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Abstract Glutamate transporter‐1 (GLT‐1) plays a central role in preventing excitotoxicity by removing excess glutamate from the synaptic clefts. 17β‐Estradiol (E2) and tamoxifen (TX), a selective estrogen receptor (ER) modulator, afford neuroprotection in a range of experimental models. ... mehr
Abstract Mesophilic glucuronidases are the most widely used reporters of gene expression in plants, but unsuitable as reporters in (hyper‐)thermophiles due their insufficient thermal stability. Here we present the native 66.8 kDa thermostable β‐glucuronidase of Sulfolobus solfataricus. T ... mehr
Abstract The gene encoding dystrobrevin‐binding‐protein‐1 (dysbindin) is expressed in many areas of the central nervous system and plays a role in intracellular vesicle trafficking, synaptic vesicle trafficking, and neurotransmitter release. At a cellular level, dysbindin is thought to m ... mehr
Abstract Many enzymatic reactions are near‐equilibrium reactions. This often limits final yield and hence application of biocatalyzed processes in the industrial production. The most widely applied strategy to overcome this issue is solvent selection. It must be underlined that measuring ... mehr
Abstract As neuroinflammatory processes are involved in the pathogenesis of Parkinson's disease (PD), we achieved the longitudinal evaluation of them in parallel with the modifications of dopaminergic function at several time‐points after 6‐hydroxydopamine (6‐OHDA) lesion in the rat mimi ... mehr
Abstract Mesophilic glucuronidases are the most widely used reporters of gene expression in plants, but unsuitable as reporters in (hyper‐)thermophiles due their insufficient thermal stability. Here we present the native 66.8 kDa thermostable β‐glucuronidase of Sulfolobus solfataricus. T ... mehr
Abstract Many enzymatic reactions are near‐equilibrium reactions. This often limits final yield and hence application of biocatalyzed processes in the industrial production. The most widely applied strategy to overcome this issue is solvent selection. It must be underlined that measuring ... mehr
Abstract Four species of 1SS‐varinats of lysozyme were almost unstructured in water, judged from their near‐UV CD and 1H‐15N‐HSQC spectra. Some preferential structure might exist in such a disordered state, but the population of molecules in such a conformation must have been too small t ... mehr
Abstract Density functional (DFT) conformational in vacuo studies of cellobiose have shown that ϕH‐anticonformations are low in energy relative to the syn forms, while the ψH‐anti forms are higher in energy. Further, as the cellulosic fragments became larger than a disaccharide and new h ... mehr
Abstract A biocompatible and elastomeric nanofibrous scaffold is electrospun from a blend of poly(1,8‐octanediol‐co‐citrate) [POC] and poly(L‐lactic acid) ‐co‐poly‐(3‐caprolactone) [PLCL] for application as a bioengineered patch for cardiac tissue engineering. The characterization of the ... mehr
ABSTRACT Objectives To investigate the levels of tumour markers CA 19–9 and CA 15–3 in the first trimester maternal serum of euploid control and trisomy 21 pregnancies. Methods Maternal serum marker levels of 69 trisomy 21 and 388 euploid controls were quantified by the Kryptor a ... mehr
ABSTRACT Objective The aim of this study is to determine the effect of interrupting prenatal Down syndrome screening for women with large nuchal translucency (NT) measurements on the performance of combined and integrated tests. Design Distribution of large NT at 11–13 weeks of g ... mehr
ABSTRACT Objective Here we describe the successful application of massively parallel sequencing for noninvasive prenatal detection of trisomy 21. In addition, for the detection of a broader spectrum of fetal aneuploidies, a target enrichment approach was successfully tested. Method ... mehr
ABSTRACT Objective The aim of this study was to examine the effectiveness of a combination of parameters at first‐trimester screening for fetal aneuploidies, including ultrasound assessment of the nasal bone (NB), blood flow in the ductus venosus (DV) and flow across the tricuspid valv ... mehr
