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Aktuelle Fachpublikationen

Immune system and cardiovascular disease

Nature Reviews Cardiology 13, 503 (2016). doi:10.1038/nrcardio.2016.127 Author: Irene Fernández-Ruiz Innate and adaptive immune responses have an essential role in the development and progression of many cardiovascular diseases. The concept of atherosclerosis — the primar ... mehr

Population dynamics

Nature Reviews Microbiology 14, 543 (2016). doi:10.1038/nrmicro.2016.123 This Focus issue on bacterial growth, highlights the versatility and adaptability with which bacterial cells respond to their environmental and community context. mehr

Underrepresented Minorities in Science: ACNP Strives to Increase Minority Representation and Inclusion

Underrepresented Minorities in Science: ACNP Strives to Increase Minority Representation and Inclusion Neuropsychopharmacology 41, 2421 (September 2016). doi:10.1038/npp.2016.71 Authors: Carlos A Bolaños-Guzmán & Carlos A Zarate Jr Keywords: mehr

PSA nadir as a predictive factor for biochemical disease-free survival and overall survival following whole-gland salvage HIFU following radiotherapy failure

PSA nadir as a predictive factor for biochemical disease-free survival and overall survival following whole-gland salvage HIFU following radiotherapy failure Prostate Cancer and Prostatic Diseases advance online publication, July 19 2016. doi:10.1038/pcan.2016.23 Authors: T T ... mehr

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies Neuropsychopharmacology 41, 2624 (September 2016). doi:10.1038/npp.2016.78 Authors: Anke Post, Trevor S Smart, Judith Krikke-Workel, Gerard R Dawson, Catherin ... mehr

Alle Fachpublikationen

Hyaluronate–Death Receptor 5 Antibody Conjugates for Targeted Treatment of Liver Metastasis

The liver is the most frequent site of metastasis with a 5-year survival rate of only 20–40%. In this work, hyaluronate (HA)–death receptor 5 antibody (DR5 Ab) conjugate was synthesized as a dual targeting therapeutic agent to treat liver metastasis. Dual targeting was achieved by DR5 Ab, a ... mehr

Characterization of Ferroplasma acidiphilum growing in pure and mixed culture with Leptospirillum ferriphilum

Abstract Biomining is defined as biotechnology for metal recovery from minerals, and is promoted by the concerted effort of a consortium of acidophile prokaryotes, comprised of members of the Bacteria and Archaea domains. Ferroplasma acidiphilum and Leptospirillum ferriphilum are the dom ... mehr

Development of a Rhodobacter capsulatus self‐reporting model system for optimizing light‐dependent, [FeFe]‐hydrogenase‐driven H2 production

Abstract The photosynthetic bacterium Rhodobacter capsulatus normally photoproduces H2 as a by‐product of its nitrogenase‐catalyzed nitrogen‐fixing activity. Such H2 production, however, is expensive from a metabolic perspective, requiring nearly four times as many photons as the equiva ... mehr

Broad‐complex, Tramtrack, and Bric‐à‐brac (BTB) Proteins: Critical Regulators of Development

Abstract Broad‐complex, Tramtrack, and Bric‐à‐brac/poxvirus and zinc finger (BTB/POZ) family proteins are a diverse family of proteins that are characterized by the presence of a common protein‐protein interaction domain, known as the BTB domain. BTB proteins have been identified in poxv ... mehr

Exhaled breath condensate as a source of biomarkers for lung carcinomas. A focus on genetic and epigenetic markers—A mini‐review

Abstract Lung carcinoma is one of the most common causes of cancer‐related mortality worldwide. It is an aggressive tumor, often diagnosed at an advanced stage when treatment options are limited. Currently, the importance of detection and assessment of various genetic alterations in canc ... mehr

Alle Fachpublikationen zu Biotechnologie

Benefits and Limitations of Prenatal Screening for Prader‐Willi Syndrome

Abstract This review the status of genetic laboratory testing in Prader‐Willi syndrome (PWS) due to different genetic subtypes, most often a paternally derived 15q11‐q13 deletion, with benefits and limitations related to prenatal screening. Medical literature was searched for prenatal sc ... mehr

An exploration of the potential utility of fetal cardiovascular MRI as an adjunct to fetal echocardiography

Abstract Objectives Fetal cardiovascular MRI offers a potential alternative to echocardiography, although in practice its use has been limited. We sought to explore the need for additional imaging in a tertiary fetal cardiology unit, and the usefulness of standard MRI sequences. M ... mehr

Diagnostic accuracy of intracranial translucency in detecting spina bifida: a systematic review and meta‐analysis

Abstract Objective To evaluate the diagnostic accuracy of intracranial translucency(IT) in the detection of spina bifida in the first trimester of pregnancy Methods We included study assessing the accuracy of sonographic measurements of IT in a mid‐sagittal view of the fetal fac ... mehr

A genotype‐phenotype correlation study reveals a non‐coding RNA might be associated with cardiovascular anomalies in WHS fetuses

