Bikunin is a Kunitz-type protease inhibitor synthesized in the liver. The gene resides in the lipocalin cluster and encodes alpha-1-microglobulin together with a Kunitz-type proteinase inhibitor, bikunin. The gene is translated into the alpha-1-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. Bikunin exhibits anti-inflammatory activity in protection against cancer and inflammation. Immunogen: Rat bikunin