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Galectins are human milk glycan receptors

The biological recognition of human milk glycans (HMGs) is poorly understood. Because HMGs are rich in galactose we explored whether they might interact with human galectins, which bind galactose-containing glycans and are highly expressed in epithelial cells and other cell types. We screen ... mehr

Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction

There is a functional relationship between the heparan sulfate proteoglycan glypican-1 and the amyloid precursor protein (APP) of Alzheimer disease. In wild-type mouse embryonic fibroblasts, expression and processing of the APP is required for endosome-to-nucleus translocation of anhydroman ... mehr

FUT1 genetic variants impact protein glycosylation of porcine intestinal mucosa

A massive use of antibiotics in industrial pig production is a major cause of the rapidly rising bacterial resistance to antibiotics. An enhanced understanding of infectious diseases and of host–microbe interactions has the potential to explore alternative ways to improve pig health and red ... mehr

Evolutionary history of the chitin synthases of eukaryotes

Chitin synthases are widespread among eukaryotes and known to have a complex evolutionary history in some of the groups. We have reconstructed the chitin synthase phylogeny using the most taxonomically comprehensive dataset currently available and have shown the presence of independently fo ... mehr

Sequence determination of synthesized chondroitin sulfate dodecasaccharides

Chondroitin sulfate (CS) is a linear acidic polysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetyl-d-galactosamine. The polysaccharide is modified with sulfate groups at different positions by a variety of sulfotransferases. CS chains exhibit various biologi ... mehr

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Transcriptomic and epigenomic characterization of the developing bat wing

Nature Genetics 48, 528 (2016). doi:10.1038/ng.3537 Authors: Walter L Eckalbar, Stephen A Schlebusch, Mandy K Mason, Zoe Gill, Ash V Parker, Betty M Booker, Sierra Nishizaki, Christiane Muswamba-Nday, Elizabeth Terhune, Kimberly A Nevonen, Nadja Makki, Tara Friedrich, Julia ... mehr

Regulatory networks in evolution

Nature Genetics 48, 475 (2016). doi:10.1038/ng.3566 Comparison of evolutionary adaptations and innovations illuminates the genetic basis for the development of animal forms. Gene networks that retain similar wiring diagrams in diverse and distantly related organisms point t ... mehr

Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme [ARTICLE]

Most of today's knowledge of the CPEB3 ribozyme, one of the few small self-cleaving ribozymes known to occur in humans, is based on comparative studies with the hepatitis delta virus (HDV) ribozyme, which is highly similar in cleavage mechanism and probably also in structure. Here we presen ... mehr

Hoogsteen-position pyrimidines promote the stability and function of the MALAT1 RNA triple helix [REPORT]

Triple-stranded RNA was first deduced to form in vitro more than 50 years ago and has since been implicated in RNA catalysis, stability, and small molecule binding. Despite the emerging biological significance of RNA triple helices, it remains unclear how their nucleotide composition contri ... mehr

Differential substrate recognition by isozymes of plant protein-only Ribonuclease P [ARTICLE]

Ribonuclease P (RNase P) catalyzes the cleavage of leader sequences from precursor tRNA (pre-tRNA). Typically, these enzymes are ribonucleic protein complexes that are found in all domains of life. However, a new class of RNase P has been discovered that is composed entirely of protein, ter ... mehr

Alle Fachpublikationen zu Biotechnologie

Chromosomal microarray use among women undergoing invasive prenatal diagnosis

Abstract Objective To study the offer and uptake of chromosomal microarray analysis (CMA) among women undergoing invasive prenatal testing. Methods This is a retrospective cohort study of women who underwent chorionic villus sampling (CVS) or amniocentesis. Charts were reviewed ... mehr

Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction.

Abstract Objective To study the effect of uteroplacental circulation restriction on endothelial kidney damage in a fetal rabbit model. Methods New Zealand rabbits were subjected to 40‐50% of uteroplacental artery ligation at day 25 of pregnancy. After 5 days, surviving fetuses w ... mehr

Non‐invasive prenatal diagnosis (NIPD) for single gene disorders: cost analysis of NIPD and invasive testing pathways

Abstract Objective Evaluate the costs of offering non‐invasive prenatal diagnosis (NIPD) for single gene disorders compared to traditional invasive testing to inform NIPD implementation into clinical practice. Method Total costs of diagnosis using NIPD or invasive testing pathwa ... mehr

