Characterization of micelles and liposomes using the Eclipse 3+ AF4 separation system coupled to a DAWN HELEOS II MALS detector Micelles and liposomes can serve as vehicles used to solubilize and carry bioactive compounds to their site of action, thus increasing their bioavailability. First experience has been made using vitamins and enzymes as functional food additives. Moreover, micelles could be useful to deliver drugs to a defined site of action, thus reducing frequently occurring side effects of systemic drug administration. Micelles are true nano-materials with a size range of 10 to 30 nm in diameter. Ideally, they should have a narrow size distribution. Furthermore, they have to be stable and should release their active compound only in the target region. Characterization of the micelle suspensions is vital to guarantee these properties and has to cover several aspects. One important point is size distribution, which has to be determined with high resolution...
Dynamic Light Scattering - an Important Tool for Protein Crystallography and Nanotechnology Dynamic Light Scattering (DLS) is an established technique in the field of protein crystallography. DLS is used to measure hydrodynamic sizes, polydispersities and aggregation effects of protein samples. These are important parameters for the crystallisation of proteins. DLS is also used in the nanotechnology research for the accurate and fast size measurement of nanoparticles made of different materials....
On-line particle analysis in wet processes Fully automated particle size measurement technology integrated with existing plant control platforms for ease of use has the potential to deliver numerous benefits. At plants where a switch to on-line analysis has been made it is frequently easier or possible to:...
Measurement of Nano particles and Proteins Colloid emulsions in their native environment require particle size determination in high concentration since there are concerns about changes in sample morphology upon dilution eg break up of aggregates. For proteins and other samples with very low concentration and for weakly scattering samples high sensitivity is required. New technologies offer both....
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