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Aktuelle Fachpublikationen

A Two-Step Binding Mechanism for Self-Binding Peptide Recognition of Target Domains

Self-binding peptides (SBPs) are a novel biomolecular phenomenon spanning between folding and binding, where a short peptide segment within a monomeric protein fulfills biological function by dynamically binding to/unbinding from its target domain in the same monomer. Here, we were able to ... mehr

In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex

Identification of novel molecules that can selectively inhibit the growth of tumor cells, avoiding patient side effects and/or intrinsic or acquired resistance, usually associated to common chemotherapeutic agents, is of utmost importance. Organometallic compounds have gained importance in ... mehr

Identification of protein complexes of microsome in rat adipocyte by native gel coupled with LC-ESI-QTOF

The study of the composition of microsome proteins and microsome protein complexes of adipocyte provides useful information for researchers related to energy metabolism disorders. The native gel approach was employed here for separation and identification of protein complexes. In the presen ... mehr

An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase, reveals novel invariable motifs as potential pharmacological targets.

The rate of Flaviviridae family viruses infections worldwide has increased dramatically in the last few years. In addition, infections caused by arthropod vectors viruses including Hepatitis C, West Nile, Dengue fever, Yellow fever and Japanese encephalitis are emerging throughout the world ... mehr

Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias

Nature Reviews Cardiology. doi:10.1038/nrcardio.2016.11 Author: Laurent Macle & Stanley Nattel mehr

Alle Fachpublikationen

Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

Nature Genetics 48, 221 (2016). doi:10.1038/ng0216-221 Author: Sonia A Melo, Santiago Ropero, Catia Moutinho, Lauri A Aaltonen, Hiroyuki Yamamoto, George A Calin, Simona Rossi, Agustin F Fernandez, Fatima Carneiro, Carla Oliveira, Bibiana Ferreira, Chang-Gong Liu, Alberto V ... mehr

OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome

Oral-facial-digital (OFD) syndromes are rare heterogeneous disorders characterized by the association of abnormalities of the face, the oral cavity and the extremities, some due to mutations in proteins of the transition zone of the primary cilia or the closely associated distal end of cent ... mehr

Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia

Type 2 diabetes mellitus (DM) is an established risk factor for a wide range of vascular diseases, including ischemic stroke (IS). Glycated hemoglobin A1c (HbA1c), a marker for average blood glucose levels over the previous 12 weeks, is used as a measure of glycemic control and also as a di ... mehr

The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome

Rett syndrome is caused by mutations in the X-linked MECP2 gene, which encodes a chromosomal protein that binds to methylated DNA. Mouse models mirror the human disorder and therefore allow investigation of phenotypes at a molecular level. We describe an Mecp2 allelic series representing th ... mehr

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2

The protease HtrA2 has a protective role inside mitochondria, but promotes apoptosis under stress. We previously identified the G399S HtrA2 mutation in Parkinson's disease (PD) patients and reported mitochondrial dysfunction in vitro. Mitochondrial dysfunction is a common feature of PD and ... mehr

Alle Fachpublikationen zu Biotechnologie

Non‐invasive prenatal diagnosis of Duchenne and Becker muscular dystrophies by relative haplotype dosage

Abstract Objective development of an accurate and affordable test for the non‐invasive prenatal diagnosis (NIPD) of Duchenne and Becker muscular dystrophies (DMD/BMD) to implement in clinical practice. Method cell‐free DNA (cfDNA) was extracted from maternal blood and prepared f ... mehr

The importance of determining the limit of detection of non invasive prenatal testing methods

Abstract Objective Several non‐invasive prenatal testing (NIPT) methods, which analyze circulating fetal cell‐free DNA (cfDNA) in maternal plasma, suggest a fetal fraction (FF) ≥4% for a reportable result, with the assumption that fetal aneuploidies may not be detectable at lower FF. T ... mehr

Adverse perinatal outcomes are more frequent in pregnancies with a low fetal fraction result on noninvasive prenatal testing

Abstract Objective To assess risk of an adverse perinatal outcome for women with a low fetal fraction result on noninvasive prenatal testing (NIPT). Study Design A retrospective cohort study whereby women with a low fetal fraction (LFF) result were compared with women who had a ... mehr

Follow‐up of Multiple Aneuploidies and Single Monosomies Detected by Noninvasive Prenatal Testing: Implications for Management and Counseling

Abstract Objective To determine the underlying biological basis for NIPT results of multiple aneuploidies or autosomal monosomies. Methods Retrospective analysis of 113,415 tests to determine the study cohort, consisting of 138 (0.12%) cases reported as a single autosomal monoso ... mehr

