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Aktuelle Fachpublikationen

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as well as the rapid degradation of messenger RNA. The latter ensures that translation closely follows programming at the level of transcription. Re ... mehr

Triple helical DNA in a duplex context and base pair opening

It is fundamental to explore in atomic detail the behavior of DNA triple helices as a means to understand the role they might play in vivo and to better engineer their use in genetic technologies, such as antigene therapy. To this aim we have performed atomistic simulations of a purine-rich ... mehr

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the pre ... mehr

Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency

Mitochondrial promoters of Saccharomyces cerevisiae share a conserved –8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation factor Mtf1. We used 2-aminopurine fluor ... mehr

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorl ... mehr

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ZBTB42 mutation defines a novel lethal congenital contracture syndrome (LCCS6)

Lethal congenital contracture syndrome (LCCS) is a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). LCCS is genetically heterogeneous with mutations in five genes identified to date, all with a role in the innervation or contractile apparatus of skeletal muscles. ... mehr

New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome

Cardio-facio-cutaneous (CFC) syndrome is one of the ‘RASopathies’, a group of phenotypically overlapping syndromes caused by germline mutations that encode components of the RAS–MAPK pathway. Germline mutations in BRAF cause CFC syndrome, which is characterized by heart defects, distinctive ... mehr

Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations

Previous reports have described several associations of PR, QRS, QT and heart rate with genomic variations by genome-wide association studies (GWASs). In the present study, we examined the association of ~2.5 million SNPs from 2994 Japanese healthy volunteers obtained from the JPDSC databas ... mehr

Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability

Mutations in glucokinase (GCK) cause a spectrum of glycemic disorders. Heterozygous loss-of-function mutations cause mild fasting hyperglycemia irrespective of mutation severity due to compensation from the unaffected allele. Conversely, homozygous loss-of-function mutations cause permanent ... mehr

Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies

Disturbances of lipid metabolism have been implicated in psychiatric illnesses. We previously reported an association between the gene for fatty acid binding protein 7 (FABP7) and schizophrenia. Furthermore, we identified and reported several rare non-synonymous polymorphisms of the brain-e ... mehr

Alle Fachpublikationen zu Biotechnologie

Sublingual allergen immunotherapy for respiratory allergies: what is new?

Sublingual immunotherapy (SLIT) is a disease-modifying treatment for respiratory allergies that has been used for many years in Europe and has also recently been approved for use in North America. Its use is thus likely to increase. There is more evidence available regarding SLIT efficacy a ... mehr

Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations

Tacrolimus is a cornerstone of the immunosuppression regimen for prevention of allograft rejection in kidney and liver transplantations, with efficacy proven in many clinical trials. The currently available and extensively used tacrolimus formulations are flawed by large inter- and intra-in ... mehr

The natural history of monoamniotic twin pregnancies: a case series and systematic review of the literature

ABSTRACT Objective To describe the natural history of monoamniotic twin pregnancies in contemporary practice. Method Cohort study of monochorionic monoamniotic twin pregnancies with two live fetuses diagnosed at less than 16 weeks and prospectively followed up between 2004 and 2 ... mehr

Domestic exposure to volatile organic compounds in relation to asthma and allergy in children and adults

Over the past decades, the prevalence of asthma, allergic disease and atopy has increased significantly and in parallel with the increased use of products and materials emitting volatile organic compounds (VOCs) in the indoor environment. The purpose of this review is to examine the evidenc ... mehr

Non‐invasive prenatal diagnostic testing for β‐thalassaemia using cell‐free fetal DNA and next generation sequencing

ABSTRACT Objective To develop an accurate non‐invasive prenatal test using next generation sequencing (NGS) for HbE and the four most common β‐thalassaemia mutations found in South East Asia (namely ‐28A > G, CD17A > T, CD41/42(‐TTCT), and IVS‐II‐654C > T). Methods Cell‐free DNA ... mehr

