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Aktuelle Fachpublikationen

Quantifying the forces guiding microbial cell adhesion using single-cell force spectroscopy

Nature Protocols 9, 1049 (2014). doi:10.1038/nprot.2014.066 Authors: Audrey Beaussart, Sofiane El-Kirat-Chatel, Ruby May A Sullan, David Alsteens, Philippe Herman, Sylvie Derclaye & Yves F Dufrêne During the past decades, several methods (e.g., electron microscopy, flow c ... mehr

PD.1. Blood pressure maintenance in MO25|[beta]| has no physiological role in electrolyte homeostasis or systemic blood pressure maintenance in the mouse

PD.1. Blood pressure maintenance in MO25β has no physiological role in electrolyte homeostasis or systemic blood pressure maintenance in the mouse Journal of Human Hypertension 28, 342 (May 2014). doi:10.1038/jhh.2013.120 Authors: K Siew, P de los Heros, D R Alessi & K ... mehr

Assessment of the genotoxicity of trichloroethylene in the in vivo micronucleus assay by inhalation exposure

The in vivo genotoxic potential of trichloroethylene (TCE) was evaluated by examining the incidence of micronucleated polychromatic erythrocytes (MN-PCEs) in the bone marrow. Groups of male CD rats were exposed by inhalation to targeted concentrations of 0 (negative control), 50, 500, 2500 ... mehr

FISH in micronucleus test demonstrates aneugenic action of rotenone in a common freshwater fish species, Nile tilapia (Oreochromis niloticus)

Aneuploidies are numerical genetic alterations that lead to changes in the normal number of chromosomes due to abnormal segregation during cell division. This type of alteration can occur spontaneously or as a result of exposure to mutagenic agents. The presence of these agents in the envir ... mehr

Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk

The early detection of colorectal cancer (CRC) can significantly improve the prognosis of affected patients. The loss of genomic stability and the resulting gene alteration play an important role in the molecular pathological steps that occur early in tumorigenesis of CRC. Thus, the identif ... mehr

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Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis

The incidence of inflammatory bowel disease is increasing worldwide and the underlying molecular mechanisms are far from being fully elucidated. Herein, we evaluated the role of N-glycosylation dysregulation in T cells as a key mechanism in the ulcerative colitis (UC) pathogenesis. The eval ... mehr

Dedifferentiation and aberrations of the endolysosomal compartment characterize the early stage of nephropathic cystinosis

Nephropathic cystinosis, a lysosomal storage disease caused by mutations in the CTNS gene encoding the lysosomal cystine transporter cystinosin, is characterized by generalized proximal tubule (PT) dysfunction that progresses, if untreated, to end-stage renal disease. The pathogenesis of de ... mehr

Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions

Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder that can be characterized by the presence of protein inclusions containing mutant huntingtin within a subset of neurons in the brain. Since their discovery, the relevance of inclusions to disease pathology has be ... mehr

Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome

Mitochondrial DNA (mtDNA) depletion syndrome (MDS) is characterized by a reduction in mtDNA copy number and consequent mitochondrial dysfunction in affected tissues. A subgroup of MDS is caused by mutations in genes that disrupt deoxyribonucleotide metabolism, which ultimately leads to limi ... mehr

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome

Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT OMIM 312750). Alternative inclusion of MECP2/Mecp2 exon 1 with exons 3 and 4 encodes MeCP2-e1 or MeCP2-e2 protein isoforms with unique amino termini. While most MECP2 mutations are located in exons 3 and 4 thus affe ... mehr

Alle Fachpublikationen zu Biotechnologie

Does a combination of ultrasound, MRI and biochemical amniotic fluid analysis improves prenatal diagnosis of esophageal atresia?

ABSTRACT Objective Prenatal diagnosis of esophageal atresia (EA) remains a challenge. Our objective was to evaluate the combination of sonography, Magnetic resonance imaging (MRI) and amniotic fluid biochemical markers in prenatal diagnosis of EA. Study design Retrospective stud ... mehr

Early fetal echocardiography: congenital heart disease detection and diagnostic accuracy in the hands of an experienced pediatric cardiology fetal program

ABSTRACT Objective Evaluate the utility of early fetal echocardiography in the hands of an experienced fetal cardiology program for detection of congenital heart disease (CHD) in high‐risk pregnancies. Methods Review of fetal echocardiograms 12‐16 weeks gestation. Results ... mehr

Maternal serum alpha‐fetoprotein levels peak at 19‐21 weeks' gestation and subsequently decline in a NPHS1 sequence variant heterozygote; implications for prenatal diagnosis of ...

