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Aktuelle Fachpublikationen

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Escherichia coli endoribonuclease E has a major influence on gene expression. It is essential for the maturation of ribosomal and transfer RNA as well as the rapid degradation of messenger RNA. The latter ensures that translation closely follows programming at the level of transcription. Re ... mehr

Triple helical DNA in a duplex context and base pair opening

It is fundamental to explore in atomic detail the behavior of DNA triple helices as a means to understand the role they might play in vivo and to better engineer their use in genetic technologies, such as antigene therapy. To this aim we have performed atomistic simulations of a purine-rich ... mehr

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP

Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadruplex (GQ) structures, which otherwise result in genomic instability. Bulk biochemical studies have shown that Bloom helicase (BLM) unfolds both intermolecular and intramolecular GQ in the pre ... mehr

Interactions of the yeast mitochondrial RNA polymerase with the +1 and +2 promoter bases dictate transcription initiation efficiency

Mitochondrial promoters of Saccharomyces cerevisiae share a conserved –8 to +1 sequence with +1+2 AA, AG or AT initiation sequence, which dictates the efficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation factor Mtf1. We used 2-aminopurine fluor ... mehr

Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity

Recent studies have shown that basic steric and connectivity constraints encoded at the secondary structure level are key determinants of 3D structure and dynamics in simple two-way RNA junctions. However, the role of these topological constraints in higher order RNA junctions remains poorl ... mehr

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Sequencing pools of individuals [mdash] mining genome-wide polymorphism data without big funding

Nature Reviews Genetics 15, 749 (2014). doi:10.1038/nrg3803 Authors: Christian Schlötterer, Raymond Tobler, Robert Kofler & Viola Nolte The analysis of polymorphism data is becoming increasingly important as a complementary tool to classical genetic analyses. Nevertheless ... mehr

Rejection of tmRNA{middle dot}SmpB after GTP hydrolysis by EF-Tu on ribosomes stalled on intact mRNA [REPORT]

Messenger RNAs lacking a stop codon trap ribosomes at their 3' ends, depleting the pool of ribosomes available for protein synthesis. In bacteria, a remarkable quality control system rescues and recycles stalled ribosomes in a process known as trans-translation. Acting as a tRNA, transfer-m ... mehr

Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation [ARTICLES]

Kaposi's sarcoma–associated herpesvirus (KSHV) is an oncogenic virus, the etiological agent of Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). One of the key viral proteins that contributes to tumorigenesis is vFLIP, a viral homolog of the FLICE inhibitory protein. This KSHV prot ... mehr

Bacterial noncoding Y RNAs are widespread and mimic tRNAs [REPORT]

Many bacteria encode an ortholog of the Ro60 autoantigen, a ring-shaped protein that is bound in animal cells to noncoding RNAs (ncRNAs) called Y RNAs. Studies in Deinococcus radiodurans revealed that Y RNA tethers Ro60 to polynucleotide phosphorylase, specializing this exoribonuclease for ... mehr

NoFold: RNA structure clustering without folding or alignment [BIOINFORMATICS]

Structures that recur across multiple different transcripts, called structure motifs, often perform a similar function—for example, recruiting a specific RNA-binding protein that then regulates translation, splicing, or subcellular localization. Identifying common motifs between coregulated ... mehr

Alle Fachpublikationen zu Biotechnologie

Immunobiology of IL-37: mechanism of action and clinical perspectives

This article provides an overview of the biological function of a recently discovered cytokine, IL-37, formerly referred to as IL-1F7, and its role in chronic inflammation and autoimmune disease. Much has been discovered about IL-37 in the past decade, including its ability to down-regulate ... mehr

Recent trends in the birth prevalence of Down syndrome in China: impact of prenatal diagnosis and subsequent terminations

ABSTRACT Objective To analyze recent trends in Down syndrome (DS) prevalence in China and evaluate the impact of prenatal diagnosis and subsequent terminations. Design Retrospective, surveillance Methods Based on the 1996‐2011 surveillance data for DS from Chinese Birth D ... mehr

A comprehensive review of myelodysplastic syndrome patients with autoimmune diseases

Primary myelodysplastic syndromes (MDS) are heterogeneous clonal hemopoietic disorders clinically presented with a varying degree of peripheral cytopenias and an increased probability of leukemic evolution. A distinct subset of MDS patients manifests overt autoimmune-inflammatory manifestat ... mehr