Alle Fachpublikationen zu Diagnostik

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats

Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats Laboratory Investigation advance online publication, November 10 2014. doi:10.1038/labinvest.2014.134 ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 1186 (November 2014). doi:10.1038/labinvest.2014.127 mehr

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.122 Authors: Kazuyo Yasuda, Toshihiko ... mehr

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration

Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration Laboratory Investigation advance online publication, October 20 2014. doi:10.1038/labinvest.2014.121 Authors: Maki K ... mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 936 (September 2014). doi:10.1038/labinvest.2014.106 mehr

Alle Fachpublikationen zu Labortechnik

Evidence Required to Demonstrate Clinical Utility of Pharmacogenetic Testing: The Debate Continues

Evidence Required to Demonstrate Clinical Utility of Pharmacogenetic Testing: The Debate Continues Clinical Pharmacology & Therapeutics 96, 655 (December 2014). doi:10.1038/clpt.2014.185 Authors: N K Gillis & F Innocenti mehr

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity Clinical Pharmacology & Therapeutics 96, 672 (December 2014). doi:10.1038/clpt.2014.174 Authors: H H Szeto & A V Birk mehr

Pseudocyanides of sanguinarine and chelerythrine and their series of structurally simple analogues as new anticancer lead compounds: Cytotoxic activity, structure–activity rela ...

Publication date: 25 January 2015 Source:European Journal of Pharmaceutical Sciences, Volume 67 Author(s): Fang-Jun Cao , Rui Yang , Chao Lv , Qun Ma , Ming Lei , Hui-Ling Geng , Le Zhou 6-Cyano dihydrosanguinarine (CNS) and 6-cyano dihydrochelerythrine (CNC) are respectively a ... mehr

Thiolated poly(aspartic acid) as potential in situ gelling, ocular mucoadhesive drug delivery system

Publication date: 25 January 2015 Source:European Journal of Pharmaceutical Sciences, Volume 67 Author(s): Gabriella Horvát , Benjámin Gyarmati , Szilvia Berkó , Piroska Szabó-Révész , Barnabás Áron Szilágyi , András Szilágyi , Judit Soós , Giuseppina Sandri , Maria Cristina ... mehr

The efficacy of vortioxetine for the treatment of major depressive disorder

Vortioxetine (Lu AA21004; Brintellix®) has received approval from various international regulatory agencies for the treatment of major depression. The drug molecule has a multimodal mechanism of action that projects it as a unique molecule for the treatment of major depression. These mechan ... mehr

Alle Fachpublikationen zu Pharma

Mycobacterium tuberculosis promotes Th17 expansion via regulation of human dendritic cells toward a high CD14 and low IL-12p70 phenotype that reprograms upon exogenous IFN-{gamma}

The capacity to develop protective immunity against mycobacteria is heterogeneously distributed among human beings, and it is currently unknown why the initial immune response induced against Mycobacterium tuberculosis (Mtb) does not provide proper clearance of this pathogen. Dendritic cell ... mehr

Corrigendum: Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

Nature Neuroscience 17, 1841 (2014). doi:10.1038/nn1214-1841b Author: Boxing Li, Wei Jie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K Friedman, Andrea L Meredith, Ming-Hu Han, Xin-Hong Zhu & Tian-Ming Gao mehr

Responses of macrophages to the danger signals released from necrotic cells

The immune system maintains homeostasis by recognizing and responding to cell death caused by various stresses. The immune response is considered to be elicited by ‘danger signals’ released from necrotic cells. However, the identity of the danger signals remains elusive. In this study, we f ... mehr

The role of phage display in therapeutic antibody discovery

Phage display involves the expression of selected proteins on the surface of filamentous phage through fusion with phage coat protein, with the genetic sequence packaged within, linking phenotype to genotype selection. When combined with antibody libraries, phage display allows for rapid in ... mehr

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation

Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53 also alters these cellular processes with similar results. The effect of IDO on p53 and on glucose metabolism was evaluated in alloreac ... mehr

Alle Fachpublikationen zu Medizin
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