What's already known about this topic? MSAFP values peak and then decline in NPHS1 carrier pregnancies while values remain elevated in affected pregnancies. Limited information is currently available on the gestational age range of this peak and decline of MSAFP values for carrier pre ... mehr

Maternal obesity and Down syndrome in the offspring: is there a link?

What's already known about this topic? Obesity has several adverse effects on the fetal and neonatal outcomes Obesity leads to underdetection of fetal sonographic markers of aneuploidies and of fetal anomalies, as well as underperformance of maternal serum screening test for common ... mehr

Dose‐ and time‐response analysis of total fatty acid ethyl esters in meconium as a biomarker of prenatal alcohol exposure

ABSTRACT Objectives Little is known on how the dose and timing of exposure co‐influence the cumulative concentration of fatty acids ethyl esters (FAEEs) in meconium. The objective of the study was to assess the cumulative concentration of FAEEs in meconium as a biomarker of light, mode ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 360 (April 2014). doi:10.1038/labinvest.2014.49 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 250 (March 2014). doi:10.1038/labinvest.2014.9 mehr

Bone and Soft Tissue Pathology

Bone and Soft Tissue Pathology Laboratory Investigation 94, 11 (February 2014). doi:10.1038/labinvest.2014.15 mehr

Infectious Disease Pathology

Infectious Disease Pathology Laboratory Investigation 94, 390 (February 2014). doi:10.1038/labinvest.2014.27 mehr

Hematopathology

Hematopathology Laboratory Investigation 94, 332 (February 2014). doi:10.1038/labinvest.2014.26 mehr

Alle Fachpublikationen zu Labortechnik

Glibenclamide in patients with poorly controlled type 2 diabetes: a 12-week, prospective, single-center, open-label, dose-escalation study

Rambiritch V, Maharaj B, Naidoo P mehr

Analysis of factors affecting rehospitalization of patients with chronic kidney disease after educational hospitalization

Kose E, An T, Kikkawa A, Matsumoto Y, Hayashi H mehr

Is regression through origin useful in external validation of QSAR models?

Publication date: Available online 8 April 2014 Source:European Journal of Pharmaceutical Sciences Author(s): Ali Shayanfar , Shadi Shayanfar The external validation of QSAR models is crucial to ensure their reliability for assessing new chemicals. The most widely used criteria for ... mehr

Effect of Experimental and Sample Factors on Dehydration Kinetics of Mildronate Dihydrate: Mechanism of Dehydration and Determination of Kinetic Parameters

The dehydration kinetics of mildronate dihydrate [3‐(1,1,1‐trimethylhydrazin‐1‐ium‐2‐yl)propionate dihydrate] was analyzed in isothermal and nonisothermal modes. The particle size, sample preparation and storage, sample weight, nitrogen flow rate, relative humidity, and sample history were ... mehr

Protein Aggregation and Particle Formation in Prefilled Glass Syringes

The stability of therapeutic proteins formulated in prefilled syringes (PFS) may be negatively impacted by the exposure of protein molecules to silicone oil–water interfaces and air–water interfaces. In addition, agitation, such as that experienced during transportation, may increase the de ... mehr

Alle Fachpublikationen zu Pharma

PD.1. Blood pressure maintenance in MO25|[beta]| has no physiological role in electrolyte homeostasis or systemic blood pressure maintenance in the mouse

PD.1. Blood pressure maintenance in MO25β has no physiological role in electrolyte homeostasis or systemic blood pressure maintenance in the mouse Journal of Human Hypertension 28, 342 (May 2014). doi:10.1038/jhh.2013.120 Authors: K Siew, P de los Heros, D R Alessi & K ... mehr

Monoclonal antibodies in rheumatoid arthritis: comparative effectiveness of tocilizumab with tumor necrosis factor inhibitors

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation, systemic inflammation, and immunological abnormalities. Because cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 play a major role in the development of RA, thei ... mehr

Explaining the increased health care expenditures associated with gastroesophageal reflux disease among elderly Medicare beneficiaries with chronic obstructive pulmonary diseas ...

Ajmera M, Raval AD, Shen C, Sambamoorthi U mehr

PIK3CA mutations define favorable prognostic biomarkers in operable breast cancer: a systematic review and meta-analysis

Liu YR, Jiang YZ, Zuo WJ, Yu KD, Shao ZM mehr

Hypofractionated helical tomotherapy (75 Gy at 2.5 Gy per fraction) for localized prostate cancer: long-term analysis of gastrointestinal and genitourinary toxicity

Kong M, Hong SE, Chang SG mehr

Alle Fachpublikationen zu Medizin
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