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Aktuelle Fachpublikationen

Taxonomic revision of the fossil genera Bulimactaeon, Hemiauricula (= Liocarenus) and Nucleopsis, with description of a new Recent genus and species (Gastropoda: Heterobranchia ...

The genus Liocarenus (Acteonidae) was originally described from Eocene fossil material and has subsequently come to include three subgenera (Liocarenus s. s., Bulimactaeon and Nucleopsis) and nine species, including a Recent one (L. globulinus). Together, these have been accorded status as ... mehr

Reviving Galápagos snails: ancient DNA extraction and amplification from shells of probably extinct endemic land snails

Snail shells represent an abundant source of information about the organisms that build them, which is particularly vital and relevant for species that are locally or globally extinct. Access to genetic information from snail shells can be valuable, yet previous protocols for extraction of ... mehr

3D-interactive microanatomy of Ventsia tricarinata Warén & Bouchet, 1993 (Vetigastropoda: Seguenzioidea) from Pacific hydrothermal vents

The microanatomy of Ventsia tricarinata Warén & Bouchet, 1993, a small coiled ‘skeneimorph’ gastropod from Pacific hydrothermal vents, is described based on computer-aided reconstructions of semithin section series and visualized by interactive 3D-modelling. This is the most complete accoun ... mehr

Acute nicotine enhances spontaneous recovery of contextual fear and changes c-fos early gene expression in infralimbic cortex, hippocampus, and amygdala [RESEARCH]

Exposure therapy, which focuses on extinguishing fear-triggering cues and contexts, is widely used to treat post-traumatic stress disorder (PTSD). Yet, PTSD patients who received successful exposure therapy are vulnerable to relapse of fear response after a period of time, a phenomenon know ... mehr

Taxonomic identity of two amnicolid gastropods of conservation concern in lakes of the Pacific Northwest of the USA

In this paper we attempt to clarify the identity of two purportedly new species of amnicolid snails in Pacific Northwest lakes that were vaguely described in grey literature and recently petitioned for federal listing. As currently understood the western American amnicolid fauna consists of ... mehr

Alle Fachpublikationen

HSS-Bin: An Unsupervised Metagenomic Binning Method Based on Hybrid Sequence Feature Recognition and Spectral Clustering

Abstract: Rapidly developing next-generation sequencing technologies significantly promote metagenomics research, yet also present extreme challenges in the analysis of metagenomic data. Metagenomic samples can contain thousands of microbial species, thus, sequencing datasets can contain f ... mehr

Identification of Differentially Expressed Gene Using Robust Singular Value Decomposition

Abstract: Identification of differentially expressed genes (DEG) in transcriptomic analyses is one of the important tasks to find out significantly activated/deactivated pathways. Outliers and/or the missing values are commonly observed in microarray data; however, most available statistic ... mehr

A Computational Study of Three Frequent Mutations of EGFR and their Effects on Protein Dimer Formation and Non-Small Cell Lung Cancer Drug Resistance

Abstract: Drug resistance is a major problem for non-small cell lung cancer (NSCLC) treatment due to mutations in patients’ DNA sequences. It is now possible to obtain the human genome information easily based on the high-throughput sequencing technology, so personalized medicine can becom ... mehr

A Fast Comparison Algorithm to Measure the Accuracy of Ortholog Clusters

Abstract: Ortholog clusters are very important for functional annotation and studies in comparative and evolutionary genomics. Their accuracy is, therefore, of considerable significance. However, it is very hard to calculate the accuracy of ortholog clusters because it takes too much time ... mehr

Amyloid Motif Prediction Using Ensemble Approach

Abstract: Misfolding of proteins results in amyloidosis: a condition where amyloid motifs build up in neuronal tissues leading to life threatening organ failures. Hence understanding the underlying cause of incorrect folding of proteins is significant followed by the identification of such ... mehr

Alle Fachpublikationen zu Biotechnologie

MCDA Twins with Discordant Malformations: Submicroscopic Chromosomal Anomalies Detected by Chromosomal Microarray Analysis and Clinical Outcomes

Abstract Objective To evaluate whether discrepant copy number variations (CNVs) contribute to the risk for discordant congenital anomalies in monochorionic diamniotic (MCDA) twins. Methods We conducted a parallel testing using both G‐banding for standard karyotyping and chromoso ... mehr

Fetal anomalies associated with HNF1B mutations: report of 20 autopsy cases

Abstract Objective To describe macroscopic and microscopic anomalies present in fetuses carrying HNF1B mutation, their frequency, genotype/phenotype correlations. Methods Clinical data, ultrasound findings, genetic studies and autopsy reports of 20 fetal autopsies were analysed. ... mehr

Detection of a case of Chronic Myeloid Leukemia with deletions at the t(9;22) translocation breakpoints by a genome‐wide non‐invasive prenatal test

Abstract Objective Non‐invasive prenatal tests (NIPT) interrogating the complete genome are able to detect not only fetal trisomy 13, 18 or 21, but additionally provide information on other (sub)chromosomal aberrations, that can be fetal or maternal in origin. We demonstrate that in a ... mehr

Utility of Fetal Magnetic Resonance Imaging in Assessing the Fetus with Cardiac Malposition