ABSTRACT Objective Trisomy is the most common type of chromosome abnormality, affecting 4% of clinically recognised pregnancies, of which, trisomies 16, 21 and 22 are the most prevalent. It has been suggested that a large proportion of maternally derived trisomic pregnancies, specifica ... mehr
Ferroportin-1 is a ‘nuclear’-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins Laboratory Investigation advance online publication, April 2, 2012. doi:10.1038/labinvest.2012.52 Authors: Naila Naz, Ihtzaz A Malik, Nadeem Sheikh, Shakil ... mehr
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis Laboratory Investigation advance online publication, March 12, 2012. doi:10.1038/labinvest.2012.45 Authors: Laura J Dixon, Michael Berk, Samjhana Thapaliya, Bettina G Papouchado ... mehr
Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms Laboratory Investigation advance online publication, February 13, 2012. doi:10.1038/labinvest.2012.9 Authors: Kei Sakamoto, Takuma Fujii, Hiroshi Kawachi, Yoshio Miki, ... mehr
Inside Lab Invest Laboratory Investigation 92, 164 (February 2012). doi:10.1038/labinvest.2011.202 mehr
Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice Laboratory Investigation advance online publication, January 16, 2012. doi:10.1038/labinvest.2011.200 Authors: Zhi-Chao Feng, Lisa Donnelly, Jinming Li, Mansa Krishnamurthy, Matthew Riopel ... mehr
Abstract In addition to its regulatory effect on bone mass, calcitonin has been shown to relieve pain and alleviate peripheral circulatory disturbance in patients with Raynaud’s syndrome and complex regional pain syndrome. In the present study, we investigated whether calcitonin ameliora ... mehr
Abstract Serial evaluations of tumour burden using imaging, mainly computed tomography and magnetic resonance imaging, form the basis for assessing treatment response in many clinical trials of anti‐cancer therapeutics. Traditionally, these evaluations have been based on linear measureme ... mehr
Abstract Adverse drug reactions are the fifth most frequent cause of deaths in developed countries, effectively a global epidemic. However, progress in ameliorating the problem has been slow. Pharmacovigilance currently operates without clear objectives in relation to individual decision ... mehr
Abstract The goal of this research work was to develop a novel technique to synthesize calcium alginate nanoparticles using pharmaceutically relevant microemulsions. Stable microemulsion‐based reactors were prepared using aqueous sodium alginate, aqueous calcium chloride, dioctyl sodium ... mehr
Abstract Breast cancer is the most common oncological disease in women worldwide. Genetic predisposition to breast cancer can be associated with single‐nucleotide polymorphisms (SNPs), which are observed in many women. Such gene polymorphisms, in combination with nutritional and environm ... mehr
Abstract Hyponatremia is a metabolic disorder characterized by increased cerebrospinal fluid (CSF) volume and pressure, although the site of brain insult is unclear. Specifically, the hippocampus, which is in direct contact with expanding CSF ventricles, may be involved. The present stud ... mehr
Abstract Transplantation of autologous Schwann cells (SCs) is a promising approach for treating various peripheral nerve disorders, including chronic denervation. However, given their drawbacks, such as invasive biopsy and lengthy culture in vitro, alternative cell sources would be neede ... mehr
ABSTRACT Autophagy is a critical cellular process orchestrating the lysosomal degradation of cellular components in order to maintain cellular homeostasis and respond to cellular stress. A growing research effort over the last decade has proven autophagy to be essential for constitutive ... mehr
Abstract N‐palmitoyl‐ethanolamine (PEA) is an endogenous substance that was first identified in lipid tissue extracts. It has been classified as a CB2 receptor agonist. Exogenous PEA has the potential to become a valid treatment for neuropathic and inflammatory pain. In spite of the well ... mehr
ABSTRACT Accidental ingestion or injection of household products sometimes occurs due to their accessibility, but the toxic manifestations have not been well characterized when they are internally administered. The aim of this study was to investigate the toxic effects induced by ingesti ... mehr
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