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Aktuelle Fachpublikationen

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

A sea change for virology

Nature Reviews Microbiology 15, 129 (2017). doi:10.1038/nrmicro.2017.13 This issue marks the publication of a Consensus Statement that proposes the integration of viruses that are only characterized by metagenomic data into virus taxonomy. mehr

Consensus statement: Virus taxonomy in the age of metagenomics

Nature Reviews Microbiology 15, 161 (2017). doi:10.1038/nrmicro.2016.177 Authors: Peter Simmonds, Mike J. Adams, Mária Benkő, Mya Breitbart, J. Rodney Brister, Eric B. Carstens, Andrew J. Davison, Eric Delwart, Alexander E. Gorbalenya, Balázs Harrach, Roger Hull, Andrew M.Q ... mehr

A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification [BIOINFORMATICS]

Introns are found in 5' untranslated regions (5'UTRs) for 35% of all human transcripts. These 5'UTR introns are not randomly distributed: Genes that encode secreted, membrane-bound and mitochondrial proteins are less likely to have them. Curiously, transcripts lacking 5'UTR introns tend to ... mehr

Alle Fachpublikationen

A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification [BIOINFORMATICS]

Introns are found in 5' untranslated regions (5'UTRs) for 35% of all human transcripts. These 5'UTR introns are not randomly distributed: Genes that encode secreted, membrane-bound and mitochondrial proteins are less likely to have them. Curiously, transcripts lacking 5'UTR introns tend to ... mehr

Revisiting GNRA and UNCG folds: U-turns versus Z-turns in RNA hairpin loops [LETTER TO THE EDITOR]

When thinking about RNA three-dimensional structures, coming across GNRA and UNCG tetraloops is perceived as a boon since their folds have been extensively described. Nevertheless, analyzing loop conformations within RNA and RNP structures led us to uncover several instances of GNRA and UNC ... mehr

A divalent cation-dependent variant of the glmS ribozyme with stringent Ca2+ selectivity co-opts a preexisting nonspecific metal ion-binding site [ARTICLE]

Ribozymes use divalent cations for structural stabilization, as catalytic cofactors, or both. Because of the prominent role of Ca2+ in intracellular signaling, engineered ribozymes with stringent Ca2+ selectivity would be important in biotechnology. The wild-type glmS ribozyme (glmSWT) requ ... mehr

The eIF3 complex of Trypanosoma brucei: composition conservation does not imply the conservation of structural assembly and subunits function [ARTICLE]

The multisubunit eukaryotic initiation factor 3 (eIF3) plays multiple roles in translation but is poorly understood in trypanosomes. The putative subunits eIF3a and eIF3f of Trypanosoma brucei (TbIF3a and TbIF3f) were overexpressed and purified, and 11 subunits were identified, TbIF3a throu ... mehr

Inhibition of nonsense-mediated RNA decay by ER stress [ARTICLE]

Nonsense-mediated RNA decay (NMD) selectively degrades mutated and aberrantly processed transcripts that contain premature termination codons (PTC). Cellular NMD activity is typically assessed using exogenous PTC-containing reporters. We overcame some inherently problematic aspects of assay ... mehr

Alle Fachpublikationen zu Biotechnologie

Right sided aortic arch in the age of microarray

Abstract Objective For fetuses with a diagnosis of right aortic arch and normal cardiac anatomy we aimed to establish the frequency of chromosomal anomaly diagnosed with SNP microarray analysis, particularly focusing on microduplications or microdeletions which would have gone undetect ... mehr

Elevation of glycosaminoglycans in the amniotic fluid of a fetus with mucopolysaccharidosis VII

Abstract Objective The aim of this study was to quantify GAGs in amniotic fluid (AF) from an MPS VII fetus compared with age‐matched fetuses obtained from normal pregnancies. Method Disaccharides were measured by liquid chromatography tandem mass spectrometry (LC/MS/MS), compare ... mehr

Chorionic villus sampling in the cell‐free DNA aneuploidy screening era: careful selection criteria can maximise the clinical utility of screening and invasive testing

Abstract Objectives To quantify the impact of cell‐free DNA (cfDNA) screening on chorionic villus sampling (CVS) test indications and outcomes in a tertiary maternity service. Methods Retrospective cohort study of all CVS procedures performed for any indication on singleton preg ... mehr

Prenatal diagnosis of congenital cytomegalovirus infection in 115 cases: a 5 years’ single centre experience

Abstract Objective To investigate the diagnostic value of invasive prenatal diagnosis (PD) of congenital CMV infection from amniotic fluid (AF) and fetal blood (FB) Methods Retrospective study on 115 pregnancies with CMV primary infection. A total of 111 AF and 106 FB samples we ... mehr

Issue Information

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Alle Fachpublikationen zu Diagnostik

Selective deletion of adipocytes, but not preadipocytes, by TNF-|[alpha]| through C|[sol]|EBP- and PPAR|[gamma]|-mediated suppression of NF-|[kappa]|B