Update on the current recommendations and outcomes in pregnant women with antiphospholipid syndrome

Pregnancy morbidity is part of the clinical spectrum of the antiphospholipid syndrome (APS), a chronic autoimmune condition serologically characterized by the persistent positivity of antiphospholipid antibodies (aPL). Antiplatelet and anticoagulant agents are the mainstay of the treatment ... mehr

Tests for evaluating non-immediate allergic drug reactions

Non-immediate drug reactions (NIR) are induced by specific immunological mechanisms and involve the recognition of hapten molecules by the immune system, with the participation of dendritic cells and other antigen-presenting cells. This process is followed by an effector response that can i ... mehr

Alle Fachpublikationen zu Diagnostik

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 936 (September 2014). doi:10.1038/labinvest.2014.106 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 820 (August 2014). doi:10.1038/labinvest.2014.88 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 704 (July 2014). doi:10.1038/labinvest.2014.74 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 596 (June 2014). doi:10.1038/labinvest.2014.67 mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 94, 476 (May 2014). doi:10.1038/labinvest.2014.56 mehr

Alle Fachpublikationen zu Labortechnik

Ellagic Acid Inhibits VEGF/VEGFR2, PI3K/Akt and MAPK Signaling Cascades in the Hamster Cheek Pouch Carcinogenesis Model

Abstract: Background: Blocking vascular endothelial growth factor (VEGF) mediated tumor angiogenesis by phytochemicals has emerged as an attractive strategy for cancer prevention and therapy. Methods: We investigated the anti-angiogenic effects of ellagic acid in a hamster model of oral o ... mehr

New Potent and Selective Inhibitor of Pim-1/3 Protein Kinases Sensitizes Human Colon Carcinoma Cells to Doxorubicin

Abstract: The Pim protein kinases (provirus insertion site of Moloney murine leukemia virus) have been identified as important actors involved in tumor cell survival, proliferation, migration and invasion. Therefore, inhibition of Pim activity by low molecular weight compounds is under inv ... mehr

Histone Deacetylase Inhibitors and Colorectal Cancer: what is new?

Abstract: Colorectal cancer is the third most common cancer in humans. Cancer has always been regarded as a disease of genetic defects such as gene mutations and deletions, chromosomal abnormalities, which lead to the loss of function of tumor-suppressor genes and/or gain of function or hy ... mehr

Graphical Abstracts:

This article is currently available as a free download on ingentaconnect mehr

Chalcones Incorporated Pyrazole Ring Inhibit Proliferation, Cell Cycle Progression, Angiogenesis and Induce Apoptosis of MCF7 Cell Line

Abstract: A Series of chalcone derivatives containing pyrazole ring was prepared and their cytotoxicity against different human cell lines, including breast (MCF-7), colon (HCT-116) liver (HEPG2) cell lines, as well as normal melanocyte HFB4 was evaluated. Two of these chalcone derivatives ... mehr

Alle Fachpublikationen zu Pharma

Cells to Surgery Quiz: November 2014

Cells to Surgery Quiz: November 2014 Journal of Investigative Dermatology 134, e7 (November 2014). doi:10.1038/jid.2014.395 Authors: Mohammad-Ali Yazdani Abyaneh, Robert D Griffith, Leyre Falto-Aizpurua & Keyvan Nouri mehr

BJD Editor's Choice

BJD Editor's Choice Journal of Investigative Dermatology 134, 2667 (November 2014). doi:10.1038/jid.2014.391 mehr

JID VisualDx Quiz: November 2014

JID VisualDx Quiz: November 2014 Journal of Investigative Dermatology 134, e22 (November 2014). doi:10.1038/jid.2014.394 Authors: Jose E Ollague & Robert S Kirsner mehr

Identifying the Stem Cell

Identifying the Stem Cell Journal of Investigative Dermatology 134, e26 (November 2014). doi:10.1038/jid.2014.393 Authors: Krisztian Nemeth & Sarolta Karpati mehr

NF-{kappa}B RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation

Bone remodeling and hematopoiesis are interrelated and bone marrow (BM) macrophages are considered to be important for both bone remodeling and maintenance of the hematopoietic niche. We found that NF-B Rela-deficient chimeric mice, generated by transplanting Rela –/– fetal liver cells int ... mehr

Alle Fachpublikationen zu Medizin
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