Issue Information ‐ JIF

No abstract is available for this article. mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 114 (February 2016). doi:10.1038/labinvest.2015.165 mehr

Canonical Wnt signaling in systemic sclerosis

Canonical Wnt signaling in systemic sclerosis Laboratory Investigation advance online publication, January 11 2016. doi:10.1038/labinvest.2015.154 Authors: Christina Bergmann & Jörg H W Distler mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 2 (January 2016). doi:10.1038/labinvest.2015.146 mehr

Wnt|[sol]||[beta]|-catenin signaling in kidney injury and repair: a double-edged sword

Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword Laboratory Investigation advance online publication, December 21 2015. doi:10.1038/labinvest.2015.153 Authors: Dong Zhou, Roderick J Tan, Haiyan Fu & Youhua Liu mehr

UM206, a selective Frizzled antagonist, attenuates adverse remodeling after myocardial infarction in swine

UM206, a selective Frizzled antagonist, attenuates adverse remodeling after myocardial infarction in swine Laboratory Investigation advance online publication, December 14 2015. doi:10.1038/labinvest.2015.139 Authors: André Uitterdijk, Kevin CM Hermans, Daphne PM de Wijs-Meijl ... mehr

Alle Fachpublikationen zu Labortechnik

Formulation and advantages of furazolidone in liposomal drug delivery systems

Publication date: 10 March 2016 Source:European Journal of Pharmaceutical Sciences, Volume 84 Author(s): Muhammad Irfan Alam, Timothy Paget, Amal Ali Elkordy Furazolidone has proven to have antiprotozoal and antibacterial activity. A number of literature supported its use agains ... mehr

Influence of PVP/VA copolymer composition on drug-polymer solubility

Publication date: Available online 28 January 2016 Source:European Journal of Pharmaceutical Sciences Author(s): Malte Bille Rask, Matthias Manne Knopp, Niels Erik Olesen, René Holm, Thomas Rades In this study, the influence of copolymer composition on drug-polymer solubilit ... mehr

Characterization of sprays for thermo-stabilized pneumatic nebulizer

Publication date: Available online 26 January 2016 Source:European Journal of Pharmaceutical Sciences Author(s): M. Ochowiak, M. Doligalski, L. Broniarz-Press, M. Matuszak, A. Gościniak The research presents the nebulizer spray chamber temperature controller responsible for ... mehr

Controlled transdermal iontophoresis for poly-pharmacotherapy: Simultaneous delivery of granisetron, metoclopramide and dexamethasone sodium phosphate in vitro and in vivo

Publication date: Available online 28 January 2016 Source:European Journal of Pharmaceutical Sciences Author(s): Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, Virginia Merino, Yogeshvar N. Kalia Iontophoresis has been used to deliver small molecules, peptides and protein ... mehr

The cellular internalization of liposome encapsulated protoporphyrin IX by HeLa cells

Publication date: Available online 28 January 2016 Source:European Journal of Pharmaceutical Sciences Author(s): Magdalena Przybylo, Daria Glogocka, Jerzy W. Dobrucki, Kaja Frączkowska, Halina Podbielska, Marta Kopaczynska, Tomasz Borowik, Marek Langner The proper lipi ... mehr

Alle Fachpublikationen zu Pharma

Arrhythmias in 2015: Advances in drug, ablation, and device therapy for cardiac arrhythmias

Nature Reviews Cardiology. doi:10.1038/nrcardio.2016.11 Author: Laurent Macle & Stanley Nattel mehr

Corrigendum: PCOS in 2015: New insights into the genetics of polycystic ovary syndrome

Nature Reviews Endocrinology. doi:10.1038/nrendo.2016.9 Author: Ricardo Azziz mehr

2,3′,4,4′,5-Pentachlorobiphenyl Induces Inflammatory Responses in the Thyroid Through JNK and Aryl Hydrocarbon Receptor-Mediated Pathway

Polychlorinated biphenyls (PCBs) are durable and widely distributed environmental contaminants that can compromise the normal functions of multiple organs and systems; one important mechanism is the induction of inflammatory disorders. In this study, we explored the influences of 2,3',4,4', ... mehr

Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells

Our previously published data show that As+3 in vivo and in vitro, at very low concentrations, inhibits lymphoid, but not myeloid stem cell development in mouse bone marrow. We also showed that the As+3 metabolite, monomethylarsonous acid (MMA+3), was responsible for the observed pre-B cell ... mehr

Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice

The heavy metal lead (Pb) has a deleterious effect on skeletal health. Because bone mass is maintained through a balance of bone formation and resorption, it is important to understand the effect of Pb levels on osteoblastic and osteoclastic activity. Pb exposure is associated with low bone ... mehr

Alle Fachpublikationen zu Medizin
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