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Aktuelle Fachpublikationen

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as well as the rapid degradation of messenger RNA. The latter ensures that translation closely follows programming at the level of transcription. Re ... mehr

Triple helical DNA in a duplex context and base pair opening

It is fundamental to explore in atomic detail the behavior of DNA triple helices as a means to understand the role they might play in vivo and to better engineer their use in genetic technologies, such as antigene therapy. To this aim we have performed atomistic simulations of a purine-rich ... mehr

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the pre ... mehr

Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency

Mitochondrial promoters of Saccharomyces cerevisiae share a conserved –8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation factor Mtf1. We used 2-aminopurine fluor ... mehr

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorl ... mehr

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De novo CNVs in bipolar affective disorder and schizophrenia

An increased rate of de novo copy number variants (CNVs) has been found in schizophrenia (SZ), autism and developmental delay. An increased rate has also been reported in bipolar affective disorder (BD). Here, in a larger BD sample, we aimed to replicate these findings and compare de novo C ... mehr

TCF7L2 is a master regulator of insulin production and processing

Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet ... mehr

ZBTB42 mutation defines a novel lethal congenital contracture syndrome (LCCS6)

Lethal congenital contracture syndrome (LCCS) is a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). LCCS is genetically heterogeneous with mutations in five genes identified to date, all with a role in the innervation or contractile apparatus of skeletal muscles. ... mehr

New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome

Cardio-facio-cutaneous (CFC) syndrome is one of the ‘RASopathies’, a group of phenotypically overlapping syndromes caused by germline mutations that encode components of the RAS–MAPK pathway. Germline mutations in BRAF cause CFC syndrome, which is characterized by heart defects, distinctive ... mehr

Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations

Previous reports have described several associations of PR, QRS, QT and heart rate with genomic variations by genome-wide association studies (GWASs). In the present study, we examined the association of ~2.5 million SNPs from 2994 Japanese healthy volunteers obtained from the JPDSC databas ... mehr

Alle Fachpublikationen zu Biotechnologie

Nationwide demonstration project of next‐generation sequencing of cell‐free DNA in maternal plasma in Japan: one‐year experience

Abstract Objective To report the one‐year experience of a nationwide demonstration project to introduce noninvasive prenatal testing of aneuploidy from maternal plasma and discuss how to implement this program in Japan. Methods The test was conducted to detect aneuploidy in high ... mehr

Sublingual allergen immunotherapy for respiratory allergies: what is new?

Sublingual immunotherapy (SLIT) is a disease-modifying treatment for respiratory allergies that has been used for many years in Europe and has also recently been approved for use in North America. Its use is thus likely to increase. There is more evidence available regarding SLIT efficacy a ... mehr

Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations

Tacrolimus is a cornerstone of the immunosuppression regimen for prevention of allograft rejection in kidney and liver transplantations, with efficacy proven in many clinical trials. The currently available and extensively used tacrolimus formulations are flawed by large inter- and intra-in ... mehr

The natural history of monoamniotic twin pregnancies: a case series and systematic review of the literature

ABSTRACT Objective To describe the natural history of monoamniotic twin pregnancies in contemporary practice. Method Cohort study of monochorionic monoamniotic twin pregnancies with two live fetuses diagnosed at less than 16 weeks and prospectively followed up between 2004 and 2 ... mehr

Domestic exposure to volatile organic compounds in relation to asthma and allergy in children and adults

Over the past decades, the prevalence of asthma, allergic disease and atopy has increased significantly and in parallel with the increased use of products and materials emitting volatile organic compounds (VOCs) in the indoor environment. The purpose of this review is to examine the evidenc ... mehr

Alle Fachpublikationen zu Diagnostik

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats Laboratory Investigation advance online publication, November 10 2014. doi:10.1038/labinvest.2014.134 ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 1186 (November 2014). doi:10.1038/labinvest.2014.127 mehr

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.122 Authors: Kazuyo Yasuda, Toshihiko ... mehr

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.121 Authors: Maki K ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 936 (September 2014). doi:10.1038/labinvest.2014.106 mehr

Alle Fachpublikationen zu Labortechnik

Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study

Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study Clinical Pharmacology & Therapeutics 96, 713 (December 2014). doi:10.1038/clpt.2014.183 Authors: K E ... mehr

Fast-Tracking the Development of Effective Therapeutics in Mitochondrial Medicine

Fast-Tracking the Development of Effective Therapeutics in Mitochondrial Medicine Clinical Pharmacology & Therapeutics 96, 641 (December 2014). doi:10.1038/clpt.2014.163 Author: S P Hersh mehr

Mitochondrial Pharmacology: Its Future Is Now

Mitochondrial Pharmacology: Its Future Is Now Clinical Pharmacology & Therapeutics 96, 629 (December 2014). doi:10.1038/clpt.2014.177 Authors: H H Szeto, L P James & A J Atkinson mehr

In This Issue

In This Issue Clinical Pharmacology & Therapeutics 96, 627 (December 2014). doi:10.1038/clpt.2014.194 mehr

Evidence Required to Demonstrate Clinical Utility of Pharmacogenetic Testing: The Debate Continues

Evidence Required to Demonstrate Clinical Utility of Pharmacogenetic Testing: The Debate Continues Clinical Pharmacology & Therapeutics 96, 655 (December 2014). doi:10.1038/clpt.2014.185 Authors: N K Gillis & F Innocenti mehr

Alle Fachpublikationen zu Pharma

Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex

Nature Neuroscience 17, 1840 (2014). doi:10.1038/nn1214-1840a Author: Froylan Calderon de Anda, Ana Lucia Rosario, Omer Durak, Tracy Tran, Johannes Gräff, Konstantinos Meletis, Damien Rei, Takahiro Soda, Ram Madabhushi, David D Ginty, Alex L Kolodkin & Li-Huei Tsai mehr

Corrigendum: Dopamine restores reward prediction errors in old age

Nature Neuroscience 17, 1840 (2014). doi:10.1038/nn1214-1840c Author: Rumana Chowdhury, Marc Guitart-Masip, Christian Lambert, Peter Dayan, Quentin Huys, Emrah Düzel & Raymond J Dolan mehr

Nature Neuroscience celebrates its 200th issue

Nature Neuroscience 17, 1623 (2014). doi:10.1038/nn.3885 December 2014 marks the 200th issue of Nature Neuroscience. We reflect on the history of the journal and the field. mehr

Corrigendum: miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

Nature Neuroscience 17, 1841 (2014). doi:10.1038/nn1214-1841c Author: Mathieu Letellier, Sara Elramah, Magali Mondin, Anaïs Soula, Andrew Penn, Daniel Choquet, Marc Landry, Olivier Thoumine & Alexandre Favereaux mehr

Erratum: Dopamine signals mimic reward prediction errors

Nature Neuroscience 17, 1840 (2014). doi:10.1038/nn1214-1840d Author: Geoffrey Schoenbaum, Guillem R Esber & Mihaela D Iordanova mehr

Alle Fachpublikationen zu Medizin
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