Abstract Objective Abnormal cardiac axis and/or malposition prompts evaluation of congenital heart disease (CHD), however etiology may be difficult to clarify using obstetrical ultrasound (US) or fetal echocardiography (echo) alone. We aimed to use fetal magnetic resonance imaging (MRI ... mehr

Sonoembryology of the fetal posterior fossa at 11 + 3 to 13 + 6 gestational weeks on three‐dimensional transvaginal ultrasound

Abstract Objective To describe the sonographic appearance and temporal changes of the structures of the posterior cranial fossa in fetuses at a crown‐rump length (CRL) between 45 to 84 mm in transvaginal acquired three‐dimensional volume blocks. Methods This was a prospective, c ... mehr

Alle Fachpublikationen zu Diagnostik

Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways

Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways Laboratory Investigation advance online publication, July 11 2016. doi:10.1038/labinvest.2016.69 Authors: Sarah Kretschmer, Mario Pieper, Gereon Hüt ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 706 (July 2016). doi:10.1038/labinvest.2016.67 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 600 (June 2016). doi:10.1038/labinvest.2016.59 mehr

ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease

ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease Laboratory Investigation advance online publication, May 16 2016. doi:10.1038/labinvest.2016.56 Authors: Dimitry A Chistiakov, Alexander N Orekhov & Yuri V Bobryshev mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 494 (May 2016). doi:10.1038/labinvest.2016.47 mehr

Alle Fachpublikationen zu Labortechnik

Thermoresponsive polymers with LCST‐ or UCST‐type phase behaviour do not induce toxicity to human endothelial cells

Abstract Thermoresponsive polymers have gained extensive attention as biomedical materials especially for targeted drug delivery systems. We have recently developed water‐soluble polypeptides based thermoresponsive polymers that exhibit lower critical solution temperature (LCST) or upper ... mehr

Safety of metamizole: a systematic review of the literature

Summary What is known and objective Metamizole was withdrawn from the market in the United States and several European countries following reports of fatal agranulocytosis among users, but is still available in many countries in Europe, South America and Asia. Over the past several dec ... mehr

Marine Drugs, Vol. 14, Pages 134: New Polyketides and New Benzoic Acid Derivatives from the Marine Sponge-Associated Fungus Neosartorya quadricincta KUFA 0081

Two new pentaketides, including a new benzofuran-1-one derivative (1) and a new isochromen-1-one (5), and seven new benzoic acid derivatives, including two new benzopyran derivatives (2a, b), a new benzoxepine derivative (3), two new chromen-4-one derivatives (4b, 7) and two new benzofuran ... mehr

6‐Methylsulfinylhexyl isothiocyanate prevents high‐fat diet‐induced fatty liver but fails to attenuate hepatic iron accumulation in mice

Abstract 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC) is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator. To determine whether 6‐MSITC ameliorates hepatic steatosis and iron accumulation, wild‐type and Nrf2‐null mice were fed t ... mehr

Factor VIII associated with lipidic nanoparticles retains efficacy in the presence of anti‐Factor VIII antibodies in Hemophilia A mice

Abstract Development of inhibitory antibodies against Factor VIII (FVIII) is a major challenge in Hemophilia A (HA) therapy. Such antibodies develop in nearly 30% of the patients receiving replacement FVIII, abrogating therapeutic efficacy. In this work, we evaluated whether B‐domain del ... mehr

Alle Fachpublikationen zu Pharma

Global epidemiology of atrial fibrillation

Nature Reviews Cardiology 13, 501 (2016). doi:10.1038/nrcardio.2016.114 Author: Faisal Rahman, Gene F. Kwan & Emelia J. Benjamin Nature Reviews Cardiology11, 639–654 (2014)In the version of this article originally published online and in print, 'Prevalence of AF' on the y ... mehr

Erratum: Deregulation and therapeutic potential of microRNAs in arthritic diseases

Nature Reviews Rheumatology. doi:10.1038/nrrheum.2016.119 Author: Rita Vicente, Danièle Noël, Yves-Marie Pers, Florence Apparailly & Christian Jorgensen mehr

Salt‐Losing Nephropathy in Mice with a Null Mutation of the Clcnk2 Gene

Abstract Aim The basolateral chloride channel ClC‐Kb facilitates Cl reabsorption in the distal nephron of the human kidney. Functional mutations in CLCNKB are associated with Bartter's syndrome type 3, a hereditary salt‐losing nephropathy. To address the function of ClC‐K2 in vivo, we ... mehr

Functional consequences of experience‐dependent plasticity on tactile perception following perceptual learning

Abstract Continuous training enhances perceptual discrimination and promotes neural changes in areas encoding the experienced stimuli. This type of experience‐dependent plasticity has been demonstrated in several sensory and motor systems. Particularly, non‐human primates trained to dete ... mehr

History of Neuroscience in Greece: From Alkmaion to Austerity

In the frame of an historical section of the 2015 Featured Regional meeting of FENS in Thessaloniki, I was asked to talk on the “History of Neuroscience in Greece”. Realizing the impossibility of the task, I focused on only two points: the dawn of neuroscience in Greece and the current situ ... mehr

Alle Fachpublikationen zu Medizin
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