Selective deletion of adipocytes, but not preadipocytes, by TNF-α through C/EBP- and PPARγ-mediated suppression of NF-κB Laboratory Investigation 97, 228 (February 2017). doi:10.1038/labinvest.2016.124 Authors: Minori Tamai, Tsuyoshi Shimada, Nobuhiko Hiramatsu, Kunihi ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 116 (February 2017). doi:10.1038/labinvest.2016.144 mehr

Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features Laboratory Investigation advance online publication, January 16 2017. doi:10.1038/labinvest.2016.147 Authors: Emily A Merkel & Pedram Gerami mehr

Unexpected UVR and non-UVR mutation burden in some acral and cutaneous melanomas

Unexpected UVR and non-UVR mutation burden in some acral and cutaneous melanomas Laboratory Investigation advance online publication, January 9 2017. doi:10.1038/labinvest.2016.143 Authors: Robert V Rawson, Peter A Johansson, Nicholas K Hayward, Nicola Waddell, Ann-Marie Patch ... mehr

The NF1 gene in tumor syndromes and melanoma

The NF1 gene in tumor syndromes and melanoma Laboratory Investigation advance online publication, January 9 2017. doi:10.1038/labinvest.2016.142 Authors: Maija Kiuru & Klaus J Busam mehr

Alle Fachpublikationen zu Labortechnik

Food effect: The combined effect of media pH and viscosity on the gastrointestinal absorption of ciprofloxacin tablet

Publication date: 1 April 2017 Source:European Journal of Pharmaceutical Sciences, Volume 101 Author(s): Asma Radwan, Abdel Naser Zaid, Nidal Jaradat, Yousef Odeh Background The clinical implications of food-drug interactions may have to be taken seriously into account with or ... mehr

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum al ...

Publication date: 1 April 2017 Source:European Journal of Pharmaceutical Sciences, Volume 101 Author(s): Raghava Choudary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni, Nagasurya Prakash Padala, Rajesh Kumar Boggavarapu, Gopinadh Bhyrapu ... mehr

Insight into stereoselective disposition of enantiomers of a potent antithrombotic agent, S002-333 following administration of the racemic compound to mice

Publication date: 1 April 2017 Source:European Journal of Pharmaceutical Sciences, Volume 101 Author(s): Manisha Bhateria, Ramakrishna Rachumallu, Sahithi Yerrabelli, Anil K. Saxena, Rabi Sankar Bhatta S002-333 [2-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-b-carboxyli ... mehr

Development and characterization of new functionalized polyurethanes for sustained and site-specific drug release in the gastrointestinal tract

Publication date: 30 March 2017 Source:European Journal of Pharmaceutical Sciences, Volume 100 Author(s): María Dolores Campiñez, Elena Benito, Lucía Romero-Azogil, Ángela Aguilar-de-Leyva, María de Gracia García-Martín, Juan Antonio Galbis, Isidoro Caraballo The main ob ... mehr

A rational approach to elucidate human monoamine oxidase molecular selectivity

Publication date: 1 April 2017 Source:European Journal of Pharmaceutical Sciences, Volume 101 Author(s): Giuseppe Felice Mangiatordi, Domenico Alberga, Leonardo Pisani, Domenico Gadaleta, Daniela Trisciuzzi, Roberta Farina, Andrea Carotti, Gianluca Lattanzi, Marco Ca ... mehr

Alle Fachpublikationen zu Pharma

A novel BCMA|[sol]|CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo

A novel BCMA/CD3 bispecific T-cell engager for the treatment of multiple myeloma induces selective lysis in vitro and in vivo Leukemia advance online publication, January 13 2017. doi:10.1038/leu.2016.388 Authors: S Hipp, Y-T Tai, D Blanset, P Deegen, J Wahl, O Thomas, B Ratte ... mehr

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells Leukemia advance online publication, January 3 2017. doi:10.1038/leu.2016.352 Authors: E J Cheadle, G Lipowska-Bhalla, S J Dovedi, E Fagnano, C Klein, J Honeyc ... mehr

Corrigendum: Brain–computer interfaces for communication and rehabilitation

Nature Reviews Neurology. doi:10.1038/nrneurol.2017.23 Author: Ujwal Chaudhary, Niels Birbaumer & Ander Ramos-Murguialday mehr

(Pro)renin receptor (ATP6AP2) depletion arrests As4.1 cells in the G0/G1 phase thereby increasing formation of primary cilia

Abstract The (pro)renin receptor [(P)RR, ATP6AP2] is a multifunctional transmembrane protein that activates local renin–angiotensin systems, but also interacts with Wnt pathways and vacuolar H+‐ATPase (V‐ATPase) during organogenesis. The aim of this study was to characterize the role of ... mehr

Sensitive Quantification of Coixol, a Potent Insulin Secretagogue, in Scoparia dulcis Extract using High Performance Liquid Chromatography combined with Tandem Mass Spectrometr ...

Abstract Diabetes is a major global health problem which requires new studies for its prevention and control. Scoparia dulcis, an herbal product, is widely used for treatment of diabetes. Recent studies demonstrate coixol as a potent and non‐toxic insulin secretagogue from S. dulcis. Thi ... mehr

Alle Fachpublikationen zu Medizin
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