association with severity and impact on postnatal outcomes

Abstract Objectives Fetuses with congenital diaphragmatic hernia (CDH) demonstrate varying degrees of left heart hypoplasia. Our study assesses the relationship between fetal left‐sided cardiac structural dimensions, lung size, percentage liver herniation, lung‐to‐head ratio, postnatal ... mehr

Clinical applications of 3D volume MR imaging of the fetal brain in utero

Abstract Objective In our earlier publication we described the methods of acquiring 3D volume MR data in second and third trimester fetuses and provided normative data from a large cohort of normal fetuses. In this paper we show the applicability of the technique by describing five fet ... mehr

Outcome of isolated enlarged cisterna magna identified in utero: experience at a single medical center in mainland China

Abstract Objective To explore the effects of prenatal isolated enlarged cisterna magna (IECM) on postnatal development. Methods We followed up 123 fetuses with an enlarged cisterna magna (ECM), who were divided into IECM (Group 1) and non‐IECM (ECM plus other anomalies, Group 2) ... mehr

The Benefits and Limitations of cell‐free DNA screening for 47, XXY (Klinefelter syndrome)

Abstract Objective The purpose of this paper is to provide an overview of the 47, XXY syndrome, which is the most commonly occurring X and Y chromosomal variation. This paper seeks to review what is currently known of noninvasive prenatal testing (NIPT) and 47, XXY, and investigate pot ... mehr

Alle Fachpublikationen zu Diagnostik

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors

The evolving concept of cancer stem-like cells in thyroid cancer and other solid tumors Laboratory Investigation advance online publication, April 10 2017. doi:10.1038/labinvest.2017.41 Authors: Heather Hardin, Ranran Zhang, Holly Helein, Darya Buehler, Zhenying Guo & Ricardo ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 354 (April 2017). doi:10.1038/labinvest.2017.27 mehr

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy Laboratory Investigation advance online publication, March 27 2017. doi:10.1038/labinvest.2017.25 Authors: Robert Sackstein, Tobias Schatton & Steven R Barthel mehr

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology Laboratory Investigation advance online publication, March 6 2017. doi:10.1038/labinvest.2017.9 Authors: Akinori Kawakami & David E Fisher mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 230 (March 2017). doi:10.1038/labinvest.2017.7 mehr

Alle Fachpublikationen zu Labortechnik

Application of GA-MLR for QSAR Modeling of the Arylthioindole Class of Tubulin Polymerization Inhibitors as Anticancer Agents

Abstract: Background: Microtubules are dynamic filamentous cytoskeletal proteins which have used widely in cancer chemotherapy. Generally, the action of these compounds depends on binding to the tubulin proteins which are α , β-heterodimers that form the core of the microtubules. Arylthioi ... mehr

Effect of N‐methyl deuteration on pharmacokinetics and pharmacodynamics of Enzalutamide

Enzalutamide, a 2nd generation antiandrogen, has been developed for the treatment of CRPC. We synthesized the deuterated analogues 6 and found that it showed higher drug exposure and thus stronger anti‐tumor potency in preclinical settings. Compound 6 is being developed clinically for the p ... mehr

Involvement of ERK1/2 in Cx43 depression induced by macrophage migration inhibitory factor in atrial myocytes

Abstract Connexin 43 (Cx43) plays an important role in the pathogenesis of atrial fibrillation (AF). The present study sought to investigate the effect of macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, on Cx43 expression and activity and determine the intracellular ... mehr

Self-Association of Rafoxanide in Aqueous Media and Its Application in Preparing Amorphous Solid Dispersions

Our primary objective is to characterize the self-association of rafoxanide in alkaline media. The second objective is to illustrate the feasibility of using rafoxanide micellar solution as the feed solution to prepare amorphous solid dispersion via spray drying. Rafoxanide is a poorly wate ... mehr

Dapagliflozin-citric acid cocrystal showing better solid state properties than dapagliflozin

Publication date: Available online 13 April 2017 Source:European Journal of Pharmaceutical Sciences Author(s): Jun-Hui Deng, Tong-Bu Lu, Changquan Calvin Sun, Jia-Mei Chen Dapagliflozin (DAP) is a potent and selective sodium-glucose contransporter-2 inhibitor, for treating typ ... mehr

Alle Fachpublikationen zu Pharma

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

Physical inactivity: a risk factor and target for intervention in renal care

Nature Reviews Nephrology 13, 318 (2017). doi:10.1038/nrneph.2017.44 Author: Dorien M. Zelle, Gerald Klaassen, Edwin van Adrichem, Stephan J.L. Bakker, Eva Corpeleijn & Gerjan Navis Nature Reviews Nephrology13, 152–168 (2017)In the original pdf and online versions of this ... mehr

Expansion of the clinical phenotype of the distal 10q26.3 deletion syndrome to include ataxia and hyperemia of the hands and feet

Distal deletion of the long arm of chromosome 10 is associated with a dysmorphic craniofacial appearance, microcephaly, behavioral issues, developmental delay, intellectual disability, and ocular, urogenital, and limb abnormalities. Herein, we present clinical, molecular, and cytogenetic in ... mehr

Headache patients’ satisfaction with telemedicine: a 12‐month follow‐up randomized non‐inferiority trial

Background and purpose We investigated non‐acute headache patients’ long‐term satisfaction with a telemedicine consultation and consultation preferences in northern Norway. We hypothesized that patients were not less satisfied with telemedicine than traditional consultations. We also exam ... mehr

Alle Fachpublikationen zu Medizin
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