Issue Information ‐ TOC

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Issue Information ‐ JIF

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Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 494 (May 2016). doi:10.1038/labinvest.2016.47 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 376 (April 2016). doi:10.1038/labinvest.2016.41 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 262 (March 2016). doi:10.1038/labinvest.2016.29 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 114 (February 2016). doi:10.1038/labinvest.2015.165 mehr

Canonical Wnt signaling in systemic sclerosis

Canonical Wnt signaling in systemic sclerosis Laboratory Investigation advance online publication, January 11 2016. doi:10.1038/labinvest.2015.154 Authors: Christina Bergmann & Jörg H W Distler mehr

Alle Fachpublikationen zu Labortechnik

Synthesis of 9-O-3-(1-piperazinyl/morpholinyl/piperidinyl)pentyl-berberines as Potential Antioxidant and Cytotoxic Agents

Abstract: A new series of 9-O-3-(1-piperazinyl/morpholinyl/piperidinyl)pentyl-berberines has been efficiently formulated via coupling 1,5-dibromopentane with berberrubine which was obtained by treating berberine in a vacuum oven at optimum temperature and pressure. Nucleophilic substitutio ... mehr

Tannic Acid Inhibits Proliferation, Migration, Invasion of Prostate Cancer and Modulates Drug Metabolizing and Antioxidant Enzymes

Abstract: The aim of this study was to investigate the effects of plant phenolic compound tannic acid (TA) on proliferative, metastatic, invasive properties of prostate cancer (PCa) cells; PC-3 and LNCaP, as well as drug metabolizing and antioxidant enzymes. Characterization of TA was done ... mehr

Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance

Abstract: The history of metal based cytostatics began in the 1970s by discovering the effects of cisplatin. Since then several generations of platinum based cytostatics have started to be the key weapon against tumor development and metastasis occurrence. Nevertheless, some attention has ... mehr

Current Status of Epigenetics and Anticancer Drug Discovery

Abstract: In recent years, there has been an expansion of the understanding of how epigenetic dysregulation plays a role in tumorigenesis, progression, metastasis and treatment resistance. Evidence has focused on two common and well-studied “epigenetic codes”, i.e., DNA methylation and his ... mehr

Synthesis and Pharmacological Evaluation of Maleopimaric N-arylimides: Identification of Novel Proapoptotic Agents

Abstract: Several N-aryl maleopimaric acid diimides (3a-3d, 4a-4g) were synthesized and evaluated their topoisomerase I inhibitory activities along with cytotoxicities against NCI, MGC-803, Bel-7404 and Hct-116 cell lines. The pharmacological dates revealed that most of structure analogs e ... mehr

Alle Fachpublikationen zu Pharma

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

Nature Reviews Clinical Oncology. doi:10.1038/nrclinonc.2016.65 Author: Danny N. Khalil, Eric L. Smith, Renier J. Brentjens & Jedd D. Wolchok mehr

NAD+ Supplementation Attenuates Methylmercury Dopaminergic and Mitochondrial Toxicity in Caenorhabditis Elegans

Methylmercury (MeHg) is a neurotoxic contaminant of our fish supply that has been linked to dopaminergic (DAergic) dysfunction that characterizes Parkinson’s disease. We have previously shown that MeHg causes both morphological and behavioral changes in the Caenorhabditis elegans DAergic ne ... mehr

Response to dopamine in prematurity: a biomarker for brain injury|[quest]|

Response to dopamine in prematurity: a biomarker for brain injury? Journal of Perinatology 36, 410 (May 2016). doi:10.1038/jp.2016.40 Authors: Z A Vesoulis, N E Ters, A Foster, S B Trivedi, S M Liao & A M Mathur mehr

Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells

Nicotine exposure during pregnancy leads to placental insufficiency impairing both fetal and neonatal development. Previous studies from our laboratory have demonstrated that in rats, nicotine augmented endoplasmic reticulum (ER) stress in association with placental insufficiency; however, ... mehr

Dose- and Time-Dependent Transcriptional Response of Ishikawa Cells Exposed to Genistein

To further define the utility of the Ishikawa cells as a reliable in vitro model to determine the potential estrogenic activity of chemicals of interest, transcriptional changes induced by genistein (GES) in Ishikawa cells at various doses (10 pM, 1 nM, 100 nM, and 10 μM) and time points (8 ... mehr

Alle Fachpublikationen zu Medizin
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