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Quality control of colorimetrically stained gels and blots
Comparison of 2 methods
In the pharmaceutical and food industry, using a scanner-based system is more recommended than using a camera-based system for the acquisition, documentation and analysis of colorimetrically stained gels, blots and TLC samples. The combination of a scanner with a suitable control and analysis software is decisively for completely meeting GxP guidelines...
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Characterization of micelles and liposomes using the Eclipse 3+ AF4 separation system coupled to a DAWN HELEOS II MALS detector
Micelles and liposomes can serve as vehicles used to solubilize and carry bioactive compounds to their site of action, thus increasing their bioavailability. First experience has been made using vitamins and enzymes as functional food additives. Moreover, micelles could be useful to deliver drugs to a defined site of action, thus reducing frequently occurring side effects of systemic drug administration. Micelles are true nano-materials with a size range of 10 to 30 nm in diameter. Ideally, they should have a narrow size distribution. Furthermore, they have to be stable and should release their active compound only in the target region. Characterization of the micelle suspensions is vital to guarantee these properties and has to cover several aspects. One important point is size distribution, which has to be determined with high resolution...
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Enzyme Kinetic Measurements for a Combinatorial Library of Inhibitors of Pseudomonas Elastase
Pseudomonas elastase (LasB) is a key drug target in various chronic and intractable infections. A library of 160 potential, in-house synthesised, elastase inhibitors were screened using a fluorescence assay with the internally quenched substrate Abz-Ala-Gly-Leu-Ala-Nba. Enzymatic kinetic measurements were done on a FLUOstar OPTIMA and Km and Vmax values were calculated for each inhibitor using the MARS Data Analysis software...
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New Silicone Technologies for Skin Care
In today's competitive skin care market, consumers look for a range of benefits, superior aesthetics and cost effectiveness. In response, formulators strive to create products that are multifunctional, easy to use and effective in small quantities. At the same time, the most successful products deliver benefits that stand out from those of the competition. Creams, lotions and color cosmetics must be easy to spread and comfortable to wear, without feeling tacky or greasy. Silicones have been popular ingredients in skin care products for more than fifty years. These versatile materials are known for their emolliency, wetting and spreading characteristics and ability to provide unique aesthetics. As technology continues to evolve, silicones increasingly offer multifunctional, high performance properties. This article reviews some of the newest silicone technologies available for the formulation of innovative skin care products...
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Burn injuries under freezing (labor protection) conditions?
Optimal protection when handling cryogenic liquefied gases
"A little splash of liquid nitrogen hasn't hurt anybody" - this happens to be a widespread opinion in many laboratories. The real dangers connected to cryogenic gases many people had to learn firsthand, unexpected and painful. Skin irritation, cell and tissue damage or severe burn injuries may occur, depending on the type of contact and exposure time. There are less possibilities of medical treatment than for injuries caused by influence of heat...
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