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Aktuelle Fachpublikationen

Precision genome editing: A small revolution for glycobiology

Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not been applied with wide success in the ... mehr

O-Linked glycosylation in Acanthamoeba polyphaga mimivirus

Acanthamoeba polyphaga mimivirus is a member of the giant nucleocytoplasmic large DNA viruses, infecting various Acanthamoeba spp. The genomes of giant viruses encode components previously thought to be exclusive to cellular life, such as proteins involved in nucleic acid and protein synthe ... mehr

Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling

G19 is a novel homogeneous sulfated oligosaccharide, prepared from Grateloupia filicina. In the present study, we first reported that oligosaccharide G19 exhibited a dose- and time-dependent anti-proliferation effect against U-87 malignant gliomas (MG) human glioma cells. Further studies in ... mehr

Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharides

Heparan sulfate and heparin are highly sulfated polysaccharides that consist of a repeating disaccharide unit of glucosamine and glucuronic or iduronic acid. The 2-O-sulfated iduronic acid (IdoA2S) residue is commonly found in heparan sulfate and heparin; however, 2-O-sulfated glucuronic ac ... mehr

Structural change of N-glycan exposes hydrophobic surface of human transferrin

Transferrin is an iron-transport protein which possesses N-glycans at Asn432 and Asn630 in humans. Transferrin glycoforms Tf-1 and Tf-2, previously identified in human cerebrospinal fluid, are defined as the lower and upper bands in gel electrophoresis, respectively. Importantly, the Tf-2/T ... mehr

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A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice

Blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) is an autosomal dominant genetic disorder characterized by small palpebral fissures and other craniofacial malformations, often with (type I) but could also without (type II) premature ovarian failure. While mutations of the fork ... mehr

Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting

In mammals, genomic imprinting governed by DNA methyltransferase DNMT3A and its cofactor DNMT3L is essential for functional gametes. Oocyte-specific methylation imprints are established during oocyte growth concomitant with DNMT3A/DNMT3L expression, although the mechanisms of oocyte-specifi ... mehr

Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1

Tuberous sclerosis complex (TSC) is a disorder arising from mutation in the TSC1 or TSC2 gene, characterized by the development of hamartomas in various organs and neurological manifestations including epilepsy, intellectual disability and autism. TSC1/2 protein complex negatively regulates ... mehr

Mutations in the FOG2/ZFPM2 gene are associated with anomalies of human testis determination

In recent years, considerable advances have been made in our understanding of genetics of mammalian gonad development; however, the underlying genetic aetiology in the majority of patients with 46,XY disorders of sex development (DSD) still remains unknown. Based on mouse models, it has bee ... mehr

Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium

Loss-of-function germline mutations in BRCA1 (MIM #113705) confer markedly increased risk of breast and ovarian cancer. The full-length transcript codifies for a protein involved in DNA repair pathways and cell-cycle checkpoints. Several BRCA1 splicing isoforms have been described in public ... mehr

Alle Fachpublikationen zu Biotechnologie

Nasal bone length:prenasal thickness ratio: a strong 2D ultrasound marker for Down syndrome

ABSTRACT Objectives To evaluate the feasibility of incorporating two‐dimensional (2D) ultrasound measurements of nasal bone length (NBL) and prenasal thickness (PT) into the second‐trimester anomaly scan and to determine whether the NBL:PT ratio could help in differentiating euploid an ... mehr

Sonographic evaluation of the fetal conus medullaris

ABSTRACT Objective To determine the most reproducible method in the sonographic evaluation of the conus medullaris (CM) and its relationship with gestational age (GA). Methods This is a prospective study of singleton structurally normal fetuses between 20 and 30 gestational week ... mehr

The effect of antidrug antibodies on the sustainable efficacy of biologic therapies in rheumatoid arthritis: practical consequences

Biologic therapies, predominantly TNF-α inhibitors, have revolutionized the treatment of rheumatoid arthritis (RA). However, their clinical utility can be limited by the development of antidrug antibodies (ADAs). Immunogenicity is a complex phenomenon related to various drug, disease, and p ... mehr

The rise of biosimilars: potential benefits and drawbacks in rheumatoid arthritis

Although biologic agents are effective in the treatment of rheumatoid arthritis, the high price of drugs and restricted health care budgets have restricted easy access to biologics. Eventually, the use of biologic disease-modifying antirheumatic drugs might be inversely associated with dise ... mehr

Immunological basis of stem cell therapy in liver diseases

Unbalanced immune cell populations or immune cell infiltration of the liver can disrupt the immune-privileged state of the liver, resulting in liver injury or fibrosis. Therefore, the treatment for liver diseases involves not only hepatic regeneration but also immunological regulation. Rece ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 704 (July 2014). doi:10.1038/labinvest.2014.74 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 596 (June 2014). doi:10.1038/labinvest.2014.67 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 476 (May 2014). doi:10.1038/labinvest.2014.56 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 360 (April 2014). doi:10.1038/labinvest.2014.49 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 250 (March 2014). doi:10.1038/labinvest.2014.9 mehr

Alle Fachpublikationen zu Labortechnik

Quetiapine for acute bipolar depression: a systematic review and meta-analysis

Suttajit S, Srisurapanont M, Maneeton N, Maneeton B mehr

Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state

Jang K, Yoon S, Kim SE, Cho JY, Yoon SH, Lim KS, Yu KS, Jang IJ, Lee H mehr

Assessing the potential impact of non-proprietary drug copies on quality of medicine and treatment in patients with relapsing multiple sclerosis: the experience with fingolimod

Correale J, Chiquete E, Milojevic S, Frider N, Bajusz I mehr

High-Density Lipoproteins in the Prevention of Cardiovascular Disease: Changing the Paradigm

High-Density Lipoproteins in the Prevention of Cardiovascular Disease: Changing the Paradigm Clinical Pharmacology & Therapeutics 96, 48 (July 2014). doi:10.1038/clpt.2014.79 Authors: S Tuteja & D J Rader mehr

A Current Approach to Statin Intolerance

A Current Approach to Statin Intolerance Clinical Pharmacology & Therapeutics 96, 74 (July 2014). doi:10.1038/clpt.2014.84 Authors: R Tompkins, A Schwartzbard, E Gianos, E Fisher & H Weintraub mehr

Alle Fachpublikationen zu Pharma
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