Abstract Wolf‐Hirschhorn syndrome (OMIM#194190) is a rare genetic disease caused by a partial deletion from the short arm of chromosome 4. It consists of a broad range of clinical manifestations, including a characteristic craniofacial appearance, growth retardation, intellectual disabil ... mehr

Associated ultrasonographic findings in fetuses with microcephaly due to suspected Zika virus (ZIKV) infection during pregnancy

Abstract Objective To describe associated fetal ultrasonographic findings and outcome in a series of cases of fetal microcephaly associated with Zika virus infection. Methods Retrospective case series of microcephaly with definite (laboratory evidence) or highly probable (specif ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 818 (August 2016). doi:10.1038/labinvest.2016.79 mehr

Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways

Autofluorescence multiphoton microscopy for visualization of tissue morphology and cellular dynamics in murine and human airways Laboratory Investigation advance online publication, July 11 2016. doi:10.1038/labinvest.2016.69 Authors: Sarah Kretschmer, Mario Pieper, Gereon Hüt ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 706 (July 2016). doi:10.1038/labinvest.2016.67 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 96, 600 (June 2016). doi:10.1038/labinvest.2016.59 mehr

ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease

ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease Laboratory Investigation advance online publication, May 16 2016. doi:10.1038/labinvest.2016.56 Authors: Dimitry A Chistiakov, Alexander N Orekhov & Yuri V Bobryshev mehr

Alle Fachpublikationen zu Labortechnik

Underrepresented Minorities in Science: ACNP Strives to Increase Minority Representation and Inclusion

Underrepresented Minorities in Science: ACNP Strives to Increase Minority Representation and Inclusion Neuropsychopharmacology 41, 2421 (September 2016). doi:10.1038/npp.2016.71 Authors: Carlos A Bolaños-Guzmán & Carlos A Zarate Jr Keywords: mehr

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies Neuropsychopharmacology 41, 2624 (September 2016). doi:10.1038/npp.2016.78 Authors: Anke Post, Trevor S Smart, Judith Krikke-Workel, Gerard R Dawson, Catherin ... mehr

Inhibition of Macrophage Migration Inhibitory Factor (MIF) tautomerase activity suppresses Microglia‐mediated inflmmatory responses

Abstract Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, is a key regulator in both innate and acquired immunity system. MIF has become a promising drug target for inflammatory diseases. Apart from its cytokine activities, MIF is known to act as a D‐ ... mehr

Graphical Abstracts:

This article is currently available as a free download on Ingenta Connect mehr

Synthesis of Methotrexate Loaded Chitosan Nanoparticles and in vitro Evaluation of the Potential in Treatment of Prostate Cancer

Abstract: The objective of the study was to investigate the cytotoxic and apoptotic effects of Methotrexate (MTX)-loaded chitosan (CS) on LNCaP prostate cancer cell line in vitro. For this purpose, CS nanoparticles (NPs) were synthesized through ionic gelation method and MTX was loaded in ... mehr

Alle Fachpublikationen zu Pharma

Immune system and cardiovascular disease

Nature Reviews Cardiology 13, 503 (2016). doi:10.1038/nrcardio.2016.127 Author: Irene Fernández-Ruiz Innate and adaptive immune responses have an essential role in the development and progression of many cardiovascular diseases. The concept of atherosclerosis — the primar ... mehr

PSA nadir as a predictive factor for biochemical disease-free survival and overall survival following whole-gland salvage HIFU following radiotherapy failure

PSA nadir as a predictive factor for biochemical disease-free survival and overall survival following whole-gland salvage HIFU following radiotherapy failure Prostate Cancer and Prostatic Diseases advance online publication, July 19 2016. doi:10.1038/pcan.2016.23 Authors: T T ... mehr

The concordance between the volume hotspot and the grade hotspot: a 3-D reconstructive model using the pathology outputs from the PROMIS trial

The concordance between the volume hotspot and the grade hotspot: a 3-D reconstructive model using the pathology outputs from the PROMIS trial Prostate Cancer and Prostatic Diseases 19, 322 (September 2016). doi:10.1038/pcan.2016.37 Authors: A El-Shater Bosaily, M Vale ... mehr

Prenatal Testosterone Exposure Decreases Colocalization of Insulin Receptors in Kisspeptin/Neurokinin B/Dynorphin (KNDy) and Agouti‐Related Peptide (AgRP) Neurons of the Adult Ewe

Abstract Insulin serves as a link between the metabolic and reproductive systems, communicating energy availability to the hypothalamus and enabling reproductive mechanisms. Adult Suffolk ewes prenatally exposed to testosterone (T) display an array of reproductive and metabolic dysfuncti ... mehr

Modulation of sensitivity to alcohol by cortical and thalamic brain regions

Abstract The nucleus accumbens core (AcbC) is a key brain region known to regulate the discriminative stimulus/interoceptive effects of alcohol. As such, the goal of the present work was to identify AcbC projection regions that may also modulate sensitivity to alcohol. Accordingly, AcbC ... mehr

Alle Fachpublikationen zu Medizin
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