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Aktuelle Fachpublikationen

Insect trehalase: Physiological significance and potential applications

Trehalose, a non-reducing disaccharide, is widespread throughout the biological world. It is the major blood sugar in insects playing a crucial role as an instant source of energy and in dealing with abiotic stresses. The hydrolysis of trehalose is under the enzymatic control of trehalase. ... mehr

Semi-rational approach for converting a GH36 {alpha}-glycosidase into an {alpha}-transglycosidase

A large number of retaining glycosidases catalyze both hydrolysis and transglycosylation reactions. In order to use them as catalysts for oligosaccharide synthesis, the balance between these two competing reactions has to be shifted toward transglycosylation. We previously designed a semi-r ... mehr

Enzymatic properties and subtle differences in the substrate specificity of phylogenetically distinct invertebrate N-glycan processing hexosaminidases

Fused lobes (FDL) hexosaminidases are the most recently genetically defined glycosidases involved in the biosynthesis of N-glycans in invertebrates, and their narrow specificity is essential for the generation of paucimannosidic N-glycans in insects. In this study, we explored the potential ... mehr

Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation

Over the last four decades, increases in the incidence of immune-mediated diseases in the Western world have been linked to changes in microbial exposure. It is becoming increasingly clear that the normal microbiota in the gut can profoundly alter susceptibility to a wide range of diseases, ... mehr

Conserved ion and amino acid transporters identified as phosphorylcholine-modified N-glycoproteins by metabolic labeling with propargylcholine in Caenorhabditis elegans cells

Phosphorylcholine (PC) modification of proteins by pathogens has been implicated in mediating host–pathogen interactions. Parasitic nematodes synthesize PC-modified biomolecules that can modulate the host's antibody and cytokine production to favor nematode survival, contributing to long-te ... mehr

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Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain

Fragile X syndrome, a common cause of intellectual disability and autism, is due to mutational silencing of the FMR1 gene leading to the absence of its gene product, fragile X mental retardation protein (FMRP). FMRP is a selective RNA binding protein owing to two central K-homology domains ... mehr

Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice

Non-coding variation within TCF7L2 remains the strongest genetic determinant of type 2 diabetes risk in humans. A considerable effort has been placed in understanding the functional roles of TCF7L2 in pancreatic beta cells, despite evidence of TCF7L2 expression in various peripheral tissues ... mehr

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown. One hypothesis is that a set of gene products preferentially expressed in the striatum could determine the particular vulnerability of this brain region to mutant huntingtin (mHtt). Here ... mehr

Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans

Fever predicts clinical outcomes in sepsis, trauma and during cardiovascular stress, yet the genetic determinants are poorly understood. We used an integrative genomics approach to identify novel genomic determinants of the febrile response to experimental endotoxemia. We highlight multiple ... mehr

Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina

Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP) are severe hereditary diseases that causes visual impairment in infants and children. SPATA7 has recently been identified as the LCA3 and juvenile RP gene in humans, whose function in the retina remains elusive. Here, w ... mehr

Alle Fachpublikationen zu Biotechnologie

Why increased nuchal translucency is associated with congenital heart disease; a systematic review on genetic mechanisms

Abstract This overview provides insight into the underlying genetic mechanism of the high incidence of cardiac defects in fetuses with increased nuchal translucency (NT). Nuchal edema, the morphological equivalent of increased NT, is likely to result from abnormal lymphatic development a ... mehr

Non‐invasive prenatal diagnosis of achondroplasia and thanatophoric dysplasia: next generation sequencing allows for a safer, more accurate and comprehensive approach

Abstract Objective Accurate prenatal diagnosis of genetic conditions can be challenging and usually requires invasive testing. Here we demonstrate the potential of next generation sequencing (NGS) for the analysis of cell free DNA in maternal blood to transform prenatal diagnosis of mo ... mehr

The accuracy of prenatal ultrasound in determining the type of orofacial cleft

Abstract Objectives The aim of this study was to assess the accuracy of prenatal transabdominal ultrasound in determining the oral cleft type. Methods A retrospective cohort study was performed on all consecutive cases of orofacial cleft diagnosed by prenatal ultrasound examinat ... mehr

Non‐invasive prenatal diagnosis for cystic fibrosis: detection of paternal mutations, exploration of patient preferences and cost analysis

ABSTRACT Objectives To develop non‐invasive prenatal diagnosis (NIPD) for cystic fibrosis (CF) and determine costs and implications for implementation. Methods A next generation sequencing assay was developed to detect 10 common CF mutations for exclusion of the paternal mutatio ... mehr

First trimester screening for other trisomies than trisomy 21, 18 and 13.

