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| Article 1 - 4 of 4 of the company SIRS-Lab GmbH |
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Pathogen detection with VYOO(TM)
Sepsis is the most common cause of death in hospitalized patients worldwide. Inadequate antibiotic therapy represents an independent determinant of patients' mortality. Promptness of pathogen detection and the appliance of appropriate antibiotics are the cornerstones of management of severe bacterial infections. Furthermore, resistance to antibiotics is an increasing public health problem that can be attributed largely to their overuse. Thus, rapid diagnostic tests with both superior positive and negative predictive values over current techniques are sorely needed....
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Molecular diagnostic test applied to ascitic fluid
Spontaneous bacterial peritonitis (SBP) is a common and life-threatening complication of patients with ascites and cirrhosis of the liver. The mortality accounts for up to 30-50% and such patients die within several hours after infection. An early diagnosis and subsequent antibiotic therapy are prerequisites for the survival of the patients. The clinical standard for a diagnosis of SBP is the increased number of polymorphic neutrophilic cells in the ascites (> 250/l), independent of the results obtained with ascites cultures. An increased cell count is not detectable in all patients. Positive ascites cultures are typically found in 40-90% of all SBP cases....
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LOOXSTERŽ concentrates bacterial DNA
LOOXSTERŽ increases the probability of a positive pathogen detection
Detection of the bacterial content of a specific sample, irrelevant from its source, is not as straightforward as it seems. In clinical microbiology laboratories, the gold standard method for the detection of pathogens in patients suspected of systemic infections is the blood culture. However, this technique is known to have many drawbacks especially with regard to patient's antibiotics treatment, low abundance and non-cultivable organisms. Moreover, it takes usually 3 to 5 days to obtain a result from blood culture which is too late to initiate proper antibiotic therapy. Amplification-based methods such as PCR allow results in a more rapid fashion. However, their sensitivity, to date, are no better, and sometimes worse, than culture-based methods....
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LooxsterŽ - Enrichment and isolation of bacterial DNA using PureproveŽ Technology
Sample preparation for pathogen detection
Detection of the bacterial content of a specific sample, irrelevant from its source (i.e. Clinical, Food or Environmental), is not as straightforward as it seems. In clinical microbiology laboratories, the gold standard method for the detection of pathogens in patients suspected of systemic infections is the blood culture. However, this technique is known to have many drawbacks especially with regard to non-cultivable organisms, low abundance (longer lag phase) and patient's antibiotics treatment....
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Additional information
 SIRS-Lab GmbH
Jena, Germany
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