Abstract Objective The objective of the study was to evaluate the performance of first trimester combined screening in cases of placental/fetal, mosaic or non‐mosaic, autosomal trisomy other than trisomy 21, 18 or 13, and in cases of aneuploidy for a marker chromosome with focus on bio ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 248 (March 2015). doi:10.1038/labinvest.2015.31 mehr

Application of GFP imaging in cancer

Application of GFP imaging in cancer Laboratory Investigation advance online publication, February 16 2015. doi:10.1038/labinvest.2014.154 Author: Robert M Hoffman mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 122 (February 2015). doi:10.1038/labinvest.2014.164 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 95, 2 (January 2015). doi:10.1038/labinvest.2014.152 mehr

Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract

Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract Laboratory Investigation advance online publication, December 22 2014. doi:10.1038/labinvest.2014.162 Authors: Gail H Leeming, Anja Kipar, D ... mehr

Alle Fachpublikationen zu Labortechnik

Improved oral therapeutic potential of nanoencapsulated cryptdin formulation against Salmonella infection

Publication date: Available online 24 February 2015 Source:European Journal of Pharmaceutical Sciences Author(s): Praveen Rishi , Akanksha Bhogal , Sumeha Arora , Satish K. Pandey , Indu Verma , Indu Pal Kaur An encapsulated system for cryptdin-2 (a Paneth cell antimicrobial pep ... mehr

Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation

Publication date: 25 April 2015 Source:European Journal of Pharmaceutical Sciences, Volume 71 Author(s): Ashish Kumar , Jurgen Vercruysse , Valérie Vanhoorne , Maunu Toiviainen , Pierre-Emmanuel Panouillot , Mikko Juuti , Chris Vervaet , Jean Paul Remon , Krist V. Gernaey , T ... mehr

Distribution profile of gadolinium in gadolinium chelate-treated renally-impaired rats: role of pharmaceutical formulation

Publication date: Available online 28 February 2015 Source:European Journal of Pharmaceutical Sciences Author(s): Nathalie Fretellier , Mariem Salhi , Josef Schroeder , Heiko Siegmund , Thibaut Chevalier , Patrick Bruneval , Gaëlle Jestin-Mayer , Francette Delaloge , Cécile F ... mehr

Multiparametric temporal analysis of the Caco-2/TC7 demonstrated functional and differentiated monolayers as early as 14 days of culture

Publication date: Available online 25 February 2015 Source:European Journal of Pharmaceutical Sciences Author(s): Perrine Zeller , Thibault Bricks , Guillaume Vidal , Sébastien Jacques , Pauline M. Anton , Eric Leclerc Reducing the differentiation period for obtaining an in vitr ... mehr

Orodispersible Drug Formulations for Children and Elderly

Publication date: Available online 28 February 2015 Source:European Journal of Pharmaceutical Sciences Author(s): Marta Slavkova , Jörg Breitkreutz Various orodispersible drug formulations have been recently introduced into the market. Oral lyophilisates and orodispersible granules, ... mehr

Alle Fachpublikationen zu Pharma

Journal Club

Journal Club Kidney International 87, 490 (March 2015). doi:10.1038/ki.2015.24 mehr

The globalization of nephrology

Nature Reviews Nephrology 11, 125 (2015). doi:10.1038/nrneph.2015.11 Author: Susan J. Allison The medical challenges faced by low-to-middle income countries (LMICs) are vast. Their populations are often disproportionately affected by a high burden of disease owing to a va ... mehr

Bone cells, sclerostin, and FGF23: what|[rsquo]|s bred in the bone will come out in the flesh

Bone cells, sclerostin, and FGF23: what’s bred in the bone will come out in the flesh Kidney International 87, 499 (March 2015). doi:10.1038/ki.2014.360 Author: Susan M Ott mehr

Patent watch: US Supreme Court revises patent claim construction standards

Nature Reviews Drug Discovery 14, 157 (2015). doi:10.1038/nrd4564 Author: Kevin Noonan The US Supreme Court handed down another practice-changing decision in its ruling on Teva Pharmaceuticals versus Sandozin January, mandating that the US Federal Circuit must defer to fa ... mehr

Kidney transplant results in children: progress made, but blacks lag behind

Kidney transplant results in children: progress made, but blacks lag behind Kidney International 87, 492 (March 2015). doi:10.1038/ki.2014.366 Authors: Vikas R Dharnidharka & Michael E Seifert mehr

Alle Fachpublikationen zu Medizin
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